Abstract: The present invention relates to inositol derivatives covalently modified with one, two or three solubility functions, particularly polyethylene glycol moieties, for use in therapy or prevention of conditions related to pathological calcium crystallization, such as cardiovascular calcifications, nephrocalcinosis, calcinosis cutis, chondrocalcinosis and kidney stones.

Abstract: The present invention relates to a method of evaluating cellulite using fibulin-3 and/or sarcoglycan gamma as an indicator in a harvested skin sample, and a method of evaluating a drug for improving, preventing or treating cellulite using fibulin-3 and/or sarcoglycan gamma as an indicator in cultured cells.

Abstract: A method of identifying locations in a virtual environment where a motion sequence can be performed by an animated character may include accessing the motion sequence for the animated character, identifying a plurality of contact locations in the motion sequence where the animated character contacts surfaces in virtual environments, accessing the virtual environment comprising a plurality of surfaces, and identifying the locations in the virtual environment where the motion sequence can be performed by the animated character by identifying surfaces in the plurality of surfaces that match the plurality of contact locations.

Abstract: The present invention provides a method for obtaining densified material comprising the steps of a. providing lignocellulosic material, b. delignification of the lignocellulosic material providing a delignified material, wherein the delignification step is performed in such a way that the lignin of the lignocellulosic material is almost completely removed and wherein the structural integrity of the lignocellulosic material is maintained in the delignified material, c. densification of the delignified material providing a densified material. Furthermore, a densified material is provided. The fibers and fibrils are maintained in the structural directionality of the raw material and that the cellulosic material is whitish.

Abstract: A method and system for propelling and controlling displacement of a microrobot in a space having a wall, includes the steps of: forming the microrobot with a body containing a magnetic field-of-force responsive material, wherein, in response to a magnetic field of force, a force is applied to the material in a direction of the magnetic field of force; positioning the microrobot in the space for displacement in that space; and generating the magnetic field of force with a predetermined gradient and applying the magnetic field of force to the microrobot propelling the microrobot through the space in a direction of a field of force. Then, a sequence of field generating steps are executed, wherein each step includes calculating the direction, amplitude and spatial variation of the net field of force to control displacement of the microrobot in the space and against the wall from one equilibrium point to another.

Abstract: The invention relates to a process for methanol synthesis comprising the steps of providing a syngas feed stream comprising hydrogen and a mixture of carbon dioxide and carbon monoxide, wherein carbon dioxide represents from 1 to 50 mol % of the total molar content of the feed stream, carbon monoxide is contained from 0.1 to 85 mol % of the total molar content, and H2 is comprised from 5 to 95 mol % of the total molar content of the feed stream; providing an indium oxide catalyst selected from a bulk catalyst and a supported catalyst comprising indium oxide (In2O3) as the main active phase; putting in contact said stream with said catalyst at a reaction temperature of at least 373 K (99.85° C.) and under a pressure ranging of at least 1 MPa; and recovering the methanol effluents. The invention also relates to an indium oxide based catalyst.

Abstract: Described herein are hypervalent iodine reagents.

Abstract: The fat burning analyzer includes a sampling part, an analysis unit and a processing unit. The sampling part collects a breath sample from the user, information on the conditions of the breath sample collection, and provides a sampling signal correlated to the collection condition of the breath sample. The analysis unit provides a detection signal corresponding to an acetone concentration in the collected breath sample and, as such, provides information on the breath acetone of the user (during exercise or resting). The processing unit receives the sampling signal and/or detection signal, and evaluates the sampling signal and/or the detection signal. The evaluation provides information correlated to the fat burning intensity of the user. These information can be provided as an output signal by the processing unit. Accordingly, the processing unit is equipped to provide an output signal correlated to the fat burning intensity of the user.

Abstract: A device for repair surgery of cylindrical organs, particularly of ruptured tendons, is configured as a tubular sheath (T) made of a mesh of elastic fibers formed by electrospinning a biocompatible and biodegradable polymer. The tubular sheath has a Young elasticity modulus of about 0.1 to about 4 MPa and a strain at break of about 50 to about 1,000%, and it has a first wall surface and a second wall surface substantially parallel thereto, with said first wall surface being comparatively smooth (WS) and said second wall surface being comparatively rough (WR). According to the invention, the elastic fibers comprise first fibers consist of polymer in neat form and second fibers consist of polymer with an admixture of a therapeutic agent for stimulating regrowth processes of a predetermined cylindrical organ.

Abstract: The present invention relates to a method of providing a graft scaffold for cartilage repair, particularly in a human patient. The method of the invention comprising the steps of providing particles and/or fibres; providing an aqueous solution of a gelling polysaccharide; providing mammalian cells; mixing said particles and/or fibres, said aqueous solution of a gelling polysaccharide and said mammalian cells to obtain a printing mix; and depositing said printing mix in a three-dimensional form. The invention further relates to graft scaffolds and grafts obtained by the method of the invention.

Abstract: The present invention relates to inositol derivatives covalently modified with one, two or three solubility functions, particularly polyethylene glycol moieties, for use in therapy or prevention of conditions related to pathological calcium crystallization, such as cardiovascular calcifications, nephrocalcinosis, calcinosis cutis, chondrocalcinosis and kidney stones.

Abstract: The present invention related to a method for producing or propagating an engineered bacteriophage, comprising the steps of: providing a functional synthetic genome of an engineered bacteriophage being able to infect a target bacterium; providing a recipient bacterium; transforming the recipient bacterium with the functional synthetic genome in a transformation step, yielding a transformed recipient bacterium; incubating the transformed recipient bacterium in a first incubation step, wherein the engineered bacteriophage is propagated within the transformed recipient bacterium; and further incubating the transformed recipient bacterium or the propagated engineered bacteriophage released from the transformed recipient bacterium with the target bacterium in a second incubation step, wherein the propagated engineered bacteriophage infects the target bacterium and is further propagated within the target bacterium, and wherein the recipient bacterium is a cell wall-deficient bacterium.

Abstract: The present invention is directed to a liposome composition for use in the peritoneal dialysis of patients suffering from endogenous or exogenous toxicopathies, wherein the pH within the liposomes differs from the pH in the intraperitoneal cavity and wherein the pH within the liposome results in a liposome-encapsulated charged toxin. The invention also relates to a pharmaceutical composition comprising said liposomes. A further aspect of the present invention relates to a method of treating patients suffering from endogenous or exogenous toxicopathies, preferably selected from drug, metabolite, pesticide, insecticide, toxin, and chemical warfare toxicopathies, more preferably hyperammonemia, comprising the step of administering liposomes of the invention in a therapeutically effective amount into the peritoneal space of a patient in need thereof. Next to human, the present invention is particularly suitable to veterinary aspects.

Abstract: A device for measuring the elastic deformability of soft tissue has a probe head having the form of a cup with a cavity, side walls and a bottom wall, a first probe channel, a pressure unit and a control unit, the first probe channel being configured to connect the pressure unit, that provides a vacuum inside first probe channel and that is controlled by the control unit with the probe head. The first probe channel has a distal end leading through the bottom wall into the cavity. The device further has a second probe channel having a distal end leading through the bottom wall into the cavity and being connected with a pressure sensor provided to determine the pressure in the cavity and to communicate it to the control unit to determine a point in time, when deformed tissue closes the distal end of the first probe channel based on a pressure difference in the two probe channels.

Abstract: A cell-based screening method is provided. The screening method aims to identify drugs for the treatment of cancers characterized by cells with an over-activated signalling pathway in a combination medicament with an inhibitor of the respective over-activated signalling pathway. In particular, the expression level of SOX2 is determined to identify compounds that prevent the development of resistance to inhibitors of the MAPK and EGFR pathway.

Abstract: A 3D printed core-shell filament comprises an elongated core radially surrounded by an outer shell with a barrier layer in between, where the elongated core comprises a ductile polymer and the outer shell comprises a stiff polymer having a Young's modulus higher than that of the ductile polymer. A lightweight lattice structure may comprise a plurality of the 3D printed core-shell filaments deposited in layers.

Abstract: The present invention relates to core-shell particles comprising encapsulated nucleic acids—a sensing sequence and a control sequence; the invention further relates to the use of such particles as a sensing element; to methods for measuring a property of interest in a setting employing such particles; to measuring systems and analytical kits comprising such particles.

Abstract: Systems, methods and articles of manufacture for rendering three-dimensional virtual environments using reversible jumps are disclosed herein. In one embodiment, mappings from random numbers to light paths are modeled as an explicit iterative random walk. Inverses of path construction techniques are employed to turn light transport paths back into the random numbers that produced them. In particular, such inverses may be used to extend the Multiplexed Metropolis Light Transport (MMLT) technique to perform path-invariant perturbations that produce a new path sample using a different path construction technique but preserve the path's geometry.

Abstract: The present disclosure relates to an apparatus, system and method for processing transmedia content data. More specifically, the disclosure provides for identifying and inserting one item of media content within another item of media content, e.g. inserting a video within a video, such that the first item of media content appears as part of the second item. The invention involves analysing a first visual media item to identify one or more spatial locations to insert the second visual media item within the image data of the first visual media item, detecting characteristics of the one or more identified spatial locations, transforming the second visual media item according to the detected characteristics and combining the first visual media item and second visual media item by inserting the transformed second visual media item into the first visual media item at the one or more identified spatial locations.

Abstract: In one aspect, the present disclosure provides a nozzle for 3-D printing. The nozzle may include a first nozzle tip defining a first outlet, where the first nozzle tip includes a first channel extending therethrough. The nozzle may further include a second nozzle tip defining a second outlet, where the second nozzle tip includes a second channel extending therethrough, and where the first channel surrounds the second outlet. The second nozzle tip may be retracted longitudinally with respect to the first nozzle tip such that the second outlet of the second nozzle tip is located in the first channel.