Abstract: A process for applying a film structure onto a lens blank is improved by implementing a wedge piece when the film structure is pressed against the lens blank using a resilient cushion. The wedge piece forces the film structure to conform more tightly to the lens blank within a depression track existing on said lens blank. Then, the lens blank assembled with the film structure has a final optically useful area which is increased.

Abstract: The present invention relates to a method for treating a Leber congenital amaurosis in a patient harboring the mutation c.2991+1655 A>G in the CEP290 gene, comprising the step of administering to said patient at least one antisense oligonucleotide complementary to nucleic acid sequence that is necessary for preventing splicing of the cryptic exon inserted into the mutant c.2291+1655 A>G CEP290 mRNA.

Abstract: A load cell includes a flexure element having a Roberval mechanism in which the respective ends of a pair of top and bottom parallel beams including a thin section are integrated in a fixed portion and in a movable portion, and a stopper for preventing an overload disposed between the pair of the top and bottom parallel beams by being fixed to the fixed portion. The front portion of the stopper is disposed in a concave portion for engaging the stopper formed on the inner side surface of the movable portion and extending in the width direction, and the front portion of the stopper of which a width is larger than the movable portion projects outwardly in the width direction of the movable portion.

Abstract: The present disclosure relates to a process for producing cream cheese using a specific combination of milk and milk fractions. It further relates to cream cheese which is characterized by a unique combination of levels of minerals, lactose and protein and which may be obtained by the process of the present disclosure.

Abstract: [Problem] To provide, at a lower cost, a microphone stand the height of which can be adjusted by an easy operation. [Solution] A support strut (5) of an acoustic characteristic measurement microphone comprises two rectangular-tube-shaped attachment parts (1, 2) that are attached to each other in the axis direction by inserting one of the attachment parts into the other such that the one can slide within the other in the axis direction. A plurality of height adjustment slits (19) that are aligned in the height direction of the microphone stand are formed in a corner portion of the one attachment part (1). In the other attachment part (2), an attachment slit (22) is formed at a position where the plurality of height adjustment slits (19) pass due to the sliding of the two attachment parts (1, 2) in the height direction of the microphone stand.

Abstract: A composition comprising: A) a transparent gel base, comprising: a) a polymeric thickener, b) a solubiliser, c) a pH adjuster, d) a calcium sequestrant, e) water, f) an optional protein, g) an optional active material, which is selected from disaccharides, lactones, inorganic salts, diacids and mixtures thereof, h) an optional dye preferably comprising violet, blue, red or mixtures thereof, wherein the solubiliser comprises a mixture of at least two components, said mixture comprising at least one high HLB component having an HLB value of from 10 to 20 and at least one low HLB component having an HLB value of from 1 to less than 10, and B) a hydrogel particle, comprising: a) a matrix, and b) a silicone or blend of silicones, wherein the silicone or blend of silicones has an average molecular weight of greater than 400 Da, and wherein the particle has an average diameter of 0.1 to 15 mm and wherein the silicone is present in an amount of from 5 to 40 wt % by total weight of the particle.

Abstract: A preparation method for a high-purity benzoxazoleoxazine ketone compound, a crystal form thereof, and an intermediate compound for preparing a compound of formula (I), and a preparation method therefor.

Abstract: A multi-level product sortation system includes sortation apparatuses interconnected on a conveyor and a station controlling loading and unloading thereof. Each apparatus includes a rack formed by a bottom wall, spaced-apart opposite side walls extending upright therefrom and a compartment above the bottom wall, between the side walls and being open at top and opposite ends. Each apparatus includes at least two carriers disposed in the compartment at different levels therein, and a product discharge control mechanism operable to selectively retain a product on and release a product from the respective carrier. One carrier is disposed above the other carrier and both extend longitudinally between open opposite ends of the compartment and laterally between opposite side walls of the rack. Each carrier is tiltable relative to the rack between a product support position and a product discharge position angularly displaced therefrom.

Abstract: A snap hook includes a body, a gate, a connection link, and a coupling. The body has a central portion positioned between an upper portion and a lower portion. The gate is pivotally coupled proximate the central portion. The gate and the body selectively form a closed configuration that defines a hook connection passage and an open configuration that provides access to the hook connection passage. The connection link has an upper end pivotally coupled proximate the central portion of the body and a lower end including a body connection aperture. The coupling interconnects the lower end and the lower portion. The coupling is configured to break when a select amount of force is applied to the lower end and release the lower end from the lower portion to redirect the select amount of force from the lower portion to the central portion of the body.

Abstract: The disclosure relates to wavelength-controlled directivity of all-dielectric optical nano-antennas. One example embodiment is an optical nanoantenna for directionally scattering light in a visible or a near-infrared spectral range. The optical nanoantenna includes a substrate. The optical nanoantenna also includes an antenna structure disposed on the substrate. The antenna structure includes a dielectric material having a refractive index that is higher than a refractive index of the substrate and a refractive index of a surrounding medium. The antenna structure includes a structure having two distinct end portions. The antenna structure is asymmetric with respect to at least one mirror reflection in a plane that is orthogonal to a plane of the substrate.

Abstract: A hydrogel particle, comprising: a) a matrix, and b) a silicone or blend or silicones, wherein the silicone or blend of silicones has an average molecular weight of greater than 400 Da, and wherein the particle has an average diameter of 0.1 to 15 mm and wherein the silicone is present in an amount of from 5 to 40 wt %, preferably from 25 to 40 wt % by total weight of the particle.

Abstract: In one aspect, the invention relates to a crystalline form of the structure: or a pharmaceutically acceptable salt thereof, having neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising this crystalline form; methods of using this crystalline form and its soluble form (I); and processes for preparing soluble (I) and crystalline (I?) forms.

Abstract: The invention proposes an adapter (12) which comprises a front body (44) of convex external profile, intended to be received in a concave front closed-end (28) of a U-shaped end hook of a wiper arm, and at least one branch (50) which extends longitudinally towards the rear from the front body (44) and which carries a projecting locking stud (62) intended to be received in a locking slot (34) of the end hook, characterized in that it comprises a series of transverse notches (86A, 86B, 86C) for the longitudinal positioning of the adapter, these being longitudinally offset relative to one another and one or another of which is Intended to collaborate with a facing transverse edge of the end hook according to the dimension of the end hook, thus allowing one and the same model of adapter to be used for connecting wiper arms of different sizes.

Abstract: Modular shelving systems, magnetic electrical connectors, conductor assemblies, and mounting inserts are disclosed. A modular shelving system includes at least one shelving module, a power module coupled to the at least one shelving module, and a conductor assembly coupled to the at least one shelving module and electrically connected to the power module. The conductor assembly includes a board including a first column of apertures and a second column of apertures, a back plate formed from a ferromagnetic material or from a magnetic material, a first conductor electrically coupled to the power module and positioned between the back plate and the board, and a second conductor electrically coupled to the power module and positioned between the back plate and the board. The first conductor is aligned with the first column of apertures of the board. The second conductor is aligned with the second column of apertures of the board.

Abstract: A compound having Formula (I), nC7—H15—O-(G)p-H, where G is a reducing sugar residue, and p is a decimal number ?1.05 and ?5. The method for preparing the compound and its use as a hydrotropic surfactant by making soluble, in an aqueous alkaline composition, at least one non-ionic surfactant having Formula (II), R—(O—CH(R?)—CH2)n-(0-CH2-CH2)m-0-H, where R is a straight, branched, saturated or unsaturated aliphatic hydrocarbon radical including 8-14 carbon atoms, R? is a methyl or ethyl radical, n and m are whole numbers ?0 and ?15, assuming that n+m?0. Cleaning compositions containing 0.5% to 20% of compounds of Formula (I), 0.5% to 80% of compounds of Formula (II), 10-50 wt % of at least one alkaline agent, 15-89 wt % of water, and optionally, 10-50 wt % of at least one anti-limescale agent are useful for cleaning hard surfaces.

Abstract: A method for fabricating a micromechanical part from a substrate in which the part is fabricated by providing a plurality of fasteners between the part and the substrate, the fasteners being sacrificial, characterized in that the fasteners include at least one hinge at the end of each fastener located beside the part, and in that the method includes a step of breaking the sacrificial fasteners. The micromechanical parts employing this type of sacrificial fastener are also described.

Abstract: The invention provides a method of diagnosing Alzheimer's Disease in a subject, by determining the level of at least one miRNA in a sample derived from the subject, wherein a change in the level of the at least one miRNA relative to a suitable control is indicative of Alzheimer's Disease in the subject. Methods for monitoring the course of Alzheimer's Disease, methods of treating a subject having Alzheimer's Disease, and kits for diagnosing Alzheimer's Disease are also provided.

Abstract: In one aspect, the invention relates to compounds having the formula: where R1, R2, R3, X, R4, R5, and R6 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.

Abstract: A method for producing a colloidal alcoholic suspension of fluorine-doped SnO2 particles. It also pertains to the colloidal suspension thus obtained and to its uses, especially in the manufacture of an antistatic coating for an optical article, such as an ophthalmic lens.

Abstract: Systems herein relate to acquiring shopper insights from home product use and influencing shoppers to make additional future purchases of products. Further, the invention relates to electronically communicating with the shopper at the second moment of truth to provide the shopper with one or more influential messages including, but not limited to product information, e-coupons, discounts, surveys, ingredients, ingredient suggestions, recipe suggestions, entertaining, consumer reports, shopping list suggestions, wish list suggestions, and inventory list suggestions.