Abstract: A device may receive vehicle operation data associated with operation of a plurality of vehicles, and may process the vehicle operation data to generate processed vehicle operation data. The device may extract multiple features from the processed vehicle operation data, and may train machine learning models, with the multiple features, to generate trained machine learning models that provide model outputs. The device may process the multiple features, with a feature selection model and based on the model outputs, to select sets of features from the plurality of features, and may process the sets of features, with the trained machine learning models, to generate indications of driving behavior and reliabilities of the indications. The device may select a set of features, from the sets of features, based on the indications and the reliabilities, where the set of features may be calculated by a device associated with a particular vehicle.

Abstract: Disclosed herein are C-mannoside compounds, compositions thereof and their application as pharmaceuticals for the treatment of human disease. Methods of inhibition of FimH activity in a human subject are also provided for the treatment of diseases such as bacterial infection, Crohn's disease (CD) and Inflammatory Bowel Disease (IBD).

Abstract: An electronic device includes a carrier substrate having a front face. An electronic chip is mounted on the front face of the carrier substrate and includes an optical component. An encapsulation cover is mounted on top of the front face of the carrier substrate and bounds a chamber within which the chip is situated. A front opening extends through the cover and is situated in front of the optical component. An optical element, designed to allow light to pass, is mounted within the chamber at a position which covers the front opening of the encapsulation cover. The optical element includes a central region designed to deviate the light and having an optical axis aligned with the front opening and the optical component. A positioning pattern is provided on the optical element to assist with mounting the optical element to the cover and mounting the cover to the carrier substrate.

Abstract: Chimeric antigen receptors (CARs) which include an antigen binding protein that binds to a discontinuous epitope on human claudin-3 comprising at least N38 and E153 of SEQ ID NO:13 are described. Also described herein includes polynucleotides encoding the antigen binding protein, the CARs, immune effector cells containing the CARs, pharmaceutical compositions containing the immune effector cells, and methods of treating cancer with the immune effector cells.

Abstract: A maneuver classification platform may obtain video data and telematic data that are associated with a driving event involving a vehicle. The maneuver classification platform may analyze the video data to identify a path of the vehicle along a roadway during the driving event, and based on markings of a plurality of roadways. The maneuver classification platform may analyze the video data to determine a type of a vehicle maneuver performed by the vehicle during the driving event. The maneuver classification platform may determine a maneuver score of the driving event based on the type of the vehicle maneuver, the path of the vehicle, and the telematic data. The maneuver classification platform may send a message associated with the maneuver score and a vehicle identifier of the vehicle to a client device to permit the client device to use the maneuver score.

Abstract: The present invention provides methods for increasing expression of ICOS on an effector T cell comprising contacting said effector T cell with an anti-PD-1 antibody. The present invention also provides methods for decreasing expression of ICOS on a regulatory T cell comprising contacting said regulatory T cell with an anti-PD-1 antibody. The present invention provides methods for increasing sensitivity to an agent directed to ICOS in a human comprising administering to the human an anti-PD1 antibody. The present invention also provides methods of treating cancer in a human in need thereof comprising administering an anti-PD-1 antibody and an anti-ICOS antibody to said human, wherein the anti-PD-1 antibody increases T cell sensitivity to the ICOS antibody.

Abstract: A device may receive an image. The device may utilize an episodic memory to determine a first classification associated with the image. The device may utilize a semantic memory to determine a second classification associated with the image. The device may determine an accuracy associated with utilizing the semantic memory to determine the second classification. The device may determine that the image is associated with the first classification when the accuracy fails to satisfy a threshold accuracy. The device may determine that the image is associated with the second classification when the accuracy satisfies the threshold accuracy.

Abstract: Embodiments of the present disclosure describe a light-field display system including a rotatable display screen subsystem, a display screen positioning apparatus, an eye tracking subsystem, and a computer. The rotatable display screen subsystem includes a lamp pole. The lamp pole includes a lamp panel. The lamp panel includes a vector pixel array. The display screen positioning apparatus includes a plurality of lasers and a photosensor. The computer device is connected to the rotatable display screen subsystem and the eye tracking subsystem. The lamp panel controller is configured to determine a position of the lamp panel according to sensed data of the display screen positioning apparatus. Each vector pixel on the lamp panel displays display content in a display direction to achieve 3D image display.

Abstract: A vehicle device may receive audio data and other vehicle data associated with a vehicle and may transform the audio data to transformed audio data in a frequency domain. The vehicle device may segment the transformed audio data into a plurality of audio segments and may process the plurality of audio segments, with different feature extraction techniques, to extract a plurality of feature vectors. The vehicle device may merge the plurality of feature vectors into a merged feature vector and may create an audio signature for the audio data based on the merged feature vector. The vehicle device may process the audio signature and the other vehicle data, with a model, to determine a classification of the audio signature and may perform one or more actions based on the classification of the audio signature.

Abstract: The present invention relates to indane compounds, methods of making them, pharmaceutical compositions containing them and their use as NRF2 activators.

Abstract: A distance from an apparatus to at least one object is determined by generating a first signal and generating light modulated by the first signal to be emitted from the apparatus. Light reflected by the at least one object is detected using a Time-of-flight detector array, wherein each array element of the Time-of-flight detector array generates an output signal from a series of photon counts over a number of consecutive non-overlapping time periods. The output signals are compared to the first signal to determine at least one signal phase difference. From this at least one signal phase difference a distance from the apparatus to the at least one object is determined.

Abstract: A rating platform can identify a point of interest (POI) among a first plurality of POIs included in a stop cluster. The rating platform can generate a plurality of unweighted user scores for the POI. Respective unweighted user scores, of the plurality of unweighted user scores is associated, can be associated with respective users of a plurality of users. The rating platform can generate a plurality of weighted user scores for the POI based on the plurality of unweighted user scores and respective weights assigned to respective users of the plurality of users. The rating platform can generate a POI score for the POI based on the plurality of weighted user scores. The rating platform can transmit, based on the POI score, an instruction to display, on the client device, information associated with the POI.

Abstract: Nanoplatelets are prepared from a 3D layered material by: providing a dispersion of the 3D layered material, pressurising the dispersion, rapidly depressurising the dispersion to create shear forces that exfoliate the 3D layered material into nanoplatelets; and/or providing a dispersion of the 3D layered material, forming a first flow of the dispersion along a first flowpath in a first direction, forming a second flow of the dispersion along a second flowpath in a second direction by reversing the first flow or by forming the second flow in a second flowpath, wherein the second flowpath is substantially reverse and non-coaxial with the first flowpath, whereby shear forces between material in the first flowpath and material in the second flowpath exfoliate the 3D layered material into nanoplatelets. Also provided are apparatuses for carrying out the invention and nanoplatelets obtained by the invention.

Abstract: An embodiment method of operating an imaging device including a sensor array including a plurality of pixels, includes: capturing a first low-spatial resolution frame using a subset of the plurality of pixels of the sensor array; generating, using a processor coupled to the sensor array, a first depth map using raw pixel values of the first low-spatial resolution frame; capturing a second low-spatial resolution frame using the subset of the plurality of pixels of the sensor array; generating, using the processor, a second depth map using raw pixel values of the second low-spatial resolution frame; and determining whether an object has moved in a field of view of the imaging device based on a comparison of the first depth map to the second depth map.

Abstract: The invention relates to substituted pyridine derivatives that are inhibitors of the activity of DNA methyltransferase 1 (DNMT1). The invention also relates to pharmaceutical compositions comprising such compounds and methods of using such compounds in the treatment of cancer, pre-cancerous syndromes, beta haemoglobinopathy disorders, and other diseases associated with inappropriate DNMT1 activity.

Abstract: Compounds of formula (I) that are capable of acting as purine receptor antagonists, pharmaceutical compositions including the compounds, and methods of making the compounds, are disclosed. The compounds and compositions can be used in treating or preventing disorders related to purine receptor hyperfunctioning.

Abstract: An electronic device includes a carrier substrate having a front face. An electronic chip is mounted on the front face of the carrier substrate and includes an optical component. An encapsulation cover is mounted on top of the front face of the carrier substrate and bounds a chamber within which the chip is situated. A front opening extends through the cover and is situated in front of the optical component. An optical element, designed to allow light to pass, is mounted within the chamber at a position which covers the front opening of the encapsulation cover. The optical element includes a central region designed to deviate the light and having an optical axis aligned with the front opening and the optical component. A positioning pattern is provided on the optical element to assist with mounting the optical element to the cover and mounting the cover to the carrier substrate.

Abstract: In one embodiment, an imaging device includes a light-emitting device, a driving circuit, a return single-photon avalanche diode (SPAD) array and readout circuitry. The driving circuit generates a driving signal, and the light-emitting device generates an optical pulse based on the driving signal. The return SPAD array is configured to receive a first portion of the optical pulse that is reflected by an object in an image scene. The readout circuitry receives a signal indicative of the received first portion of the optical pulse, and a signal indicative of the driving signal, and determines a distance between the imaging device and the object based on a difference between a time of receiving the signal indicative of the received first portion of the optical pulse and a time of receiving the signal indicative of the driving signal.

Abstract: A sensing pixel includes a single photon avalanche diode (SPAD) coupled between a first node and a second node, with a clamp diode being coupled between a turn-off voltage node and the second node. A turn-off circuit includes a sense circuit configured to generate a feedback voltage based upon a voltage at the turn-off voltage node, a transistor having a first conduction terminal coupled to the turn-off voltage node, a second conduction terminal coupled to ground, and a control terminal, and an amplifier having a first input coupled to a reference voltage, a second input coupled to receive the feedback voltage, and an output coupled to the control terminal of the transistor. A readout circuit is coupled to the SPAD by a decoupling capacitor.

Abstract: A new distinct variety of grapevine named ‘ARD8’ abundantly forms attractive crispy seedless berries with a red skin coloration, lax and large clusters which display a naturally sweet flavor with the fruit commonly ready for harvesting during August in San Joaquin Valley of Central California, U.S.A, and displays good eating qualities as a table grape, with firmness that renders the fruit well amenable for handling, shipping and storage.