Patents Assigned to Fisons Limited
  • Patent number: 4156726
    Abstract: There are described compounds of formula I, ##STR1## in which R.sub.5 to R.sub.8 may be a variety of substituents, OR AN ADJACENT PAIR OF R.sub.5, R.sub.6, R.sub.7 and R.sub.8 form a chain --COCH.dbd.C(COOH)NRh--,Or one of R.sub.5, R.sub.6, R.sub.7 and R.sub.8 form a group of formula II, ##STR2## in which Ra, Rb and Rc have the same significances as R.sub.5, R.sub.6, R.sub.7 and R.sub.8,X is an optionally interrupted or substituted hydrocarbon chain,Rg and Rh, which may be the same or different are each alkyl, alkenyl, phenyl-alkyl, alkanoyl, benzoyl or phenylalkanoyl,Or Rg and R.sub.8 and/or Rh and Rc in formula II, together form a chain --(CH.sub.2).sub.n --, and n is 2, 3 or 4.There are also described processes for making the compounds and pharmaceutical, e.g. anti-allergic, compositions containing the compounds.
    Type: Grant
    Filed: November 26, 1975
    Date of Patent: May 29, 1979
    Assignee: Fisons Limited
    Inventors: Roger C. Brown, Hugh Cairns, Anthony R. Payne
  • Patent number: 4152448
    Abstract: There is described a method of treatment of conditions of the gastro intestinal tract, in which conditions allergy or immune reactions play a contributory part, which method comprises per os administration of a compound of the formula I ##STR1## and therapeutically acceptable salts, esters and amides thereof, wherein X is a polymethylene chain containing 3 to 7 carbon atoms inclusive, which chain may be substituted by an --OH group, (as active ingredient), to a patient having such a condition.
    Type: Grant
    Filed: December 29, 1976
    Date of Patent: May 1, 1979
    Assignee: Fisons Limited
    Inventor: George Wardell
  • Patent number: 4151179
    Abstract: There are described compounds of formula I, ##STR1## in which Ra is hydrogen, alkyl, alkenyl or phenyl, R.sub.3, R.sub.5, R.sub.7 and R.sub.8, which may be the same or different, are each hydrogen, alkyl, alkoxy, halogen, hydroxy, alkenyl or phenyl,Rx is hydrogen or alkyl,Ry and Rz are both hydrogen, or together represent a carbonyl oxygen atom,Rb and Rc are both hydrogen or together represent a carbon-carbon bond,Provided that when Rx is hydrogen, Ry and Rz together represent a carbonyl oxygen atom and R.sub.5, R.sub.7 and R.sub.8 are all hydrogen then Ra is other than methyl or phenyl,And pharmaceutically acceptable derivatives thereof.There are also described methods for making the compounds and pharmaceutical, e.g. anti-inflammatory, compositions containing the compounds.
    Type: Grant
    Filed: August 9, 1976
    Date of Patent: April 24, 1979
    Assignee: Fisons Limited
    Inventors: Richard A. Appleton, Kevan Brown
  • Patent number: 4151292
    Abstract: There is described a pharmaceutical composition comprising one or more of 1,3-bis(2-carboxychromon-5-yloxy)propan-2-ol; 5-(2-hydroxy-propoxy)-8-propyl-chromone-2-carboxylic acid; 6,7,8,9-tetrahydro-4-oxo-10-propyl-4H-naphtho[2,3-b]pyran-2-carboxylic acid; 6,7,8,9-tetrahydro-5-hydroxy-4-oxo-10-propyl-4H-naphtho-[2,3-b]pyran-2-car boxylic acid; or a pharmaceutically acceptable salt of any one thereof, in combination with one or more of aspirin, indomethacin, phenylbutazone or oxyphenbutazone. (Mixtures of 1,3-bis(2-carboxychromon-5-yloxy)propan-2-ol, or a pharmaceutically acceptable salt thereof, with aspirin or indomethacin do not form part of the invention).There are also described packages containing the separate components of the composition and pharmaceutical formulations containing the composition.
    Type: Grant
    Filed: December 23, 1977
    Date of Patent: April 24, 1979
    Assignee: Fisons Limited
    Inventors: Thomas S. C. Orr, David E. Hall, John Mann
  • Patent number: 4149970
    Abstract: The present invention relates to a method for operating a nutrient film plant growth technique so as to minimize the build up of one chemical in the circulating solution without a corresponding build-up of other chemicals, notably nutrient chemicals, therein. For example the feed of nutrient chemicals is in proportion to the feed of water to the solution, or the concentration of non-nutrients is maintained at a low level or discounted when assessing the amount of nutrient to add to the solution to maintain the desired nutrient level.
    Type: Grant
    Filed: January 11, 1978
    Date of Patent: April 17, 1979
    Assignee: Fisons Limited
    Inventors: Peter S. Atkins, Francis N. Wilson
  • Patent number: 4146646
    Abstract: Bis-amides of formula ##STR1## and salts thereof, where R.sup.2 and R.sup.3 are hydrogen; alkyl of up to 9 carbon atoms, alkenyl or alkynyl of up to 4 carbon atoms, or aryl, groups optionally substituted by certain radicals; or cycloalkyl of 3-7 carbon atoms; and R.sup.1 and R.sup.4 are as R.sup.2 and R.sup.3 or amino groups optionally substituted by certain radicals, are fungicides, especially against soil borne fungal diseases of plants.
    Type: Grant
    Filed: January 27, 1977
    Date of Patent: March 27, 1979
    Assignee: Fisons Limited
    Inventors: Albert Percival, Peter J. Burton
  • Patent number: 4146634
    Abstract: A pharmaceutical composition in the form of a lozenge, chewable tablet, chewing gum, pastille, gel, paint or paste comprises from 0.01 to 20% by weight of 1,3-bis(carboxychromon-5-yloxy)-2-hydroxypropane or a pharmaceutically acceptable salt thereof in association with a suitable pharmaceutically acceptable adjuvant, diluent or carrier. The composition is useful for the treatment of mouth ulcers in man.
    Type: Grant
    Filed: June 27, 1977
    Date of Patent: March 27, 1979
    Assignee: Fisons Limited
    Inventors: Kenneth Brown, David J. Robinson, James E. Taylor
  • Patent number: 4145438
    Abstract: There is described a method of treatment of certain skin conditions, which method comprises per os administration of a compound of the formula I ##STR1## or a therapeutically acceptable salt, ester or amide thereof, wherein X is a polymethylene chain containing 3 to 7 carbon atoms inclusive, which chain may be substituted by an --OH group, (as active ingredient), to a patient having such a condition.
    Type: Grant
    Filed: October 20, 1977
    Date of Patent: March 20, 1979
    Assignee: Fisons Limited
    Inventors: Patrick J. Kingsley, Thomas S. C. Orr
  • Patent number: 4141716
    Abstract: There is provided a method of regulation of the growth of a crop of soya beans, in which (3-phenyl-1,2,4-thiadiazol-5-ylthio)acetic acid or a functional derivative thereof is applied to the locus at which the crop is growing.
    Type: Grant
    Filed: April 22, 1977
    Date of Patent: February 27, 1979
    Assignee: Fisons Limited
    Inventor: Christopher H. Cronin
  • Patent number: 4138548
    Abstract: A compound of the general formula ##STR1## in which R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are the same or different and each represents hydrogen or alkyl of 1 to 4 carbon atoms;R.sup.6 represents a group of formula COR.sup.10 in which R.sup.10 represents styryl substituted by halogen;R.sup.7 represents hydrogen, alkyl of 1 to 4 carbon atoms or benzoyl substituted by halogen; andX.sup.- represents one equivalent of an anion are acaricides, especially for use on crops.
    Type: Grant
    Filed: June 16, 1977
    Date of Patent: February 6, 1979
    Assignee: Fisons Limited
    Inventor: John H. Parsons
  • Patent number: 4136151
    Abstract: The filtration rate and/or washability of crystals of gypsum produced during the wet process for the production of phosphoric acid are improved by adjusting the notional Al.sub.2 O.sub.3 :P.sub.2 O.sub.5 and reactive SiO.sub.2 :F ratios of the phosphate rock to within certain ranges. The adjustment may be achieved by addition of sources of aluminium and silica to the phosphoric acid process.
    Type: Grant
    Filed: August 15, 1977
    Date of Patent: January 23, 1979
    Assignee: Fisons Limited
    Inventors: Thomas N. Beaumont, Norman Robinson, Geoffrey N. Quinton
  • Patent number: 4125617
    Abstract: Compounds of formula ##STR1## in which R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are the same or different and each represents hydrogen, halogen, nitro, alkyl, substituted alkyl, alkoxy, carboxy or an ester, amide or mono- or di-substituted amide thereof, aryl, heterocyclic, aralkyl, cyano or hydroxy, with the proviso that R.sup.3 does not represent a second group of formula I or II in which R.sup.3 is merely a bond;R.sup.6 represents a group of formula COR.sup.8, COOR.sup.8, CONR.sup.8 R.sup.9 or SO.sub.2 R.sup.8, in which R.sup.8 represents alkyl, substituted alkyl, aryl, substituted aryl, aralkyl, substituted aralkyl, aralkenyl, substituted aralkenyl, cycloalkyl or heterocyclic, and R.sup.9 represents hydrogen, alkyl, substituted alkyl, phenyl or substituted phenyl;R.sup.7 represents hydrogen, alkyl of 1 to 4 carbon atoms or a group as defined under R.sup.6 ; andX.sup.- represents one equivalent of an anion are acaricides, especially for use on crops.
    Type: Grant
    Filed: March 23, 1977
    Date of Patent: November 14, 1978
    Assignee: Fisons Limited
    Inventor: John H. Parsons
  • Patent number: 4120871
    Abstract: 2,3-Dihydro-benzofuranyl-5-esters, particularly esters of alkyl sulphonic acid, which possess physiological activity, being particularly useful as herbicides and plant growth regulants.
    Type: Grant
    Filed: July 11, 1977
    Date of Patent: October 17, 1978
    Assignee: Fisons Limited
    Inventors: Peter Stuart Gates, John Gillon, David Thomas Saggers
  • Patent number: 4120975
    Abstract: There is described a method of treatment of certain psychiatric conditions which method comprises administration of a compound of the formula I, ##STR1## or a therapeutically acceptacle salt, ester or amide thereof, (as active ingredient), to a patient having such a condition.
    Type: Grant
    Filed: September 8, 1977
    Date of Patent: October 17, 1978
    Assignee: Fisons Limited
    Inventors: Thomas Samuel Campbell Orr, Patrick John Kingsley
  • Patent number: 4109004
    Abstract: There are provided substituted benzimidazoles of the formula: ##STR1## (wherein at least two of the radicals X are halogen and the remainder are hydrogen, and R represents an alkyl radical of 1 to 6 carbon atoms), processes for preparing them, and compositions containing them.The compounds possess anti-protozoal activity.
    Type: Grant
    Filed: August 22, 1977
    Date of Patent: August 22, 1978
    Assignee: Fisons Limited
    Inventor: Albert Percival
  • Patent number: 4104078
    Abstract: A chromatographic method of separating a fluid mixture of dextrans of differing molecular weights into two fractions. The chromatographic method is carried out with an apparatus having a plurality compartments according to a scheme involving sequential valve operation and provision of carrier fluid.
    Type: Grant
    Filed: June 2, 1977
    Date of Patent: August 1, 1978
    Assignee: Fisons Limited
    Inventors: Philip Edwin Barker, Brian William Hatt, Frederick John Ellison
  • Patent number: 4101581
    Abstract: Azines are prepared by reacting aqueous ammonia and a carbonyl compound with chloramine in a series of two or more reactors arranged in a cascade system.
    Type: Grant
    Filed: February 16, 1971
    Date of Patent: July 18, 1978
    Assignee: Fisons Limited
    Inventors: Brian John Needham, Michael Arthur Smith
  • Patent number: 4101070
    Abstract: The invention relates to a modified bayonet type mounting for use in a centrifuge. The mounting is characterized by having the trailing wall of the socket inclined at an obtuse angle, whereby relative rotation of the drive shaft and rotor during start-up causes the pin of the bayonet mounting to move deeper into the socket.
    Type: Grant
    Filed: January 24, 1977
    Date of Patent: July 18, 1978
    Assignee: Fisons Limited
    Inventors: Gordon Harold Hoare, Brian Walter Lovegrove
  • Patent number: 4092149
    Abstract: There is provided a method of increasing the branching, boll set or yield of cotton plants in which (3-phenyl-1,2,4-thiadiazol-5-ylthio)acetic acid or a salt, ester or amide thereof is applied in an effective amount to the locus at which the plants are growing.
    Type: Grant
    Filed: May 10, 1977
    Date of Patent: May 30, 1978
    Assignee: Fisons Limited
    Inventor: Samuel David Van Hoogstraten
  • Patent number: 4091033
    Abstract: Compounds of the formula: ##STR1## wherein R.sub.1 and R.sub.2 are the same or different and each is selected from the group consisting of hydrogen, an alkyl group and together, an alkylene chain; M is alkyl of 1 to 6 carbon atoms; and R.sub.6 is selected from the group consisting of hydrogen and R.sub.5 SO.sub.2 -- wherein R.sub.5 is alkyl of 1 to 6 carbon atoms, are prepared by a procedure in which the key step is reacting benzoquinone with an enamine R.sub.1 R.sub.2 C.dbd.CHNR.sub.d 3 R.sub.4 in the presence of a compound of the formula R.sub.1 R.sub.2 CHCHO. The product contains a lower proportion of hydroquinone impurity and is useful as a herbicide.
    Type: Grant
    Filed: July 5, 1977
    Date of Patent: May 23, 1978
    Assignee: Fisons Limited
    Inventor: John Frederick Harris