Abstract: An apparatus for applying one or more substances to an area of interest, the apparatus having sensors detecting one or more conditions of a sample area proximate the sensor, wherein, the control system is configured to allow for an operator selection between distributing or not distributing a substance or substances via the independently operable outlet(s) controlled by the control system when the control system determines: the sample area proximate at least one sensor or group of sensors is having one or more conditions which meet at least one predetermined condition parameter for that or those condition(s); or the sample area proximate at least one sensor or group of sensors is having one or more conditions which do not meet at least one predetermined condition parameter for that or those condition(s).

Abstract: A driving apparatus configured to drive a light emitting device includes a driving current source module operable to supply current to the light emitting device via a node during operation. A protection module coupled to the node and the driving current source module selectively injects current to the node during operation. The driving current source module is controlled based on a detection result of a voltage on the node.

Abstract: An Fc-binding polypeptide of improved alkali stability, comprising a mutant of an Fc-binding domain of Staphylococcus Protein A (SpA), as defined by SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO:3, SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO:6, SEQ ID NO:7, SEQ ID NO:22, SEQ ID NO 51 or SEQ ID NO 52 wherein at least the asparagine or serine residue at the position corresponding to position 11 in SEQ ID NO:4-7 has been mutated to an amino acid selected from the group consisting of glutamic acid, lysine, tyrosine, threonine, phenylalanine, leucine, isoleucine, tryptophan, methionine, valine, alanine, histidine and arginine.

Abstract: A digital-to-analog converter (DAC) and a method for operating the DAC are disclosed. The DAC receives, over a first channel, a control signal that is transmitted in accordance with a binary protocol. The DAC also receives, over a second channel different than the first channel, data that is transmitted in accordance with a multilevel communication protocol that is different than the binary protocol. The DAC determines a plurality of first and second voltages based on the received data and identifies, based on the control signal, a time when data transmission or reception is switched between first and second antennas. In response to identifying, based on the control signal, the time when data transmission or reception is switched, the DAC outputs the determined plurality of first voltages to a first antenna tuning circuit or the determined plurality of second voltages to a second antenna tuning circuit.

Abstract: Methods, systems comprising one or more computer systems including a combination of hardware and software, and computer program products store, in a database associated with a user account, an inventory of computer applications and associated program data stored on a first mobile device. The method, system, and computer program product receive an indication from the first mobile device that program data associated with a first one of the computer applications stored on the first mobile device is to be stored on a second mobile device and receive an identifier corresponding to the user account from the second mobile device. After receiving the indication from the first mobile device and receiving the identifier from the second mobile device, the method, system, and computer program product transmit the program data associated with the first one of the computer applications to the second mobile device when the first one of the computer applications is compatible with the second mobile device.

Abstract: The present invention relates to a process for the manufacture of a suspension of mustard bran particles comprising the following steps: a) providing an aqueous dispersion of mustard bran particles originating from the seeds of black mustard (Brassica nigra) and/or the seeds of brown Indian mustard (Brassica juncea), said mustard bran particles having a volume weighted mean diameter of more than 300 ?m; b) producing a milled suspension of mustard bran particles by passing the dispersion one or more times through a high shear device selected from a high pressure homogenizer and an ultra-fine friction grinder, said high pressure homogenizer being operated at a pressure drop of at least 100 bar. Treatment of these types of mustard bran in a high shear device increases overall bioaccessability of the proteins contained in the bran. This is desirable in view of the high nutritional value of these proteins.

Abstract: The invention relates to a savoury concentrate comprising the following components: a) 22-85 wt. % inorganic salt; b) 2-60 wt. % fat; c) 1-9 wt. % of psyllium seed husk gum; d) 0-25 wt. % of glutamate component selected from glutamic acid, edible glutamate salts and combinations thereof; e) 0-25 w.% starch component selected from native starch, pregelatinised starch, maltodextrin, modified starch and combinations thereof; f) 0-20 wt. % of sugar selected from monosaccharides, disaccharides and combinations thereof; g) 0-45 wt. % of vegetable matter selected from vegetables, herbs, spices and combinations thereof; h) 0-10 wt. % water; wherein the components a) to e) together constitute at least 55 wt. % of the savoury concentrate and wherein the components a) to h) together constitute at least 75 wt. % of the savoury concentrate.

Abstract: The present disclosure relates to the use of contact lenses for treating one or more ophthalmologic conditions. In some embodiments, the contact lenses may be used to treat presbyopia, induced myopia, computer vision syndrome (CVS), insufficient accommodation, or a condition associated with insufficient accommodation. The contact lens may include a number of regions having different geometries (e.g., curvature, width, diameter) depending on the flattest keratonomy of the cornea to achieve a suitable fit. For example, the contact lens may include an optic zone surrounded by an inner peripheral region and an outer peripheral region surrounding the inner peripheral region, each exhibiting varying degrees of curvature. The fitted contact lens may be selected based on a measured sagittal depth and/or eccentricity of the cornea. When fitted, an appropriate amount of fluid may accumulate between the cornea of the eye and the contact lens.

Abstract: Method of manufacturing a micromechanical component intended to cooperate with another micromechanical component, the method comprising the steps of providing a substrate, forming a mould on said substrate, said mould defining sidewalls arranged to delimit said micromechanical component, providing particles on at least said sidewalls, depositing a metal in said mould so as to form said micromechanical component, and liberating said micromechanical component from said mould and removing said particles.

Abstract: A method may include inflating a first balloon within an internal carotid artery so as to block antegrade flow of blood into an ophthalmic artery. Additionally, the method may include maintaining antegrade flow of blood in the internal carotid artery via a perfusion lumen in the first balloon. Further, the method may include inserting a device into the ophthalmic artery via a lumen extending through a portion of the first balloon to a side opening in the first balloon.

Abstract: The present disclosure provides methods and systems for synchronizing motion data with an audio/video stream. An audio/video stream, which comprises at least one timing marker, is obtained. The audio/video stream is processed to detect the at least one timing marker. Motion data associated with the audio/video stream and timing information for the motion data are obtained, the timing information including timing information regarding the at least one timing marker. The audio/video stream, with the at least one timing marker detected, and the motion data, are output with the timing information.

Abstract: The invention relates to processes for preparing 2-(1-(tert-butoxycarbonyl)-piperidine-4-yl)benzoic acid having formula I: Among its various uses, this compound is useful as an intermediate for preparing ampreloxetine and salts thereof.

Abstract: An end joining piece (4) for a windscreen wiper for a glazed surface of a motor vehicle is disclosed. The end piece has at least a receipt receptacle (410) for receiving an end part of a longitudinal vertebra (20), and at least one flexible tongue (6a, 6b) which is configured to go from a first, position of rest, to a second, retracted position, by displacement in a first direction (F2a, F2b) during the insertion of the longitudinal vertebra in the receipt receptacle (410), the flexible tongue including an engagement ramp along which the vertebra is made to thrust, to provide the tongue with its second, retracted position. The engagement ramp (620a, 620b) has an inclination which is configured to exert on the longitudinal vertebra a force which tends to displace this vertebra in a second direction (F3a, F3b), which, together with the first direction of displacement, forms a non-zero angle.

Abstract: A method for updating firmware of cable modems optimizing management resources in a network comprising a web application, network collector, more than one cable modem, one or more servers. The method includes the web application receiving an update firmware policy, the policy defined by a list of cable modems to have their firmware updated, a Uniform Resource Identifier (URI) pointing to a file within a server in the network, and the web application adding a policy with this information to a policies table. The network collector polls a database engine for a new policy and computing a list of cable modems to have their firmware updated, and the network collector sends a command to a cable modem to update to a new firmware, wherein the new firmware is specified by the URI.

Abstract: In general, the invention features compounds useful for the synthesis of analogs of halichondrin B, such as eribulin or pharmaceutically acceptable salts thereof, e.g., eribulin mesylate.

Abstract: The invention provides a compound of formula 1 or a pharmaceutically-acceptable salt thereof, that is useful as a JAK inhibitor. The invention also provides crystalline forms of the compound, pharmaceutical compositions comprising the compound, methods of using the compound to treat diseases amenable to a JAK inhibitor, and processes and intermediates useful for preparing the compound.

Abstract: The present invention relates to compounds of formula (III) or to compounds of formula (IV) wherein R1, R2, R3 and R4 are as defined in the claims, and their use in therapeutic treatments of 5-lipoxygenase related diseases such as chronic airway inflammatory or dermatological disorders.

Abstract: Arrangements for small-sized, inexpensive, and innovative lensless and other micro-optic microscopy imaging and tomography are presented. An imaging region comprising flat or curved surfaces is provided with an illumination source proximate to the imaging region or arranged for collimated illumination. Light travels through the imaging region and produces a resulting light field affected by objects, materials, fluids, organisms, etc. in the light path and is presented to an image sensing surface proximate to the imaging region, responsively creating electrical image signals. The illumination surface can be light emitting elements such as LEDs, OLEDs, or OLET whose illumination can be sequenced in an image formation or tomography process. Light-emission and light detection elements can be printed, permitting extremely low-cost manufacturing and readily accommodating imaging regions having curved shapes.

Abstract: Disclosed herein is a crystalline solvate comprising the compound of formula: methanol, N,N-dimethylformamide, and water, that is useful to prepare a crystalline form of said compound, which is an inhibitor of JAK kinases.

Abstract: Methods, systems and devices are provided for cleaning a toilet having a toilet bowl, comprising: a storage and control unit comprising: a container configured to store a cleaning material of a first type for cleaning or sanitizing the toilet; a pump for delivering via pipes the cleaning material of the first type; and a power source; a treatment unit comprising: a housing having a cavity that collects and stores flushing tank fluids of the toilet flowing via an opening in the housing; a cleaning material of a second type; a spraying unit, comprising a spraying device to spray the flushing tank fluids mixed with the cleaning materials of the second type via the spraying device into the interior of the toilet bowl; and a rotatable spraying unit to receive the cleaning material of a first type from the pipes and spray it at the toilet bowl cavity; and a bridge to be hung on the toilet bowl rim and hold the treatment unit away and below the toilet bowl rim at the path of the toilet flushing water.