Abstract: The invention relates to a respiratory mask arrangement that can be used in the framework of CPAP therapy for treating sleep-related disturbances, for example. In one embodiment a respiratory mask arrangement comprises a sealing lip device to be placed on the facial surface of a mask user, a covering device which defines a mask interior in cooperation with the sealing lip device, and a respiratory gas conduit unit for delivering respiratory gas to the mask interior that is defined by the covering device and is connected to the nostril and/or oral opening of the mask user. At least some sections of the covering device are embodied as an air-permeable structure.
Type:
Grant
Filed:
July 9, 2004
Date of Patent:
October 17, 2017
Assignee:
ResMed R&D Germany GmbH
Inventors:
Stefan R. Madaus, Caspar Graff Stauffenberg, Harald Vogele
Abstract: Provided is a coating technology additionally excellent in, for example, water repellency, oil repellency, and ease of dirt removal. An article having a coating on a substrate, in which the coating contains: (a) a polyhedral oligomeric silsesquioxane; and (b) an acrylate polymer having a structural unit represented by the following general formula (II): where Ra represents a hydrogen atom or a methyl group, Rf represents —CH2—(CF2)q—CF3 or —CH(CF3)2, and q represents an integer of 0 to 8.
Type:
Grant
Filed:
April 29, 2016
Date of Patent:
October 17, 2017
Assignees:
ESSILOR INTERNATIONAL (COMPAGNIE GENERALE D'OPTIQUE), NIKON CORPORATION
Abstract: The present invention relates to a curable composition, providing, upon curing, an abrasion-resistant, transparent, antistatic coating, comprising carbon nanotubes and a binder comprising at least one epoxysilane compound, preferably an epoxyalkoxysilane, and optionally fillers such as nanoparticles of non electrically conductive oxides and/or additional binder components such as tetraethoxysilane. The invention further relates to optical articles comprising a substrate, and, starting from the substrate, an abrasion- and/or scratch-resistant coating, and an antistatic coating formed by depositing directly onto said abrasion- and/or scratch-resistant coating the above referred curable composition. The obtained optical articles exhibit antistatic properties, high optical transparency with about 91-92% of transmittance, low haze and improved abrasion resistance.
Type:
Grant
Filed:
July 14, 2014
Date of Patent:
October 17, 2017
Assignee:
ESSILOR INTERNATIONAL (COMPAGIE GENERALE D'OPTIQUE)
Abstract: A combination fishing pole holder and cleat has a bezel portion for affixing to a surface. The bezel portion has a first hole for accepting an object and a shaped indentation to accept and fit a cleat portion. The bezel portion has a pair of studs, each having a cavity formed there within. The cleat portion is shaped to fit within the shaped indentation and has a second hole, also for accepting the object. A pair of legs extends from the cleat portion and through respective studs. Each of the legs is terminated by a device/end that is wider than the cavity of the studs. A tubular portion extends from a side of the bezel and is aligned with both the first hole and the second hole for insertion of the object. The cleat portion moves between a retracted position and an extended position.
Abstract: A method for manufacturing an ammonia storage cartridge includes a step for supplying a material by ammonia absorption or adsorption by absorbent salts, a step for producing an intermediate element, including compacting the material to form the intermediate element, a step for stacking at least two intermediate elements in a shell of the cartridge, and a step for compressing the stack of intermediate elements in the shell.
Abstract: A spectacle ophthalmic lens having a front surface and a back surface, the spectacle ophthalmic lens including a nasal lateral zone and a temporal lateral zone, wherein the front surface includes a progressive or regressive front surface which provides at least a magnifying function in the nasal and/or the temporal lateral zone of the lens, and wherein the back surface substantially compensates dioptric effects of the magnifying function of the progressive or regressive front surface.
Type:
Application
Filed:
September 24, 2015
Publication date:
October 12, 2017
Applicant:
ESSILOR INTERNATIONAL (COMPAGNIE GENERALE D'OPTIQUE)
Abstract: The invention provides methods for the synthesis of eribulin or a pharmaceutically acceptable salt thereof (e.g., eribulin mesylate) through a macrocyclization strategy. The macrocyclization strategy of the present invention involves subjecting a non-macrocyclic intermediate to a carbon-carbon bond-forming reaction (e.g., an olefination reaction (e.g., Homer-Wadsworth-Emmons olefination), Dieckmann reaction, catalytic Ring-Closing Olefin Metathesis, or Nozaki-Hiyama-Kishi reaction) to afford a macrocyclic intermediate. The invention also provides compounds useful as intermediates in the synthesis of eribulin or a pharmaceutically acceptable salt thereof and methods for preparing the same.
Type:
Grant
Filed:
November 4, 2014
Date of Patent:
October 10, 2017
Assignee:
EISAI R&D MANAGEMENT CO., LTD.
Inventors:
Francis G. Fang, Dae-Shik Kim, Hyeong-Wook Choi, Charles E. Chase, Jaemoon Lee
Abstract: A method for determining a semi-finished lens blank, including the steps of: determining, for a given material, a set of faces (S1, S2, . . . Sn) to be defined for a line of ophthalmic lenses, each face (Si, Sj) being defined for a corresponding subset (SEi, SEj) of wearer data and/or frame data; determining, for each face (Si, Sj), a minimum thickness requirement (EnvSi, EnvSj) necessary to produce all the lenses of the corresponding subset (SEi, SEj); determining combinations of two faces (Si, Sj) to be paired; defining a “double-faced” semi-finished lens blank (SF(ij)) consisting of two paired defined faces (Si and Sj) and including the minimum thickness requirements (EnvSi and EnvSj) respectively determined for the faces, in a manner that allows producing all the lenses of the subsets (SEi and SEj) corresponding to said faces.
Type:
Grant
Filed:
November 9, 2012
Date of Patent:
October 10, 2017
Assignee:
ESSILOR INTERNATIONAL (COMPAGNIE GENERALE D'OPTIQUE)
Abstract: In one aspect, the invention relates to compounds having the formula I: where R1-R6 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising these compounds; methods of using these compounds; and processes and intermediates for preparing these compounds.
Type:
Grant
Filed:
January 30, 2017
Date of Patent:
October 10, 2017
Assignee:
Theravance Biopharma R&D IP, LLC
Inventors:
Melissa Fleury, Anne-Marie Beausoliel, Adam D. Hughes, Daniel D. Long, Donna A. A. Wilton
Abstract: The present invention relates to an electrochromic composition comprising at least one reducing compound and at least two oxidizing compounds, said at least two oxidizing compounds having similar oxydo-reduction potentials. More specifically, said at least two oxidizing compounds are selected from viologen derivatives. Said composition can be used as a variable transmittance medium for the manufacture of an optical article, such as an ophthalmic lens.
Type:
Grant
Filed:
September 16, 2014
Date of Patent:
October 10, 2017
Assignee:
Essilor International (Compagnie Generale d'Optique)
Inventors:
Claudine Biver, Samuel Archambeau, Fabien Berit-Debat
Abstract: A Zone Control service is disclosed which provides for hierarchically managing a plurality of networked media subsystems. This can provide a layer of abstraction for the collection in the form of a single Renderer zone interface represented by a delegated zone controller. This hierarchy establishes a virtual super-system. Although a Zone Control services can be advertised on all networked media devices, the services will typically be unavailable while a device is subservient to, or equivalently under the control of, a zone controller. A single instance of the Zone Control service can reside in a Services Device, co-existing with a Group Control service.
Abstract: The present invention provides an isolated methyl degron peptide and a fusion protein comprising a methyl degron peptide. Also, the present invention provides screening methods for agents affecting protein lifespan and anti-cancer agents. Moreover, the present invention provides methods of controlling protein lifespan, regulating protein expression, and treating cancers by using a methyl degron peptide or a methyl degron gene.
Abstract: A connector for a wiper blade, the connector is configured to cooperate pivotably, by a transverse hinge pin, with an adapter designed to allow an articulation link between the blade and a driving arm, the connector includes a body provided with two opposite side flanges, defining a housing designed to receive the adapter, and a pin between the flanges for the articulation link of the blade to the arm, the flanges include, at each of the ends of the hinge pin, a shoulder configured to allow axial guiding of the articulation link between the blade and the arm, the side flanges is configured to allow lateral flexion of the adapter bearing against the shoulder.
Abstract: A method of treatment of outdoor equipment for reducing ice adhesion thereon, the outdoor equipment defining a substrate on which a layer of linkers is intended to be coupled, the linkers being bi-functional and including: a first reacting group able to couple in a stable way in environmental conditions with the substrate, and a second reacting group able to generate a covalent bond stable in environmental conditions with polysaccharides, the method includes the steps of: coupling the linkers on at least an area of the equipment to obtain a layer of linkers coupled stably in environmental conditions with the substrate; and making react some polysaccharides on the layer of linkers to bind them with a covalent bond stable in environmental conditions with the second reacting group of the linkers and forming a layer of polysaccharides on the layer of linkers.
Type:
Grant
Filed:
June 26, 2015
Date of Patent:
October 10, 2017
Assignee:
CSEM CENTRE SUISSE D'ELECTRONIQUE ET DE MICROTECHNIQUE SA RECHERCHE ET DEVELOPPEMENT
Abstract: A method for detecting a neurological disease associated with cognitive impairment, wherein the extracellular domain of EphA4 is measured from a biological sample taken from a subject.
Abstract: Disclosed is a novel ankle strap and a toe strap that secures snowboard or splitboard rider's boots to corresponding boot bindings. The straps are generally made from a one-piece molding that includes indented portions on the outside surface of the molding that creates corresponding outdented portions on the boot-facing surface for cushioning. The indented portions are bound by ribs, the ribs forming a continuous interconnected rib structure. As the outdented portions flex, the continuous interconnected rib structure helps the strap maintain its shape and structure.
Abstract: Systems and methods for distributing an audio/visual feed of events include mixing audio signals, from microphones monitoring the event, with sound board feed from the event public address system, thereby forming a mixed audio signal. A video input signal is received at each video input in one or more video inputs at a video board from one or more corresponding cameras recording the event. A video input signal is selected as the video board output and is combined with the mixed audio signal thereby producing an audio/visual signal. This signal is encoded using a video codec, at each of several bitrates, and an audio codec, thereby forming bitrate streams each comprising the video portion of the audio/visual signal at a unique bitrate. The streams are received by a satellite router and transmitted to a satellite which sends them to one or more downlink servers for Internet distribution.
Type:
Grant
Filed:
November 24, 2015
Date of Patent:
October 10, 2017
Assignee:
THE ROGER B. AND ANN K. MCNAMEE TRUST U/T/A/D
Inventors:
Roger McNamee, Glenn Evans, Mark Richards Frederick
Abstract: A motor-driven hinge device may include a hypocycloid hinge mechanism driven by a drive shaft, two metal side plates intended for connection to the seating portion and to the backrest, a brushless motor, and a planetary gear train positioned between the brushless motor and the drive shaft. The planetary gear train may include a sun gear connected to the motor rotor, and a plurality of planet gears, each planet gear having a first set of teeth engaging with the sun gear and with a first stationary ring gear, and a second set of teeth engaging with a second ring gear rigid with the drive shaft.