Abstract: There are described compounds of formula I, ##STR1## in which R.sub.5 to R.sub.8 may be a variety of substituents, OR AN ADJACENT PAIR OF R.sub.5, R.sub.6, R.sub.7 and R.sub.8 form a chain --COCH.dbd.C(COOH)NRh--,Or one of R.sub.5, R.sub.6, R.sub.7 and R.sub.8 form a group of formula II, ##STR2## in which Ra, Rb and Rc have the same significances as R.sub.5, R.sub.6, R.sub.7 and R.sub.8,X is an optionally interrupted or substituted hydrocarbon chain,Rg and Rh, which may be the same or different are each alkyl, alkenyl, phenyl-alkyl, alkanoyl, benzoyl or phenylalkanoyl,Or Rg and R.sub.8 and/or Rh and Rc in formula II, together form a chain --(CH.sub.2).sub.n --, and n is 2, 3 or 4.There are also described processes for making the compounds and pharmaceutical, e.g. anti-allergic, compositions containing the compounds.
Type:
Grant
Filed:
November 26, 1975
Date of Patent:
May 29, 1979
Assignee:
Fisons Limited
Inventors:
Roger C. Brown, Hugh Cairns, Anthony R. Payne
Abstract: There is described a method of treatment of conditions of the gastro intestinal tract, in which conditions allergy or immune reactions play a contributory part, which method comprises per os administration of a compound of the formula I ##STR1## and therapeutically acceptable salts, esters and amides thereof, wherein X is a polymethylene chain containing 3 to 7 carbon atoms inclusive, which chain may be substituted by an --OH group, (as active ingredient), to a patient having such a condition.
Abstract: There are described compounds of formula I, ##STR1## in which Ra is hydrogen, alkyl, alkenyl or phenyl, R.sub.3, R.sub.5, R.sub.7 and R.sub.8, which may be the same or different, are each hydrogen, alkyl, alkoxy, halogen, hydroxy, alkenyl or phenyl,Rx is hydrogen or alkyl,Ry and Rz are both hydrogen, or together represent a carbonyl oxygen atom,Rb and Rc are both hydrogen or together represent a carbon-carbon bond,Provided that when Rx is hydrogen, Ry and Rz together represent a carbonyl oxygen atom and R.sub.5, R.sub.7 and R.sub.8 are all hydrogen then Ra is other than methyl or phenyl,And pharmaceutically acceptable derivatives thereof.There are also described methods for making the compounds and pharmaceutical, e.g. anti-inflammatory, compositions containing the compounds.
Abstract: There is described a pharmaceutical composition comprising one or more of 1,3-bis(2-carboxychromon-5-yloxy)propan-2-ol; 5-(2-hydroxy-propoxy)-8-propyl-chromone-2-carboxylic acid; 6,7,8,9-tetrahydro-4-oxo-10-propyl-4H-naphtho[2,3-b]pyran-2-carboxylic acid; 6,7,8,9-tetrahydro-5-hydroxy-4-oxo-10-propyl-4H-naphtho-[2,3-b]pyran-2-car boxylic acid; or a pharmaceutically acceptable salt of any one thereof, in combination with one or more of aspirin, indomethacin, phenylbutazone or oxyphenbutazone. (Mixtures of 1,3-bis(2-carboxychromon-5-yloxy)propan-2-ol, or a pharmaceutically acceptable salt thereof, with aspirin or indomethacin do not form part of the invention).There are also described packages containing the separate components of the composition and pharmaceutical formulations containing the composition.
Type:
Grant
Filed:
December 23, 1977
Date of Patent:
April 24, 1979
Assignee:
Fisons Limited
Inventors:
Thomas S. C. Orr, David E. Hall, John Mann
Abstract: The present invention relates to a method for operating a nutrient film plant growth technique so as to minimize the build up of one chemical in the circulating solution without a corresponding build-up of other chemicals, notably nutrient chemicals, therein. For example the feed of nutrient chemicals is in proportion to the feed of water to the solution, or the concentration of non-nutrients is maintained at a low level or discounted when assessing the amount of nutrient to add to the solution to maintain the desired nutrient level.
Abstract: Bis-amides of formula ##STR1## and salts thereof, where R.sup.2 and R.sup.3 are hydrogen; alkyl of up to 9 carbon atoms, alkenyl or alkynyl of up to 4 carbon atoms, or aryl, groups optionally substituted by certain radicals; or cycloalkyl of 3-7 carbon atoms; and R.sup.1 and R.sup.4 are as R.sup.2 and R.sup.3 or amino groups optionally substituted by certain radicals, are fungicides, especially against soil borne fungal diseases of plants.
Abstract: A pharmaceutical composition in the form of a lozenge, chewable tablet, chewing gum, pastille, gel, paint or paste comprises from 0.01 to 20% by weight of 1,3-bis(carboxychromon-5-yloxy)-2-hydroxypropane or a pharmaceutically acceptable salt thereof in association with a suitable pharmaceutically acceptable adjuvant, diluent or carrier. The composition is useful for the treatment of mouth ulcers in man.
Type:
Grant
Filed:
June 27, 1977
Date of Patent:
March 27, 1979
Assignee:
Fisons Limited
Inventors:
Kenneth Brown, David J. Robinson, James E. Taylor
Abstract: There is described a method of treatment of certain skin conditions, which method comprises per os administration of a compound of the formula I ##STR1## or a therapeutically acceptable salt, ester or amide thereof, wherein X is a polymethylene chain containing 3 to 7 carbon atoms inclusive, which chain may be substituted by an --OH group, (as active ingredient), to a patient having such a condition.
Abstract: There is provided a method of regulation of the growth of a crop of soya beans, in which (3-phenyl-1,2,4-thiadiazol-5-ylthio)acetic acid or a functional derivative thereof is applied to the locus at which the crop is growing.
Abstract: A compound of the general formula ##STR1## in which R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are the same or different and each represents hydrogen or alkyl of 1 to 4 carbon atoms;R.sup.6 represents a group of formula COR.sup.10 in which R.sup.10 represents styryl substituted by halogen;R.sup.7 represents hydrogen, alkyl of 1 to 4 carbon atoms or benzoyl substituted by halogen; andX.sup.- represents one equivalent of an anion are acaricides, especially for use on crops.
Abstract: The filtration rate and/or washability of crystals of gypsum produced during the wet process for the production of phosphoric acid are improved by adjusting the notional Al.sub.2 O.sub.3 :P.sub.2 O.sub.5 and reactive SiO.sub.2 :F ratios of the phosphate rock to within certain ranges. The adjustment may be achieved by addition of sources of aluminium and silica to the phosphoric acid process.
Type:
Grant
Filed:
August 15, 1977
Date of Patent:
January 23, 1979
Assignee:
Fisons Limited
Inventors:
Thomas N. Beaumont, Norman Robinson, Geoffrey N. Quinton
Abstract: Compounds of formula ##STR1## in which R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are the same or different and each represents hydrogen, halogen, nitro, alkyl, substituted alkyl, alkoxy, carboxy or an ester, amide or mono- or di-substituted amide thereof, aryl, heterocyclic, aralkyl, cyano or hydroxy, with the proviso that R.sup.3 does not represent a second group of formula I or II in which R.sup.3 is merely a bond;R.sup.6 represents a group of formula COR.sup.8, COOR.sup.8, CONR.sup.8 R.sup.9 or SO.sub.2 R.sup.8, in which R.sup.8 represents alkyl, substituted alkyl, aryl, substituted aryl, aralkyl, substituted aralkyl, aralkenyl, substituted aralkenyl, cycloalkyl or heterocyclic, and R.sup.9 represents hydrogen, alkyl, substituted alkyl, phenyl or substituted phenyl;R.sup.7 represents hydrogen, alkyl of 1 to 4 carbon atoms or a group as defined under R.sup.6 ; andX.sup.- represents one equivalent of an anion are acaricides, especially for use on crops.
Abstract: 2,3-Dihydro-benzofuranyl-5-esters, particularly esters of alkyl sulphonic acid, which possess physiological activity, being particularly useful as herbicides and plant growth regulants.
Type:
Grant
Filed:
July 11, 1977
Date of Patent:
October 17, 1978
Assignee:
Fisons Limited
Inventors:
Peter Stuart Gates, John Gillon, David Thomas Saggers
Abstract: There is described a method of treatment of certain psychiatric conditions which method comprises administration of a compound of the formula I, ##STR1## or a therapeutically acceptacle salt, ester or amide thereof, (as active ingredient), to a patient having such a condition.
Type:
Grant
Filed:
September 8, 1977
Date of Patent:
October 17, 1978
Assignee:
Fisons Limited
Inventors:
Thomas Samuel Campbell Orr, Patrick John Kingsley
Abstract: There are provided substituted benzimidazoles of the formula: ##STR1## (wherein at least two of the radicals X are halogen and the remainder are hydrogen, and R represents an alkyl radical of 1 to 6 carbon atoms), processes for preparing them, and compositions containing them.The compounds possess anti-protozoal activity.
Abstract: A chromatographic method of separating a fluid mixture of dextrans of differing molecular weights into two fractions. The chromatographic method is carried out with an apparatus having a plurality compartments according to a scheme involving sequential valve operation and provision of carrier fluid.
Type:
Grant
Filed:
June 2, 1977
Date of Patent:
August 1, 1978
Assignee:
Fisons Limited
Inventors:
Philip Edwin Barker, Brian William Hatt, Frederick John Ellison
Abstract: Azines are prepared by reacting aqueous ammonia and a carbonyl compound with chloramine in a series of two or more reactors arranged in a cascade system.
Type:
Grant
Filed:
February 16, 1971
Date of Patent:
July 18, 1978
Assignee:
Fisons Limited
Inventors:
Brian John Needham, Michael Arthur Smith
Abstract: The invention relates to a modified bayonet type mounting for use in a centrifuge. The mounting is characterized by having the trailing wall of the socket inclined at an obtuse angle, whereby relative rotation of the drive shaft and rotor during start-up causes the pin of the bayonet mounting to move deeper into the socket.
Type:
Grant
Filed:
January 24, 1977
Date of Patent:
July 18, 1978
Assignee:
Fisons Limited
Inventors:
Gordon Harold Hoare, Brian Walter Lovegrove
Abstract: There is provided a method of increasing the branching, boll set or yield of cotton plants in which (3-phenyl-1,2,4-thiadiazol-5-ylthio)acetic acid or a salt, ester or amide thereof is applied in an effective amount to the locus at which the plants are growing.
Abstract: Compounds of the formula: ##STR1## wherein R.sub.1 and R.sub.2 are the same or different and each is selected from the group consisting of hydrogen, an alkyl group and together, an alkylene chain; M is alkyl of 1 to 6 carbon atoms; and R.sub.6 is selected from the group consisting of hydrogen and R.sub.5 SO.sub.2 -- wherein R.sub.5 is alkyl of 1 to 6 carbon atoms, are prepared by a procedure in which the key step is reacting benzoquinone with an enamine R.sub.1 R.sub.2 C.dbd.CHNR.sub.d 3 R.sub.4 in the presence of a compound of the formula R.sub.1 R.sub.2 CHCHO. The product contains a lower proportion of hydroquinone impurity and is useful as a herbicide.