Abstract: The present invention relates to novel 6-acetylmorphine analogs, and methods for their synthesis and use. Such analogs are designed to provide a convenient linkage chemistry for coupling under mild conditions to a suitable group on a target protein, polypeptide, solid phase or detectable label.

Abstract: The invention provides a series of conformationally stable kinase inhibitors, and methods of using the kinase inhibitors. The effect of atropisomerism on kinase selectivity was assessed, finding improved selectivity compared to rapidly interconverting parent compounds.

Abstract: This disclosure describes related novel methods for Recombinase-Polymerase Amplification (RPA) of a target DNA that exploit the properties of recombinase and related proteins, to invade double-stranded DNA with single stranded homologous DNA permitting sequence specific priming of DNA polymerase reactions. The disclosed methods have the advantage of not requiring thermocycling or thermophilic enzymes, thus offering easy and affordable implementation and portability relative to other amplification methods. Further disclosed are conditions to enable real-time monitoring of RPA reactions, methods to regulate RPA reactions using light and otherwise, methods to determine the nature of amplified species without a need for gel electrophoresis, methods to improve and optimize signal to noise ratios in RPA reactions, methods to optimize oligonucleotide primer function, methods to control carry-over contamination, and methods to employ sequence-specific third ‘specificity’ probes.

Abstract: A cross-layer encoder for providing UEP encoding of video data configured to provide UEP encoding of video data at an application layer of a transmission channel by receiving video packets having first and second priority levels, applying first and second coding schemes to video packets having first and second priority levels, respectively, and transmitting video frames having first and second priority levels. The cross-layer encoder can be configured to provide UEP encoding of video data at a physical layer of the transmission channel by receiving encoded video frames having first and second priority levels, applying third and fourth coding schemes to video frames having first and second priority levels, respectively, and transmitting cross-layer encoded video frames having first and second priority levels. The first through fourth coding schemes can generate different percentages of the total coding overhead based on first and second priority levels, respectively.

Abstract: Some embodiments disclosed herein include systems and method for verifying meter accuracy. The system may include an electric vehicle charging station that includes a submeter that measures an amount of energy discharged from the electric vehicle charging station and to a connected electric vehicle. A meter test device may also be connected to the electric vehicle charging station to determine the accuracy of the submeter in local time.

Abstract: The invention is directed to compositions, e.g., cell-based and multiplexed platforms, to screen for small molecule drugs that inhibit enzymes such as proteases, e.g., viral proteases, e.g., HIV proteases; and methods for making and using these compositions. The invention provides compositions and methods for identifying compositions, e.g., drug molecules, that can inhibit proteases, e.g., viral proteases such as HIV proteases. In alternative embodiments, the invention provides cell-based platforms or assays to screen for compositions, e.g., small molecules or drugs, that inhibit or modify the activity of enzymes such as calcium-dependent protein convertases involved in HIV envelope protein processing, including cleavage of the HIV gp160 envelope precursor, resulting in gp120 and gp41 envelope products. In one embodiment, the invention provides a cell-based or multiplexed platform for monitoring the activity of enzymes, e.g., proteases such as viral proteases.

Abstract: The invention relates to a product and a process for fabricating a 1D, 2D, or 3D layered micro or nano component that comprises providing an electrode having a micro-scale or nano-scale tip, and applying electric current to the electrode tip in the presence of a micro-scale or nano-scale powder.

Abstract: Interconnection meter socket adapters are provided. An interconnection meter socket adapter comprises a housing enclosing a set of electrical connections. The interconnection meter socket adapter may be configured to be coupled to a standard distribution panel and a standard electrical meter, thereby establishing connections between a distribution panel and a user such that electrical power may be delivered to the user while an electrical meter measures the power consumption of the user. An interconnection meter socket adapter may be configured to be coupled to a DC-AC converter, which may be coupled to various energy sources. As such, the energy sources are coupled to an electrical power system. In addition, a connector such as a flexible cable or flexible conduit containing insulated wires can be provided for connecting various energy sources and/or sinks.

Abstract: The present invention relates to a recombinant methanotroph having an ability to produce isoprene and a method for producing isoprene using the same, and more particularly to a recombinant methanotroph having an ability to produce isoprene wherein a gene encoding an isoprene synthase having a homology of at least 70% to the amino acid sequence of Ipomoea batatas isoprene synthase is introduced into the recombinant methanotroph, and a method for producing isoprene using the recombinant methanotroph. The use of a recombinant methanotroph according to the present invention enables isoprene to be produced in high yield by using methane gas or methanol which is obtained from waste such as natural gas, biomass, municipal waste or the like as a carbon source.

Abstract: Interconnection meter socket adapters are provided. An interconnection meter socket adapter comprises a housing enclosing a set of electrical connections. The interconnection meter socket adapter may be configured to be coupled to a standard distribution panel and a standard electric meter, thereby establishing connections between a distribution panel and a user such that electrical power may be delivered to the user while an electrical meter measures the power consumption of the user. A power regulation module is disposed between the interconnection meter socket adapter, and configured to selectively connect one or more energy sources or energy sinks.

Abstract: Methods for improving immunoassays, and in particular, assays for B-Type natriuretic peptide analogues resistant to prolyl-specific dipeptidyl degradation are provided wherein one or more antibodies are selected such that the one or more antibodies detect a biologically active form of a natriuretic peptide of interest.

Abstract: A method for collecting and processing remotely sensed imagery in order to achieve precise spatial co-registration (e.g., matched alignment) between multi-temporal image sets is presented. Such precise alignment or spatial co-registration of imagery can be used for change detection, image fusion, and temporal analysis/modeling. Further, images collected in this manner may be further processed in such a way that image frames or line arrays from corresponding photo stations are matched, co-aligned and if desired merged into a single image and/or subjected to the same processing sequence. A second methodology for automated detection of moving objects within a scene using a time series of remotely sensed imagery is also presented. Specialized image collection and preprocessing procedures are utilized to obtain precise spatial co-registration (image registration) between multitemporal image frame sets.

Abstract: A wearable electronic device for proximity-based social and professional networking which features electronics and software for the passive automated local wireless exchange of personal and/or business information with other electronic devices is disclosed. In some embodiments, an electronic device includes a controller having an operations unit; a communication unit configured to receive and/or transmit data from a first external source; and a memory unit configured to communicate with the controller and receive and/or transmit data from the controller. The operations unit may be configured to determine if received data from the first external source meets a set threshold and wherein the operations unit may be configured to instruct communication unit to accept data that meets or exceeds said threshold. The communication unit may receive and transmit data from the first external source provided the external source is within a predetermined proximity.

Abstract: A system and method for tracking and managing projects assigned to one or more group of users on a web based platform is disclosed. In some embodiments, the system includes a processor, a memory attached to the processor, and a computer readable medium having instruction embedded therein. The instructions may be configured to cause the processor to perform the operations of receiving a project request from an authorized user for a project to be created and tracked by the system; generating a workflow template to be applied to the project when a first approval manger approves the project request, where the workflow template provides a starting point or shell for each project type of an approved project request; assigning a project manager to the project; and generating a web based platform to allow authorized users to supervise a workflow of the project in real-time.

Abstract: This disclosure provides for methods and reagents for rapid multiplex RPA reactions and improved methods for detection of multiplex RPA reaction products. In addition, the disclosure provides new methods for eliminating carryover contamination between RPA processes.

Abstract: Enables a coffee making apparatus with a froth spoon and at least one impeller configured to enable users to make a cup of coffee, agitate the coffee grounds with the at least one impeller, for example before or after as the plunger is pushed to the bottom of the carafe. Embodiments thus enable a user to make additional froth, pour out the coffee into a cup, and after the cup is filled to the desired level, spoon out froth over the coffee with the froth spoon without pouring excess coffee into the cup.

Abstract: Rigid non-conducting safety covers for the conductive components on an electrical utility pole are disclosed. The safety covers prevent arcing or current flowing to a user working on a utility pole. The safety covers extend over portions of the utility pole, cross arm and bracket mounting the cross arm to the utility pole.

Abstract: Interconnection meter socket adapters are provided. An interconnection meter socket adapter comprises a housing enclosing a set of electrical connections. The interconnection meter socket adapter may be configured to be coupled to a standard distribution panel and a standard electric meter, thereby establishing connections between a distribution panel and a user such that electrical power may be delivered to the user while an electrical meter measures the power consumption of the user. A power regulation module is disposed between the interconnection meter socket adapter, and configured to selectively connect one or more energy sources or energy sinks.

Abstract: A new class of nucleic acid substrates for AP endonucleases and members of the glycosylase/lyase family of enzymes is described. Representatives of each family, the enzymes Nfo and fpg, respectively, cleave nucleic acid backbones at positions in which a base has been replaced by a linker to which a variety of label moieties may be attached. The use of these synthetic substrates embedded within oligonucleotides is of utility in a number of applications.