Abstract: A half-rate clock and data recovery (CDR) circuit includes a first and a second gated voltage-controlled oscillators (GVCOs) and a first and a second frequency detectors. The first frequency detector generates a first output current according to a reference signal and a second divided clock, and the second frequency detector generates a second output current according to a first divided clock and the second divided clock. A loop filter converts either the first output current or the second output current to a first control voltage to control the second clock, and generates a second control voltage according to the first control voltage to control the first clock. A lock detector receives the reference signal and the second divided clock, and accordingly generates a lock signal.

Abstract: A method for exchanging information with an Optical Network Unit (ONU), the method comprising: receiving, by the ONU, downstream signals that comprise a pilot signal and downstream information signals; wherein the downstream information signals embed first polarization modulated information and second polarization modulated information; wherein the pilot signal is received at a pilot frequency slot and the downstream information signals are received at a downstream information frequency slot that differs from the pilot frequency slot; splitting the downstream signals to first, second, third and fourth sets of signals; wherein the splitting comprises performing a polarization based splitting to provide first and second intermediate sets of signals; wherein the first and second sets of signals originate from the first intermediate set of signals and the third and fourth sets of signals originate from the second intermediate set of signals; generating a fifth set of signals by providing the second and fourth set

Abstract: A microparticle for cell encapsulation is provided, having a core which comprises continuous fibers of decellularized extracellular matrix (ECM).

Abstract: Cell-targeted serine protease constructs are provided. Such constructs can be used in methods for targeted cell killing such as for treatment cell of proliferative diseases (e.g., cancer). In some aspects, recombinant serine proteases, such as Granzyme B polypeptides, are provided that exhibit improved stability and cell toxicity. Methods and compositions for treating lapatinib or trastuzumab-resistant cancers are also provided.

Abstract: A method of applying a nondestructive mechanical force on one or more cells in aqueous environment by inducing heat generated acoustic pressure pulses. The method comprises providing an energy transmission pattern to induce the applying of a desired nondestructive mechanical force on a at least one cell by forming a plurality of heat generated acoustic pressure pulses in an aqueous environment and instructing the radiation of a target area in proximity to the at least one cell in the aqueous environment with light energy according to the energy transmission pattern.

Abstract: A composition-of-matter comprising an antibody or antibody fragment including an antigen-binding region capable of specifically binding an antigen-presenting portion of a complex composed of a human antigen-presenting molecule and an antigen derived from a pathogen is disclosed.

Abstract: A method of preserving organisms in viable form, the method comprising: suspending organisms in a solution of electrospinnable polymer; drawing droplets of said solution through a spinneret; applying an electrostatic field to said droplets under electrospinning conditions; so as to form fibers having a diameter no greater than about 5 ?m within which distinct organisms are encapsulated in viable form.

Abstract: The present invention relates to antibodies against specific domains of Olfml3 and the use of such in angiogenesis. In particular aspects, angiogenesis-related conditions, such as cancer, can be treated by the composition comprising the Olfml3 antagonists.

Abstract: The present invention provides HIV-derived lentivectors which are multiply modified to create highly safe, efficient, and potent vectors for expressing transgenes for gene therapy. The lentiviral vectors comprise various combinations of an inactive central polypurine tract, a stuffer sequence, which may encode drug susceptibility genes, and a mutated hairpin in the 5? leader sequence that substantially abolishes replication. These elements are provided in conjunction with other features of lentiviral vectors, such as a self-inactivating configuration for biosafety and promoters such as the EF1? promoter as one example. Additional promoters are also described. The vectors can also comprise additional transcription enhancing elements such as the wood chuck hepatitis virus post-transcriptional regulatory element.

Abstract: Provided are methods for protein engineering, such as engineering proteases or kinases. The methods may utilize yeast display and/or ER sequestration of proteins or substrates. In some aspects, TEV proteases with altered substrate specificity, potency, and/or efficiency are provided.

Abstract: An electronic device is presented, such as a thin film transistor. The device comprises a patterned electrically-conductive layer associated with an active element of the electronic device. The electrically-conductive layer has a pattern defining an array of spaced-apart electrically conductive regions. This technique allows for increasing an electric current through the device.

Abstract: An adaptive switched-capacitor equalizer includes a first variable capacitor that is switchably connected between an input voltage and an output voltage, and a second variable capacitor that is switchably connected between the input voltage and the output voltage. The equalizer operates in a sequence of three phases, in a first phase of which the first variable is reset; in a second phase of which the first variable capacitor and the second variable capacitor are electrically connected in parallel between the input voltage and the output voltage; in a third phase of which calibration is performed according to the input voltages received in sequence.

Abstract: An isolated homogeneous population of cells comprising a plurality of human ectodermal progenitor cells. Also provided are methods of generating and using the population of cells.

Abstract: A successive approximation register analog-to-digital converter (SAR ADC) includes a comparator coupled to receive a sampled input voltage; a pair of arrays each including individually switchable binary-weighted capacitors that are switchably coupled to an output of the comparator via phase switches, respectively. A phase signal for controlling a corresponding phase switch associated with a current bit becomes asserted when a preceding bit finishes comparison, and the phase signal becomes de-asserted when the current bit finishes comparison.

Abstract: A receiver and a multi-symbol-differential-detection (MSDD) module, the MSDD may include an input node for receiving an input signal having a noisy phase; a summation and rotation unit; and an output unit; wherein the output unit is arranged to output an output signal and a normalized output signal; wherein the output signal represents the input signal but has a reconstructed phase; wherein the summation and rotation unit is arranged to receive the input signal and the output signal and to provide a reference signal that reflects a weighted sum of phase rotated and delayed previously received input signals; wherein the output unit comprises a phase difference calculator, a slicer, a delay unit and a normalizer; wherein the phase difference calculator is arranged to generate a difference signal indicative of a phase difference between the reference signal and the input signal; wherein the slicer and the delay unit are arranged to generate the output signal by slicing the difference signal to provide a sliced s

Abstract: A new class of paromomycin-derived aminoglycosides, which exhibit efficient stop-codon mutation suppression activity, low toxicity and high selectivity towards eukaryotic cells are provided. Also provided are chemical and chemo-enzymatic processes of preparing these paromomycin-derived aminoglycosides and intermediates thereof, as well as pharmaceutical compositions containing the same, and uses thereof in the treatment of genetic disorders.

Abstract: A method of diagnosing oral cancer or oral pharyngeal cancer in a subject in need thereof is provided. The method comprising determining a level or activity of at least one marker in a saliva sample of the subject, wherein a significant alteration in the level or the activity of the marker with respect to an unaffected saliva sample is indicative of the cancer, wherein the saliva marker is selected from the group consisting of Cyclin D1, phospho-Src, 8-oxoguanine DNA glycosylase (OGG1), Maspin, KI67 and translocator protein 18 kDa (TSPO).

Abstract: Methods and compositions involving polypeptides having an aglycosylated antibody Fc domain. In certain embodiments, polypeptides have an aglycosylated Fc domain that contains one or more substitutions compared to a native Fc domain. Additionally, some embodiments involve an Fc domain that is binds some Fc receptors but not others. For example, polypeptides are provided with an aglycosylated Fc domain that selectively binds Fc?RIIa, but that is significantly reduced for binding to the highly homologous Fc?RIIb receptors. Furthermore, methods and compositions are provided for promoting antibody-dependent cell-mediated toxicity (ADCC) using a polypeptide having a modified aglycosylated Fc domain and a second non-Fc binding domain, which can be an antigen binding region of an antibody or a non-antigen binding region. Some embodiments concern antibodies with such polypeptides, which may have the same or different non-Fc binding domain.

Abstract: Disclosed are compositions-of-matter composed of a continuous elastomeric matrix and a liquid; the matrix entrapping the liquid therein in the form of closed-cell droplets dispersed throughout the matrix. The disclosed compositions-of-matter are characterized by a low tensile/compressive modulus and are capable of retaining the liquid for exceedingly long periods of time. Further disclosed are processes for forming the compositions-of-matter and uses thereof.

Abstract: A self-propelled device for locomotion through a lumen, comprising a set of serially arranged inflatable chambers, the end ones of which expand at least radially when inflated. Connecting passages provide fluid communication between each pair of adjacent chambers. A fluid source is attached to one of the end chambers. The connecting passages are such that the fluid inflates the chambers in a sequence, beginning with the chamber closest to the source, and ending with the chamber furthest from the source. The same sequence occurs when the chambers deflate, beginning with the chamber closest to the source, and ending with the chamber furthest from the source. The fluid source can either be a fluid supply tube, extending to a supply outside the lumen, or it can be built-in and carried by the device. The device can crawl either along the lumen wall or on an inserted guide wire.