Patents Assigned to Fisons Limited
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Patent number: 4211777Abstract: There is described a pharmaceutical composition comprising a compound having sodium cromoglycate like activity, as active ingredient, in combination with an aminosalicyclic acid or a pharmaceutically acceptable derivative thereof.There are also described packages containing the separate components of the composition and pharmaceutical formulations containing the composition.Type: GrantFiled: May 17, 1978Date of Patent: July 8, 1980Assignee: Fisons LimitedInventor: Albert Chambers
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Patent number: 4199578Abstract: There is described a pharmaceutical composition comprising a mixture of particulate beclomethasone dipropionate, at least 90% by weight of the particles of becolmethasone dipropionate having an effective particle size below 10 micrometers, and a powder carrier, preferably in the absence of free liquid.The compositions are indicated for use in the treatment of asthma or hay fever.Type: GrantFiled: November 27, 1978Date of Patent: April 22, 1980Assignee: Fisons LimitedInventor: Neil A. Stevenson
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Patent number: 4198397Abstract: Pesticidal bendiocarb granules comprise either (a) base granules to which the bendiocarb adheres by means of a sticker comprising a hydrocarbon of viscosity at least 20 centipoises, the bendiocarb granules bearing a surface coating of a flowability agent, or (b) absorbent base granules impregnated with the bendiocarb.Type: GrantFiled: February 14, 1978Date of Patent: April 15, 1980Assignee: Fisons LimitedInventors: Christopher Gillings, John H. Palmer
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Patent number: 4192860Abstract: There is described a method for the prophylactic or curative treatment of a disease condition having an allergic basis in cats, dogs or horses or a condition of the respiratory tract having an allergic basis in cattle which comprises administering an active ingredient having sodium cromoglycate like activity to an animal suffering, or liable to suffer, from such a condition.There are also described compositions and mixtures for use in the treatment of the animals.Type: GrantFiled: April 27, 1978Date of Patent: March 11, 1980Assignee: Fisons LimitedInventor: Alan J. Griffiths
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Patent number: 4192886Abstract: There is described a method for the prophylactic or curative treatment of a disease condition of the gastrointestinal tract, which condition has an allergic basis, in cattle or pigs, which comprises administering an active ingredient having sodium cromoglycate like activity to an animal suffering, or liable to suffer, from such a condition.There are also described compositions and mixtures for use in the treatment of the animals.Type: GrantFiled: May 19, 1978Date of Patent: March 11, 1980Assignee: Fisons LimitedInventors: Richard G. Towlerton, Michel Lapras
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Patent number: 4189571Abstract: There are described compounds of formula I, ##STR1## in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are the same or different and each represent hydrogen, halogen, hydroxy, alkyl C 1 to 6, alkoxy C 1 to 6, hydroxy-alkoxy C 1 to 6, or alkoxy C 1 to 6-alkoxy C 1 to 6,X is a straight or branched C 2 to 10 hydrocarbon chain which may be substituted by an --OH group,Q is a group --CHR--ZR is hydrogen, alkyl C 1 to 8, phenyl, or alkoxy (C 1 to 8)-carbonyl,Z is a group --O--CO--Ra, --CO--ORa or --CONRbRc,Ra is cyclohexyl or cyclopentyl; straight or branched alkyl C 1 to 12, which is optionally substituted by cyclohexyl or cyclopentyl; alkenyl C 2 to 6, which is optionally substituted by phenyl; or, when Z is --CO--ORa, hydrogen, andRb and Rc, which are the same or different, are each alkyl C 1 to 12.There are also described processes for making the compounds, and pharmaceutical, e.g. anti-allergic, compositions containing the compounds.Type: GrantFiled: February 7, 1978Date of Patent: February 19, 1980Assignee: Fisons LimitedInventors: Nicholas S. Bodor, Jack A. Zupan
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Patent number: 4188202Abstract: The invention provides herbicidal aqueous suspensions comprising from 0.05 to 700 g/l of a substituted benzofuran herbicide of the formula: ##STR1## (where R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.10, R.sup.11 and R.sup.12 are as defined in the specification), at least 85% by weight of the particles of said compound having a diameter less than 5 microns, from 0.5 to 50 g/l of a suspending agent (preferably a polycarboxylated vinyl polymer), and from 0.5 to 30%, based on the total content of compounds of formula I present, of a block copolymer of ethylene oxide and propylene oxide having a reversible thickening temperature as defined in the specification of 45.degree. C. or above.Type: GrantFiled: May 19, 1978Date of Patent: February 12, 1980Assignee: Fisons LimitedInventors: Christopher Gillings, Ian C. Jewry, Harold G. Haynes
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Patent number: 4183741Abstract: There are provided the compounds of the formula: ##STR1## (wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4, which may be the same or different, each represent hydrogen, a substituted or unsubstituted alkyl, aryl or aralkyl group, a nitro group, a cyano group or a halogen atom, R.sup.5 represents a quaternized nitrogen-containing heterocyclyl radical linked via a ring carbon atom, X represents one equivalent of an anion, R.sup.7 represents a substituted or unsubstituted alkyl group or a substituted or unsubstituted, saturated or unsaturated heterocyclyl group which, if nitrogen-containing, is quaternized, linked via a ring carbon atom, and R.sup.6 either represents an alkyl group or, when R.sup.7 represents a quaternized nitrogen-containing heterocyclyl group, and the quaternized nitrogen atom is ortho to the linked ring carbon atom, may represent a methylene, dimethylene, trimethylene or alkyl-substituted ethenylene chain to that nitrogen atom.The compounds are selective herbicides.Type: GrantFiled: May 20, 1977Date of Patent: January 15, 1980Assignee: Fisons LimitedInventors: Peter J. West, John H. Parsons
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Patent number: 4183822Abstract: The present invention relates to a process for expanding thermoplastic polymer compositions, notably those containing polymers having processing temperatures in excess of 200.degree. C. and/or containing an ingredient which is susceptible to ammonia, characterized in that as the blowing agent certain carbonates (notably zinc carbonate) are used. Preferably a nucleating agent and a weak acid are present to aid cell formation.The invention also includes expandable polymer compositions and blowing agent formulations containing the carbonates.Type: GrantFiled: January 18, 1978Date of Patent: January 15, 1980Assignee: Fisons LimitedInventors: Kenneth T. Collington, Rishi R. Puri, Peter J. Gibson
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Patent number: 4182916Abstract: There is described a process for the production of 6-hydroxy-1,2,3,4-tetrahydronaphthalene of formula I, ##STR1## which comprises treatment of beta naphthol with an absorbant, removal of the absorbant and selective hydrogenation of the resulting beta naphthol, preferably in a solvent which is inert under the reaction conditions. There is also described a process for the production of a compound of formula I using a rhodium catalyst.Type: GrantFiled: December 27, 1977Date of Patent: January 8, 1980Assignee: Fisons LimitedInventors: Lewis J. Baskeyfield, John D. Bell, John Townend, Simon D. A. Pollock
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Patent number: 4178716Abstract: The present invention relates to a method for operating a nutrient film plant growth technique so as to minimise the build up of one chemical in the circulating solution without a corresponding build-up of other chemicals, notably nutrient chemicals, therein. For example the feed of nutrient chemicals is in proportion to the feed of water to the solution, or the concentration of non-nutrients is maintained at a low level or discounted when assessing the amount of nutrient to add to the solution to maintain the desired nutrient level.Type: GrantFiled: January 11, 1978Date of Patent: December 18, 1979Assignee: Fisons LimitedInventors: Douglas C. Harper, Derek C. Attenburrow
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Patent number: 4172960Abstract: Pyrogallol is prepared by (A) reacting a halo compound of formula ##STR1## where X represents Br or I, R.sup.1 represents hydrogen, secondary or tertiary alkyl of up to 10 carbon atoms, carboxy or alkoxycarbonyl of 2-5 carbon atoms and R.sup.2 represents hydrogen or alkyl of 1-4 carbon atoms, with an alkali metal alkoxide of formula ROM where M represents an alkali metal and R represents alkyl of 1-4 carbon atoms, to replace each X by OR, and then (B) dealkylating each OR and each OR.sup.2 where R.sup.2 represents alkyl of 1-4 carbon atoms and removing the R.sup.1 group where this is not hydrogen.Type: GrantFiled: December 20, 1977Date of Patent: October 30, 1979Assignee: Fisons LimitedInventors: Derek Baldwin, Peter S. Gates
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Patent number: 4171372Abstract: The pesticide 2,2-dimethyl-1,3-benzodioxol-4-yl N-methylcarbamate has been found to be capable of existence in several crystalline forms, which can be identified by their infra red spectra. The form commercially available has been form B but the new form A is superior.Type: GrantFiled: May 6, 1977Date of Patent: October 16, 1979Assignee: Fisons LimitedInventors: Harold G. Haynes, Robert W. Taylor
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Patent number: 4166840Abstract: The present invention relates to a process for reacting ammonia and wet process phosphoric acid to produce ammonium phosphates, which process comprises feeding the reagents to a vessel comprising two tubular members in fluid flow communication with one another and with a gas disengagement vessel, at least one of said tubular members being generally upright, the ammonia being fed to the basal portion of the upright member, the phosphoric acid being fed to the other tubular member; allowing the resultant reaction mixture to circulate spontaneously up the upright member, through the gas disengagement vessel and through the other member to the upright member; and recovering the ammonium phosphate reaction products from the reaction system.Type: GrantFiled: November 30, 1976Date of Patent: September 4, 1979Assignee: Fisons LimitedInventor: John D. Chapman
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Patent number: 4163846Abstract: There are provided, as novel herbicides, the substituted pyrazolopyrimidines of the formula: ##STR1## where A represents -CO-NR.sup.6 - or -C(OR.sup.7).dbd.N-, and R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.6 and R.sup.7 are substituent groups as defined in the specification, and the salts and acid addition salts thereof. Processes for their preparation are provided, as also are herbicidal compositions containing them and methods of combating weeds in which they are used.Type: GrantFiled: May 13, 1977Date of Patent: August 7, 1979Assignee: Fisons LimitedInventors: Albert Percival, Philip N. Judson
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Patent number: 4162154Abstract: The invention provides herbicidally-active sulphonates of the formula ##STR1## wherein X represents a group --CHR.sup.3 --OR.sup.4 and Y represents a group --OR.sup.5, or X and Y together represent a group --CHR.sup.3 --O-- or a group --CHR.sup.3 --O--Z--O--, the free oxygen atom of which is attached to the benzene ring; R.sup.1, R.sup.2 and R.sup.3, which may be the same or different, each represent hydrogen or C 1 to 6 alkyl, or R.sup.1 and R.sup.2 together or R.sup.2 and R.sup.3 together form a C 3 to 6 alkylene chain; R.sup.4 and R.sup.5, which may be the same or different, each represent hydrogen, C 1 to 6 alkyl, C 2 to 6 alkenyl, C 2 to 6 alkynyl, phenyl, a group --O(.dbd.O)R.sup.10 or a group --SO.sub.2 R.sup.11 ; R.sup.6, R.sup.7 and R.sup.8, which may be the same or different, each represent hydrogen, C 1 to 6 alkyl, halogen, cyano, C 2 to 6 carboxylic acyl, or C 1 to 4 alkoxy; R.sup.Type: GrantFiled: February 3, 1978Date of Patent: July 24, 1979Assignee: Fisons LimitedInventors: Peter S. Gates, Derek Baldwin
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Patent number: 4161516Abstract: There is described a medicament in pellet form characterized in that the pellet is soft, is from 10 to 1,000, preferably 30 to 500 microns, in diameter and comprises an agglomeration of individual medicament particles at least 90%, and preferably at least 95%, by weight of which have a diameter of less than 10 microns. Processes for making the soft pellets are also described.Type: GrantFiled: January 14, 1977Date of Patent: July 17, 1979Assignee: Fisons LimitedInventor: John H. Bell
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Patent number: 4160844Abstract: There is described a pharmaceutical composition suitable for application to the skin and comprising, as active ingredient, a compound of formula I, ##STR1## in which R.sub.1 represents hydrogen, hydroxy or --NR.sub.5 R.sub.6, in which R.sub.5 and R.sub.6, which may be the same or different, each represent hydrogen or alkyl C 1 to 6,An adjacent pair of R.sub.2, R.sub.3 and R.sub.4 form a --(CH.sub.2).sub.4 -- chain, and the remaining substituent R.sub.2 or R.sub.4 represents alkyl C 1 to 9,E represents a 5-(IH)tetrazolyl- or a --COOH group, andX represents oxygen or a group --NR.sub.7 -- in which R.sub.7 may be hydrogen or alkyl C 1 to 6, or a pharmaceutically acceptable derivative thereof.Type: GrantFiled: May 5, 1977Date of Patent: July 10, 1979Assignee: Fisons LimitedInventors: Thomas S. C. Orr, Raymond W. Keogh
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Patent number: 4159273Abstract: There are described compounds of formula I, ##STR1## in which R.sub.3 represents hydrogen, or alkyl C 1 to 6, R.sub.5 represents hydrogen, hydroxy, alkoxy C 1 to 6, alkanoyloxy C 2 to 6, alkenyloxy C 2 to 6, nitro, -NR.sub.1 R.sub.2, halogen, alkyl C 1 to 6, hydroxy-alkyl C 1 to 6, or hydroxy-alkoxy C 1 to 6,An adjacent pair of X, Y and Z form a --(CH.sub.2).sub.4 --, --CH.dbd.CH--CH.dbd.CH--or --O(CH.sub.2).sub.3 --chain, each of the chains optionally being substituted by one or two C 1 to 6 alkyl groups, and the remaining substituent X or Z represents alkenyl C2 to 6 optionally substituted by phenyl; halogen; or alkyl C 1 to 9 optionally substituted by one or more of the groups hydroxy, halogen, carbonyl oxygen, phenyl, or alkoxy C 1 to 6,Or, when an adjacent pair of X, Y and Z form a chain substituted by one or two C 1 to 6 alkyl groups, the remaining substituent X or Z may be hydrogen, andR.sub.1 and R.sub.Type: GrantFiled: January 16, 1978Date of Patent: June 26, 1979Assignee: Fisons LimitedInventors: Roger C. Brown, Richard Hazard, John Mann
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Patent number: 4157255Abstract: 5-Benzofuranyl esters of the general formula ##STR1## wherein the substituents are as defined in the specification, possess physiological activity, particularly plant physiological activity and may be used as herbicides, plant growth regulants, fungicides, insecticides and anthelmintics.Type: GrantFiled: October 31, 1977Date of Patent: June 5, 1979Assignee: Fisons LimitedInventors: Peter S. Gates, John Gillon, David T. Saggers