Abstract: The present invention relates to certain substituted heterocycles of Formula (200), wherein B, H, I, J and K together with the Ar5 form a ring containing at least one amide residue, and W, X, Y and Z together form a 2,4-thiazolidinedione, 2-thioxo-thiazolidine-4-one, 2,4-imidazolidinedione or 2-thioxo-imidazolidine-4-one residue; or a pharmaceutically acceptable salt thereof. The compounds are useful in the treatment of diseases such as type 2 diabetes, and related disorders of lipid and carbohydrate metabolism, including atherosclerosis. The compounds are also useful for treating diseases of uncontrolled proliferation, such as cancers in general, including breast cancer.

Abstract: A viewer can save content and context related to a transaction conducted via an interactive television system. The transaction can involve obtaining information or ordering goods/services available from the Internet via the interactive television system. As an example, while the viewer is watching a television commercial on a first screen, the viewer can defer a transaction, capable of being conducted on a second screen, related to a product advertised in the television commercial or defer the viewing of the television commercial itself. Information related to the television commercial may be saved in a shopping cart for subsequent processing. Later, when the viewer wishes to continue the transaction or view the television commercial, the viewer may retrieve the shopping cart information, replay the television commercial, and then complete of the previously deferred transaction.

Abstract: Provided are structure coordinates relating to MvaS and its various uses.

Abstract: A system is described comprising: a finite state machine having a plurality of states interconnected through a plurality of events, wherein certain states and events in said plurality are implemented in software and other states and events in said plurality are implemented in hardware; and a scheduler communicatively coupled to the finite state machine and being programmable with one or more parameters defining scheduled operations to be performed by the scheduler, wherein the finite state machine is configured to select one or more of said parameters to be used by said scheduler upon transition by said finite state machine from a first state to a second state.

Abstract: The present invention relates to certain compounds of Formula (I) which can be useful in the treatment of diseases, such as, cancer, metabolic disorders, Type 2 Diabetes, dyslipidemia and/or hyperchloesterolemia:

Abstract: An apparatus and methods for concealing missing packets in a CVSD bit stream are disclosed. In one embodiment, an indication from a packet loss indicator (PLI) that a packet is missing is received. Next the status of the missing packet is determined. Based on the status of the missing packet, a sample packet is generated to replace the missing packet, and a memory of the CVSD is updated. A compressed copy of the sample packet may be stored in a first memory buffer in either ?-law or a-law format.

Abstract: A microfluidic method is provided that comprises: delivering a first fluid to a first lumen of a microfluidic device and a second, different fluid to a second lumen of the microfluidic device, the first and second lumens sharing a common wall which allows for diffusion between the lumens over at least a portion of the length of the lumens; and having the first and second fluids diffuse between the first and second lumens.

Abstract: An apparatus and method for measuring spatial displacement of an animal's paw injected with irritant. This apparatus comprises an electromagnetic detecting assembly having (1) a transmitting oscillator for generating electrical current (2) an electromagnetic transmitter coil coupled to the oscillator for generating an electromagnetic field (3) an electromagnetic receiving coil placed in axial plane directly below the transmitter coil (4) a first, receiving amplifier connected to the receiving coil (5) an amplitude detector connected to the receiving amplifier (6) a second amplifier connected to the amplitude detector (7) a metal object attached to the animal's paw (8) and a cylindrical observation chamber of a diameter not greater than the diameter of the generated magnetic field.

Abstract: Systems and methods related to ultrasonic microtube dental instruments designed to cut around a broken instrument by allowing the broken instrument to be placed within a lumen of the microtube instrument while simultaneously boring with the broken instrument and being guided by the broken instrument.

Abstract: The present invention relates to certain substituted heterocycles of Formula (I) which are useful in the treatment of diseases related to lipid and carbohydrate metabolism, such as type 2 diabetes, adipocyte differentiation, uncontrolled proliferation, such as lymphoma, Hodgkin's Disease, leukemia, breast cancer, prostate cancer or cancers in general; and inflammation, such as osteoarthritis, rheumatoid arthritis, Crohn's Disease or Inflammatory Bowel Disease.

Abstract: Plate and electrode assemblies include configurations allowing for relatively uniform electric field production. The electrodes may comprise strips of conductive material plated onto the bottom surface of sample wells or they may comprise plate electrodes extending down into the well. In some embodiments, the electric field strength varies by less than about 10% from a mean field intensity over at least about 20% of the surface area of the bottom surface of a sample well.

Abstract: A portable thread environment comprising: an application programming interface configured to support multiple application program tasks with each task comprised of one or more threads; host adaptation logic for communicatively interfacing the tasks and threads with a host processing environment; and a scheduler configured to determine an execution order of the one or more threads based on one or more execution variables.

Abstract: The invention provides a method of nonenzymatic ligation of a nucleic acid. The method consists of contacting a polynucleotide-3? phosphorothiolate with an acceptor polynucleotide under conditions that allow formation of a phosphodiester bond between the polynucleotide-3? phosphorothiolate and the acceptor polynucleotide. The invention also provides methods of molecular cloning. In one embodiment, the method consists of contacting an insert comprising a polynucleotide-3? phosphorothiolate with an acceptor vector under conditions that allow formation of a phosphodiester bond between the insert and the acceptor vector to generate a vector comprising an insert polynucleotide. The invention further provides a compound consisting of a polynucleotide-3? phosphorothiolate and a kit containing a polynucleotide-3? phosphorothiolate. Also provided is a method of ligating a nucleic acid using a non-sequence specific topoisomerase.

Abstract: A method for emulating a physical connection using a wireless connection includes establishing a communication connection with a host controller according to a first communication protocol and establishing a wireless connection with a wireless device coupled to a peripheral. The method further includes receiving a wireless signal comprising registration information for the peripheral formatted according to a second communication protocol and communicating the registration information to the host controller using the communication connection. The communication of the registration information to the host controller allows the host controller to recognize the peripheral.

Abstract: A diagnostic tool for a portable thread environment is disclosed. In one embodiment, a system comprises a first portable thread environment (PTE), comprising a diagnostic tool; a second PTE configured to receive and send threads; a third PTE configured to receive and send the threads; and a PTE router configured to receive the threads and route said threads, wherein the router copies the threads and routes the copies to the diagnostic tool.

Abstract: A method for identifying endogenous microbial proliferation genes for growth and viability is disclosed herein. The method involves exogenous nucleic acids that are used to conditionally produce antisense inhibitors of endogenous complementary mRNAs in a microorganism. Antisense fragments that result in lethality when expressed indicate that the endogenous gene is a proliferation gene. The method can also be used with sequences in sense orientation. The strategy can be used to identify new gene targets for novel antibiotics.

Abstract: A dental tool for use with an ultrasonic transducer, includes an elongated unitary shaft member having a longitudinal axis, a proximal end and a distal end having an outer surface, an attachment member at the proximal end to enable detachable attachment to an ultrasonic transducer; and a cutting surface defined by a plurality of grooves on the outer surface forming sharp edges.

Abstract: A portable thread environment comprising: an application programming interface configured to support multiple application program tasks, wherein each task is either a preemptive task comprised of preemptive threads or a cooperative task comprised of cooperative threads; host adaptation logic for communicatively interfacing said cooperative tasks, preemptive tasks, cooperative threads and preemptive threads with a host processing environment; a scheduler configured to determine an execution order of cooperative threads and preemptive threads based on each cooperative thread's and preemptive thread's priority levels.

Abstract: Provided herein are serine proteases designated CVSP16. CVSP16 polypeptides exhibit protease activity as a single chain or as a multi-chain form. Methods using the polypeptides to identify compounds that modulate the protease activity thereof are provided. The polypeptides also serve as tumor markers.

Abstract: The measurement of the wavelength shifts in the reflectometric interference spectra of a porous semiconductor substrate such as silicon, make possible the highly sensitive detection, identification and quantification of small analyte molecules. The sensor of the subject invention is effective in detecting multiple layers of biomolecular interactions, termed “cascade sensing”, including sensitive detection of small molecule recognition events that take place relatively far from the semiconductor surface.