Abstract: This invention relates to novel compounds according to Formula (I) which are inhibitors of furin, to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy for the treatment of fibrotic diseases, including pulmonary fibrosis, renal fibrosis, liver fibrosis, skin fibrosis, ocular fibrosis, cardiac fibrosis, and other miscellaneous fibrotic conditions. The disclosed compounds may also be useful for treating other furin-mediated conditions, including but not limited to, hypertension, cancer, infectious diseases, and genetic disorders (e.g., cystic fibrosis (CF)), and neurodegenerative disorders.

Abstract: In a method, substrate elements are provided wherein each substrate element has a first side and a second side meeting at a corner point. The substrate elements are picked and then placed on a support device in alignment. A cutting operation is then performed where each of the substrates elements are cut along a cut line having a common first direction which intersects the first and second sides of each of the substrate elements in order to create a third side on each substrate element. The third side of each of the substrate elements meets the first and the second sides at corresponding corner points.

Abstract: A device may receive sensor data and video data associated with a vehicle, and may process the sensor data, with a rule-based detector model, to determine whether a probability of a vehicle accident satisfies a first threshold. The device may preprocess acceleration data of the sensor data to generate calibrated acceleration data, and may process the calibrated acceleration data, with an anomaly detector model, to determine whether the calibrated acceleration data includes anomalies. The device may filter the sensor data to generate filtered sensor data, and may process the filtered sensor data and anomaly data, with a decision model, to determine whether the probability of the vehicle accident satisfies a second threshold. The device may process the filtered sensor data, the anomaly data, and the video data, with a machine learning model, to determine whether the vehicle accident has occurred, and may perform one or more actions.

Abstract: A photonic device includes a PCB having an integrated circuit mounted thereon, with a cap mounted to the PCB and carrying a lens positioned over the integrated circuit. The cap is formed by: an outer wall mounted to the PCB, extending upwardly from the PCB, and surrounding a portion of the integrated circuit; a first retention structure extending inwardly from the outer wall and across the integrated circuit, the first retention structure having a hole defined therein; and a second retention structure having a hole defined therein, the second retention structure being affixed within the first retention structure such that the hole in the second retention structure is axially aligned with the hole in the first retention structure. The lens is mechanically constrained within the cap between the first retention structure and the second retention structure.

Abstract: A track driven work machine including a body, a first track laying assembly pivotally connected to the body, and a second track laying assembly pivotally connected to the body. The second track laying assembly is spaced apart from the first track laying assembly in a direction transverse to a running direction of the track laying assemblies. In order to navigate uneven grounds, the track driven work machine includes a hydraulic system for synchronizing pivotal movement of the first and second track laying assembly and which is configured to pivot the second track laying assembly in an opposite direction to the first track laying assembly when the first track laying assembly is pivoted in a first direction, and vice versa.

Abstract: A trip planning system may receive, from a user device, trip data identifying a starting point and a destination point for a trip and feature data identifying weights for trip features. The trip planning system may determine a geographical region of interest based on the starting point and the destination point. The trip planning system may receive viewpoint data identifying viewpoints located within the geographical region and may calculate, based on the feature data, viewpoint relevance scores for the viewpoints. The trip planning system may determine, based on the viewpoint data and the trip data, paths for the trip and driving times for the paths. The trip planning system may calculate an optimized path, from the paths, based on the viewpoint relevance scores and the driving times associated with the paths. The trip planning system may perform one or more actions based on the optimized path.

Abstract: An optical module includes an optical detector, laser emitter, and first and second support structures, each carried by a substrate. An optical layer includes first and second fixed portions carried by the support structures, a movable portion affixed between the fixed portions by a spring structure, and a lens system carried by the movable portion, the lens system including an objective lens and a beam shaping lens. The optical layer includes a comb drive with a first comb structure extending from the first fixed portion to interdigitate with a second comb structure extending from the movable portion, a third comb structure extending from the second fixed portion to interdigitate with a fourth comb structure extending from the movable portion, and actuation circuitry applying voltages to the comb structures to cause the movable portion of the optical layer to oscillate back and forth between the fixed portions.

Abstract: Various embodiments provide an optical lens that includes wafer level diffractive microstructures. In one embodiment, the optical lens includes a substrate, a microstructure layer having a first refractive index, and a protective layer having a second refractive index that is different from the first refractive index. The microstructure layer is formed on the substrate and includes a plurality of diffractive microstructures. The protective layer is formed on the diffractive microstructures. The protective layer provides a cleanable surface and encapsulates the diffractive microstructures to prevent damage and contamination to the diffractive microstructures. In another embodiment, the optical lens includes a substrate and an anti-reflective layer. The anti-reflective layer is formed on the substrate and includes a plurality of diffractive microstructures.

Abstract: A combining network for an array of SPAD devices includes: synchronous sampling circuits, wherein each synchronous sampling circuit is coupled to an output of a corresponding SPAD device and is configured to generate a pulse or an edge each time an event is detected; and a summation circuit coupled to an output of each of the synchronous sampling circuits and configured to count a number of pulses or edges to generate a binary output value.

Abstract: A hydrogen production system comprises a hydrogen pyrolysis reactor which has a hydrocarbon input, an electrical input and at least one hydrogen output. The hydrogen production system also comprises a hydrogen-fuelled generator. Means are provided to route part of the hydrogen from one of the at least one hydrogen outputs to the hydrogen-fuelled generator. The hydrogen-fuelled generator then generates an electrical output, which is routed to the electrical input of the hydrocarbon pyrolysis reactor. A related method of operating a hydrogen production system is also described.

Abstract: A transmit integrated circuit includes a light source configured to generate a beam of light. A receive integrated circuit includes a first photosensor. A transmit optic is mounted over the transmit and receive integrated circuits. The transmit optic is formed by a prismatic light guide and is configured to receive the beam of light. An annular body region of the transmit optic surrounds a central opening which is aligned with the first photosensor. The annular body region includes a first reflective surface defining the central opening and further includes a ring-shaped light output surface surrounding the central opening. Light is output from the ring-shaped light output surface in response to light which propagates within the prismatic light guide in response to the received beam of light and which reflects off the first reflective surface.

Abstract: A device may receive geographical data identifying a geographical area, and may receive, from vehicle devices of vehicles, first vehicle data identifying engine off conditions, locations during engine off conditions, and durations of the engine off conditions. The device may divide, based on the geographical data, the geographical area into clusters with particular dimensions, and may process data identifying the clusters and the first vehicle data, with a machine learning model, to determine parking data identifying public parking spaces in the geographical area. The device may receive, from a set of the vehicle devices associated with vehicles parked in the public parking spaces, vehicle data identifying engine on conditions and locations during the engine on conditions, and may identify available public parking spaces based on the second vehicle data and the parking data. The device may perform one or more actions based on data identifying the available public parking spaces.

Abstract: An electronic device includes laser emitters, and a laser driver generating a laser drive signal for the laser emitters based upon a feedback control signal. A steering circuit selectively steers the laser drive signal to a different selected one of the plurality of laser emitters and prevents the laser drive signal from being steered to non-selected ones of the plurality of laser emitters, during each of a plurality of time periods. Control circuitry senses a magnitude of a current of the laser drive signal and generates the feedback control signal based thereupon. The feedback control signal is generated so as to cause the laser driver to generate the laser drive signal as having a current with a substantially constant magnitude.

Abstract: A device may process the video data, with a first machine learning model, to identify a driver of a vehicle and may process the video data associated with the driver, with a second machine learning model, to detect behavior data identifying a behavior of the driver. The device may process the behavior data, with a third machine learning model, to determine distraction data identifying whether the behavior is classified as a distracted behavior. The device may process the behavior data, with a fourth machine learning model, to determine policy compliance data identifying whether the behavior satisfies one or more policies. The device may calculate a distraction score based on the distraction data and the video data, and may calculate a policy compliance score based on the policy compliance data and vehicle data. The device may perform one or more actions based on the distraction score and the policy compliance score.

Abstract: A vehicle device may receive audio data and other vehicle data associated with a vehicle and may transform the audio data to transformed audio data in a frequency domain. The vehicle device may segment the transformed audio data into a plurality of audio segments and may process the plurality of audio segments, with different feature extraction techniques, to extract a plurality of feature vectors. The vehicle device may merge the plurality of feature vectors into a merged feature vector and may create an audio signature for the audio data based on the merged feature vector. The vehicle device may process the audio signature and the other vehicle data, with a model, to determine a classification of the audio signature and may perform one or more actions based on the classification of the audio signature.

Abstract: A system and method for a scalable depth sensor. The scalable depth sensor having an emitter, a receiver, and a processor. The emitter is configured to uniformly illuminate a scene within a field-of-view of the emitter. The receiver including a plurality of detectors, each detector configured to capture depth and intensity information corresponding to a subset of the field-of-view. The a processor connected to the detector and configured to selectively sample a subset of the plurality of the detectors in accordance with compressive sensing techniques, and provide an image in accordance with an output from the subset of the plurality of the detectors, the image providing a depth and intensity image corresponding to the field-of-view of the emitter.

Abstract: In some implementations, a device may receive an image that depicts an environment associated with a vehicle. The device may partition the image into a plurality of subsections. The device may analyze the plurality of subsections to determine respective subsection information, wherein subsection information, for an individual subsection, indicates: a probability score that the subsection includes a line segment associated with an object class, a position of a representative point of the line segment, and a direction of the line segment. The device may identify, based on the respective subsection information of the plurality of subsections, a line associated with the object class that is associated with a set of subsections of the plurality of subsections. The device may perform one or more actions based on identifying the line associated with the object class.

Abstract: A new distinct variety of grapevine named ‘ARD45’abundantly forms attractive crunchy seedless berries with a red skin coloration, lax and large clusters which display a Labrusca flavor commonly ready for harvesting during July-August in San Joaquin Valley of Central California, U.S.A., and displays good eating qualities as a table grape having a firmness that renders the fruit well amenable for handling, shipping, and storage.

Abstract: A new distinct variety of grapevine plant named ‘ARD44’ abundantly forms attractive crunchy seedless berries with a green skin coloration, medium density and medium clusters which display a Muscat flavor which is commonly ready for harvesting during July in San Joaquin Valley of Central California, U.S.A., and displays good eating qualities as a table grape having a firmness that renders the fruit well amenable for handling, shipping, and storage.

Abstract: A new distinct variety of grapevine plant named ‘ARD46’ abundantly forms attractive meaty seedless berries with a red skin coloration, lax and large clusters which display a Labrusca flavor, the fruit commonly is ready for harvesting during July-August in San Joaquin Valley of Central California, U.S.A, and displays good eating qualities as a table grape having a fruit firmness which renders the fruit well amenable for handling, shipping, and storage.