Abstract: A class D amplifier receives and amplifies a differential analog signal which is then differentially integrated. Two pulse width modulators generate pulse signals corresponding to the differentially integrated analog signal and two power units generate output pulse signals. The outputs the power units are coupled to input terminals of integrators via a resistor feedback network. An analog output unit converts the pulse signals to an output analog signal. The differential integration circuitry implements a soft transition between mute/un-mute. In mute, the integrator output is fixed. During the soft transition, the PWM outputs change slowly from a fixed 50% duty cycle to a final value to ensure that no pop noise is present in the output as a result of mode change.

Abstract: A body protector includes a plurality of outer left and right front side pad members with a flexible break being formed between adjacent outer left and right front side pad members. A plurality of inner left and right front side pad members is disposed behind said plurality of outer left and right front side pad members for overlapping the respective flexible breaks formed in the plurality of outer left and right front side pad members. A plurality of outer left and right rear side pad members is provided with a flexible break being formed between adjacent outer left and right rear side pad members and a plurality of inner left and right rear side pad members is disposed behind said plurality of outer left rear side pad members for overlapping the respective flexible breaks formed in the plurality of outer left and right rear side pad members.

Abstract: The invention provides compounds of formula (I): wherein X is and the variables are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are useful as JAK kinase inhibitors. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat respiratory diseases, and processes and intermediates useful for preparing such compounds.

Abstract: Provided is a novel double-stranded ribonucleic acid for suppressing expression of complement C5. A double-stranded ribonucleic acid comprising a combination of sense strand and antisense strand, wherein the combination of the sense strand and antisense strand are selected from the group consisting of combinations: SEQ ID NO: 13/14, SEQ ID NO: 159/160, SEQ ID NO: 115/116, SEQ ID NO: 117/118, SEQ ID NO: 119/120, SEQ ID NO: 121/122, SEQ ID NO: 123/124, SEQ ID NO: 125/126, SEQ ID NO: 127/128, SEQ ID NO: 129/130, SEQ ID NO: 131/132, SEQ ID NO: 133/134, SEQ ID NO: 137/138, SEQ ID NO: 139/140, SEQ ID NO: 141/142, SEQ ID NO: 143/144, SEQ ID NO: 145/146, SEQ ID NO: 147/148, SEQ ID NO: 149/150, SEQ ID NO: 151/152, and SEQ ID NO: 153/154.

Abstract: Approaches useful to operation of scalable processors with ever larger numbers of logic devices (e.g., qubits) advantageously take advantage of QFPs, for example to implement shift registers, multiplexers (i.e., MUXs), de-multiplexers (i.e., DEMUXs), and permanent magnetic memories (i.e., PMMs), and the like, and/or employ XY or XYZ addressing schemes, and/or employ control lines that extend in a “braided” pattern across an array of devices. Many of these described approaches are particularly suited for implementing input to and/or output from such processors. Superconducting quantum processors comprising superconducting digital-analog converters (DACs) are provided. The DACs may use kinetic inductance to store energy via thin-film superconducting materials and/or series of Josephson junctions, and may use single-loop or multi-loop designs. Particular constructions of energy storage elements are disclosed, including meandering structures.

Abstract: The invention relates methods for detecting antibody-secreting B-cells specific for at least an HLA in a subject. The invention also relates to kits for developing said methods and to the use of said methods for determining the risk of a subject having humoral rejection against an allogeneic transplant, for determining the risk of a subject of suffering endarteritis associated with post-transplant humoral rejection after allogeneic organ or tissue transplant, for selecting a subject to receive a transplant, and for determining the presence of humoral sensitization against HLA.

Abstract: A method for determining, by reanalysis, a vibratory environment of a coupled vehicle/passenger system. A vehicle is subjected to external forces Fext and is coupled to a new passenger including multiple payloads (e.g., x=I, . . . N payload(s)). At the level of vehicle/passenger interfaces Ix, the method comprising a step DET1) for determining, based on reference interfacial acceleration ?x_ref of a reference passenger, the interfacial acceleration ?x? relative to the new passenger.

Abstract: A connecting system comprising a hollow transfer tube having at least two openings and one or more walls defining an aperture sealed at one end with a polymeric seal, the aperture being large enough to accommodate the transfer tube. The invention is also directed to a refill cartridge and to a dispenser. The dispenser includes a housing having an opening suitable for accommodating the refill cartridge. The housing includes at least one of i) one or more walls defining an aperture sealed at one end with a polymeric seal, the aperture being large enough to accommodate a transfer tube, the opening being in fluid communication with a conduit within the housing or ii) a hollow transfer tube, having at least two openings, extending from the housing, one opening being in communication with a conduit in the housing and the second opening in fluid communication with the exterior of the dispenser housing. The dispenser may include a u-shaped vent tube and a double valve liquid pump.

Abstract: The present disclosure provides a FINFET device integrated with a TFET and its manufacturing method. Two end portions of the fin structure respectively form an N-type doped drain and a source which is consisted by a top P-type doped region and a bottom N-type doped region. As a result, the bottom N-type doped region of the source, the drain, the channel, the high-k dielectric layer and the gate structure on the surface of the sidewall of the fin structure form a MOS FINFET device, and the top P-type doped region of the source, the drain, the channel, the high-k dielectric layer and the gate structure on the top surface of the fin structure form the TFET device. The integration of the TFET and the FINFET is achieved, which decreases the cost.

Abstract: The invention relates to a cleaning device intended for spraying at least one fluid onto a surface to be cleaned of a motor vehicle, such as an optical sensor of an optical detection system, which comprises at least one conveyor body (8) inside of which a distribution duct (11) is arranged and which includes, at the terminal distribution portion (36) thereof, a fluid distribution element (9) in which at least one cleaning fluid spray nozzle (10) is formed, the distribution element (9) including a distribution channel (12) in fluid connection with the distribution duct (11) arranged in the conveyor body (8) and with the spray nozzle (10). According to the invention, the cleaning fluid distribution element (9) is made up of two portions (16, 17): a first portion (16) including a base (16a) of the distribution element (9) attached to the conveyor body (8) and a second portion (17) including a cover (17a) urged against the first portion (16).

Abstract: A rigid packet of smoking articles and method for manufacturing the same, wherein the packet comprises: a group of articles; a first rigid container containing the group of articles and comprising an extraction opening for extracting the articles; a resealable label which is fixed to the first container and movable between an open position, in which access to the articles is allowed, and a closed position, in which it closes the extraction opening preventing the access to the articles; a second rigid container which comprises a containing portion, containing the first container and comprising an opening from which the first container protrudes, and a lid which is hinged to the containing portion and is movable to open and close the opening.

Abstract: A connecting system comprising a hollow transfer tube having at least two openings and one or more walls defining an aperture sealed at one end with a polymeric seal, the aperture being large enough to accommodate the transfer tube. The invention is also directed to a refill cartridge and to a dispenser. The dispenser includes a housing having an opening suitable for accommodating the refill cartridge. The housing includes at least one of i) one or more walls defining an aperture sealed at one end with a polymeric seal, the aperture being large enough to accommodate a transfer tube, the opening being in fluid communication with a conduit within the housing or ii) a hollow transfer tube, having at least two openings, extending from the housing, one opening being in communication with a conduit in the housing and the second opening in fluid communication with the exterior of the dispenser housing. The dispenser may include a u-shaped vent tube and a double valve liquid pump.

Abstract: A damper for an object is placed in a medium subjected to vibrations. The damper has an idle state in the absence of vibrations, a first operating state in case of vibrations of a first type, and a second operating state in case of vibrations of a second type. The level of each vibration of the first type is less than the level of each vibration of the second type. The damper includes an outer support structure, an inner support structure, and at least one pair of membranes formed of a first membrane and a second membrane. Each membrane is formed of a viscoelastic material including fibers aligned substantially in a same direction.

Abstract: A method of analyzing sentiments includes receiving one or more strings of text, identifying sentiments related to a first topic from the one or more strings of text, and assigning a sentiment score to each of the sentiments related to the first topic, where the sentiment score corresponds to a degree of positivity or negativity of a sentiment of the sentiments. The method further includes calculating an average sentiment score for the first topic based on the sentiment score for each of the sentiments related to the first topic, determining a percentile for the first topic based on a frequency of sentiments related to the first topic, where the percentile for the first topic is determined with respect to a maximum frequency of sentiments related to one or more other topics, and computing an X-Score based on the average sentiment score and the percentile of the first topic.

Abstract: The invention relates to compounds of formula I: where a, R1, and R3-6 are as defined in the specification, or a pharmaceutically acceptable salt thereof. The compounds of formula I are serotonin and norepinephrine reuptake inhibitors. The invention also relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.

Abstract: A washing fluid spray device for a wiper arm for a system for wiping a window of a motor vehicle is disclosed. The device includes a cowling intended to cover a support yoke of a wiper arm and also a washing fluid spray nozzle that is held in a removable manner by the cowling.

Abstract: The invention provides a detachable wind guard for a flute-type instrument comprising an elongate, arcuate cover configured to wrap over a flute barrel. The cover has a center section with a radius larger than the radius of the flute barrel and includes a tapered, recessed facing edge configured to leave an embouchure hole uncovered. A domed apex of the center section is sized to accommodate a microphone, and a microphone clip is coupled inside the domed apex. End sections taper to a radius sized to conform to the flute barrel. An elongate, arcuate holder positioned opposite the cover has a radius sized to conform to the flute barrel. A connector pin passes through knuckles on both the cover and holder to form a hinge that allows the wind guard to open in a clamshell manner. Torsion springs around the connector pin bias the holder in a closed position.

Abstract: The invention provides compounds of formula (I): where the variables are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are useful as JAK kinase inhibitors. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat respiratory diseases, and processes and intermediates useful for preparing such compounds.

Abstract: The invention relates to a method for differentiating ischemic stroke from hemorrhagic stroke in a patient and to a method for selecting a patient suffering stroke for a therapy with an antithrombotic agent or with an agent capable of reducing blood pressure based on the determination of the level of GFAP in a sample of said patient in combination with one or more markers selected from the group consisting of NEF3, ?-synuclein, CARNS1 and RBP4, or based on determining the level of RBP4 in a sample of said patient. Furthermore, the invention relates to a kit comprising a reagent for detecting the level of a marker selected from GFAP NEF3, ?-synuclein, CARNS1, RBP4 or a combination thereof and to the use of the said kit in the methods of the invention.

Abstract: Intermediates and methods of their use in the synthesis of analogs of halichondrin B are provided.