Abstract: The present invention concerns methods, in particular in vitro methods, for diagnosing liver fibrosis in a subject suffering from obesity, or for selecting a subject suffering from obesity for liver biopsy or for treatment. The present invention also pertains to methods for screening a probiotic, a prebiotic, a chemical compound or a biological compound suitable for preventing and/or treating liver fibrosis.
Type:
Grant
Filed:
April 23, 2015
Date of Patent:
July 2, 2019
Assignees:
VAIOMER, UNIVERSITÀ DEGLI STUDI DI ROMA TOR VERGATA, FUNDACIÓ INSTITUT D'INVESTIGACIÓ BIOMÈDICA DE GIRONA DR. JOSEP TRUETA
Inventors:
Michael Courtney, Benjamin Lelouvier, Massimo Federici, Jose Manuel Fernandez-Real, Sandrine Païssé
Abstract: The Mobile Dental Intelligence Center (MobiDIC) will roll up alongside the patient's Bedside or Chairside where Oral Hygiene can be performed by the patient's Caregiver, with no need to have a sink or basin in the area. Using the MobiDIC the Caregiver will be able to brush the patient's teeth, rinse and suction the patient's mouth at the Bedside or Chairside; also the Caregiver will monitor the patients Vital Signs. The unit's unique cylindrical design makes it easy for the Caregiver to wipe clean and disinfect the unit. The air, water, suction and power supply hoses are internal to the unit reducing cord entanglement and trip hazards. The MobiDIC allows the Caregiver the ability to easily connect various medical monitoring devices including Intra and Extra Oral Cameras capturing images of the patient's mouth inside and the patient's general appearance. All MobiDIC innovations will facilitate assessing the patient's current general health.
Abstract: A connecting device for connecting an adjustable spoiler blade to a vehicle includes a basic body including: a fastening interface having a Z clearance in a Z direction for fastening to spoiler kinematics of the vehicle in at least two different Z relative positions with respect to the spoiler kinematics, wherein an alignment body is fastened to the basic body, and an alignment interface having an XY clearance in an X direction and a Y direction for fastening in at least two different XY relative positions with respect to the basic body. The basic body has a spoiler interface for fastening of the spoiler blade and furthermore at least one adjuster for setting a Z relative position.
Type:
Grant
Filed:
September 25, 2017
Date of Patent:
June 25, 2019
Assignee:
DR. ING. H.C. F. PORSCHE AKTIENGESELLSCHAFT
Inventors:
Sebastian Strubel, Haiko Neher, Bernd Kasperowski, Uwe Heller
Abstract: A method for operating a hybrid vehicle, wherein the hybrid vehicle has an electric engine, an electric traction energy accumulator interacting with the electric engine, an internal combustion engine, and a fuel tank interacting with the internal combustion engine, includes starting from a purely electric driving mode in which the internal combustion engine is shut down and in which a shut-off valve of the fuel tank is closed, opening the shut-off valve of the fuel tank and starting up the internal combustion engine depending on defined operating conditions. The defined operating conditions include a current charging state of the traction energy accumulator and a current pressure in the fuel tank.
Type:
Grant
Filed:
September 27, 2017
Date of Patent:
June 25, 2019
Assignee:
DR. ING. H.C. F. PORSCHE AKTIENGESELLSCHAFT
Inventors:
Thomas Rauner, Thomas Beck, Francesco Piccolo
Abstract: A device (10) for counteracting gastroesophageal reflux in babies, including at least a flat rigid support (12), with a supporting side covered with stuffing or a cushion (11). The device includes mechanisms of assemblage (19) with a frame (30, 30?) including wheels. The supporting side of the rigid support has an inclination of 70-90° compared to the horizontal. The device also includes a sling (13) coupled with the rigid support (12) and fitted on the supporting side for placing and securing a baby (20) with his abdomen facing the cushion, in the space between the cushion and the sling. The sling includes a back rest (15) inclined in the same direction of the rigid support (12) and having an upper extremity higher than an upper extremity of the rigid support (12) and the cushion (11).
Abstract: A rollover protective device for a motor vehicle has a rollover protective body (1) with a top side. A deformation cross bar (2) is attached to the top side of the rollover protective body (1) and has hollow profile body (3). The deformation cross bar (2) has at least one reinforcing body (4) inserted into the hollow profile body (3).
Type:
Grant
Filed:
June 6, 2017
Date of Patent:
June 25, 2019
Assignee:
Dr. Ing. h.c. F. Porsche Aktiengesellschaft
Abstract: Aspects of the present application relate to solid forms of Venetoclax and preparative processes thereof. Specific aspects relate to an amorphous form of Venetoclax, its solid dispersion and crystalline forms of Venetoclax or salts thereof. Further aspects of the present application relate to processes for the preparation of Venetoclax.
Abstract: A transformer apparatus for a charging station for electrically charging vehicles. The charging station includes at least two charging points. The transformer apparatus includes an input connection for electrical connection to an electrical power source. The transformer apparatus further includes at least one primary winding, and connected downstream electrically in series, at least three electrically parallel secondary windings that are DC-isolated from one another. The secondary windings are configured to be connected to at least two output connections of the at least two charging points of the charging station by switching logic. The switching logic connects at least two secondary windings electrically in parallel with a respective output connection of a respective charging point.
Type:
Application
Filed:
November 6, 2018
Publication date:
June 20, 2019
Applicant:
Dr. Ing. h.c. F. Porsche Aktiengesellschaft
Abstract: A power electronic module (10) fora charging station having an input-side power factor correction circuit, a voltage link and an output-side DC chopper. The power factor correction circuit is of three-phase (11) design for three-phase current; each phase (11) has at least one high-voltage-side switch and one low-voltage-side switch; and diodes that prevent current from flowing back are installed. Also disclosed is a corresponding charging station and an electricity charging station.
Type:
Application
Filed:
December 19, 2018
Publication date:
June 20, 2019
Applicant:
Dr. Ing. h.c. F. Porsche Aktiengesellschaft
Inventors:
Karsten Hähre, Raoul Heyne, Marija Jankovic, Christian Metzger
Abstract: A mixture and method of production of a topical formulation for facial rejuvenation using cannabis extract that results in the remedy of alterations in a skin's appearance when applied to such skin.
Type:
Application
Filed:
December 14, 2018
Publication date:
June 20, 2019
Applicant:
Dr. Magana Products, Inc.
Inventors:
Jose Luis Magaña Garcia, Liliana Marisalto Ruiseco Lopez
Abstract: A transformer device for a charging station for electrically charging vehicles with at least two charging points, having an input connection for electrical connection to an electrical power source, also having a primary winding and at least one secondary winding for each charging point. The secondary windings are DC isolated from one another and each have at least one winding section which is connected electrically in parallel. Adjacent winding sections of at least one secondary winding overlap one another at least partially in an axial direction or radial direction.
Type:
Application
Filed:
December 11, 2018
Publication date:
June 20, 2019
Applicant:
Dr. Ing. h.c. F. Porsche Aktiengesellschaft
Abstract: A charging apparatus (1) for a vehicle that can be driven electrically has a charging cradle (4) with an access opening (8) and an electrical charging socket (5) is arranged in the charging cradle (4). A closure cover (7) is mounted pivotably in the charging cradle (4) and, in a closed position, covers the access opening (8) in the charging cradle (4) and, in an open position, opens said access opening. A sealing ring (12) which extends around the charging socket (5), and the closure cover (7) has a ring attachment (13) that makes contact with the sealing ring (12) along a ring contour of the sealing ring when the closure cover (7) is closed. Thus, the charging socket is sealed off reliably to the outside.
Type:
Grant
Filed:
October 14, 2015
Date of Patent:
June 18, 2019
Assignee:
Dr. Ing. h.c. F. Porsche Aktiengesellschaft
Inventors:
Sven Meinl, Siegfried Walter, Jochen Eppele
Abstract: A rotor for an electric motor has a shaft and a rotor laminated core connected to the shaft. A coolant duct is formed in the rotor in order to enable coolant to flow through the coolant duct. The coolant duct has a first portion, which runs at least in regions in the rotor laminated core. The rotor laminated core has a sleeve on the outer circumferential surface in order to avoid coolant escaping at the outer circumferential surface of the rotor laminated core. In a method for producing a rotor, a material having glass fibers or carbon fibers and a resin are applied to the rotor laminated core, and the resin is subsequently cured in order to produce the sleeve.
Type:
Application
Filed:
November 1, 2018
Publication date:
June 13, 2019
Applicant:
Dr. Ing. h.c. F. Porsche Aktiengesellschaft
Inventors:
Philipp Berendes, Bernhard Wiedemann, Stefan Oechslen, Jan David Schmitz-Hübsch
Abstract: An air inlet device for a coding device of an electric vehicle, having an air inlet duct with a duct wall delimiting a duct volume and at least one duct opening for the admission of ambient air for guiding to the cooling device. An acoustic, device for pedestrian protection is arranged in the duct wall in a flow-neutral manner with respect to the flow of ambient air, with a speaker device for generating a protective noise.
Type:
Application
Filed:
November 1, 2018
Publication date:
June 13, 2019
Applicant:
Dr. Ing. h.c. F. Porsche Aktiengesellschaft
Inventors:
Stefan Schmitt, Carsten Gürtler, Joachim Steidle, Tobias Hillers
Abstract: A battery device for an at least partially electrically operated motor vehicle and to a motor vehicle having such a battery device. The battery device comprises at least one battery module with a module housing device, which provides a receiving compartment for a plurality of battery cells and surrounds same in the manner of a housing and which comprises two housing end parts which dose a housing center part on the end sides. The module housing device is provided with a duct system for conducting a temperature control medium for controlling the temperature of the battery cells. Here, one of the housing end parts has at least one integrated first cooling duct. The first cooling duct can be fluidically connected to at least one second cooling duct integrated into the housing center part.
Type:
Application
Filed:
November 6, 2018
Publication date:
June 13, 2019
Applicant:
Dr. Ing. h.c. F. Porsche Aktiengesellschaft
Abstract: A support device for an air guiding means of a vehicle includes a basic body and at least one adjustment device fastened to the basic body, the adjustment device configured to adjust the air guiding means in a Z direction. The at least one adjustment device has at least one adjustment element which is mounted displaceably in a guide device of the adjustment device. The at least one adjustment element has an adjuster for displacing the adjustment element from a first Z position into a second Z position. The at least one adjustment element has a fastening interface for fastening to a drive unit for moving the air guiding means.
Type:
Grant
Filed:
September 20, 2017
Date of Patent:
June 11, 2019
Assignee:
DR. ING. H.C. F. PORSCHE AKTIENGESELLSCHAFT
Inventors:
Pierre Charpentier, Riccardo-Valerio Rume, Martin Siefer
Abstract: A front end module for covering a front of a front vehicle part of a motor vehicle includes a crossmember that is connectable to longitudinal carriers of a motor vehicle frame so as to absorb loads of a bumper. An upper frame element is connected to the crossmember for supporting an engine hood. A receiving region for receiving a radiator grill is disposed between the crossmember and the upper frame element. Fastening elements disposed on the crossmember and/or the upper frame element are configured to fasten an intercooler for cooling charge air of a turbocharger, with respect to the driving direction, in front of a wheel arch that receives a front wheel. A crash structure is connected to the fastening elements for absorbing impact energy by way of plastic deformation and covers a majority of the front wheel in an installed state of the front end module.
Type:
Grant
Filed:
July 15, 2016
Date of Patent:
June 11, 2019
Assignee:
DR. ING. H.C. F. PORSCHE AKTIENGESELLSCHAFT
Inventors:
Markus Keller, Frank Burbulla, Herbert Klamser, Thomas Ruckstuhl, Franz-Rudolf Wierschem, Xuan Li
Abstract: A parking apparatus having at least two parking areas, on each of which a motor vehicle can be parked. The parking apparatus includes at least one movable parking area which is movable relative to at least one fixed parking area. In order to simplify the charging of electrically operable motor vehicles, the parking apparatus is combined with a charging apparatus for charging electrical energy accumulators of electrically operable motor vehicles. The charging apparatus is simultaneously connectable in terms of charging to electrically operable motor vehicles on both parking areas.
Type:
Grant
Filed:
July 23, 2018
Date of Patent:
June 11, 2019
Assignee:
Dr. Ing. h.c. F. Porsche Aktiengesellschaft
Abstract: A cleaning device for cleaning a removable dental appliance is described. The device includes a rotatable upper cleaning brush having a plurality of downwardly protruding bristles for cleaning an upper surface of a removable dental appliance. The device also includes a lower dental appliance holder for holding the dental appliance and which is used in connection with the rotatable upper cleaning brush to limit movement of the dental appliance relative to the rotatable upper cleaning brush wherein, in use, a cleaning action can be applied to the dental appliance by rotating the rotatable upper cleaning brush relative to the dental appliance. The cleaning device further includes a casing connector for temporarily rotatably interconnecting the rotatable upper cleaning brush and the lower dental appliance holder so as to form a single integrated unit when assembled.