Abstract: The present invention relates to a sample holder on which a crystal sample for serial crystallography is mounted, or the like. Compared to an existing sample holder, the sample holder according to the present invention can be manufactured by a very simple manufacturing process and at low costs, and does not physically and chemically affect other equipment therearound while collecting X-ray diffraction data. Therefore, it is possible to stably operate a beam line, to increase beam time efficiency, and further to perform raster scanning so that many diffraction images can be obtained even in a small-sized chip. In addition, since the problem of evaporation of a crystallized solution does not occur even when the crystallized solution is stored in the air for a long time, the sample holder is generally easy to use compared to a previously reported sample holder.

Abstract: The present invention provides honokiol crystal forms A, B and C and amorphous form and a preparation method thereof, wherein the preparation method comprises dissolving honokiol in n-heptane and standing at room temperature overnight to obtain the separated crystal as honokiol crystal form A; heating the honokiol crystal form A and cooling to room temperature to obtain a solid as honokiol crystal form B; heating the honokiol crystal form A to the molten state and then standing at quenching temperature to obtain the separated crystal as honokiol crystal form C; and adding the honokiol crystal form A with an antisolvent in DMSO/H2O system, and thus obtaining the oily matter as honokiol amorphous form. The honokiol crystal forms A, B and C and the amorphous form of the present invention have the advantages of good solubility, good stability, low hygroscopicity, long-term storage and/or good reproducibility, and are suitable for drug development.

Abstract: An apparatus and computerized method for determining a set of principal components in a multivariate medical data corresponding to a group of subjects comprises: providing a computing device comprising an input/output interface, a memory and one or more processors communicably coupled to the input/output interface and the memory; receiving the multivariate medical data via the input/output interface or the memory; identifying a set of variables based on metabolic patterns between the subjects in the multivariate data using the one or more processors; representing the multivariate medical data corresponding to the set of variables in a high dimensional space between the subjects using the one or more processors; determining the set of principal components by reducing the high dimensional space between the subjects to a compact representational space using the one or more processors; and providing the set of principal components via the input/output interfaces.

Abstract: Disclosed herein is a process for the conversion of polymers, oligomers, or mixtures thereof into shorter alkanes, carboxylic acids, alcohols, alkyl halides or aldehydes. This process includes contacting the polymers, oligomers, or mixtures thereof with the compound of formula (I): Al(R1)3??(I) where R1 is independently selected at each occurrence thereof from the group consisting of H, aryl, C1-C8 alkyl, and C1-C8 alkoxy, as a reaction mixture, in the presence of a catalyst selected from the group consisting of a transition metal catalyst, a lanthanide series metal catalyst, or combinations thereof.

Abstract: A laparoscopic surgery support system can include a plurality of ports configured to receive a trocar therethrough and a plurality of arms connecting the plurality of ports together and configured to allow fixation of a relative position of the plurality of ports. For example, the plurality of ports can include three or more ports.

Abstract: The present disclosure relates to a novel method for lateral flow immunoassay (LFIA) by utilizing plasmonic enhancement strategy. More specifically, the present disclosure provides a plasmonic enhanced lateral flow sensor (pLFS) concept by introducing a liposome-based amplification of the colorimetric signals on the lateral flow platform for ultrasensitive detection of pathogens.

Abstract: A display device includes a display device including a substrate, and a display unit disposed on the substrate. An encapsulating unit encapsulates the display unit. The encapsulating unit includes a barrier organic layer. The barrier organic layer includes a plurality of organic materials and a plurality of inorganic materials. The inorganic materials are arranged in free volumes between the organic materials.

Abstract: The present disclosure provides for the diagnosis and prediction of neuromyelitis optica (NMO) in subject. It also provides for treatment of multiple sclerosis (MS) in a subject.

Abstract: A system and methods for heating and cooling are provided. The system may include an energy collector and an adaptive panel connected to the energy collector. The adaptive panel may a radiative cooling layer configured to dissipate heat from the energy collector. The radiative cooling layer may further include a thermo-responsive polymer configured to adjust transparency depending on temperature. The system may include a solar heating layer configured to absorb solar irradiation that passes through the radiative cooling layer and transfer heat to the energy collector.

Abstract: Embodiments herein report compositions of alpha-1 antitrypsin fusion polypeptides or peptide derivatives thereof. In certain embodiments, compositions and methods relate to generating a construct of use in pharmaceutically acceptable compositions to treat a subject in need of alpha-1 antitrypsin therapy or treatment. In other embodiments, compositions and methods disclosed herein concern linking alpha-1 antitrypsin or derivative thereof to an immune fragment.

Abstract: The present application provides, inter alia, a compound of Formula (I): or a pharmaceutically acceptable salt thereof, wherein Y, Ar, X1, X2, X3, R1, R2, R3, R4, R5, and R6 are as described herein. Methods of making these compounds and methods of using these compound for treating diseases such as cancer are also provided.

Abstract: The present disclosure relates to a novel device for selective collection and condensation of an exhaled breath, and the method of using the novel device. The novel device is portable and capable of collecting and condensing reproducible volumes of exhaled breath under about 10 minutes by using a unique temperature-based algorithm.

Abstract: An optical coherence tomography system for ocular diagnosis includes a light source unit generating and transmitting light, a light distribution unit dividing the transmitted light into first light and second light, a reference arm generating first reference light and second reference light, whose optical path length is larger than that of the first reference light, from the first light, a sample arm irradiating the second light onto a central optical axis directed towards the central portion of the eye lens to generate first measurement light and irradiating the second light onto the eye lens in an oblique direction inclined with respect to the central optical axis at a time different from the time when the first measurement light is generated, to generate second measurement light, an interference unit allowing the first reference light to interfere with the first measurement light and the second reference light to interfere with the second measurement light to generate corresponding interference signals, an

Abstract: A system enabling interactions in virtual environments comprises one or more cloud server computers comprising at least one processor and memory storing data and instructions implementing a virtual environment platform comprising at least one virtual environment; at least one camera obtaining live data feed from a user of a client device; and a client device communicatively connected to the one or more cloud server computers and at least one camera. The system generates a user graphical representation from the live data feed that is inserted into a selected virtual environment and is therein updated, enabling real-time multi-user collaboration and interactions in the virtual environment. Suitable system architectures and methods thereof are also herein disclosed.

Abstract: A peptide and a peptide multimer according to the present invention serve to control tight bonding between cells, and thereby facilitate the absorption, through a mucous membrane, of an active ingredient of co-administered drugs and the like. Thus, the bioavailability of the active ingredient can be significantly improved, and as a result, the therapeutic effect of the active ingredient can be significantly improved.

Abstract: The present invention relates to a screening method for a therapeutic agent for pulmonary damage induced by the administration of high-concentration oxygen, and more specifically, to a screening method for a candidate material for a therapeutic agent for bronchopulmonary dysplasia (BPD) induced by the administration of high-concentration oxygen. The present inventors have discovered that FPR1 is over-expressed in lung tissues exposed to high-concentration oxygen, and as a result of focusing on the correlation between the expression of FPR1 and the development of BPD, have confirmed that BPD can be suppressed by inhibiting the expression or activity of FPR1. In view of this fact, a prophylactic or therapeutic material for BPD may be discovered in a rapid and accurate manner by checking whether the expression or activity level of FPR1 is inhibited, and thus, the screening method of the present invention may be beneficially used to effectively select and develop therapeutic agents for BPD.

Abstract: Compounds and compositions are provided that can inhibit microsomal prostaglandin E synthase-1 (mPGES-1). The compounds and compositions can reduce inflammation in a subject, such as inflammation caused by an inflammation disorder or symptoms thereof. Pharmaceutical compositions comprising the compound are also provided. Furthermore, methods are provided for reducing inflammation and/or inhibiting mPGES-1. The methods can comprise administering an effective amount of the composition to a subject.

Abstract: A new and distinct cultivar of Ilex plant named ‘RutHol10’ is characterized by a combination of its unique globose habit for plants with this parentage, leaf coloration and upright leaf angle that give ‘RutHol10’ more of a boxwood (Buxus) appearance, and its higher tolerance of spider mites than other I. crenata cultivars.

Abstract: A new and distinct cultivar of Coleus (Coleus scutellarioides) plant named ‘UF20-103-6’ having a combination of desirable traits that make it well-suited for use as an annual plant in the summer landscape. ‘UF20-103-6’ has consistent tri-color foliage patterning, compact growth habit, and moderate growth rate in the greenhouse and landscape. ‘UF20-103-6’ has ruffled, deeply lobed foliage with predominant centers colored purplish red surrounded by dark red sections, and consistent yellow green accents and leaf margins. ‘UF20-103-6’ maintains these contrasting colors and patterns in both sun and shade. ‘UF20-103-6’ is compact in habit, but it is highly branched and spreading in form, growing wider than it does tall.