Patents Assigned to DEVELOPMENT FOUNDATION
  • MOLYBDENUM TRIOXIDE-COATED HYDROGEN-TERMINATED DIAMOND SURFACE AND USES THEREOF
    Publication number: 20140319542
    Abstract: The present invention provides a conducting material comprising a carbon-based material selected from a diamond or an insulating diamond-like carbon, having a hydrogen-terminated surface and a layer of MoO3 coating said surface; as well as a method for the fabrication of such a material. The conducting material of the invention is useful in the fabrication of electronic components, electrodes, sensors, diodes, field effect transistors, and field emission electron sources.
    Type: Application
    Filed: April 24, 2014
    Publication date: October 30, 2014
    Applicant: Technion Research and Development Foundation Ltd.
    Inventors: Rafi KALISH, Moshe TORDJMAN
  • OPTICAL IMAGING BASED ON VISCOELASTIC FOCUSING
    Publication number: 20140322801
    Abstract: An apparatus arranged for examining particles, comprising: a cartridge having at least one microchannel, a viscoelastic fluid flowing in the microchannel, the fluid comprising a suspension of particles, thereby effecting alignment of the particles in at least one-dimensional array parallel to the fluid flow, and an optical magnifying means generating an image of the particles in the microchannel.
    Type: Application
    Filed: July 14, 2014
    Publication date: October 30, 2014
    Applicants: Technion Research & Development Foundation Ltd., Pixcell Medical Technologies Ltd.
    Inventors: Avishay Bransky, Max Herzberg
  • PROTEIN-POLYSACCHARIDE CONJUGATES AND USE FOR ENCAPSULATING NUTRACEUTICALS FOR CLEAR BEVERAGE APPLICATIONS
    Publication number: 20140322340
    Abstract: The present invention provides protein (or peptide)-polysaccharide (or oligosaccharide) conjugates (PPC) as nanocapsular vehicles for nanoencapsulation of biologically active compounds, particularly nutraceuticals. The PPCs efficiently protect both hydrophobic (i.e., water insoluble) and hydrophilic (i.e., water soluble) nutraceuticals, to provide a composition which, when added to a beverage, disperses so as to provide a clear or transparent solution. In some embodiments, the PPCs are Maillard reaction based PPCs. Advantageously, the conjugates of the present invention protect the nutraceuticals from degradation, both during shelf life and upon gastric digestion.
    Type: Application
    Filed: May 4, 2014
    Publication date: October 30, 2014
    Applicant: Technion Research and Development Foundation LTD.
    Inventor: Yoav D. Livney
  • MEMRISTOR BASED MULTITHREADING
    Publication number: 20140325192
    Abstract: A method and a device that includes a set of multiple pipeline stages, wherein the set of multiple pipeline stages is arranged to execute a first thread of instructions; multiple memristor based registers that are arranged to store a state of another thread of instructions that differs from the first thread of instructions; and a control circuit that is arranged to control a thread switch between the first thread of instructions and the other thread of instructions by controlling a storage of a state of the first thread of instructions at the multiple memristor based registers and by controlling a provision of the state of the other thread of instructions by the set of multiple pipeline stages; wherein the set of multiple pipeline stages is arranged to execute the other thread of instructions upon a reception of the state of the other thread of instructions.
    Type: Application
    Filed: March 19, 2014
    Publication date: October 30, 2014
    Applicant: Technion Research and Development Foundation LTD.
    Inventors: Avinoam Kolodny, Uri Weiser, Shahar Kvatinsky
  • RTEF-1 VARIANTS AND THE USE THEREOF FOR INHIBITION OF ANGIOGENESIS
    Publication number: 20140322205
    Abstract: Dominant negative (DN) variants of transcriptional enhancer factor 1-related (RTEF-1) are described. DN RTEF-1 polypeptides may be directly targeted to cells or delivered in nucleic acid expression vectors to alter cellular transcription. Methods for inhibiting VEGF production and thereby treating angiogenic disorders such as cancer are described. For example, in certain aspects, DN RTEF-1 may be used to treat angiogenic disorders of the eye such as age related macular degeneration (AMD).
    Type: Application
    Filed: May 5, 2014
    Publication date: October 30, 2014
    Applicant: RESEARCH DEVELOPMENT FOUNDATION
    Inventors: J. Timothy STOUT, Trevor J. MCFARLAND, Binoy APPUKUTTAN
  • ULTRA-FLAT PLASMONIC OPTICAL HORN ANTENNA
    Publication number: 20140321805
    Abstract: An optical device includes a substrate, a metallic layer, a dielectric filling and a light collection element. The substrate has first and second opposite surfaces, and has a funnel-shaped cavity between a first aperture on the first surface and a second aperture on the second surface. The metallic layer covers an inner wall of the funnel-shaped cavity. The dielectric filling is disposed over the metallic layer and fills the funnel-shaped cavity. The light collection element is coupled to the second aperture, and is configured to collect light that impinges on the first aperture and is directed to the second aperture by the metallic layer and dielectric filling.
    Type: Application
    Filed: April 10, 2014
    Publication date: October 30, 2014
    Applicant: Technion Research & Development Foundation Ltd.
    Inventors: Shay Yosub, Meir Orenstein
  • Medical scaffold, methods of fabrication and using thereof
    Patent number: 8871237
    Abstract: Articles of manufacturing comprising electrospun elements having continuous or stepwise gradients of porosity, average pore size, weight per volume and/or of agents for promoting cell colonization, differentiation, extravasation and/or migration are provided. Also provided are methods of manufacturing and using same for guiding tissue regeneration.
    Type: Grant
    Filed: April 4, 2006
    Date of Patent: October 28, 2014
    Assignee: Technion Research & Development Foundation Limited
    Inventors: Eyal Zussman, Erella Livne, Samer Srouji, Shmuel Chervinsky
  • Beta-casein assemblies for mucosal delivery of therapeutic bioactive agents
    Patent number: 8871276
    Abstract: The present invention discloses a dried composition comprising ?-casein micelles, assemblies and complexes thereof. The dried composition is stable in the dried state as well as upon re-suspension The dried composition retains the biological activity, drug load capacity, particle size and particle size distribution of the ?-casein micelles, assemblies and complexes comprising the active pharmaceutical ingredient, within the dried state and upon resuspension in a buffer or an aqueous pharmaceutical carrier.
    Type: Grant
    Filed: August 18, 2011
    Date of Patent: October 28, 2014
    Assignee: Technion Research and Development Foundation Ltd.
    Inventors: Yechezkel Barenholz, Dganit Danino
  • METHOD AND SYSTEM FOR TRANSMITTING LIGHT
    Publication number: 20140313315
    Abstract: A temporal focusing system is disclosed. The temporal focusing system is configured for receiving a light beam pulse and for controlling a temporal profile of the pulse to form an intensity peak at a focal plane. The temporal focusing system has a prismatic optical element configured for receiving the light beam pulse from an input direction parallel to or collinear with the optical axis of the temporal focusing system and diffracting the light beam pulse along the input direction.
    Type: Application
    Filed: November 15, 2012
    Publication date: October 23, 2014
    Applicant: Technion Research & Development Foundation Limited
    Inventors: Shy Shoham, Hod Dana
  • SERINE PROTEASE MOLECULES AND THERAPIES
    Publication number: 20140314760
    Abstract: Cell-targeted serine protease constructs are provided. Such constructs can be used in methods for targeted cell killing such as for treatment cell of proliferative diseases (e.g., cancer). In some aspects, recombinant serine proteases, such as Granzyme B polypeptides, are provided that exhibit improved stability and cell toxicity. Methods and compositions for treating lapatinib or trastuzumab-resistant cancers are also provided.
    Type: Application
    Filed: July 2, 2014
    Publication date: October 23, 2014
    Applicant: RESEARCH DEVELOPMENT FOUNDATION
    Inventors: Michael G. ROSENBLUM, Khalid Amanali MOHAMEDALI, Lawrence H. CHEUNG
  • Beta-casein assemblies for enrichment of food and beverages and methods of preparation thereof
    Patent number: 8865222
    Abstract: The invention relates to a composition for the enrichment of food and/or beverage and to a method of preparing such composition. The composition comprises additive loaded beta-casein micelles which are of a diameter of about 100 nm or less. These nano-sized beta-casein assemblies are formed at pH values which are preferably one or more pH units above or below the pI of the protein (pI=5.3). More preferably the beta-casein nano-assemblies are formed at a pH range between about 6.0 and about 8, or between about 2.0 and about 4.2. The invention provides vehicles for delivery of additives via transparent beverages and other foods and drinks and/or acidic foods and drinks and/or non fat foods and drinks.
    Type: Grant
    Filed: February 11, 2009
    Date of Patent: October 21, 2014
    Assignee: Technion Research and Development Foundation Ltd.
    Inventors: Dganit Danino, Yoav D. Livney, Ory Ramon, Irina Portnoy, Uri Cogan
  • Methods and devices of separating molecular analytes
    Patent number: 8864970
    Abstract: A method of separating a mixture of a plurality of molecular analytes having different isoelectric points (pIs). The method comprises placing a solution containing a mixture of a plurality of molecular analytes in a separation volume, generating a pH profile having a plurality of pH zones across an axis of the separation volume, and adjusting a profile of the pH profile to induce a migration of a first molecular analyte along the axis apart from a second molecular analyte. The first and second molecular analytes having different pIs.
    Type: Grant
    Filed: August 18, 2010
    Date of Patent: October 21, 2014
    Assignee: Technion Research & Development Foundation Limited
    Inventors: Uri Sivan, Elad Brod
  • Beta-casein assemblies for mucosal delivery of therapeutic bioactive agents
    Patent number: 8865223
    Abstract: Nanoparticulate assemblies of isolated beta-casein, are useful for encapsulation of bioactive therapeutic substances, particularly therapeutic agents with poor bioavailability. These nano-sized beta-casein assemblies are preferably formed at pH values which are at least one or more pH units below or above the pI of the protein. Pharmaceutical compositions comprising the beta-casein micelles may be used to administer the agents to the GI tract for treatment of local or systemic conditions. These carriers are stable over a wide temperature range (optionally at least from about 1° C. to at least about 45° C.).
    Type: Grant
    Filed: February 11, 2009
    Date of Patent: October 21, 2014
    Assignee: Technion Research and Development Foundation Ltd.
    Inventors: Yechezkel Barenholz, Dganit Danino
  • CHARGE-DISCHARGE ELECTRO-OPTICAL MICRORING MODULATOR
    Publication number: 20140307999
    Abstract: An apparatus includes an optical ring resonator, first and second optical couplers, and control circuitry. The first optical coupler is configured to modulate an input optical signal traversing an optical waveguide, by tuning cross-coupling of energy between the optical waveguide and the ring resonator with a first variable coupling coefficient. The second optical coupler is configured to tune cross-coupling of energy between the ring resonator and an auxiliary optical signal, different from the input optical signal, with a second variable coupling coefficient. The control circuitry is configured to modulate the first coupling coefficient with a first control signal so as to modulate the input optical signal, and to modulate the second coupling coefficient with a second control signal, so as to retain a constant electrical-field complex envelope in the ring resonator.
    Type: Application
    Filed: April 10, 2014
    Publication date: October 16, 2014
    Applicant: Technion Research & Development Foundation Ltd.
    Inventors: Anna Kodanev, Meir Orenstein
  • Optically sensitive cell network
    Patent number: 8858929
    Abstract: A neural network is disclosed. The neural network comprises a plurality of optogenetically modified neural cells being three-dimensionally distributed in a hydrogel medium and being disconnected from any solid support having a shear modulus above 1 GPa.
    Type: Grant
    Filed: January 3, 2013
    Date of Patent: October 14, 2014
    Assignee: Technion Research & Development Foundation Limited
    Inventors: Shy Shoham, Anat Marom, Sanjeev Kumar Mahto
  • System and method for fast retinal imaging
    Patent number: 8851671
    Abstract: An optical system and measurement method for imaging three-dimensional objects with low light scatter comprising at least one source of radiation; a radiation projection means for creating a set of foci through a volume of an object; and a means for imaging the returned light from the set of foci on at least one camera, wherein the imaging of the volume of the object is at a different angle from the projection, allowing for detection of the returned light on separate camera pixels. The measurement method further comprises projecting a longitudinal grid of elongated foci through the volume of an object; imaging returned light from the object at a different angle on at least one camera, so as to avoid overlapping the elongated images; and analyzing the imaged, returned light to yield depth information of the object at a multiplicity of points.
    Type: Grant
    Filed: July 4, 2012
    Date of Patent: October 7, 2014
    Assignee: Technion Research and Development Foundation Ltd
    Inventor: Erez Ribak
  • Culturing mammalian embryonic stem cells in human foreskin fibroblast conditioned medium
    Patent number: 8846400
    Abstract: A cell culture comprising human foreskin cells, the human foreskin cells being capable of maintaining stem cells in an undifferentiated state when co-cultured therewith.
    Type: Grant
    Filed: November 26, 2012
    Date of Patent: September 30, 2014
    Assignee: Technion Research & Development Foundation Limited
    Inventors: Michal Amit, Joseph Itskovitz-Eldor
  • ANALOG MULTIPLIER USING A MEMRISTIVE DEVICE AND METHOD FOR IMPLEMENING HEBBIAN LEARNING RULES USING MEMRISOR ARRAYS
    Publication number: 20140289179
    Abstract: A device, comprising: an array of cells, wherein the cells are arranged in columns and rows; wherein each cell comprises a memristive device; an interfacing circuit that is coupled to each cell of the array of cells; wherein the interfacing circuit is arranged to: receive or generate first variables and second variables; generate memristive device input signals that once provided to memristive devices of the array will cause a change in a state variable of each of the memristive devices of the cells of the array, wherein the change in the state variable of each of the memristive devices of the cells of array reflects a product of one of the first variables and one of the second variables; provide the memristive device input signals to memristive devices of the array; and receive output signals that are a function of at least products of the first variables and the second variables;
    Type: Application
    Filed: March 19, 2014
    Publication date: September 25, 2014
    Applicant: Technion Research and Development Foundation LTD.
    Inventors: Dotan Di Castro, Daniel Soudry, Shahar Kvatinsky, Asaf Gal, Avinoam Kolodny
  • UROCORTIN-III AND USES THEREOF
    Publication number: 20140288161
    Abstract: A search of the public human genome database identified a human EST, GenBank accession number AW293249, which has high homology to known pufferfish urocortin sequences. The full length sequence was amplified from human genomic DNA and sequenced. Sequence homology comparisons of the novel sequence with human urocortin I and urocortin II revealed that the sequence encoded a novel human urocortin, which was designated urocortin III (UcnIII). While urocortin III does not have high affinity for either CRF-R1 or CRF-R2, the affinity for CRF-R2 is greater than the affinity for CRF-R1. Urocortin III is capable stimulating cyclic AMP production in cells expressing CRF-R2? or ?. Thus, the affinity is high enough that urocortin III could act as a native agonist of CRF-R2. However, it is also likely that urocortin III is a stronger agonist of a yet to be identified receptor.
    Type: Application
    Filed: February 12, 2014
    Publication date: September 25, 2014
    Applicant: RESEARCH DEVELOPMENT FOUNDATION
    Inventors: Wylie W. VALE, JR., Kathy A. LEWIS, Marilyn H. PERRIN, Koichi KUNITAKE, Jean E. F. RIVIER, Jozsef GULYAS
  • APPARATUS AND METHODS FOR PATHLENGTH MULTIPLEXING FOR ANGLE RESOLVED OPTICAL COHERENCE TOMOGRAPHY
    Publication number: 20140288418
    Abstract: Exemplary embodiments include an apparatus and method for performing angle-resolved imaging of scattering samples such as tissue, including the use of a pathlength multiplexing element.
    Type: Application
    Filed: March 17, 2014
    Publication date: September 25, 2014
    Applicant: RESEARCH DEVELOPMENT FOUNDATION
    Inventors: Thomas MILNER, Jordan DWELLE, Biwei YIN, Bingqing WANG, Austin McELROY, Grady RYLANDER