Abstract: The present invention is directed to a system and method for photoeradication of microorganisms from a target. A light source is configured to irradiate the target with purple or blue light in a pulsed mode of irradiation at an average irradiance that preferably ranges from 0.1 mW/cm2 to 20 mW/cm2. An electronic circuit is configured to control the light source in accordance with an irradiation schedule that includes a plurality of irradiation sessions. The light source is controlled to provide the purple or blue light at a radiant exposure that preferably ranges from 0.5 J/cm2 to 60 J/cm2 during each of the irradiation sessions. The irradiation sessions are provided at a plurality of time intervals so as to cause photoeradication of all or a portion of the microorganisms.
Type:
Grant
Filed:
April 18, 2018
Date of Patent:
May 5, 2020
Assignees:
CAREWEAR CORP., SAN DIEGO STATE UNIVERSITY RESEARCH FOUNDATION
Abstract: The invention provides a series of conformationally stable kinase inhibitors, and methods of using the kinase inhibitors. The effect of atropisomerism on kinase selectivity was assessed, finding improved selectivity compared to rapidly interconverting parent compounds.
Type:
Application
Filed:
December 18, 2019
Publication date:
April 30, 2020
Applicant:
SAN DIEGO STATE UNIVERSITY RESEARCH FOUNDATION
Inventors:
Jeffrey L. GUSTAFSON, Davis E. SMITH, David HECHT, Isaac MARQUEZ, Sean TOENJES
Abstract: A power exchange includes an energy exchange server and a plurality of exchange controllers, each exchange controller communicatively coupled to an interconnect socket adapter, wherein the energy exchange server receives a real-time energy consumption data set, a real-time energy production data set, a set of environmental parameters and a starting energy price, and generates a current aggregate electricity demand value as a function of the real-time energy consumption data set and the environmental parameters, a current aggregate electricity supply value as a function of the real-time energy production dataset and the environmental parameters, and a current energy price as a function of the starting energy price, the current aggregate electricity demand value, and the current aggregate electricity supply value.
Abstract: A microfluidic device includes an inlet port configured to receive a sample, a first reaction chamber fluidically coupled to the inlet port, a first pump fluidically coupled to the inlet port, a second pump fluidically coupled to a mixing chamber, a metering channel fluidically coupled to the first reaction chamber and to the mixing chamber, and one or more second reaction chambers fluidically coupled to the mixing chamber. The first pump is configured to move fluid from the inlet port to the first reaction chamber and from the first pump to the inlet port. The second pump is configured to move fluid from the second pump to the mixing chamber, from the first reaction chamber to the mixing chamber, and from the mixing chamber to the one or more second reaction chambers.
Type:
Grant
Filed:
February 27, 2018
Date of Patent:
April 28, 2020
Assignee:
ALERE SAN DIEGO, INC.
Inventors:
Alexander Schenk zu Schweinsberg, Austin Matthew Derfus, Justin Davidson, Karthikeyan Kumaravadivelu, Maulik Vinod Patel, Olaf Piepenburg, Catherine Jean Greenwood, Oliver Nentwich
Abstract: Non-conductive films for constructing lighter than air balloons are provided. A non-conductive film may comprise multiple layers of gas barrier polymers. An outer surface printable layer and an interior heat or ultrasonically sealable layer may also be included. Each gas barrier film may comprise multiple (e.g., from 3 to approximately 75) barrier layers. A gas barrier core has a nano-layer structure. A gas barrier core may also comprise a biodegradable film or a bio-based film. A non-conductive film may comprise a metal layer for enhancing gas barrier properties. The metal layer may be discontinuous. The metal layer may be conductive and coated with an insulating top coat.
Type:
Grant
Filed:
April 8, 2016
Date of Patent:
March 3, 2020
Assignee:
SAN DIEGO GAS & ELECTRICAL COMPANY
Inventors:
Eldridge M. Mount, III, Denis S. Sanford
Abstract: A system for managing grid interaction with an energy storage device includes an energy exchange server, a plurality of energy storage devices, a plurality of interconnect socket adapters, and a plurality of energy exchange controllers, each energy exchange controller coupling to one of the plurality of interconnect socket adapters and dictating energy consumption based on energy pricing data received from the energy exchange server.
Abstract: The invention provides a series of conformationally stable kinase inhibitors, and methods of using the kinase inhibitors. The effect of atropisomerism on kinase selectivity was assessed, finding improved selectivity compared to rapidly interconverting parent compounds.
Type:
Grant
Filed:
August 15, 2016
Date of Patent:
February 4, 2020
Assignee:
San Diego State University Foundation
Inventors:
Jeffrey L. Gustafson, Davis E. Smith, David Hecht, Isaac Marquez, Sean Toenjes
Abstract: This disclosure provides for methods and reagents for rapid multiplex RPA reactions and improved methods for detection of multiplex RPA reaction products. In addition, the disclosure provides new methods for eliminating carryover contamination between RPA processes.
Type:
Grant
Filed:
December 11, 2015
Date of Patent:
January 21, 2020
Assignee:
ALERE SAN DIEGO, INC.
Inventors:
Olaf Piepenburg, Colin H. Williams, Niall A. Armes
Abstract: An auxiliary power system for electrical substations is provided. The auxiliary power system enables both AC and DC equipment to be powered during prolonged power outages, and utilizes a substation fuel cell to provide a backup power source for designated black start cranking path substations.
Abstract: A system for managing grid interaction with a solar power source includes an energy exchange server, a plurality of solar energy sources, a plurality of interconnect socket adapters, and a plurality of energy exchange controllers, each energy exchange controller coupling to one of the plurality of interconnect socket adapters and dictating energy consumption based on energy pricing data received from the energy exchange server.
Abstract: A system for managing grid interaction with a wind power source includes an energy exchange server, a plurality of wind energy sources, a plurality of interconnect socket adapters, and a plurality of energy exchange controllers, each energy exchange controller coupling to one of the plurality of interconnect socket adapters and dictating energy consumption based on energy pricing data received from the energy exchange server.
Abstract: Some embodiments disclosed herein include systems and method for verifying meter accuracy. The system may include an electric vehicle charging station that includes a submeter that measures an amount of energy discharged from the electric vehicle charging station and to a connected electric vehicle. A meter test device may also be connected to the electric vehicle charging station to determine the accuracy of the submeter in local time.
Abstract: Interconnection meter socket adapters are provided. An interconnection meter socket adapter comprises a housing enclosing a set of electrical connections. The interconnection meter socket adapter may be configured to be coupled to a standard distribution panel and a standard electric meter, thereby establishing connections between a distribution panel and a user such that electrical power may be delivered to the user while an electrical meter measures the power consumption of the user. A power regulation module is disposed between the interconnection meter socket adapter, and configured to selectively connect one or more energy sources or energy sinks.
Abstract: A device and method is described for electronic human prosthetics, and specifically a skull- and/or spine implantable bi-directional neural-communication/brain-machine interface (BBMI) device where the input, output and on-board computing are combined into a single unit to form a compact neuro-prosthetics device. This invention is also directed to a fully implantable wireless spinal electronic recording and stimulation system using the BBMI in a human. The bi-directional devices (BBMIs) communicate with other bi-directional brain-machine interface devices (BBMI) and/or with external controllers wirelessly. The compact implantable stimulator has ultrasonic secondary battery charging system. One or more BBMI can be wirelessly connected so that a closed loop of BBMIs, or a BBMI and an external controller, can wirelessly send trigger pulses to this fully implanted stimulator over the spinal cord.
Type:
Grant
Filed:
October 17, 2016
Date of Patent:
October 22, 2019
Assignees:
San Diego State University Research Foundation, Electronics and Telecommunication Research Institute
Inventors:
Kee S. Moon, Yusuf Ozturk, Sung Q. Lee, Woosub Youm, Gunn Hwang
Abstract: Non-conductive films for constructing lighter than air balloons are provided. A non-conductive film may comprise multiple layers of gas barrier polymers. An outer surface printable layer and an interior heat or ultrasonically sealable layer may also be included. Each gas barrier film may comprise multiple (e.g., from 3 to approximately 75) barrier layers. A gas barrier core has a nano-layer structure. A gas barrier core may also comprise a biodegradable film or a bio-based film. A non-conductive film may comprise a metal layer for enhancing gas barrier properties. The metal layer may be discontinuous. The metal layer may be conductive and coated with an insulating top coat.
Type:
Grant
Filed:
April 8, 2016
Date of Patent:
October 8, 2019
Assignee:
San Diego Gas & Electric Company c/o Sempra Energy
Inventors:
Eldridge M. Mount, III, Denis S. Sanford
Abstract: The present invention relates to novel 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine analogs, and methods for their synthesis and use. Such analogs are designed to provide a convenient linkage chemistry for coupling under mild conditions to a suitable group on a target protein, polypeptide, solid phase or detectable label.
Abstract: Some embodiments disclosed herein include systems and method for verifying meter accuracy. The system may include an electric vehicle charging station that includes a submeter that measures an amount of energy discharged from the electric vehicle charging station and to a connected electric vehicle. A meter test device may also be connected to the electric vehicle charging station to determine the accuracy of the submeter in local time.
Abstract: Materials and methods for treating an infection or disease, activating an immune cell at a site of infection or disease, and for directly killing microorganisms, using response-selective carboxy-terminal C5a analogs, are provided.
Type:
Grant
Filed:
January 12, 2018
Date of Patent:
July 30, 2019
Assignees:
Board of Regents of The University of Nebraska, San Diego State University Research Foundation
Inventors:
Sam D. Sanderson, Joy Arlene Phillips, Edward Leroy Morgan, Marilyn Louise Thoman, Tamsin Sheen, Kelly S. Doran, Elizabeth Louise Virts, Tammy Kielian, Mark Hanke
Abstract: As part of an integrated banking platform, an internet banking platform includes a banking server, a processor, and a memory module. The memory module includes stored computer program code. The memory module, the stored computer program code, and the processor are configured to cause the banking server to receive access to a rewards program server associated with a rewards account platform. Further, the server is caused to receive enrollment information associated with a user, and to connect to the rewards program server. The server is also caused to transmit an enrollment request message to the rewards program server. The enrollment request message includes at least a subset of the enrollment information. Additionally, the server is caused to receive an enrollment response message that indicates whether the user has been enrolled in a rewards account maintained by the rewards account platform.
Abstract: This disclosure describes related novel methods for Recombinase-Polymerase Amplification (RPA) of a target DNA that exploit the properties of recombinase and related proteins, to invade double-stranded DNA with single stranded homologous DNA permitting sequence specific priming of DNA polymerase reactions. The disclosed methods have the advantage of not requiring thermocycling or thermophilic enzymes. Further, the improved processivity of the disclosed methods may allow amplification of DNA up to hundres of megabases in length.
Type:
Grant
Filed:
December 30, 2016
Date of Patent:
June 25, 2019
Assignee:
Alere San Diego, Inc.
Inventors:
Olaf Piepenburg, Colin H. Williams, Niall A. Armes, Derek L. Stemple