Abstract: A transparent proxy for malware detection includes a monitor module, a protocol determination module, a challenge generation module, a response determination module, and a data control module. The monitor module examines data originating from an application towards a remote server. The protocol determination module identifies the protocol type used for the data. The challenge generation module produces a challenge for the application based upon the protocol type, sends the challenge to the application, and maintains a state related to the data and the challenge. The response determination module makes a determination if an automatic non-interactive application response is received in response to the challenge from the application. The data control module allows the first data to continue to the remote server when the determination is valid. The data control module reports malware detection and blocks the data to continue to the remote server when the determination is invalid.

Abstract: The disclosure relates to capacitive heatsink devices and systems. In one embodiment, the heat sink capacitor includes a positive (P) bus plate; a negative (N) bus plate; a first dielectric material; a second dielectric material; and a heat sink comprising a first side and a second side, the first side of the heat sink attached to the first dielectric material and the second dielectric material, wherein the first dielectric material and the second dielectric material are separated by a portion of the heat sink, wherein the first dielectric material electrically insulates the P bus plate from the first side of the heat sink to form a first capacitor, and wherein the second dielectric material electrically insulates the N bus plate from the first side of the heat sink to form a second capacitor.

Abstract: A method of generating an output movement layout for a traffic intersection is disclosed which includes receiving intersection geographical data, establishing a center point for the intersection, receiving vehicle global positioning system (GPS) data, establishing a radius of interest for the intersection based on the received vehicle GPS data, establishing entry and exit headings for each vehicle based on the GPS data, generating an angular cluster chart based on the entry and exit headings of each vehicle, and generating an output movement layout for the intersection based on the generated angular cluster chart. Further, a method for green time reallocation at traffic signals is disclosed that is based on the congestion experienced by vehicles identified as following specific movements.

Abstract: Mechanoluminescent devices and articles, such as wearable articles, that include mechanoluminescent devices. The mechanoluminescent devices may have a lateral type architecture or a vertical type architecture. The mechanoluminescent devices may be sensors, including pressure sensors.

Abstract: The present invention relates to a method and an apparatus for estimating a user pose using a three-dimensional virtual space model. The method of estimating a user pose including the position and orientation information of a user for a three-dimensional space includes a step of receiving user information including an image acquired in a three-dimensional space, a step of confirming a three-dimensional virtual space model constructed based on spatial information including depth information and image information for the three-dimensional space, a step of generating corresponding information corresponding to the user information in the three-dimensional virtual space model, a step of calculating similarity between the corresponding information and the user information, and a step of estimating a user pose based on the similarity.

Abstract: The invention generally relates to ion generation using modified wetted porous materials. In certain aspects, the invention generally relates to systems and methods for ion generation using a wetted porous substrate that substantially prevents diffusion of sample into the substrate. In other aspects, the invention generally relate to ion generation using a wetted porous material and a drying agent. In other aspects, the invention generally relates to ion generation using a modified wetted porous substrate in which at least a portion of the porous substrate includes a material that modifies an interaction between a sample and the substrate.

Abstract: In one aspect, the disclosure relates to methods for preparation of intermediates useful for the preparation of aryl-cycloheptene scaffolds. In a further aspect, the disclosed methods pertain to the preparation of compounds comprising an aryl-cycloheptene structure. The disclosed methods utilize abundant starting materials and simple reaction sequences that can be used to modularly and scalably assemble common such cores. In various aspects, the present disclosure pertains to compounds prepared using the disclosed methods. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

Abstract: Aspects of the disclosure are directed to methods and apparatus involving the extrusion of polymers or other materials. As may be implemented in accordance with various embodiments, a polymer is delivered into an inlet of a nozzle structure having the inlet and an outlet. The polymer is viscously heated and melted by rotating the nozzle structure about an axis extending through the inlet and the outlet, therein facilitating extrusion of the melted polymer through the nozzle structure outlet. A polymer supply may deliver the polymer into the nozzle structure inlet, and a coupler may facilitation rotation of the nozzle structure. A driver may further operate to control rotation of the nozzle structure relative to the coupler, for instance by generating a rotational output that causes rotation of the nozzle structure.

Abstract: A self-healing alloy contains 5 to 11% by weight of molybdenum (Mo), iron (Fe) as a remainder, and unavoidable impurities. A method for manufacturing the self-healing alloy includes heat treating the alloy or preparing an alloy raw material powder and sintering, homogenizing, and cooling the alloy raw material powder.

Abstract: The present disclosure generally relates to a method for reducing the toxicity of polymyxins as a therapeutic agent comprising the step of coadministration of an aminoglycoside; a method for improving the aerosolization of an aminoglycoside comprising the step of combination formulation with a polymyxin; and a process for manufacturing a dry powder composition comprising a polymyxin and aminoglycoside. Pharmaceutical compositions and methods of treatment for lung infections are within the scope of this invention.

Abstract: A method of manufacturing a conductive electrolyte layer according to various embodiments of the present disclosure for achieving the objects is disclosed. The method includes loading a substrate into a sputter chamber, connecting a plurality of targets to the chamber, injecting a mixed gas into the chamber, supplying power to each of the plurality of targets and forming a conductive electrolyte layer on one surface of the substrate, and sintering the conductive electrolyte layer at a set sintering temperature.

Abstract: The disclosure relates to a pulse amplitude modulation (PAM) data encoding technique capable of reducing effects due to supply noise. A data transmission method according to an embodiment includes identifying an encoding rule of mapping a plurality of pieces of N-bit data and M data symbols, according to a designated level, obtaining a plurality of segmented pieces of data by performing segmentation on input data in units of N bits, mapping the obtained plurality of segmented pieces of data to the M data symbols based on the identified encoding rule, and transmitting the M data symbols obtained as a result of mapping through a plurality of single-ended data lines, wherein an absolute value of a sum of the M data symbols has a value equal to or less than the designated level.

Abstract: A system for training a neural network includes a neural network configured to receive a training input in an image space and produce an enhanced image. The system further includes an error signal generator configured to compare the enhanced image to a ground truth and generate an error signal that is communicated back to the neural network to train the neural network. Additionally, the system includes a neural input enhancer configured to modify the training input in response to receiving at least one of an output from the neural network or the error signal. Modifying the training input improves one of an efficiency or a training result of the neural network beyond the communication of the error signal to only the neural network.

Abstract: Provided is a pose estimation method in a 3D pose estimation apparatus for estimating a 3D pose of an object based on a graph convolution network (GCN). The pose estimation method comprises inputting a feature vector for a joint of the object; generating an affinity matrix according to the feature vector; generating a dynamic graph matrix by fusing the affinity matrix with a predefined static graph matrix of the graph convolution network; and estimating a 3D pose of the object for the feature vector by replacing the static graph matrix of the graph convolution network with the dynamic graph matrix. As a result, the performance of estimating a 3D pose can be greatly improved while almost maintaining the memory usage and inference time of the existing graph convolution network (GCN).

Abstract: Provided herein are methods related to detecting overexpression of an oncogene through translocations in the immunoglobulin heavy (IGH) locus, as well as methods of treatment, uses, and kits related thereto. As demonstrated herein, IGH translocations lead to oncogene overexpression when the distance from a breakpoint of the translocation to the transcription start site (TSS) of an oncogene is within 0-1.3 Mb. As such, detecting IGH translocations in which a breakpoint is 1.3 Mb or less from an oncogene TSS may find use, e.g., in detecting oncogene overexpression, providing assessment/diagnosis, identifying individuals for treatment, selecting therapies, identifying treatment options, and treating or delaying progression of cancer, e.g., using relevant targeted and/or non-targeted therapies.

Abstract: An apparatus for modelling a computing system including a processor configured to generate a plurality of classes related to properties of a computing system based on received information related to a first hardware of the computing system, generate a profile result based on the plurality of classes, and predict a performance of second hardware in the computing system in place of the first hardware, the prediction being based on the profile result.

Abstract: A method of forming a conductive electrolyte layer according to various embodiments of the present disclosure for achieving the objects is disclosed. The method includes loading a substrate into a sputtering chamber, connecting multiple targets to the chamber, injecting a mixed gas into the chamber, supplying power to each of the multiple targets and forming the conductive electrolyte layer on one surface of the substrate, and sintering the conductive electrolyte layer at a set sintering temperature.

Abstract: Autoregulatory systems that have been implemented to control the expression and activity of Cast 3d, including the activity of Cast 3d in vivo, thereby reducing collateral damage in cells at off-target sites (e.g., non-target messenger RNA transcripts. The autoregulatory system is in the form of a nucleic acid molecule comprising a zinc finger binding site, a promoter, and a nucleotide sequence encoding a Cast 3d fusion protein, and a transcriptional repressor domain, and wherein the Cast 3d fusion protein binds to the zinc finger binding site and represses transcription of the nucleotide sequence encoding the Cast 3d fusion protein.

Abstract: The present invention provides an improved technique for cryogenically fixing biological samples in amorphous ice for analysis by cryo-electron microscopy (cryo-EM). Analyte particles are cooled to very low temperatures prior to depositing the particles onto a cooled substrate surface, such as a transmission electron microscope (TEM) grid. This approach “locks” in the particle structure prior to deposition. Either concurrently with or after deposition, the analyte particles are further contacted with a vapor stream of atoms or molecules at cryogenic or near cryogenic temperatures. As a result, a thin layer of an amorphous solid is formed around each particle without significant conformational changes in the particle structure, thereby forming an improved sample for EM analysis.

Abstract: Described herein are compositions of modified binding agents and modified carrier proteins, as well as nanoparticle complexes comprising modified binding agents and modified carrier proteins with optionally at least one therapeutic agent, and methods of making and using the same, in particular, as a cancer therapeutic.