Abstract: In one aspect, the invention relates to a compound of the structure: or a pharmaceutically acceptable salt thereof, and a crystalline form of this compound, having neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising this compound; methods of using this compound; and processes for preparing this compound.

Abstract: Linker toxins and antibody-drug conjugates that bind to human oncology antigen targets such as folate receptor alpha and/or provide anti-tubulin drug activity are disclosed. The linker toxins and antibody-drug conjugates comprise an eribulin drug moiety and can be internalized into target antigen-expressing cells. The disclosure further relates to methods and compositions for use in the treatment of cancer by administering the antibody-drug conjugates provided herein.

Abstract: The invention provides compounds of formula (I): which contain a 4-membered heterocyclic amide, where the variables are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are useful as JAK kinase inhibitors. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat respiratory diseases, and processes and intermediates useful for preparing such compounds.

Abstract: Systems and methods for employing macroscopic resonant tunneling operations in quantum processors are described. New modes of use for quantum processor architectures employ probe qubits to determine energy eigenvalues of a problem Hamiltonian through macroscopic resonant tunneling operations. A dedicated probe qubit design that may be added to quantum processor architectures is also described. The dedicated probe qubit enables improved performance of macroscopic resonant tunneling operations and, consequently, improved performance of the new modes of use described.

Abstract: Techniques for improving the performance of a quantum processor are described. Some techniques employ reducing intrinsic/control errors by using quantum processor-wide problems specifically crafted to reveal errors so that corrections may be applied. Corrections may be applied to physical qubits, logical qubits, and couplers so that problems may be solved using quantum processors with greater accuracy.

Abstract: A method of forming an integral manifold adjacent a cell stack of a flowing electrolyte battery enables improved bonding of a molten material to the battery cell stack. The method includes defining a mould cavity adjacent the cell stack, with the mould cavity open to capillary openings of half cells of the cell stack; locating a plurality of pins in the mould cavity, with end regions of the pins being contiguous with the capillary openings; preheating the mould cavity by passing a fluid into a first end of the mould cavity and out of a second end of the mould cavity; and filling the mould cavity with molten material.

Abstract: The invention relates to methods of treating ocular diseases and certain respiratory diseases using the compound 5-ethyl-2-fluoro-4-(3-(5-(1-methylpiperidin-4-yl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridin-2-yl)-1H-indazol-6-yl)phenol or a pharmaceutically-acceptable salt thereof.

Abstract: A lubricating layer having wear resistance and reliability on the wear resistance, and a compressor including a lubricating layer are provided. The compressor may include a lubricating layer coated on a frictional portion between a rotational shaft and a bearing. The lubricating layer may include at least one metal phase selected from a group consisting of Titanium (Ti); and Copper (Cu), Cobalt (Co), Nickel (Ni), and Zirconium (Zr), and may be a composite structure of amorphous and nanocrystalline materials.

Abstract: A vehicle seat having a pivoting function about a vertical axis (Z1). The seat includes a base configured for connection to the floor (PL) of the vehicle via longitudinal rails, a support frame mounted so as to rotate on the base by means of a pivot joint (JP) of axis Z1 and three curved slide connections (G1,G2,G3), a seating portion frame connected to the support frame directly or via a raising mechanism, and a motorization device interposed between the base and the support frame and configured to cause rotational movement of the support frame relative to the base. The axis Z1 of the pivot joint is eccentric with respect to a central area of the seating portion frame.

Abstract: In one aspect, the invention relates to compounds having the formula: where R1-R6, a, b, and X are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and processes and intermediates for preparing such compounds.

Abstract: The invention relates to a method of preparing a meat analogue, said method comprising the steps of: providing proteinaceous fibres comprising, by weight of the proteinaceous fibres, 40-80 wt. % of water and 5-50 wt. % protein selected from dairy protein, egg protein, plant protein, fungal protein and combinations thereof; providing an aqueous gelling composition, comprising by weight of the gelling composition: i. 0.01-2 wt. % xanthan gum; ii. 0.01-2 wt. % galactomannan; iii. at least 80 wt. % water; combining 100 parts by weight of the proteinaceous fibres with 2-50 parts by weight of the aqueous gelling composition. The invention further relates to a meat analogue comprising an aqueous gelling composition and to the use of the aqueous gelling composition for enhancing juiciness in meat analogues.

Abstract: A detection system (1) intended to equip a motor vehicle comprises at least one optical sensor (2) delimited by at least one curved optical surface (20). It also comprises at least one cleaning device (3) for cleaning the optical surface (20) that comprises a delivery ramp (4) for delivering at least one cleaning and/or drying fluid. According to the invention, the delivery ramp (4) has a curved shape, the curvature (C?) of which is substantially equal to the curvature (C) of at least a portion (201, 202) of the optical surface (20).

Abstract: Disclosed is a container suitable for containing a frozen confection. The container comprises a receptacle comprising a product outlet through which the frozen confection can be dispensed and wherein the outlet is closed by a self-closing valve. Inside of the receptacle is a flexible bag for containing the frozen confection. The container also comprises a propellant inlet through which pressurized gas can be introduced to a region inside the receptacle and outside of the bag to urge the frozen confection towards the product outlet. The self-closing valve is a slit valve made from a resilient material having a Shore hardness of greater than 30 but less than 50 as determined on the A scale.

Abstract: The present invention discloses an method for mm-wave radar sensor to be deployed in the vehicles for parking sensor, as well as in industrial environments, robotics environments and other environments for addressing distance calculations from 0 cm to above 10 m. The key system relevant components of the proposed systems are: utilization of mm-wave integrated radar SOC, supporting Frequency modulated Continues Wave (FMCW) radar operation principle and continues wave (CW) radar operations, with additional analog functionality being integrated on SOC, planar antenna structure, and specific method of operation of switching from FMCW operation mode to the CW operation mode. Preferably, the system, being integrated as HW module with SW components is using non licensed 60 GHz or 77-79 GHz frequency band with integrated RF radar SOC with PLL, with physical size less than 2×2×0.5 cm, and it is used for moving and parking assistance, being integrated as invisible in the vehicle body.

Abstract: Apparatus and methods are described for use with a digital microscope unit that includes a digital microscope. A biological cell sample disposed within a sample carrier, is received into the digital microscope unit. For at least one imaging field of the biological cell sample, it is determined that, within the imaging field, there is a variation in the focal depth of the biological sample with respect to the microscope. At least one image of the imaging field is captured. A characteristic of the biological sample is determined by analyzing the captured image of the imaging field, the analyzing including, in response to determining that there is a variation in the focal depth of the biological sample with respect to the microscope, accounting for the variation in the focal depth of the biological sample with respect to the microscope. Other applications are also described.

Abstract: The invention relates to an assembly (200) for connecting a windscreen wiper drive arm to a vehicle drive shaft, the connection assembly (200) comprising at least one fixing device (220) configured to rotatably connect the drive arm to the drive shaft and at least one cover (210) mounted pivotably on the fixing device (220) by means of a pivoting connection (600), the cover (210) being configured to adopt a closed position in which it prohibits access to a fixing zone (300) between the fixing device (220) and the drive shaft or an open position in which it permits access to the fixing zone (300) between the fixing device (220) and the drive shaft, this pivoting connection (600) comprising at least one bore and at least one trunnion received in the bore, characterized in that the connection assembly (200) comprises at least one device for locking the open position of the cover (210), this locking device being arranged on the inner perimeter of the bore and on the outer perimeter of the trunnion.

Abstract: A foot for household appliance and a household appliance are provided. The foot includes: a hydraulic plate; a sheath, fixedly connected with the hydraulic plate; an adjustable foot, arranged in the sheath and capable of axially moving relative to the sheath, an accommodating chamber is formed by the hydraulic plate, the sheath and the adjustable foot; a hydraulic medium, arranged in the accommodating chamber, and the hydraulic medium is compressed or expanded depending on pressure changes to drive the adjustable foot to move axially in the sheath for leveling. At least two feet are communicated with each other to allow the hydraulic medium to flow between the feet. A liquid flowing passage for allowing the hydraulic medium to flow is arranged in the hydraulic plate. A control device for controlling the liquid flowing passage to open or close is arranged on at least one of the feet.

Abstract: A bitstream converter for converting a 1-bit pulse density modulated (PDM) bitstream signal into an analog audio signal, the bitstream converter comprising: a processor configured to process the 1-bit PDM bitstream signal using a return to zero clock having a frequency higher than a sampling frequency of the 1-bit PDM bitstream signal to output a corresponding 1-bit return to zero signal, wherein the processor is configured to process the 1-bit PDM signal to ensure a portion of each bit of the 1-bit PDM bitstream signal is zero for a duration which is based on the frequency of the return to zero clock; and signal processing means configured to extract the analog audio signal from the 1-bit return to zero signal by filtering the 1-bit return to zero signal.

Abstract: Continuing a sequence of lensless light-field imaging camera patents beginning 1999, the present invention adds light-use efficiency, predictive-model design, distance-parameterized interpolation, computational efficiency, arbitrary shaped surface-of-focus, angular diversity/redundancy, distributed image sensing, plasmon surface propagation, and other fundamentally enabling features. Embodiments can be fabricated entirely by printing, transparent/semi-transparent, layered, of arbitrary size/curvature, flexible/bendable, emit light, focus and self-illuminate at zero-separation distance between (planar or curved) sensing and observed surfaces, robust against damage/occultation, implement color sensing without use of filters or diffraction, overlay on provided surfaces, provided color and enhanced multi-wavelength color sensing, wavelength-selective imaging of near-infrared/near-ultraviolet, and comprise many other fundamentally enabling features.