Abstract: The present application relates to a series of substituted pyrazolo[1,5-a]pyridine compounds, their use as tropomyosin receptor kinase (Trk) family protein kinase inhibitors, method of making and pharmaceutical compositions comprising such compounds.

Abstract: A battery module (10) for the purely electric driving of a motor vehicle has a trough-shaped battery box (12) that runs around a circumferential direction, an inlet for feeding a coolant into a cooling space (30) partially bounded by the battery box (12), an outlet for conducting the coolant away from the cooling space (30), battery cells (14) in the battery box (12) and arranged in the cooling space (30), and an insulating layer (16) for fluid-tight sealing of the cooling space (30). At least one electrical pole (18) of the battery cell (14) projects out of the cooling space (30) through the insulating layer (16). The insulating layer (16) is formed from a previously liquid cured sealing compound. The insulating layer (16) can simultaneously make available a high sealing effect and a statically stabilizing effect for the battery box (12) together with a low intrinsic weight.

Abstract: An angular-position measuring device includes a shaft rotatable relative to a body about an axis extending in a z-direction. A measuring standard having an end face is fastened on the shaft in rotatably fixed manner. The body includes a scanning device for scanning the measuring standard. Both the roller bearing and a sealing unit are provided on the side of the measuring standard facing the end face relative to the z-direction, The sealing unit includes rings that are rotatable relative to each other and are separated from each other by a gap, the gap being filled at least partially with a fluid.

Abstract: The present invention relates to an apparatus for generating electromechanical composite high-frequency oscillations includes, with a composite high-frequency oscillation system having at least one oscillation-generating element and at least one bracing element for applying pressure to the oscillation-generating element, wherein the bracing element is positioned outside of the material cross-section of at least one oscillation-generating element.

Abstract: A drill has a central axis, a front side, a circumferential surface, at least two main edges on the front side, which reach up to the circumferential surface and merge there with secondary edges, at least two central edges extending from the end of the main edge facing away from the circumferential surface, cutting surfaces associated with the main edges and central edges, chip flutes associated with the main edges and central edges and introduced into the circumferential surface, at least one cross edge adjoined by the ends of the central edges facing away from the main edges which passes through the central axis, a point thinning and chip run-up shoulders associated with at least the cutting surfaces of the central edges. An angle ? of the chip run-up shoulder decreases in the region of the point thinning towards the central axis as the distance from the front side increases.

Abstract: A device for interferential distance measurement that includes a measurement reflector having a surface and a light source emitting a beam parallel to the surface. The device includes a splitter element including a splitter grating that is disposed perpendicular to the surface, wherein the splitter grating receives the beam and splits the beam into a measurement beam and a reference beam, wherein the measurement beam acts at least twice upon the measurement reflector along a path of the measurement beam. The device including a combining element, at which the measurement beam and the reference beam enter into interferential superposition to form interfering measurement and reference beams. The device further includes a detector arrangement, by way of which a scanning signal pertaining to a distance between the measurement reflector and a component of said device in a measuring direction can be generated from the interfering measurement and reference beams.

Abstract: The present application relates to a series of substituted imidazo[1,2-a]pyridine compounds of formula (I), pharmaceutically acceptable salts, pharmaceutically acceptable solvates or stereoisomers thereof, their use as tropomyosin receptor kinase (Trk) family protein kinase inhibitors, method of making and pharmaceutical compositions comprising such compounds.

Abstract: The present invention relates to an optical position-measuring device for generating a plurality of phase-shifted scanning signals regarding the relative position of a fiber optic scanning head and a reflection measuring standard movable relative thereto in at least one measuring direction. In the fiber optic scanning head, a scanning reticle is disposed before the measuring standard end of an optical fiber. The scanning signals are coded in a wavelength-dependent manner. To this end, a beam incident on the scanning reticle is split into at least two sub-beams which strike the reflection measuring standard and are subsequently recombined to interfere with each other so as to generate the phase-shifted scanning signals. The sub-beams travel different optical path lengths between splitting and recombination.

Abstract: An optical position-measuring device includes a measuring standard having a first grating in a form of a periodic incremental graduation and an absolute mark. A scanning unit is displaceable relative to the measuring standard in a measuring direction. The scanning unit has at least one second grating disposed at a scanning distance from the first grating. A first detector array is configured to obtain a first scanning signal for purposes of position determination in which the gratings are illuminated with light of a first wavelength. A second detector array is configured to obtain a second scanning signal for purposes of position determination in which the absolute mark is illuminated with light of a second wavelength. The first wavelength is shorter than the second wavelength.

Abstract: A linear encoder includes a housing, a scale disposed within the housing and a sensor unit disposed within the housing facing the scale with a gap between the sensor unit and the scale. The sensor unit is configured to scan the scale and obtain position information. At least one adjustment hole for a gap adjustment is disposed in at least one of the housing and an end cover of the housing at a position corresponding to a position of the gap.

Abstract: The present invention relates to co-crystals of tramadol and co-crystal formers selected from NSAIDs, processes for preparation of the same and their uses as medicaments or in pharmaceutical formulations, more particularly for the treatment of pain.

Abstract: The invention refers to the use of a sigma ligand of formula (I) to prevent or treat pain induced by a chemotherapeutic agent, especially pain induced by taxanes, vinca alkaloids or platinum-containing chemotherapeutic drugs.

Abstract: An optical position measuring instrument including a first scale having a first graduation, wherein the first scale is disposed movable in a first measuring direction, and at a first defined position in the first measuring direction, the first scale includes a spatially limited first marking that differs from the first graduation. The optical position measuring instrument further including a second scale having a second graduation, wherein the second scale is disposed movable in a second measuring direction, and at a second defined position, the second scale includes a second reference marking that is usable for generating at least one reference signal at a reference position of the second scale only if the first scale is located in the first defined position.

Abstract: A position-measuring device, as well as a system having such a position-measuring device, is used for determining the position of a first object relative to a second object, the first and the second object being movable relative to one another along at least two measuring directions. The position-measuring device has an optical unit that is linked to one of the two objects and includes at least one light source, a detector system, as well as further optical elements in a defined configuration. In addition, the position-measuring device includes a measuring standard-reflector unit, which is provided on the other object, and has at least two differently formed regions in one track that are optically scannable by the optical unit for position sensing.

Abstract: A pressure tank system for a motor vehicle has a fuel tank (4) operated in a differential pressure range between a low pressure and a high pressure. To ensure a simple construction and can be produced cost-effective construction, the low pressure is between ambient pressure minus 50 hectopascals ambient pressure and plus 50 hectopascals.

Abstract: A battery system for driving an electric motor of a hybrid vehicle or of an electric vehicle has an exchangeable auxiliary battery to improve the comfort, performance and/or the range of the vehicle. The auxiliary battery can be placed from below into a space beneath the trunk compartment floor. The trunk compartment floor is vertically movable to increase the size of the trunk compartment when the auxiliary battery is not being used.

Abstract: The invention relates to a rail transport system comprising at least two runners (20) having a shaped profile, a transport rail (61) and a transport carriage (2), the runners (20) with a shaped profile being extended over a staircase or over a flat section and the transport carriage (2) being moved along the transport rail (61). The transport carriage is provided with at least one electric motor. The runners (20) having a shaped profile and the transport rail (61) are stored in the transport carriage (2). The invention also relates to a method for constructing a rail transport system and for transporting at least one container for loading and/or unloading the galley of an aeroplane, and to a system for simultaneously loading and/or unloading the galley of an aeroplane.

Abstract: A device and method for cooling an axle differential of a motor vehicle includes an air-guiding plate for guiding the air stream under the motor vehicle. An air-guiding plate is provided for guiding the air stream under the motor vehicle.