Abstract: The invention relates to a product and a process for fabricating a 1D, 2D, or 3D layered micro or nano component that comprises providing an electrode having a micro-scale or nano-scale tip, and applying electric current to the electrode tip in the presence of a micro-scale or nano-scale powder.

Abstract: A patch antenna array system is provided. The patch antenna array system can include a plurality of patch antennas oriented with respect to each other to provide a nearly symmetric radiation pattern over a range of frequencies, such as from 1500 Megahertz (MHz) to 1700 MHz. The patch antenna array system can include a sequential phase feed network that is in communication with the plurality of patch antennas. The sequential phase feed network can be configured to provide a radio frequency (RF) signal to each patch antenna of the plurality of patch antennas such that the patch antenna array system has an axial ratio of less than 1 decibel (dB) over the range of frequencies.

Abstract: An antenna assembly is provided. The antenna assembly includes a tube structure disposed on a circuit board. The antenna assembly further includes a helical antenna comprising a plurality of conductive traces disposed on a flexible substrate wrapped around the tube structure.

Abstract: The invention provides a series of conformationally stable kinase inhibitors, and methods of using the kinase inhibitors. The effect of atropisomerism on kinase selectivity was assessed, finding improved selectivity compared to rapidly interconverting parent compounds.

Abstract: A system is described where antenna beam steering techniques are implemented to optimize time and frequency channel resources in wireless communication systems where repeaters are used. Beam steering modes of the antenna systems in the repeaters as well as the nodes are optimized to improve system capacity and load balancing. Client devices in a wireless LAN system can be configured to work as repeaters, with the repeaters containing a beam steering capability. The beam steering capability can be implemented in one or multiple nodes and repeaters in the communication system.

Abstract: This patent document discloses techniques, systems, and devices for detecting a target substance using optical nonlinear wave mixing for enhanced detection sensitivity and accuracy. In one aspect, a method for measuring ?-synuclein in a body fluid of a patient with high detection sensitivity and accuracy and providing early stage Parkinson's disease detection is provided. The method may comprise: supplying to a capillary analyte cell a fluidic sample that includes a body fluid of a patient containing ?-synuclein, wherein the capillary analyte cell is located in a nonlinear optical four-wave mixing device; directing laser light from the nonlinear optical four-wave mixing device into the capillary analyte cell to cause nonlinear optical four-wave mixing in the fluidic sample to generate a four-wave mixing signal that contains information on the ?-synuclein in the fluidic sample; and processing the four-wave mixing signal to extract information on the ?-synuclein in the fluidic sample.

Abstract: Embodiments described herein are directed to methods and apparatus for power distribution. The apparatus can include a power distribution network for a plurality of integrated circuits (IC). According to embodiments, the power distribution network includes a plurality of overlapping power/ground (PG) plane segments and one or more non-overlapping PG (no-PG) plane segments. Each overlapping-PG plane segment is separated from another overlapping-PG plane segment by at least one no-PG plane segment. The no-PG plane segments can include at least one of a multilayered power (P) plane segment with no ground reference of any PG plane and a multilayered ground (G) plane segment with no power reference of any PG plane.

Abstract: A pipeline inspection system is described. The system comprises a body, cameras, support members, and light sources. The cameras are coupled to the body and configured to obtain image information related to an interior surface of the pipe. The support members extend away from the body in a radial direction to contact the interior surface of the pipe and support the body. An individual support member has a first end coupled to the body, and a second end configured to contact the interior surface of the pipe. The light sources are configured to light the interior surface of the pipe. They are coupled to the support members at or near the second end such that the light sources are located in one or more radial positions near the interior surface of the pipe, separated from the one or more cameras and the body by the one or more support members.

Abstract: A multiport RF switch assembly with integrated impedance tuning capability is described that provides a single RFIC solution to switch between transmit and receive paths in a communication system. Dynamic tuning is integrated into each switch sub-assembly to provide the capability to impedance match antennas or other components connected to the multiport switch. The tuning function at the switch can be used to shape the antenna response to provide better filtering at the switch/RF front-end (RFFE) interface to allow for reduced filtering requirements in the RFFE. Memory is designed into the multiport switch assembly, allowing for a look-up table or other data to reside with the switch and tuning circuit. The resident memory will result in easier integration of the tunable switch assembly into communication systems.

Abstract: Fluorescent nucleobase surrogates capable of Watson-Crick hydrogen bonding are essential probes of nucleic acid structure and dynamics. Their limited brightness and short absorption and emission wavelengths have rendered them unsuitable for single-molecule detection. Herein, we synthesized a new tricyclic pyrimidine nucleoside analogue with a push-pull conjugated system. The resulting C-linked 8-(diethylamino)benzo[b][1,8] naphthyridin-2(1H)-one nucleoside (ABN), exhibits ?442=20,000 M?1 cm?1 and ?em,540=0.39 in water, increasing to ?em=0.50-0.53 when base paired with adenine in duplex DNA oligonucleotides. Single-molecule fluorescence measurements of ABN using both one-photon and two-photon excitation demonstrate its excellent photostability and indicate that the nucleoside is present to >95% in a bright state with count rates of at least 15 kHz per molecule.

Abstract: The present invention is directed to a system and method for photoeradication of microorganisms from a target. The method includes the step of obtaining test data for a plurality of experiments each of which comprises irradiating test microorganisms with a plurality of light pulses having a wavelength that ranges from 380 nm to 500 nm. The light pulses have a plurality of pulse parameters (peak irradiance, pulse duration, and off time between adjacent light pulses) and are provided at a radiant exposure that ranges from 0.5 J/cm2 to 60 J/cm2 during each of a plurality of irradiation sessions. The test data comprises a survival rate for the test microorganisms after irradiation with the light pulses. The method also includes the step of analyzing the test data to identify the pulse parameters for the light pulses and the radiant exposure for each of the irradiation sessions that result in a desired survival rate for the test microorganisms.

Abstract: Provided are compositions and methods for treating, ameliorating and preventing various infections, disorders and conditions in mammals, including genetically-predisposed and chronic disorders, where a microbial or bacterial flora is at least one causative or symptom-producing factor, where exemplary compositions are products of manufacture, a food, a drink, a nutraceutical, a dietary supplement, a formulation, a pharmaceutical or a pharmaceutical preparation comprising at least one or several of a plurality of isolated, or substantially purified bacteriophages or prophages, or bacteriophage subunits, a milk, a milk product, milk lipid, milk fat globule (MFG) macromolecule, a milk mucin, a milk glycolipid, a milk free glycan, a milk mucin-like glycoprotein, a milk protein, a milk sugar or lactose, a milk fat or butterfat, a milk vitamin.

Abstract: Disclosed are devices and methods of detecting and mitigating oscillatory instabilities in systems with turbulent flow, such as thermoacoustic, aeroacoustic or aeroelastic equipment. The system includes a sensor array for measuring one or more parameters of an operating equipment S, and an analysis and prediction unit. The analysis and prediction unit is configured to estimate a state tensor to identify a state of the equipment indicating stable operation or impending oscillatory instability. The system further includes an actuator array configured to implement a control action to promote stable operation of the equipment. Methods for robust prediction of the state of stability are also disclosed. A neural ordinary differential equation (ODE) method of predicting stability or instability is disclosed, involving forming a neural network that incorporates an equation characteristic of the operational state.

Abstract: Embodiments described herein are directed to wireless power transfer systems, which can include a vertical pair of an inner and an outer coupling capacitors. According to certain embodiments, one plate from each of the outer coupling capacitor at least in part overlaps one plate of the inner coupling capacitor on a primary side and another plate from the outer coupling capacitor at least partially overlaps another plate of the inner coupling capacitor on a secondary side. Each plate of the outer coupling capacitor has a larger area than each plate of the inner coupling capacitor. Further, a power transfer unit is included and configured to transfer power capacitively through the vertical pair of coupling capacitors, where the power transfer unit can include first and second inductors coupled to each plate of the outer coupling capacitor, respectively.

Abstract: In alternative embodiments, provided are compositions comprising chemically or structurally modified bacteriophages of the genus Caudovirales having an exterior or outer surface comprising at least one heterologous carbohydrate binding domain (CBD) comprising a lectin or a plurality of additional homologous CBDs, or more CBDs than found on a comparable wild type (WT) bacteriophage.

Abstract: Nature is capable of storing solar energy in chemical bonds via photosynthesis through a series of C—C, C—O and C—N bond-forming reactions starting from CO2 and light. Direct capture of solar energy for organic synthesis is a promising approach. Lead (Pb)-halide perovskite solar cells reach 24.2% power conversion efficiency, rendering perovskite a unique type material for solar energy capture. We show that photophysical properties of perovskites is useful in photoredox organic synthesis. Because the key aspects of these two applications are both relying on charge separation and transfer. Here we demonstrated that perovskites nanocrystals are exceptional candidates as photocatalysts for fundamental organic reactions, i.e. C—C, C—N and C—O bond-formations. Stability of CsPbBr3 in organic solvents and ease-of-tuning their bandedges garner perovskite a wider scope of organic substrate activations.

Abstract: The present invention relates to novel 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine analogs, and methods for their synthesis and use. Such analogs are designed to provide a convenient linkage chemistry for coupling under mild conditions to a suitable group on a target protein, polypeptide, solid phase or detectable label.

Abstract: A manually actuated chromatography device comprising a chamber for receiving a liquid sample, a pump with a metering valve, and a chromatography element, wherein the pump moves a predetermined volume of liquid from the sample chamber to the chromatography element.

Abstract: A system and method for detecting, amplifying, and sorting non-transitory signals stemming from cellular activity of tissue in an extracellular medium is presented herein. Weak signals are difficult to detect, especially when they originate far from the measuring electrode. The invention takes advantage of stochastic resonance, i.e. adding noise to signals to amplify them and make them more detectable, to improve signal detection from a single electrode.

Abstract: Interconnection meter socket adapters are provided. An interconnection meter socket adapter comprises a housing enclosing a set of electrical connections. The interconnection meter socket adapter may be configured to be coupled to a standard distribution panel and a standard electric meter, thereby establishing connections between a distribution panel and a user such that electrical power may be delivered to the user while an electrical meter measures the power consumption of the user. A power regulation module is disposed between the interconnection meter socket adapter, and configured to selectively connect one or more energy sources or energy sinks.