Abstract: In some aspects, methods for treating a bacterial infection in a mammalian subject are provided. In some embodiments, a class IIa HDAC inhibitor such as, e.g., a HDAC4 inhibitor, may be used to treat a bacterial infection such as, e.g., anthrax, pertussis, tuberculosis, or cholera.

Abstract: A method for space-variant manipulating of thermal emission from a surface of a material that supports surface waves includes providing a grating with a spatially varying grating parameter on the surface of the material.

Abstract: A computerized method of creating a presentation of multidimensional objects in a multidimensional presentation space. The method comprises providing a core element which applies any of functions on a multidimensional object in a multidimensional presentation space, providing a plurality of adaptation components each contains instructions for converting any media object of another of different media types each to a multidimensional object in the multidimensional presentation space, receiving a media object, identifying a matching adaptation component from the adaptation components according to a respective media type of the media object, converting the media objects into a multidimensional object in the multidimensional presentation space using the matching adaptation component, and applying any of the functions on the multidimensional object, using the core element, according to a user selection.

Abstract: An apparatus includes an optical ring resonator, first and second optical couplers, and control circuitry. The first optical coupler is configured to modulate an input optical signal traversing an optical waveguide, by tuning cross-coupling of energy between the optical waveguide and the ring resonator with a first variable coupling coefficient. The second optical coupler is configured to tune cross-coupling of energy between the ring resonator and an auxiliary optical signal, different from the input optical signal, with a second variable coupling coefficient. The control circuitry is configured to modulate the first coupling coefficient with a first control signal so as to modulate the input optical signal, and to modulate the second coupling coefficient with a second control signal, so as to retain a constant electrical-field complex envelope in the ring resonator.

Abstract: Silicon-oxygen batteries comprising a silicon anode as chemical fuel, an air-cathode for dissociating oxygen and a non-aqueous electrolyte, and applications using the same are provided. The silicon-batteries may utilize air for generating oxygen.

Abstract: A method and system are presented for reconstructing an input field where the latter is sensed by a measurement system. The method comprises: providing measured data corresponding to output field of said measurement system; providing data about sparsity of the input field, and data about effective response function of the measurement system; and processing the measured data based on said known data, the processing comprising: determining a sparse vector as a function of said measured data, said data about the sparsity of the input field, and said data about the effective response function; and using the sparse vector for reconstructing the input information. The invention allows for sub-wavelength resolution in imaging applications, and allows for detection of very short pulses by slow detectors in some other applications.

Abstract: A method includes receiving a signal, which includes reflections of multiple pulses from one or more targets (24). A Doppler focusing function, in which the reflections of the multiple pulses from each target accumulate in-phase to produce a respective peak associated with a respective delay and a respective Doppler frequency of the target, is evaluated based on the received signal. Respective delays and Doppler frequencies of the targets are estimated based on the Doppler focusing function.

Abstract: Provided herein are antimicrobial conjugates of two antibiotic agents, exhibiting improved activity also against resistant bacteria, compared to each of the agents separately or their mixture, and having substantially no resistance emerged thereagainst, as well as processes for preparation the same, compositions containing the same, and uses thereof in medical treatments against pathogenic microorganisms. The disclosed antimicrobial conjugates are composed of aminoglycosides and non-ribosomal active antibiotics. Some of the antimicrobial conjugates are prepared via “click” chemistry.

Abstract: The present invention relates to compositions and methods for analyzing and modulating (e.g., enhancing or inhibiting) protein-protein interactions. In particular, compositions and methods of the present invention find use in identifying, reconstituting and characterizing protein-protein interactions, identifying binding subunits, and drug screening. The methods and compositions of the invention may also be used to identify agents that may agonize or antagonize a protein-protein interaction (e.g., using test compounds).

Abstract: Provided are methods of isolating an extracellular matrix from mesenchymal progenitor cells which are characterized by a reduced differentiation ability into an adipogenic lineage as compared to adipose-derived mesenchymal stem cells. Also provide isolated extracellular matrix and hybrid devices comprising electrospun elements and extracellular matrix which can be used for various tissue regeneration, repair and reconstruction surgeries.

Abstract: A novel process of preparing a Grignard reagent is disclosed. The process is effected by electrochemically reacting a Grignard precursor with an electrode which comprises a metal for forming the Grignard reagent, in the presence an electrolyte solution that comprises a room temperature ionic liquid (RTIL). Electrochemical cells and systems for performing the process, and uses thereof in various applications are also disclosed.

Abstract: A half-rate clock and data recovery (CDR) circuit includes a first and a second gated voltage-controlled oscillators (GVCOs) and a first and a second frequency detectors. The first frequency detector generates a first output current according to a reference signal and a second divided clock, and the second frequency detector generates a second output current according to a first divided clock and the second divided clock. A loop filter converts either the first output current or the second output current to a first control voltage to control the second clock, and generates a second control voltage according to the first control voltage to control the first clock. A lock detector receives the reference signal and the second divided clock, and accordingly generates a lock signal.

Abstract: The present invention concerns gp36 immunoreactive compositions for E. canis and gp 47 immunoreactive compositions for E. chaffeensis. In particular, epitopes for E. canis gp36 and E. chaffeensis gp 47 are disclosed. In certain embodiments, the immunoreactive compositions comprise tandem repeats having carbohydrate moieties.

Abstract: A compact endfire tapered slot antenna, which may be advantageously printed on a low permittivity Liquid Crystal Polymer substrate. The antenna features a microstrip-to-slot transition, in which the matching stubs of the slotline antenna feed and the microstrip input line are collinear. This is achieved using a 90° bend in the slotline. The antenna is consequently of smaller size, and has improved bandwidth over prior art geometries. The antenna may be carried on a fork-shaped metallic carrier, which gives it good rigidity, and may incorporate a metallic reflector, which increases its directive gain. The antenna is simpler to manufacture and a less costly alternative to conventional 60-GHz tapered slot antennas printed on multilayer LTCC substrates. It can be used both as an individual radiator as well as an element of an antenna array and is readily integrated with an RF module for use in future WPAN applications.

Abstract: A duobinary voltage-mode transmitter comprises a first branch including a first logic circuit and a first driver, and a second branch including a second logic circuit and a second driver. When a transition occurs between NRZ signals, two ends of a first match circuit are electrically coupled between the output nodes of the first driver and the second driver, respectively, and the first driver and the second driver are turned off.

Abstract: A method includes accepting an analog input signal that includes a sequence of pulses. The analog input signal is filtered so as to produce a filter output, using a filter whose time-domain response is confined to a finite time period and whose frequency-domain response is non-zero at a finite set of integer multiples of a frequency shift ??, and is zero at all other integer multiples of ??. The filter output is sampled so as to produce digital samples. Respective amplitudes and time positions of the pulses in the sequence are calculated based on the digital samples.

Abstract: A method of expanding and maintaining human embryonic stem cells (ESCs) in an undifferentiated state by culturing the ESCs in a suspension culture under culturing conditions devoid of substrate adherence is provided. Also provided are a method of deriving ESC lines in the suspension culture and methods of generating lineage-specific cells from ESCs which were expanded in the suspension culture of the present invention.

Abstract: A novel method to reduce B-cell lymphoma cell migration to and engraftment of the spleen in patients with JAM-C positive B-cell lymphomas is described. In certain aspects, a method for identifying and treating JAM-C positive B-cell lymphoma patients with anti-JAM-C antibodies is provided. Recombinant antibody molecules that specifically bind to JAM-C are also disclosed.

Abstract: Provided are novel serum-free culture media which comprise basic fibroblast growth factor (bFGF), transforming growth factor beta-3 and ascorbic acid at a concentration of at least about 50 microgram/ml; ascorbic acid at a concentration range of about 400-600 microgram/ml, bFGF at a concentration range of about 50-200 ng/ml, xeno-free serum replacement and a lipid mixture; the IL6RIL6 chimera at a concentration range of about 50-200 picogram per milliliter (pg/ml); or leukemia inhibitory factor (LIF) at a concentration of at least 2000 units/ml; cell cultures comprising same with pluripotent stem cells such as human embryonic stem cells and induced pluripotent stem (iPS) cells, and methods of using same for expanding pluripotent stem cells in an undifferentiated state using two-dimensional or three-dimensional culture systems; and methods of expanding iPS cells in a suspension culture devoid of substrate adherence and cell encapsulation.

Abstract: A conducting material includes a carbon-based material selected from a diamond or an insulating diamond-like carbon, having a hydrogen-terminated surface and a layer of MoO3 coating the surface. A method for the fabrication of such a material. The conducting material is useful in the fabrication of electronic components, electrodes, sensors, diodes, field effect transistors, and field emission electron sources.