Abstract: The present invention is notably directed to a computerized method for providing real-time feedback to a user from states of a model physical system, or MPS, via a computerized system comprising one or more processors and a user interface system, or UIS. The method comprises the following steps, each performed via the one or more processors. Configuration inputs are repeatedly received, to modify a configuration of the MPS, said inputs including user inputs received via said UIS. While receiving said configuration inputs: configurations of the MPS are updated based on the configuration inputs received; and a state of the MPS is repeatedly computed, whereby each computed state corresponds to a latest updated configuration that was available before starting to compute said each computed state.

Abstract: Systems and methods for applying a pulsed electromagnetic fields. A system for applying a pulsed electromagnetic field (PEMF) to a cell, comprising: a sensor for obtaining a characteristic of the cell; a memory module having stored therein a plurality of characteristics and PEMF efficacy window data, each characteristic having its corresponding PEMF efficacy window data; a pulse generator coupled to a set of PEMF coils and configured to generate an output of electrical pulses to drive the set of PEMF coils; and a controller in communication with the sensor, the memory module and the pulse generator, wherein the controller is configured to: retrieve, from the memory module, the PEMF efficacy window data that corresponds to the characteristic of the cell obtained by the sensor; and control the output of the pulse generator based on the retrieved PEMF efficacy window data such that the set of PEMF coils apply a PEMF in accordance with the PEMF efficacy window data.

Abstract: Some implementations of the disclosure are directed to capturing facial training data for one or more subjects, the captured facial training data including each of the one or more subject's facial skin geometry tracked over a plurality of times and the subject's corresponding jaw poses for each of those plurality of times; and using the captured facial training data to create a model that provides a mapping from skin motion to jaw motion. Additional implementations of the disclosure are directed to determining a facial skin geometry of a subject; using a model that provides a mapping from skin motion to jaw motion to predict a motion of the subject's jaw from a rest pose given the facial skin geometry; and determining a jaw pose of the subject using the predicted motion of the subject's jaw.

Abstract: A versatile, highly efficient process for the preparation of acylphosphines such as mono- and bisacylphosphines via reaction of phosphines (PH3 and higher homologues) or silylated phosphines with acylhalides in the presence of at least one lewis acid. Further a novel acyl phosphines obtainable by the process.

Abstract: The present invention relates to chiral phosphoramidites represented by formula (Ia) or formula (Ib) as novel monomers for the synthesis of stereodefined phosphorothioate MOE oligonucleotides. Furthermore, the present invention relates to a method for synthesizing stereodefined phosphorothioate MOE oligonucleotides using said novel chiral phosphoramidites.

Abstract: The present disclosure relates to techniques for reconstructing an object in three dimensions that is captured in a set of two-dimensional images. The object is reconstructed in three dimensions by computing depth values for edges of the object in the set of two-dimensional images. The set of two-dimensional images may be samples of a light field surrounding the object. The depth values may be computed by exploiting local gradient information in the set of two-dimensional images. After computing the depth values for the edges, depth values between the edges may be determined by identifying types of the edges (e.g., a texture edge, a silhouette edge, or other type of edge). Then, the depth values from the set of two-dimensional images may be aggregated in a three-dimensional space using a voting scheme, allowing the reconstruction of the object in three dimensions.

Abstract: An automated costume augmentation system includes a computing platform having a hardware processor and a system memory storing a software code. The hardware processor executes the software code to provide an image including a posed figure to an artificial neural network (ANN), receive from the ANN a 2D skeleton data including joint positions corresponding to the posed figure, and determine a 3D pose corresponding to the posed figure using an optimization algorithm applied to the skeleton data. The software code further identifies one or more proportion(s) of the posed figure based on the skeleton data, determines bone directions corresponding to the posed figure using another optimization algorithm applied to the 3D pose, parameterizes a costume for the posed figure based on the 3D pose, the proportion(s), and the bone directions, and outputs an enhanced image including the posed figure augmented with the fitted costume for rendering on a display.

Abstract: The present invention relates to the field of antibodies useful in therapy and diagnosis. It specifically discloses bioconjugates comprising one or more antibodies bound to functionalized, magnetic nanoparticles. These bioconjugates are useful in cancer therapy, particularly for removing circulating tumor cells. The invention further pertains to specific functionalized, magnetic nanoparticles and to the manufacturing of such bioconjugates and such functionalized, magnetic nanoparticles.

Abstract: The invention relates to manufacturing processes for waterproof and breathable porous polymer membranes by coating a substrate with a dispersion comprising polymer, coated particles and diluent and removing the particles by dissolution, wherein the particles are made of organic salts, metal salts or metal oxides and the coating material is selected from carboxylic acids and alkoxy silanes. The invention further relates to dispersions to obtain such membranes, to polymer membranes obtained, to shaped articles containing such membranes; to the use of such membranes, shaped articles and intermediates.

Abstract: The invention relates to a chimeric antigen-receptor polypeptide heterodimer comprising two polypeptides, wherein the first contains an extracellular part of the major histocompatibility complex I alpha chain and the second contains a 32-microglobulin domain, or the first contains an extracellular part of the major histocompatibility complex II alpha chain and the second contains a major histocompatibility complex II beta chain. One of the polypeptides further contains a transmembrane domain, a hinge region and an intracellular domain of the T cell receptor alpha chain and the other one contains a transmembrane domain, a hinge region and an intracellular domain of the T cell receptor beta chain, and additionally an antigen-peptide covalently linked to said extracellular MHC domain. The invention further relates to a method for the identification of a TCR recognizable peptide sequence making use of the heterodimer of the invention.

Abstract: A method for generating an image data set of an image area located in a measurement volume of a magnetic resonance system comprising a gradient system and an RF transmission/reception system, comprises the following method steps: —reading out k-space corresponding to the imaging area, by: (a) activating a frequency encoding gradient in a predetermined spatial direction and with a predetermined strength G0 by means of said gradient system, (b) after the activated frequency encoding gradient achieves its strength G0, radiating a non-slice-selective RF excitation pulse by means of said RF transmission/reception system, (c) after a transmit-receive switch time ?tTR following the radiated excitation pulse, acquiring FID signals with said RF transmission/reception system and storing said FID signals as raw data points in k-space along a radial k-space trajectory that is predetermined by the direction and strength G0 of the frequency encoding gradient, (d) repeating (a) through (c) with respectively different freque

Abstract: According to one implementation, a system includes a computing platform having a hardware processor and a system memory storing a software code including multiple artificial neural networks (ANNs). The hardware processor executes the software code to partition a multi-dimensional input vector into a first vector data and a second vector data, and to transform the second vector data using a first piecewise-polynomial transformation parameterized by one of the ANNs, based on the first vector data, to produce a transformed second vector data. The hardware processor further executes the software code to transform the first vector data using a second piecewise-polynomial transformation parameterized by another of the ANNs, based on the transformed second vector data, to produce a transformed first vector data, and to determine a multi-dimensional output vector based on an output from the plurality of ANNs.

Abstract: According to a first aspect of the invention, a method for the generation of a cell line is provided, comprising the steps of (a) providing a plurality of mammalian B cells, wherein each of the plurality of B cells comprises a transgenic genomic DNA sequence encoding a marker protein inserted into an endogenous immunoglobulin locus comprised in said B cell, and wherein the transgenic genomic DNA sequence is amenable to cleavage by a site directed nuclease, particularly Cas9; (b) replacing the transgenic genomic DNA sequence encoding a marker protein with a second transgenic DNA sequence encoding a protein of interest; (c) sorting B cells based on the presence or absence of the marker protein; and (d) collecting B cells in which the marker protein is absent.

Abstract: A laser ablation cell (1) comprises a flow channel (11) having an essentially constant cross-sectional area so as to ensure a strictly laminar flow in the flow channel. A sample chamber (21) is provided adjacent to a lateral opening (14) of the flow channel. A laser beam (41) enters the sample chamber (21) through a lateral window (16) and impinges on a surface (24) of a sample (23) to ablate material from the sample. The sample may be positioned in such a distance from the flow channel that the laser-generated aerosol mass distribution has its center within the flow channel. This leads to short aerosol washout times. The laser ablation cell is particularly well suited for aerosol generation in inductively coupled plasma mass spectrometry (ICPMS), including imaging applications.

Abstract: Supervised machine learning using convolutional neural network (CNN) is applied to denoising images rendered by MC path tracing. The input image data may include pixel color and its variance, as well as a set of auxiliary buffers that encode scene information (e.g., surface normal, albedo, depth, and their corresponding variances). In some embodiments, a CNN directly predicts the final denoised pixel value as a highly non-linear combination of the input features. In some other embodiments, a kernel-prediction neural network uses a CNN to estimate the local weighting kernels, which are used to compute each denoised pixel from its neighbors. In some embodiments, the input image can be decomposed into diffuse and specular components. The diffuse and specular components are then independently preprocessed, filtered, and postprocessed, before recombining them to obtain a final denoised image.

Abstract: The present invention is directed to a cellular biosensor system comprising (A) a repressor module comprising one or more genes, which in their cumulative gene action exert repressing and/or inhibitory effect(s) on (B), an output module comprising at least one gene comprising at least one output sequence generating one or more output signals (i) in the absence of repressing and/or inhibitory effect(s) of the repressor module (A) and (ii) in the presence of at least one recombinase expressed by (C), a recombinase module comprising at least one gene comprising at least one sequence encoding a site-specific recombinase that enables gene rearrangement in the output module resulting in one or more output signals in the absence of repressing and/or inhibitory effect(s) of the repressor module, wherein the repressing and/or inhibitory effects of the repressor module are controlled by one or more inputs that negatively affect the repressing and/or inhibitory effects of the repressor module (A).

Abstract: A waveguide heterostructure for a semiconductor laser with an active part, comprising an active region layer depending of the type of semiconductor used, which is sandwiched between an electrode layer and a substrate, usable for dispersion compensation in a semiconductor laser frequency comb setup, an optical frequency comb setup and a manufacturing method.

Abstract: The invention relates to a method for generating electromagnetic radiation by a laser-produced plasma, wherein a target comprising a target material is provided, at least one pulse sequence is directed to said target, wherein the pulse sequence comprises four to nine conditioning laser pulses, wherein time intervals between subsequent conditioning laser pulses are 200 ns or less, and a main laser pulse is directed to said target along a first axis, such that a radiation-emitting plasma is formed from at least a part of said target material. The invention further relates to a device for generating electromagnetic radiation by means of a laser-produced plasma comprising a dispensing device and at least one laser source, wherein the device is configured such that at least one pulse sequence comprising four to nine conditioning laser pulses and a main laser pulse can be generated by the at least one laser source.

Abstract: The present invention relates to inositol derivatives covalently modified with one, two or three solubility functions, particularly polyethylene glycol moieties, for use in therapy or prevention of conditions related to pathological calcium crystallization, such as cardiovascular calcifications, nephrocalcinosis, calcinosis cutis, chondrocalcinosis and kidney stones.

Abstract: The present invention relates to a method of evaluating cellulite using fibulin-3 and/or sarcoglycan gamma as an indicator in a harvested skin sample, and a method of evaluating a drug for improving, preventing or treating cellulite using fibulin-3 and/or sarcoglycan gamma as an indicator in cultured cells.