Abstract: The application relates to the field of cancer, particularly to the field of solid tumors. It was found that a particular long non-coding RNA (lncRNA), NEAT1, an essential architectural component of nuclear paraspeckles, is required for the survival of cancer, but not that of normal, non-transformed, cells. Inhibition of NEAT1 reduces cell viability of cancer cells and induces apoptosis. These data identify NEAT1 as a novel therapeutic target for treatment of solid tumors.

Abstract: A method of fixing an artwork on a surface of a rigid substrate includes providing an ink receptive layer comprised of a dispersing pigment in a binder selected from the group consisting of: PVOH, EVA, PUD, latex polymer, and combinations of these, applying the ink receptive layer to the surface of the rigid substrate, drying the ink receptive layer, and printing the artwork onto the ink receptive layer by inkjet.

Abstract: Disclosed is a machining method by turning at least one surface of an ophthalmic lens, using a turning machine having at least one geometrical defect. The method includes a step (101-104) of determining a turning configuration for machining by turning the at least one surface of the ophthalmic lens, the turning configuration including turning parameters and machine defects parameters associated to the turning parameters.

Abstract: The invention relates to a wiper blade (10) for the cleaning of windows (1) of motor vehicles, with a carrier element (15) which has a first mounting (16) for the form-fitting fastening of a wiper rubber (11) and a second mounting (22) for fastening at least one spring rail (20) serving as a support element. According to the invention, provision is made that the second mounting (22) in the longitudinal direction of the carrier element (15) forms laterally two guides (23, 24) for the spring rail (20), which embrace the lateral edge regions of the spring rail (20) in a form-fitting manner, and that the region between the guides (23, 24), viewed over the longitudinal direction of the carrier element (15), is constructed at least partially, preferably completely, as an open central zone (28).

Abstract: A clean-water-washing function control method of a washing machine, the method comprising: step A: receiving a selection instruction of a laundry process; step B: enabling or disabling selection of a clean-water-washing function of the washing machine according to the selection instruction. A user at self-select the laundry process and decide whether to use the water-washing function, so that the control method not only helps guide the user in choosing to wash clothing in a water saving manner, but can also wash the clothing effectively, and protect the clothing and a recycled water filtration system. Moreover, an autonomous and intelligent washing environment is created for the user.

Abstract: Calibration methods use a calibration target for obtaining the intrinsic and extrinsic camera parameters of one or more cameras are. The methods can include acquiring, with each camera, a sequence of target images representing the calibration target in different target poses and at different acquisition times. The methods can include identifying reference images from the target images, and defining volume bins, angle bins and multi-camera bins into which the reference images are stored. The reference images can be used to determine the intrinsic and extrinsic parameters of the one or more cameras. In some implementations, the calibration methods can enable a user to monitor the progress of the calibration process, for example by providing an interactive calibration target including an input/output user interface to guide the user in real-time during the acquisition of the target images and/or sensors to provide positional information about the target poses.

Abstract: A method for testing the internal structure of a refractory part, has the following steps: a) by a transmission antenna, sending at least one electromagnetic wave, termed a “pulse”, into the refractory part to be tested; b) by a reception antenna, receiving the pulse after reflection thereof by a reflecting zone of the refractory part; c) analyzing the time offset between the two preceding steps in order to deduce the position, in the refractory part, of the reflecting zone, the pulse having a duration less than or equal to 0.5 nanoseconds.

Abstract: An exercise device includes a frame and a crank assembly. A pair of foot links each has a forward end, a rearward end, and a mid-portion. Each foot link has a crank attachment at the forward end that is connected the crank assembly. A foot receiving area is defined at the rearward end of each foot link. Each foot receiving area is longitudinally fixed with respect to the respective foot link and the mid portion of each foot link has a defined support location. The frame supports the support locations of the support links at a generally constant vertical height while allowing horizontal motion relative to the frame. The rearward length of the foot links is at least 1.5 times the forward length such that the foot receiving areas move in a path of travel having more vertical travel than horizontal travel.

Abstract: The positioning signals broadcast by the GNSS constellations on civilian frequencies are likely to be counterfeited, while the use of authentic signals is becoming increasingly critical for certain applications. According to the invention, the authentication of GNSS signals is performed by analysis of consistency between the measurements of parameters characteristic of the signals (direction of arrival, amplitude, phase) and their state model, said state model taking account of an emulation by software and electronic means of displacements of the phase centre of the antenna and/or of the main lobe of the radiation pattern. Advantageously, these displacements are generated by a pseudo-random code. Advantageously, the analysis of consistency between measurements and models is a multiple-criterion analysis, the combination of criteria being chosen as a function of a reception quality indicator and/or of a presumed location.

Abstract: A method and system for permanently attaching a take-up screw for taking-up the axial clearance of the armature shaft of a windscreen wiper motor are disclosed. The take-up screw is screwed axially into a bore in the motor base (SM) until the screw reaches a stop position in relation to the armature shaft locked in the screw. At least one surface discontinuity is provided in the bore and/or the thread of the screw, allowing the screw to be screwed into the bore until it reaches the stop position. The screw is screwed into the bore until the stop position is reached and a screw- and/or motor base-deformation strain is applied at the discontinuity in order to deform the side surface of the screw and/or motor base (SM) and permanently attach the screw and/or motor base by wedging in the discontinuity.

Abstract: In order to provide the method for manufacturing the three-dimensional shaped object which is capable of preventing the occurrence of the raised portion at the sintered portion or the melted and subsequently solidified portion by the irradiation of the light beam, there is provided a method for manufacturing a three-dimensional shaped object by alternate repetition of a step (i) forming a powder-layer and a step (ii) forming a solidified layer by irradiating a predetermined portion of the powder layer with a light beam, wherein the light beam-irradiated portion is vibrated in the step (ii).

Abstract: Disclosed is a highly reliable secondary battery, as well as an electrode and a conductive agent used therefor, which battery has a long cycle life and is also less likely to be damaged or rupture even when the battery temperature becomes abnormally high. The conductive agent of the battery electrode contains, as the main component, a reaction product between a ?-conjugated carbon material and a soluble polyimide, preferably a soluble block copolymerized polyimide. The battery electrode is formed by coating a composition containing this conductive agent and an electrode active substance onto a current collector. The battery comprises this electrode.

Abstract: Liposomal topical compositions containing phenolic anti-inflammatory agents, and methods for making thereof, are presented. These compositions are generally used for helping to prevent solar radiation-induced skin damage and helping to prevent and/or treat inflammatory dry skin conditions caused by eczema and contact dermatitis.

Abstract: A current limiting circuit includes a current sensing module that is configured to sense an output current of a power transistor and to generate a corresponding sensing current which is proportional to the output current. A first current limiting module coupled to the current sensing module is configured to generate a first limiting current based on the sensing current when a variation of the output current of the power transistor exceeds a first current level. A second current limiting module coupled to the current sensing module is configured to generate a second limiting current based on the sensing current when a variation of the output current of the power transistor exceeds a second current level. A converting module coupled to the first and second current limiting modules and the power transistor controls a gate voltage of the power transistor based at least on the first and second limiting currents.

Abstract: The present invention relates to a curable composition providing upon curing a transparent antistatic coating comprising a silica organosol, a salt comprising an alkali cation and a Bronsted acid. The invention further relates to optical articles comprising a substrate at least partially coated with a transparent antistatic coating formed by depositing onto substrate and curing the above curable composition. The obtained optical articles exhibit enhanced antistatic properties, high optical transparency, low haze and good mechanical properties, in particular a good abrasion resistance.

Abstract: A system may include first and second qubits that cross one another and a first coupler having a perimeter that encompasses at least a part of the portions of the first and second qubits, the first coupler being operable to ferromagnetically or anti-ferromagnetically couple the first and the second qubits together. A multi-layered computer chip may include a first plurality N of qubits laid out in a first metal layer, a second plurality M of qubits laid out at least partially in a second metal layer that cross each of the qubits of the first plurality of qubits, and a first plurality N times M of coupling devices that at least partially encompasses an area where a respective pair of the qubits from the first and the second plurality of qubits cross each other.

Abstract: Methods, systems comprising one or more computer systems including a combination of hardware and software, and computer program products receive from a first mobile device an identifier corresponding to an account associated with the first mobile device and a second mobile device. An inventory of computer applications and program data stored on the first mobile device is stored in a database. An indication is received from a user of the first mobile device that program data associated with a first one of the computer applications is to be mirrored on the second mobile device. The identifier is received from the second mobile device. After receiving the identifier from the second mobile device, the program data associated with the first one of the computer applications is transmitted to the second mobile device.

Abstract: Clinical information, molecular information and/or computer-generated morphometric information is used in a predictive model for predicting the occurrence of a medical condition. In an embodiment, a model predicts whether a patient is likely to have a favorable pathological stage of prostate cancer, where the model is based on features including one or more (e.g., all) of preoperative PSA, Gleason Score, a measurement of expression of androgen receptor (AR) in epithelial and stromal nuclei and/or a measurement of expression of Ki67-positive epithelial nuclei, a morphometric measurement of a ratio of area of epithelial nuclei outside gland units to area of epithelial nuclei within gland units, and a morphometric measurement of area of epithelial nuclei distributed away from gland units. In some embodiments, quantitative measurements of protein expression in cell lines are utilized to objectively assess assay (e.g.

Abstract: Disclosed is a highly reliable secondary battery, as well as an electrode and a conductive agent used therefor, which battery has a long cycle life and is also less likely to be damaged or rupture even when the battery temperature becomes abnormally high. The conductive agent of the battery electrode contains, as the main component, a reaction product between a ?-conjugated carbon material and a soluble polyimide, preferably a soluble block copolymerized polyimide. The battery electrode is formed by coating a composition containing this conductive agent and an electrode active substance onto a current collector. The battery comprises this electrode.