Abstract: The present disclosure provides mutant vaccinia virus strains that can selectively replicate in tumor cells. The present disclosure also provides use of the mutant vaccinia virus strains for preventing and treating tumors.

Abstract: The invention provides two crystalline freebase forms of biphenyl-2-ylcarbamic acid 1-(2-{[4-(4-carbamoylpiperidin-1-ylmethyl)benzoyl]methylamino}ethyl)piperidin-4-yl ester. The invention also provides pharmaceutical compositions comprising the crystalline freebase or prepared using the crystalline freebases; processes and intermediates for preparing the crystalline freebases; and methods of using the crystalline freebases to treat a pulmonary disorder.

Abstract: Configurations and applications for data signatures are disclosed. Such a data signature may be specific to a particular data element in a data set, and may define this particular data element in relation to one or more other data elements. These data signatures may be used for any appropriate purpose. For instance, data signatures of this type may be generated from a given data set and may be used to analyze this data set in at least some respect, including to identify one or more features in the data set (e.g., for feature extraction purposes). Data signatures of this type may also be used in at least some fashion to generate a presentation or output that relates to the associated data set (including digitally on an appropriate display, as well as in “hard copy” form).

Abstract: The invention relates to a new identified mutation in the epidermal growth factor receptor gene, leading to an amino acidic change which highly correlates with the resistance to a therapy regimen comprising cetuximab and the sensitivity to a therapy regimen comprising panitumumab. The invention includes peptide sequences, primers and probes to detect such a mutation, as well as kits for predicting the response of a subject to a therapy regime comprising cetuximab and/or panitumumab. In particular, the invention is useful in the therapy regimen applicable to metastasic colorectal cancer and to head and neck cancer.

Abstract: Compounds of formula (I): wherein Ra, Rb, Rc, Rd, R3, R4, R5, A1, A2, T and W are as defined in the description. Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.

Abstract: A method of evaluating the efficiency of a myopia control product for a wearer, the method comprising: an initial myopia indicator providing step S1, during which the initial value of a myopia indicator of the wearer is provided, a myopia condition step S2, during which the wearer using the myopia control product is placed in myopia inducing conditions, a resulting myopia indicator determining step S3, during which the resulting value of the myopia indicator of the wearer is determined after the wearer has been placed in the myopia inducing conditions, an efficiency evaluation step S4, during which the efficiency of the myopia control product is evaluated by comparing the initial value of the myopia indicator and the resulting value of the myopia indicator.

Abstract: Compounds of formula (I) that are capable of acting as purine receptor antagonists, pharmaceutical compositions including the compounds, and methods of making the compounds, are. disclosed. The compounds and compositions can be used in treating or preventing disorders related to purine receptor hyperfunctioning.

Abstract: A contact sensor apparatus comprises: a first insulative layer (100); a second insulative layer (200); a first resistor strip (101) on the first insulative layer; a second resistor strip (201) on the second insulative layer; a plurality of first conductive traces (102) provided on the first insulative layer and electrically connected to the first resistor strip; and a plurality of second conductive traces (202) provided on the second insulative layer and electrically connected to the second resistor strip. The first insulative layer and second insulative layer face each other such that the plurality of first conductive traces face the plurality of second conductive traces with each of the first conductive traces extending across the plurality of second conductive traces and each of the second conductive traces extending across the plurality of first conductive traces thereby forming an array of points of intersection of the first and second conductive traces.

Abstract: A lighting device configured to accommodate an optical fiber is provided. The lighting device includes a breaking structure which accommodates a portion of the optical fiber in a state in which the portion includes two or more bends. The breaking structure is configured to break and sever the portion of the optical fiber when the optical fiber is subjected to a load of a predetermined magnitude.

Abstract: The present invention relates to a chromatography ligand, which comprises Domain C from Staphylococcus protein A (SpA), or a functional fragment or variant thereof. The chromatography ligand presents an advantageous capability of withstanding harsh cleaning in place (CIF) conditions, and is capable of binding Fab fragments of antibodies. The ligand may be provided with a terminal coupling group, such as arginine or cysteine, to facilitate its coupling to an insoluble carrier such as beads or a membrane. The invention also relates process of using the ligand in isolation of antibodies, and to a purification protocol which may include washing steps and/or regeneration with alkali.

Abstract: Devices and methods are disclosed for charging fuel molecules in a delivery conduit. The devices are monopole charging devices having at least three individual magnets. A one piece orienting mount having insert formations equal in number to the number of magnets and spaced a selected distance from each other receives and holds the magnets, and is secured around the delivery conduit. The mount holds the magnets in an orientation with a common pole of each contacting the conduit and the opposite pole of each spaced from and facing away from the conduit.

Abstract: ‘ARAANTRED1’ is a new and distinctive variety of Anthurium which is characterized by the combination of a vibrant red, glossy spathe with a nearly horizontal aspect and a relatively short spadix which is colored white with a yellow apex, an abundance of narrowly cordate foliage which is dark green and glossy, inflorescences held above the foliage, and the stability of all characteristics from generation to generation. The new variety is typically produced as an indoor ornamental plant.

Abstract: The invention relates to a wiper motor (10), with an output shaft (11) which rotates in exclusively one direction (12) and is designed at least indirectly to move at least one wiper blade (1) between two reversal positions (A, B). According to the invention, it is provided that the wiper motor (10) has means (30) which are designed at least indirectly to activate a pump (25) for conveying a cleaning fluid in such a manner that cleaning fluid can be applied to a vehicle window (2) exclusively in front of the wiper blade (1) in the respective wiping direction.

Abstract: The invention relates to an ophthalmic lens comprising: a substrate having a given refractive index; and a coating that minimizes ultraviolet reflections, said coating having a given refractive index and being deposited on a rear face of the substrate. According to the invention, the thickness of the ultraviolet-reflection-minimizing coating is between I ?m and approximately 200 ?m and the refractive index of the ultraviolet-reflection-minimizing coating is at least 0.15 units less than the refractive index of the substrate. The invention also relates to a method for the production of such a lens.

Abstract: Liquid screen-wash for vehicle windscreen, comprising between 0.01% and 10% by weight of a surfactant or of a mixture of surfactants, between 5% and 15% by weight of a glycol ether, and water.

Abstract: ‘ARAANTRED3’ is a new and distinctive variety of Anthurium which is characterized by the combination of a bright red cordate spathe with an upright attitude, a generally white spadix, dark green and glossy foliage with an upright attitude, and the stability of all characteristics from generation to generation. The new variety is typically produced as an indoor ornamental plant.

Abstract: A compact spraying device (10) connectable to a surface and for spraying a fluid comprises a housing (16) with an inlet (20), a pump (28) in fluid communication with the inlet (20), a retractable nozzle (24) in fluid communication with the pump (28), a nozzle cover (22) and a drive system (30). The retractable nozzle (24) selectively extends forward relative to a front side of the housing (16) into a spraying position for spraying the fluid and retracts inside the housing to a retracted position when not spraying. The nozzle cover (22) is selectively moveable from a closed position in which the cover (22) covers the nozzle (24) when the nozzle (24) is in a retracted position, to an open position in which the cover (22) moves to allow the nozzle (24) to extend into the spraying position. The drive system (30) moves the retractable nozzle (24) and the nozzle cover (22) and operates the pump (28).

Abstract: ‘ARAANTPIN1’ is a new and distinctive variety of Anthurium which is characterized by large and attractive inflorescences consisting of a vibrant pink spathe with a nearly horizontal aspect and a white spadix with a yellow apex, dark green and glossy foliage, and the stability of all characteristics from generation to generation. The new variety is typically produced as an indoor ornamental plant.

Abstract: Systems and devices for providing differential input/output communication with a superconducting device are described. Each differential I/O communication is electrically filtered using a respective tubular filter structure incorporating superconducting lumped element devices and high frequency dissipation by metal powder epoxy. A plurality of such tubular filter structures is arranged in a cryogenic, multi-tiered assembly further including structural/thermalization supports and a device sample holder assembly for securing a device sample, for example a superconducting quantum processor. The interface between the cryogenic tubular filter assembly and room temperature electronics is achieved using hermetically sealed vacuum feed-through structures designed to receive flexible printed circuit board cable.

Abstract: A pair of progressive ophthalmic lenses (1, 2) meets special conditions for improving binocular vision of a wearer, while avoiding discomfort for peripheral vision. A first one of the conditions sets a minimum value for the difference between nasal and temporal half-widths of far vision field and/or proximate vision field for at least one of the lens. A second one of the conditions sets a maximum value for the relative difference in mean refractive power gradient between both lenses.