Abstract: Disclosed herein are viral vectors suitable for transfection into woody trees for purposes of delivering and expressing beneficial genes with increased stability. Specifically exemplified herein are vectors for transfecting citrus trees. The vectors allow for the expression of useful proteins, such as those that can protect the tree from disease.
Type:
Grant
Filed:
July 16, 2008
Date of Patent:
January 14, 2014
Assignee:
University of Florida Research Foundation, Inc.
Inventors:
William O. Dawson, Svetlana Y. Folimonova, Alexey S. Folimonov
Abstract: A process for inhibiting a mammalian cancerous cell or virally infected cell includes providing a Trichomonas vaginalis purine nucleoside phosphorylase enzyme or a tail mutant purine nucleoside phosphorylase enzyme in proximity to the mammalian cancerous cell or the virally infected cell and exposing the enzyme to a purine nucleoside phosphorylase enzyme cleavable substrate to yield a cytotoxic purine analog. The process includes introducing to the cell a vector containing the phosphorylase enzyme, or a DNA sequence coding for the same and delivering to the cell an effective amount of the substrate such as 9-(?-D-arabinofuranosyl)-2-fluoroadenine (F-araA).
Type:
Grant
Filed:
August 17, 2009
Date of Patent:
January 14, 2014
Assignees:
The UAB Research Foundation, Southern Research Institute
Abstract: Provided herein are polypeptides comprising or consisting essentially of a QSYDNTLSGSYVF (SEQ ID NO:1) or LSADSSGSYLYVF (SEQ ID NO:2) amino acid sequence. Also provided herein are methods of treating or preventing cast nephropathy in a subject. The methods comprise identifying a subject with or at risk of developing cast nephropathy and administering to the subject any of the polypeptides disclosed herein.
Type:
Grant
Filed:
April 1, 2011
Date of Patent:
January 14, 2014
Assignees:
The UAB Research Foundation, The United States of America, as Represented by the Department of Veterans Affairs
Abstract: The present disclosures provides isolated or purified compounds, each of which bind to a metal atom. Generally, the compounds are small in size (e.g, molecular weight of less than about 1 kDa) and peptidic in nature, inasmuch as the compounds comprise amino acids. In some embodiments, the compound comprises a structure of Formula I: M1-P1-M2-P2 wherein each of P1 and P2 is a peptide comprising at least two amino acids, M1 is a first metal binding moiety comprising a substituted imidazolone ring, M2 is a second metal binding moiety comprising a substituted oxazolone ring, and wherein M1 and M2 bind to a single metal atom. Also provided are related complexes, conjugates, cells which synthesize the compounds of the present disclosures, substantially homogenous cultures thereof, kits and compositions, and methods of making or using the materials of the present disclosures.
Type:
Grant
Filed:
August 4, 2011
Date of Patent:
January 14, 2014
Assignees:
Iowa State University Research Foundation, Inc., The Regents of the University of Michigan, WiSys Technology Foundation
Inventors:
Jeremy D. Semrau, Warren Gallagher, Sukhwan Yoon, Jeongdae Im, Alan A. DiSpirito, Sung-Woo Lee, Scott Hartsel, Marcus T. McEllistrem
Abstract: The present invention relates to a network management system for analyzing Internet application traffic. An apparatus for Internet application traffic classification benchmark according to the present invention configures two or more Internet application traffic classifications in plug-in scheme to perform a benchmarking function for the performance of each Internet application traffic classification. The apparatus can provide an objective and accurate evaluation for each classification technology by aggregating various Internet application traffic classification technologies by the plug-in scheme.
Type:
Grant
Filed:
September 30, 2010
Date of Patent:
January 14, 2014
Assignee:
SNU R&DB Foundation
Inventors:
Su Chul Lee, Sung Ryoul Lee, Hyun Chul Kim, Chong Kwon Kim
Abstract: A container, for example for a food product or the like, provides an elevating lower inner surface that may sealably support a contained food product to raise the upper surface of the food product as it is consumed. Importantly, the container avoids an extension of the elevating mechanism into the product itself, reducing problems of contamination and leakage.
Type:
Grant
Filed:
August 25, 2011
Date of Patent:
January 14, 2014
Assignee:
WiSys Technology Foundation
Inventors:
Birgit Leisen Pollack, Michael Andrew Ludka, Allison Amanda Popple
Abstract: A method and a kit for the identification of chromosomal inversions are described. Single-stranded sister chromatids are generated, for example by CO-FISH. A plurality of non-repetitive, labeled probes of relatively small size are hybridized to portions of only one of a pair of single-stranded sister chromatids. If no inversion exists, all of the probes will hybridize to a first chromatid. If an inversion has occurred, these marker probes will be detected on the sister chromatid at the same location as the inversion on the first chromatid.
Type:
Grant
Filed:
November 14, 2011
Date of Patent:
January 14, 2014
Assignees:
Colorado State University Research Foundation, Board of Regents of the University of Texas System
Inventors:
Susan M. Bailey, F. Andrew Ray, Edwin H. Goodwin, Joel S. Bedford, Michael N. Cornforth
Abstract: The invention relates to a method for aiding the diagnosis of a disorder in a subject, said method comprising; providing a sample from said subject wherein the sample comprises blood; assaying at least two characteristics of said sample, said characteristics selected from: the structural composition of a polypeptide comprised by said sample; a metabolite comprised by said sample; and a catalytic activity comprised by said sample, wherein each of said at least two characteristics is determined from a multiplexed analysis of the same sample. The invention also relates to certain compositions.
Type:
Grant
Filed:
December 5, 2008
Date of Patent:
January 14, 2014
Assignees:
King's College London, Guy's and St. Thomas' NHS Foundation Trust
Abstract: Methods and composition for the screening and isolation of aglycosylated antibody Fc domain polypeptides. For example, in certain aspects methods for identifying aglycosylated Fc domains that bind to Fc receptors or preferentially bind to particular Fc receptors are described. Furthermore, the invention provides aglycosylated Fc domains that bind to Fc receptors with high affinity. Enhanced methods and media for prokaryotic based interaction screening are also provided.
Abstract: Reagents and methods are provided that permit simultaneous analysis of multiple diverse small molecule analytes present in a complex mixture. Samples are labeled with chemically identical but isotopically distinct forms of the labeling reagent, and analyzed using mass spectrometry. A single reagent simultaneously derivatizes multiple small molecule analytes having different reactive functional groups.
Type:
Grant
Filed:
May 1, 2009
Date of Patent:
January 14, 2014
Assignee:
Purdue Research Foundation
Inventors:
Jiri Adamec, Wen-Chu Yang, Fred E. Regnier
Abstract: Provided herein are methods for assessing the risk a test subject with heart failure has of experiencing a major adverse cardiac event, requiring revascularization, requiring a heart transplant, requiring unscheduled hospitalization for heart failure, progression of heart failure status, or any combination thereof. Also provided herein are methods for assessing the risk a test subject has of developing heart failure. The present methods comprise determining the levels of paraoxonase 1 activity in the serum, non-chelated plasma, or both in the test subject and comparing the level of PON1 activity in the test subject's sample with a control or baseline value based on levels of PON1 activity in serum, non-chelated plasma, or both samples from a population of control subjects. Also provided herein are kits useful in assessing such risks.
Abstract: A hybrid vehicle comprises an internal combustion engine, a traction motor, a starter motor, and a battery bank, all controlled by a microprocessor in accordance with the vehicle's instantaneous torque demands so that the engine is run only under conditions of high efficiency, typically only when the load is at least equal to 30% of the engine's maximum torque output. In some embodiments, a turbocharger may be provided, activated only when the load exceeds the engine's maximum torque output for an extended period; a two-speed transmission may further be provided, to further broaden the vehicle's load range. A hybrid brake system provides regenerative braking, with mechanical braking available in the event the battery bank is fully charged, in emergencies, or at rest; a control mechanism is provided to control the brake system to provide linear brake feel under varying circumstances.
Abstract: A zwitterionic/amphiphilic pentablock copolymer was prepared using atom transfer radical polymerization (ATRP). The pentablock copolymer is prepared for the atom transfer radical polymerization of a PDMS-PEO-Br macroinitiator and SBMA. The pentablock copolymer is incorporated into a polyurethane coating composition which is useful for antifouling and/or fouling release applications.
Type:
Grant
Filed:
October 9, 2009
Date of Patent:
January 14, 2014
Assignee:
NDSU Research Foundation
Inventors:
Dean C. Webster, Robert J. Pieper, Mohammed J. Nasrullah
Abstract: Hydrophobic weak base compounds such as hydrophobic weak base chemotherapeutic agents (which are not an anthracycline) for use in the treatment of medical conditions such as proliferative disease or disorder in a subject, in combination with illumination of a region in a body of the subject which is characterized by the presence of proliferating cells, are disclosed. The hydrophobic weak base compound and a wavelength of illumination are selected such that the hydrophobic weak base compound acts as a therapeutically effective photosensitizer when exposed to the illumination.
Type:
Grant
Filed:
March 8, 2012
Date of Patent:
January 14, 2014
Assignee:
Technion Research & Development Foundation Limited
Inventors:
Yehuda G. Assaraf, Yamit Adar Turgeman, Andrzej M. Skladanowski, Arjan W. Griffioen, Henk Verheul, Kristy Gotink, Hubert Van Den Bergh, Patrycja Nowak-Sliwinska
Abstract: A method for controlling a data center, comprising a plurality of server systems, each associated with a cooling system and a thermal constraint, comprising: a concurrent physical condition of a first server system; predicting a future physical condition based on a set of future states of the first server system; dynamically controlling the cooling system in response to at least the input and the predicted future physical condition, to selectively cool the first server system sufficient to meet the predetermined thermal constraint; and controlling an allocation of tasks between the plurality of server systems to selectively load the first server system within the predetermined thermal constraint and selectively idle a second server system, wherein the idle second server system can be recruited to accept tasks when allocated to it, and wherein the cooling system associated with the idle second server system is selectively operated in a low power consumption state.
Type:
Grant
Filed:
July 21, 2010
Date of Patent:
January 14, 2014
Assignee:
The Research Foundation for The State University of New York
Abstract: A fast and sensitive method and device for protein sequencing are disclosed. The method uses a combination of Edman degradation chemistry and mass spectrometry to sequence proteins and polypeptides. A peptide degradation reaction is performed on a polypeptide or protein ion reactant in the gas phase. The reaction yields a first ion product corresponding to a first amino acid residue of the polypeptide or protein reactant and a polypeptide or protein fragment ion. The mass-to-charge ratio for the first ion product, or the polypeptide or protein fragment ion, or both, is then determined. The first amino acid residue of the polypeptide or protein reactant is then identified from the mass-to-charge ratio so determined.
Type:
Grant
Filed:
July 15, 2005
Date of Patent:
January 14, 2014
Assignee:
Wisconsin Alumni Research Foundation
Inventors:
Xiaoyu Chen, Michael S. Westphall, Lloyd M. Smith, Brian L. Frey
Abstract: Provided are a touch screen and a method for compensating sensing capacitance variations and offset variations thereof. The touch screen includes: a touch panel where a plurality of driving lines and a plurality of sensing lines intersect and are wired; a driving unit for activating the driving lines sequentially; an input unit for measuring a sensing capacitance formed in a sensing line corresponding to an activated driving line; a multiplexer for serializing and outputting the measured sensing capacitance; an analog-to-digital converter for sampling the sensing capacitance outputted from the multiplexer by reflecting an initial sensing capacitance as an offset and performing analog-to-digital conversion for the sampling result; and a host processor for determining a touch event in response to the analog-to-digital conversion result.
Type:
Grant
Filed:
September 9, 2010
Date of Patent:
January 14, 2014
Assignees:
Electronics and Telecommunications Research Institute, Industry-University Cooperation Foundation Hanyang Univ.
Inventors:
Oh-Kyong Kwon, Jang Hyun Park, Yea Chul Roh, Chang Sun Kim
Abstract: Disclosed herein, in certain instances, is a novel photovoltaic cell that uses unique microarchitectural and multi-layer functional designs. Further disclosed herein, in certain instances, is a 3-dimensional electrode.
Type:
Grant
Filed:
June 9, 2009
Date of Patent:
January 14, 2014
Assignee:
San Diego State University Research Foundation
Inventors:
Kee Suk Moon, Khaled Morsi, Samuel Kassegne
Abstract: The present invention relates to a method for constructing a cable-stayed bridge with a tensionless stay cable, including the steps for: constructing a main tower 100, continuously installing a suspension cable 200 over a main span and a side span, installing a plurality of hangers 210 on the suspension cable 200, arranging an anchorage cable 220 in a longitudinal direction by connecting the anchorage cable 220 to a lower end of the hanger 210, installing a stay cable 110 in sequence, constructing a girder by connecting a segment 300 constituting the girder to each of the stay cables 110 in sequence, and connecting the segments 300 one another in a longitudinal direction, and removing the suspension cable 200, the hanger, and the anchorage cable 220.
Type:
Grant
Filed:
November 4, 2010
Date of Patent:
January 14, 2014
Assignee:
Dong-A University Research Foundation for Industry-Academy Cooperation
Abstract: A thermoacoustic energy converter for converting heat energy to electricity includes an annular resonator with a regenerator disposed therein. An electro-mechanical transducer is coupled to the annular resonator and in fluid communication with the working fluid. When heat is applied to one end of the annular resonator, a traveling acoustic wave is generated in the annular resonator causing vibrations in the working fluid that actuate the electro-mechanical transducer to generate electricity.
Type:
Grant
Filed:
May 10, 2010
Date of Patent:
January 14, 2014
Assignee:
University of Utah Research Foundation
Inventors:
Orest G. Symko, Ivan A. Rodriguez, Ryan Behunin, Marie Urry