Abstract: The present disclosure relates to the technical field of chelating agents, in particular to a bifunctional macrocyclic chelate, a conjugate, a metal complex, and use thereof. The bifunctional macrocyclic chelate is a compound of following Formula I or an isomer thereof, wherein R1, R3, R5, and R7 are each independently selected from alkyls or long-chain polymer groups, R2, R4, R6, and R8 are each independently selected from functional groups, Ra, Rb, Rc, and Rd are each independently selected from any one of H, substituted or unsubstituted alkyls, halogens, substituted or unsubstituted cyano groups, substituted or unsubstituted ester groups, substituted or unsubstituted alkoxys, substituted or unsubstituted amines, and substituted or unsubstituted aryls, ring The bifunctional macrocyclic chelate can complex most nuclides, and expand use of the bifunctional macrocyclic chelate, and the metal complex chelating different nuclides can realize integration of diagnosis and treatment.

Abstract: A device may include one or more processors configured to receive sensor data from an external sensor associated with an autonomous driving zone; generate a map of the autonomous driving zone based on the sensor data; determine that a vehicle is entering the autonomous driving zone; and transmit a signal to the vehicle based on the vehicle entering the autonomous driving zone. The signal may cause the vehicle to begin operating in a full autonomous mode. The one or more processors may be configured further to determine an objective associated with the vehicle; receive first data obtained by one or more first sensors associated with the vehicle and second data obtained by the external sensor; determine a route based on the objective, the first data, and the second data; and transmit information identifying the route to the vehicle. The route may allow the vehicle to satisfy the objective.

Abstract: A time-of-flight system includes an emitter-circuit generating and directing pulses of light toward a target, and a receiver-circuit including a photodetector coupled between a bias node and a sensing node to detect pulses that have reflected off the target, a comparison circuit comparing a sense voltage at the sensing node to a reference, a timing measurement circuit measuring elapsed time between generation of a given pulse and detection thereof after reflection off the target, and a programmable current sink that sinks a current from the sensing node equal to a portion of a photocurrent generated by the photodetector due to detection of ambient light. A timing-generation circuit synchronizes generation of the pulses and measurement of elapsed time by the timing circuit. A processor adjusts a magnitude of the current sunk from the sensing node based upon output of the comparison circuit when the emitter circuit is deactivated.

Abstract: This disclosure relates to a time-of-flight sensor including, on a same base substrate, a light emitter configured to emit light into an image scene, a reference sensor configured to detect light emitted by the light emitter, and a signal reception sensor array separated from the light emitter by an optical barrier. The optical barrier is configured to prevent light emitted by the light emitter from directly reaching the signal reception sensor array, with the signal reception sensor array being configured to detect light reflected by the image scene. The reference sensor and the signal reception sensor array are based on semiconductor nanoparticles.

Abstract: In some implementations, a device may receive an image that depicts an environment associated with a vehicle. The device may partition the image into a plurality of subsections. The device may analyze the plurality of subsections to determine respective subsection information, wherein subsection information, for an individual subsection, indicates: a probability score that the subsection includes a line segment associated with an object class, a position of a representative point of the line segment, and a direction of the line segment. The device may identify, based on the respective subsection information of the plurality of subsections, a line associated with the object class that is associated with a set of subsections of the plurality of subsections. The device may perform one or more actions based on identifying the line associated with the object class.

Abstract: A ToF sensor includes an array of pixels having first and second subsets of pixels, first and second pluralities of TDCs, a routing bus having first and second pluralities of bus drivers, and a controller configured to: when the first subset of pixels is active and the second subset of pixels is not active, control the first plurality of bus drivers to route events from half of the pixels of the first subset to the first plurality of TDCs and control the first and second pluralities of bus drivers to route events from the other half of the pixels of the first subset to the second plurality of TDCs, and when the first subset of pixels is not active and the second subset of pixels is active, control the first plurality of bus drivers to route events from the second subset of pixels to the first plurality of TDCs.

Abstract: A load planning platform may generate, according to one or more loading rules, a preliminary packing solution that simulates placing unpacked items, in a set of items, into a container. The load planning platform may generate a set of packing solutions by applying one or more available moves to the preliminary packing solution. The load planning platform may select a final packing solution from the set of packing solutions based on one or more optimization criteria associated with the container and the set of items. The load planning platform may provide access to a three-dimensional rendering of the final packing solution that differentiates each item in the set of items based on a sequence in which the set of items are to be unloaded from the container.

Abstract: A method can be used for controlling pixel scanning within a range detector. A spatially controllable point light source generates a first series of light source pulses associated with a first spatial direction. The first series of light source pulses are generated during a first time period. The spatially controllable point light source generates a second series of light source pulses associated with a second spatial direction. The second series of light source pulses are generated during a second time period that overlaps with the first time period so that the second series of light source pulses are started during the first series of light source pulses.

Abstract: An electronic device includes a stack of a first level having a SPAD, a second level having a quench circuit for said SPAD, and a third level having a circuit for processing data generated by said SPAD. A method for making the device includes: a) forming of the first level; b) bonding, on the first level, by molecular bonding, of a stack of layers including a semiconductor layer; and c) forming the quench circuit of the second level in the semiconductor layer.

Abstract: Various embodiments provide an optical lens that includes wafer level diffractive microstructures. In one embodiment, the optical lens includes a substrate, a microstructure layer having a first refractive index, and a protective layer having a second refractive index that is different from the first refractive index. The microstructure layer is formed on the substrate and includes a plurality of diffractive microstructures. The protective layer is formed on the diffractive microstructures. The protective layer provides a cleanable surface and encapsulates the diffractive microstructures to prevent damage and contamination to the diffractive microstructures. In another embodiment, the optical lens includes a substrate and an anti-reflective layer. The anti-reflective layer is formed on the substrate and includes a plurality of diffractive microstructures.

Abstract: A sensor has plurality of pixels arranged in a plurality of rows and columns with row control circuitry for controlling which one of said rows is activated and column control circuitry for controlling which of said pixels in said activated row is to be activated. The column circuitry has memory configured to store information indication as to which of the pixels are defective, wherein each of the pixels has a photodiode and a plurality of transistors which control the activation of the photodiode. A first transistor is configured to be controlled by a column enable signal while a second transistor is configured to be controlled by a row select signal.

Abstract: A device may generate a shortest path tree based on a passenger starting point identified in driving data. The device may generate a graph with a first layer and a second layer that correspond to the shortest path tree and may add paths from nodes in the first layer to corresponding nodes in the second layer. The device may identify a first shortest path that starts from a driver starting node in the first layer and ends at a passenger end node in the second layer and a second shortest path that starts from the passenger end node and ends at a driver end node in the second layer. The device may calculate a shared cost associated with the driver and the passenger sharing a ride based on the first shortest path and the second shortest path. The device may generate a recommendation based on the shared cost.

Abstract: Provided herein are interleukin 7 (IL-7) binding proteins, pharmaceutical compositions and their use in the treatment or prevention of a disease or condition.

Abstract: A method includes receiving a histogram output from a detector sensor, and calculating a median point of a pulse waveform within the histogram. The pulse waveform has an even probability distribution over at least one quantization step of the histogram around the median point. A corresponding apparatus can include a detector sensor and a co-processor coupled to the detector sensor.

Abstract: A device may receive, from a first vehicle, video data for video captured of a location associated with an accident for a second vehicle, and may process the video data, with a first model, to generate a sparse point cloud of the location associated with the accident. The device may process the video data, with a second model, to generate depth maps for frames of the video data, and may utilize the depth maps with the sparse point cloud to generate a dense point cloud. The device may process the video data, with a third model, to generate a dense semantic point cloud, and may process the dense semantic point cloud, with a fourth model, to determine a dense semantic overhead view of the location associated with the accident. The device may perform actions based on the dense semantic overhead view.

Abstract: A method includes dividing a field of view into a plurality of zones and sampling the field of view to generate a photon count for each zone of the plurality of zones, identifying a focal sector of the field of view and analyzing each zone to select a final focal object from a first prospective focal object and a second prospective focal object.

Abstract: The invention relates to retroviral producer cell comprising nucleic acid sequences encoding: gag and pol proteins; envelope protein or a functional substitute thereof; amplifiable selection marker; and the RNA genome of the retroviral vector particle, wherein said nucleic acid sequences are all integrated at a single locus within the retroviral producer cell genome. The invention also relates to nucleic acid vectors comprising a non-mammalian origin of replication and the ability to hold at least 25 kilobases (kb) of DNA, characterized in that said nucleic acid vector comprises retroviral nucleic acid sequences encoding: gag and pol proteins, and an env protein or a functional substitute thereof. The nucleic acid vector additionally comprises nucleic acid sequences encoding an amplifiable selection marker. The invention also relates to uses and methods using said nucleic acid vector in order to produce stable retroviral packaging and producer cell lines.

Abstract: An optical sensor includes pixels. Each pixel has a photodetector. A readout circuit performs a process over an exposure time where the photodetector is connected to a reverse bias voltage supply to reset a voltage across the photodetector, and the photodetector is disconnected from the reverse bias voltage supply until that the voltage across the photodetector decreases in response to received ambient light. An ambient light level is then determine an based on a number of times the voltage across the photodetector is reset over the exposure time.

Abstract: An input stage circuit for a sigma-delta analog-to-digital converter circuit receives a digital-to-analog converter generated feedback signal and an analog current input signal to generate a difference signal applied to an integrator circuit. A single bit quantization circuit quantizes an output of the integrator circuit to generate a bit signal that is applied to an input of the digital-to-analog converter. The input stage circuit includes a switched input capacitor controlled by first and second, non-overlapping, clock signals.

Abstract: The invention relates to substituted pyridine derivatives that are inhibitors of the activity of DNA methyltransferase 1 (DNMT1). The invention also relates to pharmaceutical compositions comprising such compounds and methods of using such compounds in the treatment of cancer, pre-cancerous syndromes, beta haemoglobinopathy disorders, and other diseases associated with inappropriate DNMT1 activity.