Abstract: The present invention relates hydroxypyridoxazepine compounds, methods of making them, pharmaceutical compositions containing them and their use as Nrf2 activators. In particular, the invention relates to compounds of Formula (I), and pharmaceutically acceptable salts thereof, or a tautomer thereof, or a hydrate thereof.

Abstract: In certain embodiments, a method includes accessing image information for a scene in a movement path of a mobile robot. The image includes image information for each of a plurality of pixels of the scene, the image information comprising respective intensity values and respective distance values. The method includes analyzing the image information to determine whether to modify the movement path of the mobile robot. The method includes initiating, in response to determining according to the image information to modify the movement path of the mobile robot, sending of a command to a drive subsystem of the mobile robot to modify the movement path of the mobile robot.

Abstract: A system-on-a-chip (SOC) within a package includes a reference generator, a matching circuit, a programmable current generator, a PWM controller, an overvoltage/undervoltage detector receiving a high voltage from a third output pad, a multiplexer passing an input signal to a second output pad, and a SPAD receiving the high voltage. Switching circuitry includes a first switch between the reference generator and an input of the programmable current generator, a second switch between the input of the current generator and the output of the matching circuit, a third switch between the reference generator and an input of the matching circuit, a fourth switch between an output of the current generator and a tap of a ladder within the overvoltage/undervoltage detector, a fifth switch between an output of the current generator and the first output pad, and a sixth switch between the output of the PWM controller and the first output pad.

Abstract: Compounds of formula (I) are described, wherein each of the variable groups is as defined in the specification. Also described are pharmaceutical compositions containing a compound of formula (I), and uses of the compounds and pharmaceutical compositions for inhibiting Nav1.8 voltage-gated sodium channels and treating Nav1.8 mediated diseases, disorders, and conditions, such as pain and pain-associated diseases, disorders, and conditions and cardiovascular diseases, disorders, and conditions, such as atrial fibrillation.

Abstract: In some implementations, a device may receive video data associated with video frames that depict an environment of a vehicle. The device may identify an object depicted in the video frames, wherein an object detection model indicates bounding boxes associated with the object. The device may determine, based on the bounding boxes, a configuration of the bounding boxes within the video frames. The device may determine, based on the configuration of the bounding boxes, that the object is a vulnerable road user (VRU) that is in the environment. The device may determine a trajectory of the VRU based on a change in the configuration between video frames of a set of the video frames. The device may determine, based on the trajectory, a probability of a collision between the VRU and the vehicle. The device may perform, based on the probability, an action associated with the vehicle.

Abstract: A device may receive schedule data identifying schedules of appointments for drivers of vehicles and may receive location data identifying geographical locations of the vehicles. The device may receive traffic data identifying traffic conditions, and may process the received data, with a first model, to determine status data identifying estimated statuses of the appointments. The device may process the received data, with a second model, to generate sets of isochrones for destinations of the appointments, and may calculate, based on the sets of isochrones and the location data, estimated travel time data identifying estimated travel times for the appointments. The device may process the status data, the estimated travel time data, and the schedule data, with a third model, to calculate estimated time of arrival data identifying estimated times of arrival for the appointments, and may perform actions based on the estimated time of arrival data.

Abstract: A device may receive a first image. The device may process the first image to identify an object in the first image and a location of the object within the first image. The device may extract a second image from the first image based on the location of the object within the first image. The device may process the second image to determine at least one of a coarse-grained viewpoint estimate or a fine-grained viewpoint estimate associated with the object. The device may determine an object viewpoint associated with the second vehicle based on the at least one of the coarse-grained viewpoint estimate or the fine-grained viewpoint estimate. The device may perform one or more actions based on the object viewpoint.

Abstract: An electronic device includes a stack of a first level having a SPAD, a second level having a quench circuit for said SPAD, and a third level having a circuit for processing data generated by said SPAD. A method for making the device includes: a) forming of the first level; b) bonding, on the first level, by molecular bonding, of a stack of layers including a semiconductor layer; and c) forming the quench circuit of the second level in the semiconductor layer.

Abstract: The invention relates to compounds of Formula (I), (Ia), (Ib), (II) or (III), salts thereof, pharmaceutical compositions thereof, as well as therapeutic methods of treatment and prevention.

Abstract: A violation detection platform may obtain image data, location data, and sensor data associated with a vehicle. The violation detection platform may determine a probability that a frame of the image data includes an image of a stop sign. The violation detection platform may determine that the probability satisfies a probability threshold. The violation detection platform may identify location data and sensor data associated with the frame of the image data based on the probability satisfying the probability threshold. The violation detection platform may determine an occurrence of a type of a stop sign violation based on the probability, the location data, and the sensor data. The violation detection platform may perform one or more actions based on determining the occurrence of the type of the stop sign violation.

Abstract: In an embodiment, a method includes: receiving a first plurality of digital codes from a time-to-digital converter (TDC); TDC; generating a coarse histogram from the first plurality of digital codes; detecting a peak coarse bin from the plurality of coarse bins; after receiving the first plurality of digital codes, receiving a second plurality of digital codes from the TDC; and generating a fine histogram from the second plurality of digital codes based on the detected peak coarse bin, where a fine histogram depth range is narrower than a coarse histogram depth range, where a lowest fine histogram depth is lower or equal to a lowest coarse peak depth, and where a highest fine histogram depth is higher or equal to a highest coarse peak depth.

Abstract: Provided herein are interleukin 7 (IL-7) binding proteins, pharmaceutical compositions and their use in the treatment or prevention of a disease or condition.

Abstract: The invention relates to compounds of Formula (I), (Ia), (Ib), (II) or (III), salts thereof, pharmaceutical compositions thereof, as well as therapeutic methods of treatment and prevention.

Abstract: Disclosed herein is a method of treating cancer, such as multiple myeloma, involving the combination of an anti-BCMA antigen binding protein (e.g., an anti-BCMA antibody) and an immunomodulatory drug (e.g. pomalidomide or lenalidomide). The combinations can also include an anti-inflammatory compound (e.g. dexamethasone).

Abstract: A device includes a single photon avalanche diode in a portion of a substrate, wherein the portion has an octagonal profile. The octagonal profile is delimited by a wall forming an octagonal contour around the portion. The device further includes an array of diodes, wherein each diode is located in a corner between four adjacent single photon avalanche diodes. Each single photon avalanche diode further includes a doped anode region. A shallow trench isolation is formed in each doped anode region. A polysilicon line forming a resistor is supported at the upper surface of the shallow trench isolation.

Abstract: An optical sensor includes pixels. Each pixel has a photodetector. A readout circuit performs a process over an exposure time where the photodetector is connected to a reverse bias voltage supply to reset a voltage across the photodetector, and the photodetector is disconnected from the reverse bias voltage supply until that the voltage across the photodetector decreases in response to received ambient light. An ambient light level is then determine an based on a number of times the voltage across the photodetector is reset over the exposure time.

Abstract: A device includes a single photon avalanche diode in a substrate and a resistor. The resistor is provided resting on an insulating trench located in a doped anode region of the single photon avalanche diode.

Abstract: An optical element is positioned in a holder over a laser light source. The optical element includes an electrical trace that is coupled between first and second pads. A sensing circuit that is also coupled to the first and second pads performs a voltage/current sensing operation to detect displacement of the optical element and control enablement of the laser light source.

Abstract: An electronic device includes a stack of a first level having a SPAD, a second level having a quench circuit for said SPAD, and a third level having a circuit for processing data generated by said SPAD. A method for making the device includes: a) forming of the first level; b) bonding, on the first level, by molecular bonding, of a stack of layers including a semiconductor layer; and c) forming the quench circuit of the second level in the semiconductor layer.