Abstract: The present invention relates to antibodies having specificity to nectin-4 and uses thereof.

Abstract: A spin coating device includes a base plate, a spin chuck on which a substrate material is placed, and an actuator mechanism to engage the base plate with the spin chuck such that the base plate synchronously spins along with the spin chuck. The substrate material includes a top surface coated with a film-forming substance and a bottom surface. The cleaning mechanism is below the base plate and out of optimal exposure to the bottom surface and edges of the substrate material in a state of base plate engagement. In response to disengagement of a lid configured to synchronously co-rotate with the base plate, the actuator mechanism is further configured to disengage the base plate from the spin chuck and to enable the optimal exposure of the cleaning mechanism to the bottom surface and the edges of the substrate material.

Abstract: Disclosed is a topical composition comprising: (i) a first extract comprising botanical actives extracted from Rubia cordifolia; and, (ii) a second extract comprising volatile botanical actives extracted from Camellia sinensis, wherein said second extract comprises E-2-hexenal and linalool at ratio of 0.1:1 to 10:1 parts by weight. The cosmetic composition is useful for upregulation of at N a marker associated with differentiation of keratinocytes to provide epidermal skin barrier benefits.

Abstract: A method and system for selecting a treatment for a subject based on a value for the interstitial space volume of the subject utilizes plurality of sample data values representing concentrations of small and large markers in plurality of blood samples over time. The sample concentrations are utilized to predict a hypothetical peak concentration of the small marker prior to the dissipation of the markers during the test period. This hypothetical peak concentration and other sample values are utilized with either a bi-exponential or tri-exponential decay curve fitting algorithm to define a decay curve, the curve characteristics of which are then utilized to calculate values for glomerular filtration rate, a leakage rate of the small marker into interstitial space, and finally a value for the interstitial volume. The determined value for the interstitial volume can then be compared with number thresholds and decisions made for recommended therapy for the subject, if desired.

Abstract: Compounds of formula (I) that are capable of acting as purine receptor antagonists, pharmaceutical compositions including the compounds, and methods of making the compounds, are. disclosed. The compounds and compositions can be used in treating or preventing disorders related to purine receptor hyperfunctioning.

Abstract: A support for washing machine with automatic leveling function comprises a sheath; a regulating mechanism arranged inside the sheath in an axial movable manner, whose circumferential rotation is limited by the sheath; and a flexible body inside the regulating mechanism for accommodating a hydraulic medium. The flexible body comprises a telescopic end which acts on the regulating mechanism, the telescopic end expands and contracts under an action of the hydraulic medium and drives the regulating mechanism to move axially for automatic leveling. Based on the hydraulic principle, the support can perform adaptive regulation automatically by means of the fluidity of the hydraulic medium of different pressures. Moreover, the structures of the regulating mechanism and the sheath are designed to avoid that the automatic leveling for washing machine is influenced by the regulating mechanism's rotation in inside the sheath. Thus, the automatic leveling effect is ensured.

Abstract: Systems, devices and methods for monitoring and managing parts, enterprise resources and other assets, and alleviating risks, in a complex collaboration environment are provided. A device with a hardware- and software-based control system scans and/or writes unique asset-related information within a plurality of chemical, electromagnetic, or written data-bearing tags within, on or throughout an asset for use in a manufacturing, maintenance and/or tracking process. A system records that asset-specific information (e.g., using secure network(s) and/or a blockchain), providing it for later access and modification by a number of trusted users, to track and control manufacturing-, maintenance-relevant or other factors. An enterprise resource planning system both outputs information to, and receives information from, the control system, reconciling changes in the data.

Abstract: A personal monitoring system for musicians playing in a group situation, wherein each musician is allowed to change his or her own personal mix audio signals coming from the other musicians and the sound of his or her own instrument. Each musician has a personal mixer which can receive audio signals wirelessly from the remaining musicians in the group. The mixer also has a wired input for receiving the audio signal from the musician's own musical instrument. The mixer may also be configured to receive mix control commands from a mobile wireless controller device operated by the musician.

Abstract: The present invention relate to liquid cleansing compositions comprising 12-HSA which are both processable and stable. Applicants have defined a specific composition window (defined by specific types and ratios of fatty acid and/or fatty acid soaps, as well as critical ceiling for 12-HSA and floor levels of polyol) where these objectives can be met.

Abstract: Freeze dried active compositions are described. The compositions comprise less than 6.5% by weight water and they may be hydrated or added to end use compositions in order to yield compositions for delivering superior topical benefits to consumers.

Abstract: Disclosed embodiments include apparatuses, systems, and methods for providing a sheath tip with a solid end surface configured to be pierceable by an instrument, where the solid end surface is configured to distribute force of impact with a tissue surface across the solid end surface. In an illustrative embodiment, an apparatus includes a closed sheath tip has a solid end surface configured to be pierceable by an instrument. The closed sheath tip is configured to be disposed at a distal end of a sheath defining therein a lumen configured to convey the instrument therethrough. When the closed sheath tip is presented at a tissue surface, the solid end surface of the closed sheath tip is configured to distribute force of impact with the tissue surface across the solid end surface and to permit the instrument to pierce the solid end surface and extend therethrough toward the tissue surface.

Abstract: A method may include accessing an artery in communication with an ophthalmic artery of a subject, and advancing a microcatheter along the accessed artery so as to align a distal end of the microcatheter with an ostium of the ophthalmic artery, wherein the microcatheter includes a lumen having a guidewire positioned therein. In addition, the method includes proximally withdrawing the guidewire relative to the microcatheter so as to enable a distal portion of the microcatheter to assume a curved relaxed configuration, and cannulating the ostium with the distal portion of the microcatheter when the distal portion is in the curved relaxed configuration.

Abstract: A snap-acting hinge with damped closure and opening angle of more than 90°, comprising a first articulated quadrilateral and a second articulated quadrilateral, which have a first lever and a second lever in common and are provided with respective base elements constituted by a plate for coupling to a fixed element and by a plate for fixing to a movable element, the hinge being movable between an open configuration and a closed configuration; the hinge further comprises first elastic elements for holding the open configuration which are associated with the first quadrilateral, second elastic elements for holding the closed configuration which are associated with the second quadrilateral and a damper that acts in the transition from the open configuration to the closed configuration and which is interposed between the first lever and the fixing plate.

Abstract: A craps gaming system is directed to a craps table including a dice area and one or more sensors configured to sense when dice are added to the dice area and when dice are removed from the dice area. A plurality of player consoles located in close proximity to the craps table are connected over a network to the one or more sensors. Each player console is configured to enable players to place bets on a craps game played on the craps table. Each player console is configured to disable the player console from accepting further bets on the craps game when a signal is received from the one or more sensors indicating that dice have been removed from the dice area.

Abstract: The present invention provides an infrared pixel structure and a hybrid imaging device which use comb-shaped top plates and bottom plates to form capacitors. The upper electrode has a non-fixed end such that the infrared sensitive element in the upper electrode generates thermal stress and deforms when absorbing the infrared light, which changes the capacitance of the capacitors formed by the top plates and the bottom plates to achieve infrared detection and increase the device sensitivity. Furthermore, the infrared pixel structure can be used in an infrared light and visible light hybrid imaging device to achieve visible light imaging and infrared imaging in a same silicon substrate, so as to increase the imaging quality.

Abstract: The present disclosure provides a composition consisting of ceftriaxone sodium and sulbactam sodium, a pharmaceutical formulation comprising the same and the application thereof. The composition is characterized by having an X-ray powder diffraction pattern with peaks at specific angles. The pharmaceutical formulation according to the present disclosure have better antibacterial activity and stability compared with known compositions, and are thus very suitable for the treatment of bacterial infections, especially for the treatment of refractory urogenital system infections caused by Neisseria gonorrhoeae which has drug-resistance to a variety of antibiotics (?-lactams, tetracyclines, macrolides, fluoroquinolones and aminoglycosides).

Abstract: The present invention relates to a complex comprising at least one lanthanide (Ln) and at least one compound (C) comprising a unit of formula (I) below: said unit of formula (I) being covalently connected to at least one antenna which absorbs at a wavelength ranging from 500 nm to 900 nm.

Abstract: A computational method via a hybrid processor comprising an analog processor and a digital processor includes determining a first classical spin configuration via the digital processor, determining preparatory biases toward the first classical spin configuration, programming an Ising problem and the preparatory biases in the analog processor via the digital processor, evolving the analog processor in a first direction, latching the state of the analog processor for a first dwell time, programming the analog processor to remove the preparatory biases via the digital processor, determining a tunneling energy via the digital processor, determining a second dwell time via the digital processor, evolving the analog processor in a second direction until the analog processor reaches the tunneling energy, and evolving the analog processor in the first direction until the analog processor reaches a second classical spin configuration.

Abstract: A container for liquids comprising a first portion forming an approximate half container portion; a second portion forming an approximate half container portion, the first and second portions having a generally convex exterior shape with flange portions along perimeters thereof; a liquid impermeable barrier film being disposed on a concave interior portion of each of the first and second portions and extending onto the flange portions; the first and second portions being sealed together at the flange portions to form a liquid impermeable container; and there being provided a location on the container for the disposition of a closure device to allow contents of the container, once filled, to be removed.