Abstract: There is described a method of treatment of secretory otitis media, which method comprises administration of a compound of the formula I: ##STR1## wherein X is a polymethylene chain containing 3 to 7 carbon atoms inclusive, which chain may be substituted by an--OH group,or a pharmaceutically acceptable salt, ester or amide thereof, to a patient having secretory otitis media.

Abstract: A pyrogallol compound of formula ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 each represent hydrogen or alkyl of 1-6 carbon atoms, or a salt thereof, is prepared by hydrolyzing the corresponding 2,2,6,6-tetrachlorocyclohexanone or 2,2,6,6-tetrabromocyclohexanone.

Abstract: The invention provides herbicidally-active 2,3-dihydro-5-cyanobenzofurans of the formula: ##STR1## (wherein: R.sup.1 and R.sup.2 together represent .dbd.O or R.sup.1 represents hydrogen and R.sup.2 represents hydrogen, hydroxy, alkoxy, acyloxy, alkoxycarbonyloxy, alkylthiocarbonyloxy, halogen, isothiocyanato, amino, alkylamino, dialkylamino, arylamino, acylamino, alkoxycarbonylamino, alkylthiocarbonylamino, N-bonded heterocyclyl, cyano or alkylthio; R.sup.3 and R.sup.4 together represent alkylene or each represent hydrogen or alkyl; and R.sup.5, R.sup.6 and R.sup.7, which may be the same or different, each represent hydrogen, halogen, alkyl, alkoxy, acyl or cyano), processes for their preparation and herbicidal compositions containing them.

Abstract: An inhalation device for powdered medicaments in which the opening of the container in which the medicament is initially contained is achieved simply and reliably in situ in the device, the device being provided with means (24) for locating the container in a position to be opened and with appropriate opening means (20, 21) for the container, said opening means being normally in a non-opening position but movable successively into and out of a container opening position by movement in one direction of a cam surface (7, 8, 30, 31) acting thereon, the cam surface being provided with a step or steps (9, 10) to prevent reverse movement of the cam surface after opening of the container has been achieved. The cam surface (7, 8) is preferably provided on one housing member (1) and the opening means (20, 21) on a second housing member (2) so that attachment of the housing members (1, 2) simultaneously opens the container.

Abstract: The intermediate 2,2,6,6-tetrachloro (or tetrabromo) cyclohexanone is prepared by reacting chlorine (or bromine) with a cyclohexanol compound of the formula ##STR1## where each Y represents an atom of hydrogen or chlorine (or hydrogen or bromine) in the presence of, as catalyst, a certain organophosphorus compound.

Abstract: There is described a salt of 2,8-dicarboxy-4,6-dioxo-10-propyl-4H,6H-benzo(1,2-b:5,4-b')dipyran with a pharmaceutically acceptable inorganic cation, the salt having a solubility of less than 3% w/w in water a 20.5.degree. C.There are also described processes for making the salts and pharmaceutical, e.g. anti-allergic, compositions containing them.

Abstract: There is described a method for the treatment of psychiatric conditions which method comprises inhalation administration of 1,3-bis(2-carboxychromon-5-yloxy)-2-hydroxy propane, or a pharmaceutically acceptable salt thereof (as active ingredient), to a patient suffering, or liable to suffer, from such a condition.

Abstract: There are described compounds of formula I, ##STR1## in which R.sub.3 represents hydrogen, or alkyl C 1 to 6,R.sub.S represents hydrogen, hydroxy, alkoxy C 1 to 6, alkanoyloxy C 2 to 6, alkenyloxy C 2 to 6, nitro, --NR.sub.1 R.sub.2, halogen, alkyl C 1 to 6, hydroxy-alkyl C 1 to 6, or hydroxy-alkoxy C 1 to 6,an adjacent pair of X, Y and Z form a --(CH.sub.2).sub.4 --, --CH.dbd.CH--CH.dbd.CH-- or --O(CH.sub.2).sub.3 -- chain, each of the chains optionally being substituted by one or two C 1 to 6 alkyl groups, and the remaining substituent X or Z represents alkenyl C 2 to 6 optionally substituted by phenyl; halogen; or alkyl C 1 to 9 optionally substituted by one or more of the groups hydroxy, halogen, carbonyl oxygen, phenyl, or alkoxy C 1 to 6,or, when an adjacent pair of X, Y and Z form a chain substituted by one or two C 1 to 6 alkyl groups, the remaining substituent X or Z may be hydrogen, andR.sub.1 and R.sub.

Abstract: The substituted tetrazines of the formula: ##STR1## and of the formula: ##STR2## wherein: R.sup.1, R.sup.2 and R.sup.4 each represent hydrogen, phenyl, alkyl of 1 to 6 carbon atoms, or alkenyl or alkynyl of 3 to 6 carbon atoms, each of which may be unsubstituted or substituted by one or more halogen atoms, hydroxy groups, cyano groups, carboxy groups, alkoxycarbonyl groups of 2 to 5 carbon atoms, or alkoxy groups of 1 to 4 carbon atoms; or R.sup.1 and R.sup.2 together represent a single bond; R.sup.3 represents alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 7 carbon atoms, phenyl or phenylalkyl of 7 to 10 carbon atoms, each of which may be unsubstituted or substituted by one or more halogen atoms, alkyl or alkoxy groups of 1 to 6 carbon atoms, nitro groups, cyano groups, mercapto groups, or alkylmercapto groups of 1 to 4 carbon atoms; and R.sup.6 represents a phenyl group substituted in at least the 2-position by fluorine, chlorine, bromine or iodine; are effective to combat acarids and their eggs.

Abstract: There is described a pharmaceutical composition comprising one or more of 1,3-bis(2-carboxychromon-5-yloxy)propan-2-ol; 5-(2-hydroxy-propoxy)-8-propyl-chromone-2-carboxylic acid; 6,7,8,9-tetrahydro-4-oxo-10-propyl-4H-naphtho[2,3-b]pyran-2-carboxylic acid; 6,7,8,9-tetrahydro-5-hydroxy-4-oxo-10-propyl-4H-naphtho[2,3-b]pyran-2-carb oxylic acid; or a pharmaceutically acceptable salt of any one thereof, in combination with one or more of aspirin, indomethacin, phenylbutazone or oxyphenbutazone. (Mixtures of 1,3-bis(2-carboxychromon-5-yloxy)propan-2-ol, or a pharmaceutically acceptable salt thereof, with aspirin or indomethacin do not form part of the invention).There are also described packages containing the separate components of the composition and pharmaceutical formulations containing the composition.

Abstract: There are described compounds of formula I, ##STR1## in which an adjacent pair of R.sub.5, R.sub.6, R.sub.7 and R.sub.8 form a chain --COCH.dbd.CE--O--, and the remainder of R.sub.5, R.sub.6, R.sub.7 and R.sub.8, which may be the same or different, each represent hydrogen, hydroxy, alkyl, halogen, alkenyl, alkoxy, or --NR.sub.1 R.sub.2 in which R.sub.1 and R.sub.2, which are the same or different, are each hydrogen or alkyl, andE is --COOH, a 5-tetrazolyl group or an (N-tetrazol-5-yl) carboxamido group,and pharmaceutically acceptable derivatives thereof.There are also described processes for making the compounds and pharmaceutical, e.g. anti-allergic, compositions containing them.

Abstract: Valid signals from a cell in a centrifuge rotor are distinguished from extraneous signals by passing the signals through circuits which compare the amplitude and duration of the signal with the minimum expected values for those signals. Signals having the desired amplitude and duration are passed to the appropriate recorder which can be selected by a switching mechanism actuated by a circuit triggered at the release of the signal from the duration comparison circuit. The duration comparison circuit counts signals emitted from the rotor as it rotates and hence will operate over a wide range of speeds of rotation.

Abstract: There is described a pharmaceutical composition suitable for application to the skin and comprising, as active ingredient, a compound of formula I, ##STR1## in which R.sub.1 represents hydrogen, hydroxy or --NR.sub.5 R.sub.6, in which R.sub.5 and R.sub.6, which may be the same or different each represents hydrogen or alkyl C 1 to 6,an adjacent pair of R.sub.2, R.sub.3 and R.sub.4 form a --(CH.sub.2).sub.4 --chain and the remaining substituent R.sub.2 or R.sub.4 represents alkyl C 1 to 9,E represents a 5-(1H)tetrazolyl- or a --COOH group, andX represents oxygen or a group --NR.sub.7 -- in which R.sub.7 may be hydrogen or alkyl C 1 to 6,or a pharmaceutically acceptable derivative thereof, together with a mixture of a solvent for the active ingredient and a non-solvent for the active ingredient, the solvent and the non-solvent being miscible in the relevant proportions and the proportion of the non-solvent being such that the active ingredient forms a solution in the mixture.

Abstract: The invention provides herbicidally-active sulphonates of the formula ##STR1## wherein X represents a group --CHR.sup.3 --OR.sup.4 and Y represents a group --OR.sup.5, or X and Y together represent a group --CHR.sup.3 --O-- or a group --CHR.sup.3 --O--Z--O--, the free oxygen atom of which is attached to the benzene ring; R.sup.1, R.sup.2 and R.sup.3, which may be the same or different, each represent hydrogen or C 1 to 6 alkyl, or R.sup.1 and R.sup.2 together or R.sup.2 and R.sup.3 together form a C 3 to 6 alkylene chain; R.sup.4 and R.sup.5, which may be the same or different, each represent hydrogen, C 1 to 6 alkyl, C 2 to 6 alkenyl, C 2 to 6 alkynyl, phenyl, a group --C(.dbd.O)R.sup.10 or a group --SO.sub.2 R.sup.11 ; R.sup.6, R.sup.7 and R.sup.8, which may be the same or different, each represent hydrogen, C 1 to 6 alkyl, halogen, cyano, C 2 to 6 carboxylic acyl, or C 1 to 4 alkoxy; R.sup.

Abstract: The pesticide 2,2-dimethyl-1,3-benzodioxol-4-yl N-methylcarbamate has been found to be capable of existence in several crystalline forms, which can be identified by their infra red spectra. The form commercially available has been form B but the new form A is superior.

Abstract: The anti-scaling effect of additives added to control the formation of scale during the washing of calcium sulphate anhydrite or hemihydrate crystals is increased when the additives are added as soon as possible after the wash liquors leave the crystals. The invention is of especial use in the washing of calcium sulphate hemihydrate produced during the production of phosphoric acid and is carried out by adding the additives via the central valve of the rotating pan filter on which the hemihydrate crystals are washed.

Abstract: 2,2,6,6-Tetrachloro(or tetrabromo)cyclohexanone is prepared by reacting in the liquid phase chlorine or bromine with a cyclohexanone compound of formula ##STR1## where Y is hydrogen or chlorine (to produce the tetrachloro compound) or hydrogen or bromine (to produce the tetrabromo compound) in the presence as catalyst of an organophosphorus compound of formula ##STR2## where Z is chlorine or bromine; n is 0 or 1; and when n is 0, m is 0 or 2, R.sup.1 is alkyl or phenyl, and R.sup.2 and R.sup.3 are hydrogen, alkyl or phenyl; and when n is 1, m is 0, and R.sup.1, R.sup.2 and R.sup.3 are the same and each is ##STR3## alkyl or phenyl, or R.sup.1 is hydrogen and R.sup.2 and R.sup.3 are alkyl or phenyl;or a salt thereof.Each alkyl is of 1-10 carbon atoms.

Abstract: Method and apparatus for treating water with a regeneratable material (e.g. an ion exchange resin) in which the regenerating reagents are fed to the material by pneumatic means. Preferably, the reagent is diluted in a small multi-fill dilution tank feeding the container(s) for the water treatment material.

Abstract: The present invention relates to salts with basic amino sugars or basic amino acids of certain 2-carboxy or 2-tetrazolo-chromones.

Abstract: There are described compounds of formula I, ##STR1## in which E is a --COOH, a 5-tetrazolyl or an (N-tetrazol-5-yl) carboxamido group,R.sub.3 is hydrogen or alkyl,an adjacent pair of W, X, Y and Z form a 5 membered chain comprising alkylene groups and optionally one or two oxygen atoms, the chain optionally being substituted by one or two alkyl groups,the remaining substituents W, X, Y or Z are hydrogen; halogen; alkyl optionally substituted by one or more of the groups hydroxy, halogen, carbonyl oxygen, phenyl, or alkoxy; alkenyl optionally substituted by phenyl; hydroxy; alkoxy; alkanoyloxy; alkenyloxy; nitro; --NR.sub.1 R.sub.2 or hydroxyalkoxy,R.sub.1 and R.sub.2, which may be the same or different, are each hydrogen or alkyl,and pharmaceutically acceptable derivatives thereof.There are also described processes for making the compounds and pharmaceutical, e.g. anti-allergic, compositions containing the compounds.