Abstract: A detection device for detecting at least the occurrence and location of occurrence of sensor element signals that are generated by sensor elements, includes an array of detector element circuits each generating a element row output and at least one element column output. The detection device determines, for each row of detector element circuits, at least a first row summation signal corresponding to a sum of the element row outputs of the detector element circuits of this row, and a row address signal indicating that the first row summation signal crosses a threshold. The detection device also determines, for each column of detector element circuits, at least a first column summation signal corresponding to a sum of the element column outputs of the detector element circuits of this column, and a column address signal indicating that the first column summation signal crosses a threshold.

Abstract: Techniques are disclosed for learning a machine learning model that maps control data, such as renderings of skeletons, and associated three-dimensional (3D) information to two-dimensional (2D) renderings of a character. The machine learning model may be an adaptation of the U-Net architecture that accounts for 3D information and is trained using a perceptual loss between images generated by the machine learning model and ground truth images. Once trained, the machine learning model may be used to animate a character, such as in the context of previsualization or a video game, based on control of associated control points.

Abstract: The present invention relates to small-molecule inhibitors of the FRS2-FGFR interaction. The present invention relates the small-molecule inhibitors for use as a medicament and for use in cancer or metastasis treatment or prevention.

Abstract: The present invention relates to small-molecule inhibitors of the FRS2-FGFR interaction. The present invention relates the small-molecule inhibitors for use as a medicament and for use in cancer treatment or prevention.

Abstract: A method is disclosed for steering a physical analog system (e.g., an electric motor) using a discrete-level (e.g., binary) control signal. The discrete-level control signal is computed by an iterative scheme that can handle a long planning horizon. A preference for infrequent level switches can be taken into account. The quality of the fit to the target trajectory can be expressed not only by the quadratic error, but also by other norms. The method can be used also for digital-to-analog conversion.

Abstract: In one aspect the invention relates to a mobile robotic end-effector tool for generating a mesh structure for use in reinforced concrete building systems.

Abstract: An automatic camera head for panning and tilting a video camera, comprising at least one ring actuator arranged to act on a ring control of an objective of the camera, wherein said ring control is one of: zoom, iris, and focus; and said ring actuator includes a torque measurement unit delivering a signal indicative of the torque applied to the ring control.

Abstract: A system (1) for measuring the optical activity of a sample (2) comprises at least one frequency modulation device (3), at least one synchronization device (4), and at least one detection device (5). The frequency modulation device (3) is configured to modulate a frequency of incident electromagnetic radiation being emitted from a sample (2) and/or being irradiated on to a sample (2) with at least one frequency modulation signal (Sf). The synchronization device (4) is configured to receive the at least one frequency modulation signal (Sf) and to emit at least one detection modulation signal (Sd) being synchronized with the at least one frequency modulation signal (Sf). The system (1) is configured such that the detection device (5) detects the electromagnetic radiation (EMs) in synchronization with the detection modulation signal (Sd).

Abstract: In various embodiments, a training application generates training items for three-dimensional (3D) pose estimation. The training application generates multiple posed 3D models based on multiple 3D poses and a 3D model of a person wearing a costume that is associated with multiple visual attributes. For each posed 3D model, the training application performs rendering operation(s) to generate synthetic image(s). For each synthetic image, the training application generates a training item based on the synthetic image and the 3D pose associated with the posed 3D model from which the synthetic image was rendered. The synthetic images are included in a synthetic training dataset that is tailored for training a machine-learning model to compute estimated 3D poses of persons from two-dimensional (2D) input images. Advantageously, the synthetic training dataset can be used to train the machine-learning model to accurately infer the orientations of persons across a wide range of environments.

Abstract: A system includes a computing platform having a hardware processor and a memory storing a software code and a neural network (NN) having multiple layers including a last activation layer and a loss layer. The hardware processor executes the software code to identify different combinations of layers for testing the NN, each combination including candidate function(s) for the last activation layer and candidate function(s) for the loss layer. For each different combination, the software code configures the NN based on the combination, inputs, into the configured NN, a training dataset including multiple data objects, receives, from the configured NN, a classification of the data objects, and generates a performance assessment for the combination based on the classification. The software code determines a preferred combination of layers for the NN including selected candidate functions for the last activation layer and the loss layer, based on a comparison of the performance assessments.

Abstract: Bi— or multicomponent fibre (3) comprising a reinforcing core (1) of a first material and at least one sheath (2) of a second, thermoplastic or pre-polymerized thermoset material, for the manufacturing of composite parts, the matrix of which composite parts consists of the material of said sheath (2), wherein said first material has a degradation temperature, ignition temperature, glass transition temperature, melting temperature or liquidus temperature which is higher than the melting temperature, flowing temperature, r softening temperature of said second, thermoplastic or pre-polymerized thermoset material, wherein said reinforcing core (1) has a core volume fraction (vf) defined as the volume fraction of the reinforcing core (1) in the bi- or multicomponent fibre (3), which is in the range of 0.3-0.8, and wherein along a longitudinal axis (Z) of the bi- or multicomponent fibre outer surface (4) of the sheath (2) has a corrugated, preferably irregular corrugated shape.

Abstract: A moving device for moving a human thumb, in particular for moving the thumb between a resting position and a grasping position. A thumb bending section is adapted to at least partially move the thumb between a flexed position and an extended position. The thumb bending section has a gear unit for transforming a rotation of a rotation element, which is rotatably mounted to a housing, into an essentially linear movement between a translation element and the housing. The thumb bending section further has a first flexion spring mechanically connected to the translation element and adapted to be fixed with a first proximal end of the first flexion spring relative to a human thumb at a position in a proximal distance to the metacarpophalangeal joint or at a position between the metacarpophalangeal joint and the carpometacarpal joint.

Abstract: A process for preparing a nitrated compound, including the step of reacting a compound (A) including at least one substituted or unsubstituted aromatic or heteroaromatic ring, wherein the heteroaromatic ring includes at least one heteroatom selected from the group consisting of oxygen, sulfur, phosphor, selenium and nitrogen, with a compound of formula (I) wherein Y is selected from the group consisting of hydrogen and nitro.

Abstract: An additive for producing a hardenable building material, especially a mineral composition comprising clays, comprising or consisting of: a) a dispersing agent, selected from aluminates, aluminate precursors, phosphates, silicates and/or polyacrylates, which is capable of dispersing clay particles in an aqueous slurry, and b) a coagulating agent, selected from salts of divalent metal cations, preferably salts of alkaline earth metals and/or iron, especially magnesium, calcium and/or iron salts, capable of causing clay particles to agglomerate in a aqueous slurry.

Abstract: The present invention is directed to a composition comprising at least one fibronectin binding polypeptide (FnBP) linked to at least one diagnostic or therapeutic agent, a nucleic acid encoding a fusion polypeptide comprising at least one fibronectin binding polypeptide (FnBP) linked to at least one diagnostic or therapeutic polypeptide agent as well as a corresponding recombinant vector and host cell comprising such a nucleic acid and preferably expressing said fusion polypeptide. The invention also relates to a kit of parts comprising at least one fibronectin binding polypeptide (FnBP), at least one diagnostic or therapeutic agent, and optionally one or more chemical agents for linking the fibronectin binding polypeptide (FnBP) to the diagnostic or therapeutic agent.

Abstract: A computer-implemented simulation method of predicting local concentrations of constituents in coolant water anywhere along fuel rods within any fuel assembly mechanical design of a Boiling Water Reactor (BWR) potentially resulting in crud deposits on said fuel rods. The method is based on a sub-channel approach of predicting local mass fluxes of vapor and liquid in coolant water anywhere along fuel rods within any fuel assembly mechanical design of a Boiling Water Reactor (BWR) for given steady-state or transient boundary conditions. The sub-channel approach is based on the solution of mass, momentum and energy conservation equations for the vapor phase and the liquid phase, the liquid phase is represented by more than one field variable, and is specifically represented by three fields, with the vapor phase as a fourth field, consisting of droplets, a liquid base film, and disturbance waves.

Abstract: Techniques are disclosed for creating digital faces. In some examples, an anatomical face model is generated from a data set including captured facial geometries of different individuals and associated bone geometries. A model generator segments each of the captured facial geometries into patches, compresses the segmented geometry associated with each patch to determine local deformation subspaces of the anatomical face model, and determines corresponding compressed anatomical subspaces of the anatomical face model. A sculpting application determines, based on sculpting input from a user, constraints for an optimization to determine parameter values associated with the anatomical face model. The parameter values can be used, along with the anatomical face model, to generate facial geometry that reflects the sculpting input.

Abstract: The present invention relates to a method of providing a graft scaffold for cartilage repair, particularly in a human patient. The method of the invention comprising the steps of providing particles and/or fibres; providing an aqueous solution of a gelling polysaccharide; providing mammalian cells; mixing said particles and/or fibres, said aqueous solution of a gelling polysaccharide and said mammalian cells to obtain a printing mix; and depositing said printing mix in a three-dimensional form. The invention further relates to graft scaffolds and grafts obtained by the method of the invention.

Abstract: A virtual puppeteering system includes a portable device including a camera, a display, a hardware processor, and a system memory storing an object animation software code. The hardware processor is configured to execute the object animation software code to, using the camera, generate an image in response to receiving an activation input, using the display, display the image, and receive a selection input selecting an object shown in the image. The hardware processor is further configured to execute the object animation software code to determine a distance separating the selected object from the portable device, receive an animation input, identify, based on the selected object and the received animation input, a movement for animating the selected object, generate an animation of the selected object using the determined distance and the identified movement, and render the animation of the selected object.

Abstract: The present invention is directed to cell-protective, in particular, cardio- and renal-protective organic compounds, preferably to organic compounds that inhibit substrate phosphorylation by the G-protein-coupled receptor kinase 2 (GRK2, ADRBK1). Preferably, the organic compounds inhibit the GRK2-mediated phosphorylation of serine/arginine-rich splicing factor 1 (SRSF1, ASF-1, SF2) and/or phosducin for treating hypertension, heart diseases, heart dysfunction or failure and heart disease-associated pathologies, e.g. cardiomyocyte necrosis, ischemic cardiac disease and/or ischemic heart damage or ageing. Furthermore, the present invention is directed to a method for the identification of inhibitors of the (GRK2)-mediated phosphorylation of (SRSF1) and/or phosducin.