Abstract: A system, computer readable medium and a method of operating a non volatile memory (NVM) array that comprises multiple NVM cells, the method comprises: receiving input data to be written to the non volatile memory; performing constraint coding on the input data to provide encoded data; wherein the constraint coding prevents the encoded data from comprising forbidden combinations of values; wherein the forbidden combinations of values are defined based on expected inter-cell coupling induced errors resulting from coupling between NVM cells; and writing the encoded data to the non volatile memory.
Type:
Grant
Filed:
August 16, 2011
Date of Patent:
January 5, 2016
Assignee:
TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD.
Abstract: Microelectronic network devices and components are fabricated by binding or complexing at least one electronically functional substance to a molecular fiber, such as a nucleic acid fiber. The devices and components can be combined by interconnecting the complexed fibers to provide microelectronic circuits or networks. Assembly processes involve interactions of various combinations of the fibers and substances used in fabrication.
Type:
Application
Filed:
June 22, 2015
Publication date:
December 24, 2015
Applicant:
TECHNION RESEARCH AND DEVELOPMENT FOUNDATION, LTD.
Inventors:
Erez Braun, Yoav Eichen, Uri Sivan, Gdalyahu Ben-Joseph
Abstract: Recombinant gelonin polypeptides with decreased antigenicity are provided. Cell-targeted constructs comprising said recombinant gelonin polypeptides are also provided. Such constructs can be used in methods for targeted cell killing, such as for treatment of cell proliferative diseases (e.g., cancer).
Abstract: Decellularized tissue-derived extracellular matrices (ECM) and methods of generating and using same are provided. The method of generating a decellularized matrix includes the steps of: (a) subjecting the tissue to washes and a hypertonic buffer; (b) subjecting the tissue to an enzymatic proteolytic digestion with an enzyme such as trypsin; and (c) removing all cellular components from the tissue using a detergent solution which includes Triton-X-100 and ammonium hydroxide. Specifically, there is provided a decellularized myocardium-derived matrix which is completely devoid of all cellular components and hence non-immunogenic in a subject, exhibits suitable structural and mechanical properties for cardiac tissue engineering or replacement therapy of damaged cardiac tissue, and is capable of remodeling upon seeding of cells.
Type:
Grant
Filed:
March 7, 2006
Date of Patent:
December 22, 2015
Assignee:
Technion Research & Development Foundation Limited
Abstract: Method comprising: applying uncured pre-gel (UP) to surface; contacting UP with cross-linking agents; allowing applied UP to cure, increasingly adhere to first surface, source of agents: solid support comprising agent, or insoluble agent salt in UP, wherein trigger compound is added to UP, or spraying/coating agent, with solid support added.
Type:
Grant
Filed:
June 1, 2010
Date of Patent:
December 22, 2015
Assignee:
Technion Research & Development Foundation Ltd.
Abstract: Systems and methods using contrast enhanced ultrasound imaging for quantitative assessment of neovascularization, such as within a tumor or a plaque. The contrast agent moves in small blotches rather than in continuous flow, but image processing methods enable the detection and quantification of the blood flow, even in the tiny blood vessels of the vasculature tree. The image processing includes compensation for motion of the tissue arising from body movement. The position and extent of the discrete positions of contrast material may be accumulating during a complete heart cycle onto a single 2D image, to enable an indication of a vascular tree based on this local accumulated image. Dynamic processing (DP) of the discrete positions of contrast material enables a complete vascular tree to be obtained. The neovascularization is quantified by the ratio of its total area to that of the plaque in which the neovascularization has grown.
Type:
Grant
Filed:
January 30, 2013
Date of Patent:
December 22, 2015
Assignee:
Technion Research & Development Foundation Limited
Inventors:
Assaf Hoogi, Avinoam Bar-Zion, Dan Adam
Abstract: A new class of paromomycin-derived aminoglycosides, which exhibit efficient stop-codon mutation suppression activity, low toxicity and high selectivity towards eukaryotic cells are provided. Also provided are chemical and chemo-enzymatic processes of preparing these paromomycin-derived aminoglycosides and intermediates thereof, as well as pharmaceutical compositions containing the same, and uses thereof in the treatment of genetic disorders.
Type:
Application
Filed:
June 14, 2015
Publication date:
December 10, 2015
Applicant:
Technion Research & Development Foundation Limited
Inventors:
Timor BAASOV, Tamar Ben-Yosef, Igor Nudelman, Annie Rebibo-Sabbah, Dalia Shallom-Shezifi, Mariana Hainrichson
Abstract: An isolated primate embryonic cell is provided as well as cell cultures and cell lines derived therefrom. Also provided are methods of generating and using such cells.
Type:
Grant
Filed:
December 27, 2012
Date of Patent:
December 8, 2015
Assignee:
Technion Research & Development Foundation Limited
Abstract: A method of applying a nondestructive mechanical force on one or more cells in aqueous environment by inducing heat generated acoustic pressure pulses. The method comprises providing an energy transmission pattern to induce the applying of a desired nondestructive mechanical force on a at least one cell by forming a plurality of heat generated acoustic pressure pulses in an aqueous environment and instructing the radiation of a target area in proximity to the at least one cell in the aqueous environment with light energy according to the energy transmission pattern.
Type:
Application
Filed:
August 3, 2015
Publication date:
November 26, 2015
Applicant:
TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED
Inventors:
Eitan KIMMEL, Shy SHOHAM, Boris KRASOVITSKI
Abstract: The present invention concerns gp19 immunoreactive compositions for E. canis and compositions related thereto, including vaccines, antibodies, polypeptides, peptides, and polynucleotides. In particular, epitopes for E. canis gp19 are disclosed.
Type:
Application
Filed:
June 3, 2015
Publication date:
November 26, 2015
Applicant:
RESEARCH DEVELOPMENT FOUNDATION
Inventors:
Jere W. McBRIDE, Christopher Kuyler DOYLE
Abstract: The present invention concerns VLPT immunoreactive compositions for E. chaffeensis and compositions related thereto, including vaccines, antibodies, polypeptides, peptides, and polynucleotides. In particular, epitopes for E. chaffeensis VLPT are disclosed.
Abstract: A resonator system for electron spin resonance (ESR) is disclosed. The resonator system comprises: a generally planar resonator layer defining an open-loop gapped by a non-conductive gap in the layer, and a microwave feed, positioned configured for transmitting microwave to the resonator layer such as to concentrate, with a quality factor of at least 100, a magnetic field within an effective volume of less than 1 nL above the layer.
Type:
Grant
Filed:
October 18, 2011
Date of Patent:
November 24, 2015
Assignee:
Technion Research & Development Foundation Limited
Abstract: A method for comparing systems includes running, simultaneously, a first system and a second system, wherein the first system and the second system process events, collecting first data from the first system based on the processing of the events, collecting second data from the second system based on the processing of the events, wherein the second system includes at least one feature different than the first system, and performing a sequential probability ratio test based on the first data and the second data.
Type:
Grant
Filed:
May 25, 2013
Date of Patent:
November 24, 2015
Assignees:
INTERNATIONAL BUSINESS MACHINES CORPORATION, TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LIMITED
Inventors:
Robyn L. Focazio, Yefim H. Michlin, Larisa Shwartz, Maheswaran Surendra
Abstract: A novel class of antimicrobial polymeric agents, which include a plurality of positively charged amino acid residues and at least one omega-amino-fatty acid residue linking therebetween, designed to exert antimicrobial activity while being stable, non-toxic and avoiding development of resistance thereto and a process of preparing same are disclosed. Further disclosed are pharmaceutical compositions containing same and a method of treating medical conditions associated with pathological microorganisms, a medical device, an imaging probe and a food preservative utilizing same. Further disclosed are conjugates of an amino acid residue and a hydrophobic moiety residue and a process of preparing same.
Type:
Application
Filed:
August 6, 2015
Publication date:
November 19, 2015
Applicant:
TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED
Abstract: A methodology is provided for generating hydrophobic superhydrophobic, oleophobic and/or superoleophobic surfaces. Compositions of matter made of a substrate having deposited on a surface thereof (e.g., by thermal evaporation) hydrocarbon waxes, including fluorinated waxes, are disclosed. Process of preparing such compositions of matter and articles of manufacturing incorporating such compositions are also disclosed. Further disclosed are articles of manufacturing and methods which are useful in inhibiting, reducing and/or retarding biofilm formation, and which include applying waxes (e.g., by thermal evaporation) on a surface of the articles.
Type:
Application
Filed:
December 12, 2013
Publication date:
November 12, 2015
Applicant:
TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED
Abstract: Disclosed are polypeptides that are analogs of urocortin 2 that have pharmacological activity similar to urocortin 2 but have improved water solubility compared to urocortin 2, and pharmaceutical compositions of the polypeptides of the present invention. Also disclosed are polynucleotides encoding the polypeptides, and methods of treating pathophysiological states employing pharmaceutical compositions of the polypeptides and polynucleotides of the present invention. In addition, disclosed are vectors and host cells that include a nucleic acid encoding a polypeptide of the present invention, and kits that include pharmaceutical compositions of the present invention.
Type:
Application
Filed:
July 17, 2015
Publication date:
November 5, 2015
Applicant:
RESEARCH DEVELOPMENT FOUNDATION
Inventors:
Wylie W. VALE, JR., Joan M. VAUGHAN, Cindy DONALDSON, Wolfgang FISCHER, Jean E. F. RIVIER
Abstract: A new class of pseudo-trisaccharide aminoglycosides having an alkyl group at the 5? position, exhibiting efficient stop codon mutation readthrough activity, low cytotoxicity and high selectivity towards eukaryotic translation systems are provided. Also provided are pharmaceutical compositions containing the same, and uses thereof in the treatment of genetic disorders, as well as processes of preparing these aminoglycosides. The disclosed aminoglycosides can be represented by the general formula I: or a pharmaceutically acceptable salt thereof, wherein R1 is selected from the group consisting of alkyl, cycloalkyl and aryl; and all other variables and features are as described in the specification.
Type:
Grant
Filed:
August 18, 2014
Date of Patent:
November 3, 2015
Assignee:
Technion Research & Development Foundation Limited
Inventors:
Timor Baasov, Dana Atia-Glikin, Jeyakumar Kandasamy, Valery Belakhov
Abstract: A system of image stereo matching includes at least one stereo matching unit (SMU) each receives a first view and a second view of a view pair, according to which the SMU generates a first depth map for the first view. The system also includes a backward tracer operable to receive the first depth map, according to which a second depth map for the second view is derived.
Type:
Grant
Filed:
December 26, 2012
Date of Patent:
October 27, 2015
Assignees:
NCKU Research and Development Foundation, Himax Technologies Limited
Inventors:
Ming-Der Shieh, Der-Wei Yang, Li-Chia Chu, Tzung-Ren Wang
Abstract: A memory cell (32C), including a first non-insulator (34C) and a second non-insulator (40C), different from the first non-insulator. The second non-insulator forms a junction (46C) with the first non-insulator. The cell further includes a first electrode (48C) which is connected to the first non-insulator and a second electrode (50C) which is connected to the second non-insulator. At least one of the first and second non-insulators is chosen from a group consisting of a solid electrolyte and a mixed ionic electronic conductor and has an ionic transference number less than 1 and greater than or equal to 0.5.
Type:
Grant
Filed:
September 18, 2011
Date of Patent:
October 27, 2015
Assignee:
TECHNION RESEARCH & DEVELOPMENT FOUNDATION
Abstract: The present invention relates to antibodies against specific domains of Olfml3 and the use of such in angiogenesis. In particular aspects, angiogenesis-related conditions, such as cancer, can be treated by the composition comprising the Olfml3 antagonists.
Type:
Application
Filed:
July 7, 2015
Publication date:
October 22, 2015
Applicant:
Research Development Foundation
Inventors:
Beat A. IMHOF, Marijana MILJKOVIC-LICINA, Philippe HAMMEL