Patents Assigned to Fisons Limited
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Patent number: 4345932Abstract: 5-Benzofuranyl esters of the general formula ##STR1## wherein the substituents are as defined in the specification, possess physiological activity, particularly plant physiological activity and may be used as herbicides, plant growth regulants, fungicides, insecticides and anthelmintics.Type: GrantFiled: June 8, 1977Date of Patent: August 24, 1982Assignee: Fisons LimitedInventors: Peter S. Gates, John Gillon, David T. Saggers
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Patent number: 4335048Abstract: There is described the compound of formula I, ##STR1## and pharmaceutically acceptable derivatives thereof. Processes for making the compound and pharmaceutical, e.g. anti-asthmatic, compositions containing it are also described.Type: GrantFiled: February 19, 1980Date of Patent: June 15, 1982Assignee: Fisons LimitedInventors: Hugh Cairns, Richard Hazard, John King, Thomas B. Lee
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Patent number: 4333759Abstract: The invention provides herbicidally-active 2,3-dihydro-5-cyanobenzofurans of the formula: ##STR1## (wherein: R.sup.1 and R.sup.2 together represent .dbd.O or R.sup.1 represents hydrogen and R.sup.2 represents hydrogen, hydroxy, alkoxy, acyloxy, alkoxycarbonyloxy, alkylthiocarbonyloxy, halogen, isothiocyanato, amino, alkylamino, dialkylamino, arylamino, acylamino, alkoxycarbonylamino, alkylthiocarbonylamino, N-bonded heterocyclyl, cyano or alkylthio; R.sup.3 and R.sup.4 together represent alkylene or each represent hydrogen or alkyl; and R.sup.5, R.sup.6 and R.sup.7, which may be the same or different, each represent hydrogen, halogen, alkyl, alkoxy, acyl or cyano), processes for their preparation and herbicidal compositions containing them.Type: GrantFiled: December 4, 1980Date of Patent: June 8, 1982Assignee: Fisons LimitedInventors: Peter S. Gates, Derek Baldwin, Carol A. Wilson, John Gillon
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Patent number: 4328341Abstract: There is described a process for the production of a 1,4-dihydro-4-oxo-quinoline-2-carboxylic acid, or a salt, ester or amide thereof, which comprises cyclization of a corresponding 2-aminobenzoyl pyruvic acid or an ester thereof, and if desired or necessary converting the resulting product to an appropriate salt, ester or amide thereof, or vice versa.Type: GrantFiled: December 2, 1980Date of Patent: May 4, 1982Assignee: Fisons LimitedInventors: Richard A. Raphael, Stephen C. Eyley, Stephen C. W. Coltman
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Patent number: 4328230Abstract: There are described compounds of formula I, ##STR1## in which R.sub.5 to R.sub.8 may be a variety of substituents, or an adjacent pair of R.sub.5, R.sub.6, R.sub.7 and R.sub.8 form a chain--COCH.dbd.C(COOH)NRh--,or one of R.sub.5, R.sub.6, R.sub.7 and R.sub.8 form a group of formula II, ##STR2## in which Ra, Rb and Rc have the same significances as R.sub.5, R.sub.6, R.sub.7 and R.sub.8,X is an optionally interrupted or substituted hydrocarbon chain,Rg and Rh, which may be the same or different are each alkyl, alkenyl, phenyl-alkyl, alkanoyl, benzoyl or phenylalkanoyl,or Rg and R.sub.8 and/or Rh and Rc in formula II, together form a chain --(CH.sub.2).sub.n --, and n is 2, 3 or 4.There are also described processes for making the compounds and pharmaceutical, e.g. anti-allergic, compositions containing the compounds.Type: GrantFiled: March 5, 1979Date of Patent: May 4, 1982Assignee: Fisons LimitedInventors: Roger C. Brown, Hugh Cairns, Anthony R. Payne
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Patent number: 4317833Abstract: There is described a method for the prevention or inhibition of gastric acid secretion, and/or the treatment of conditions involving excess gastric acid secretion, which method comprises administration of a compound of the formula I, ##STR1## or a pharmaceutically acceptable derivative thereof (as active ingredient), to a patient having, or liable to have, excess gastric acid secretion and/or a condition involving excess gastric acid secretion, or in whom a reduction in gastric acid secretion is desired.Type: GrantFiled: December 10, 1979Date of Patent: March 2, 1982Assignee: Fisons LimitedInventor: Thomas J. Sullivan
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Patent number: 4299841Abstract: Insect and acarid pests, particularly those of crops, are combated by applying (a) 2,2-dimethyl-1,3-benzodioxol-4-yl N-methylcarbamate and (b) a soil applied systemic insecticide or acaricide, particularly immediately before planting the crop.Type: GrantFiled: October 10, 1979Date of Patent: November 10, 1981Assignee: Fisons LimitedInventor: Quinton A. Geering
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Patent number: 4299832Abstract: The substituted theophyllines of the formula: ##STR1## (wherein R.sup.1, R.sup.2 and R.sup.3, which may be the same or different, each represent alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 7 carbon atoms, phenyl or phenylalkyl of 7 to 10 carbon atoms, each of which may be unsubstituted or substituted by one or more hydroxy groups, alkoxy or alkylthio groups of 1 to 4 carbon atoms, halogen atoms, cyano groups, nitro groups, carboxy groups, alkoxycarbonyl groups of 2 to 5 carbon atoms, amino groups, alkylamino groups of 1 to 4 carbon atoms or dialkylamino groups of 2 to 8 carbon atoms, or when the group is phenyl or phenylalkyl, by one or more alkyl groups of 1 to 4 carbon atoms;or R.sup.2 and R.sup.3 together represent a hydrocarbon chain of 3 to 6 carbon atoms optionally interrupted by a heteroatom;and n represents an integer of from 1 to 6)and the acid additional salts thereof, are novel compounds which are useful in the treatment of cardiac disorders.Type: GrantFiled: October 30, 1979Date of Patent: November 10, 1981Assignee: Fisons LimitedInventors: Roger C. Brown, Rodney A. Brown, Stephen E. O'Connor
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Patent number: 4296114Abstract: There are described compounds of formula I, ##STR1## in which R.sub.1 is phenyl substituted by halogen, alkoxy, alkyl, carboxy-alkyl, --NR.sub.4 R.sub.5, carboxy or alkoxy carbonyl,R.sub.3 is hydrogen, alkyl, mono- or di-carboxy alkyl, halo, alkoxy, phenyl, halo-phenyl, hydroxy, phenoxy, thiol, thioalkoxy, thiophenoxy, --NR.sub.4 R.sub.5, cyano, --COOH, carboxyureido, --CF.sub.3, --COR.sub.6, hydroxyalkyl, aminoalkyl, or alkoxy substituted by NR.sub.4 R.sub.5,ring A is a benzene or a pyridine ring which optionally carries up to 4 substituents R.sub.3, which may be the same or different,R.sub.4 and R.sub.5, which may be the same or different, each represent hydrogen, phenyl, halophenyl or alkyl, the alkyl optionally being substituted by alkoxy or by a mono- or di-alkyl or unsubstituted amino group; or R.sub.4 and R.sub.5, together with the nitrogen atom to which they are attached, form a piperidine, morpholine or an optionally alkyl substituted piperazine ring, andR.sub.Type: GrantFiled: August 2, 1979Date of Patent: October 20, 1981Assignee: Fisons LimitedInventors: Richard A. Appleton, David Johnston
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Patent number: 4293541Abstract: There is described a salt of 2,8-dicarboxy-4,6-dioxo-10-propyl-4H,6H-benzo(1,2-b:5,4-b')dipyran with a pharmaceutically acceptable organic cation, the salt having a solubility of less than 31 w/w in water a 20.5.degree. C.There are also described processes for making the salts and pharmaceutical, e.g. anti-allergic, compositions containing them.Type: GrantFiled: April 25, 1980Date of Patent: October 6, 1981Assignee: Fisons LimitedInventors: Hugh Cairns, Thomas B. Lee
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Patent number: 4292068Abstract: The invention provides a method of combating rhizomatous and stoloniferous weeds by the application to a locus either infested or liable to infestation therewith an effective amount of 2,3-dihydro-3,3-dimethylbenzofuran-5-yl ethanesulphonate.Type: GrantFiled: December 4, 1979Date of Patent: September 29, 1981Assignee: Fisons LimitedInventors: Samuel D. van Hoogstraten, David H. K. Davies
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Patent number: 4291052Abstract: Bendiocarb granules combat corn rootworm. Preferred bendiocarb granules comprise (A) base granules to which the bendiocarb adheres by means of a sticker comprising a hydrocarbon of viscosity at least 20 centipoises, the bendiocarb granules bearing a surface coating of a flowability agent, (B) absorbent base granules impregnated with the bendiocarb, or especially (C) base granules to which the bendiocarb adheres by means of a sticker comprising a water-soluble sticker.Type: GrantFiled: December 31, 1979Date of Patent: September 22, 1981Assignee: Fisons LimitedInventors: Christopher Gillings, John H. Palmer
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Patent number: 4284613Abstract: A process which comprises reacting ammonia with phosphoric acid in a reaction vessel to form a reaction mixture comprising ammonium phosphate characterized in that the reaction mixture is allowed to foam whereby there is formed a foaming reaction mixture comprising steam and ammonium phosphate; and in that steam and ammonium phosphate are discharged from the reaction vessel through a common outlet. Preferably the ammoniation is carried out under pressure and the foam reaction mixture is discharged via a spray nozzle into a zone of lower pressure where water is evolved spontaneously, e.g. by flash evaporation as the product is sprayed, to give a solid particulate product.Type: GrantFiled: October 4, 1979Date of Patent: August 18, 1981Assignee: Fisons LimitedInventors: Donald M. Martin, Peter A. Rowe
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Patent number: 4281008Abstract: The compounds of the formula: ##STR1## wherein: R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.7, which may be the same or different, each represent hydrogen, hydroxy, alkyl or alkoxy of 1 to 6 carbon atoms, amino, acyl or acylamino of 2 to 6 carbon atoms, alkenyl of 2 to 6 carbon atoms, halogen, or alkoxy of 1 to 6 carbon atoms substituted by phenyl,X is a hydrocarbon chain of 1 to 10 carbon atoms optionally substituted by a hydroxy group,A is oxygen or is absent,Q represents a straight or branched alkylene, alkenylene or alkynylene group of 2 to 6 carbon atoms, andD represents carboxy, 5-tetrazolyl or carboxamido-5-tetrazolyl,and pharmaceutically acceptable salts, esters and amides thereof,are pharmaceutically active, being antagonists of the slow reacting substance of anaphylaxis (SRS-A) or its pathological effects.Pharmaceutical compositions containing the compounds are also described, as well as processes for preparing the compounds.Type: GrantFiled: March 6, 1980Date of Patent: July 28, 1981Assignee: Fisons LimitedInventors: Terence R. Chamberlain, John R. Bantick
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Patent number: 4275060Abstract: Combinations of (A) bendiocarb and (B) at least one of methyl parathion and a synthetic pyrethroid combat pests such as Insecta eggs.Type: GrantFiled: July 17, 1979Date of Patent: June 23, 1981Assignee: Fisons LimitedInventor: Quinton A. Geering
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Patent number: 4275247Abstract: Pyrogallol or a salt thereof is prepared by a process comprising deoximating cyclohexane-1,2,3-trione oxime or an oxime derivative thereof or a salt of either. Preferably the oxime itself is exployed, especially the 1,3-dioxime. The deoximation is preferably effected by hydrolysis.Type: GrantFiled: December 27, 1979Date of Patent: June 23, 1981Assignee: Fisons LimitedInventor: John F. Harris
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Patent number: 4271182Abstract: The present invention relates to methods of treating chronic skin disorders by externally applying to the skin compounds by the following formula ##STR1## and therapeutically acceptable salts, esters and amides thereof, wherein R.sub.1 through R.sub.6 and X are as hereinafter defined.Type: GrantFiled: December 9, 1974Date of Patent: June 2, 1981Assignee: Fisons LimitedInventor: Thomas J. Sullivan
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Patent number: 4269853Abstract: There is described a pharmaceutical composition suitable for application to the skin and comprising, as active ingredient, a compound of formula I, ##STR1## in which R.sub.1 represents hydrogen, hydroxy or --NR.sub.5 R.sub.6, in which R.sub.5 and R.sub.6, which may be the same or different, each represent hydrogen or alkyl C 1 to 6,an adjacent pair of R.sub.2, R.sub.3 and R.sub.4 form a --(CH.sub.2).sub.4 -- chain, and the remaining substituent R.sub.2 or R.sub.4 represents alkyl C 1 to 9,E represents a 5-(IH)tetrazolyl- or a -COOH group, andX represents oxygen or a group --NR.sub.7 -- in which R.sub.7 may be hydrogen or alkyl C 1 to 6, or a pharmaceutically acceptable derivative thereof.Type: GrantFiled: March 5, 1979Date of Patent: May 26, 1981Assignee: Fisons LimitedInventors: Thomas S. C. Orr, Raymond W. Keogh
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Patent number: 4269854Abstract: There are described compounds of formula I, ##STR1## in which R is hydrogen, hydroxy or alkoxy C 1 to 6, and X is hydroxy, carbonyl oxygen or alkoxy C 1 to 6, and pharmaceutically acceptable derivatives thereof.There are also described methods for making the compounds and pharmaceutical, e.g. anti-allergic, compositions containing them.Type: GrantFiled: August 10, 1979Date of Patent: May 26, 1981Assignee: Fisons LimitedInventor: Dennis A. Smith
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Patent number: 4268518Abstract: There is described a method of treatment of mammalian cystitis, which method comprises administration of a compound of the formula I, ##STR1## wherein X is a polymethylene chain containing 3 to 7 carbon atoms inclusive, which chain may be substituted by an --OH group,or a pharmaceutically acceptable salt, ester or amide thereof, to a patient having cystitis.Type: GrantFiled: May 7, 1980Date of Patent: May 19, 1981Assignee: Fisons LimitedInventor: David M. Turner