Patents Assigned to Foundation
  • Publication number: 20090241206
    Abstract: The invention provides a transgenic Mustelidae in which a gene associated with a human disease or condition comprises a targeted genetic modification, and uses thereof. Also provided is a method to cryopreserve Mustelidae embryos or cells, and to enhance the number of live offspring from cryopreserved Mustelidae embryos.
    Type: Application
    Filed: March 4, 2009
    Publication date: September 24, 2009
    Applicant: University of Iowa Research Foundation
    Inventors: Xingshen Sun, Yaling Yi, Gregory H. Leno, John F. Engelhardt, Ziying Yan, Michael J. Welsh, Chris Rogers
  • Publication number: 20090235969
    Abstract: A thermoelectric material and a method of fabricating a thermoelectric material are provided. The thermoelectric material includes a compound having an elemental formula of A1?xB1+yC2+z and having a coefficient of thermal expansion greater than 20 parts-per-million per degree Celsius in at least one direction at one or more operating temperatures. The A component of the compound includes at least one element selected from the group consisting of: at least one Group Ia element and at least one Group Ib element, the B component of the compound includes at least one element selected from the group consisting of: at least one Group V element and at least one Group VIII element, and the C component of the compound includes at least one Group VI element. In addition, x is between ?0.2 and 0.3, y is between ?0.2 and 0.4, and z is between ?0.2 and 0.8.
    Type: Application
    Filed: January 23, 2009
    Publication date: September 24, 2009
    Applicants: The Ohio State University Research Foundation, The Board of Trustee of Michigan State University
    Inventors: Joseph P. Heremans, Vladimir Jovovic, Donald T. Morelli
  • Patent number: 7591883
    Abstract: A nanofiber membrane is formed on a microfiber membrane. The nanofiber membrane may be electro sprayed directly onto the microfiber membrane and becomes integrated with the microfiber membrane to form a filter. The microfiber membrane provides structural integrity to for the nanofiber membrane, and an additional microfiber membrane may be added to sandwich the nanofiber membrane.
    Type: Grant
    Filed: October 28, 2005
    Date of Patent: September 22, 2009
    Assignee: Cornell Research Foundation, Inc.
    Inventors: Jun Kameoka, Keiyo Nakano
  • Patent number: 7592341
    Abstract: Improved methods and preparations are provided for ocular administration of therapeutic drugs. The preparations include respective quantities of a drug and a peptide which enhances transport of the drug across ocular tissues. The drug and peptide components may be separately administered or used as a mixture. The preferred peptide is NC-1059 (SEQ. ID NO. 1).
    Type: Grant
    Filed: December 15, 2005
    Date of Patent: September 22, 2009
    Assignee: Kansas State University Research Foundation
    Inventors: John M. Tomich, Takeo Iwamoto
  • Patent number: 7592161
    Abstract: The present invention provides a system and methods for analyzing the function of nucleotide integrases and modified group II introns. The system comprises a donor plasmid comprising a wild-type or modified group II intron, a recipient plasmid comprising a DNA recognition site and a promoterless reporter gene downstream of the DNA target site, and a host cell. The method comprises the steps of transforming a host cell with the donor and recipient plasmids, assaying for expression of the reporter gene, isolating plasmid DNA from the cotransformed cells, and analyzing the plasmid DNA to confirm that the group II intron has been inserted into the target sequence. The present invention also provides a method for simultaneously analyzing the activity of two or more modified nucleotide integrases. The present invention also relates to methods of preparing a library of donor plasmids containing a plurality of diverse modified group II intron DNA sequences.
    Type: Grant
    Filed: October 22, 2002
    Date of Patent: September 22, 2009
    Assignees: The Ohio State University Research Foundation, The University of Texas Board of Regents of the University of Texas System
    Inventors: Alan M. Lambowitz, Huatao Guo, Michael Karberg
  • Patent number: 7592446
    Abstract: The present invention provides selenium derivatives of nucleosides, nucleoside phosphoramidites, nucleotides, nucleotide triphosphates, oligonucleotides, polynucleotides, and larger nucleic acids and methods for their synthesis. Selenium derivatives of both ribonucleic acids and deoxyribonulcleic acids, as well as methods for their synthesis, crystallization and uses in structural determinations, particularly by X-ray crystallographic techniques are disclosed. The selenium derivatives of the present invention are also useful as food supplements.
    Type: Grant
    Filed: March 22, 2002
    Date of Patent: September 22, 2009
    Assignee: Georgia State University Research Foundation, Inc.
    Inventor: Zhen Huang
  • Patent number: 7592001
    Abstract: An electroless method of forming high aspect ratio metal particles includes the steps of mixing a metal or metal salt with at least one acid to form an acidified metal halide salt solution, and mixing the solution with a supersaturated sol to form a sol comprising solution. Metal cations provided by the acidified metal salt are reduced to form a plurality of high aspect ratio metal particles. Instead of using a sol, an organic compound can be oxidized to generate the reducing agent. A metal comprising particle assembly includes a plurality of high aspect ratio metal platelets having an aspect ratio of a major dimension averaging from 10 to 200 times a nanoscale minor dimension of the platelet. The platelets can be used for nail polish, eye liner or the cores for medical delivery vehicles.
    Type: Grant
    Filed: August 2, 2004
    Date of Patent: September 22, 2009
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Kevin William Powers, Marie Kissinger
  • Patent number: 7592387
    Abstract: A clay-polyurethane nanocomposite comprising a clay and a polyurethane covalently bonded to the surface of the clay wherein the polyurethane is formed by reacting a clay-containing diisocyanate compound with a polyol, the clay-containing diisocyanate compound contains a diisocyanate compound covalently bonded to surface silanol groups of the clay and 0.5˜5% by weight of the clay based on the diisocyanate compound, and the clay is exfoliated by the polyurethane such that no wide-angle X-ray diffraction (WAXD) peak is detected between 2° and 10° by XRD measurement. The clay-polyurethane nanocomposite structure has clay layers are completely exfoliated. In addition, the clay-polyurethane nanocomposite can be foamed to prepare a foamed clay-polyurethane nanocomposite.
    Type: Grant
    Filed: January 7, 2005
    Date of Patent: September 22, 2009
    Assignee: Korea University Industry and Academy Cooperation Foundation
    Inventors: Woo-Nyon Kim, Won-Jin Seo, Jae-Sung Han
  • Patent number: 7592003
    Abstract: The discovery of Toll-like receptors (TLRs) on the surface of hematopoietic cells provides new methods for the stimulation and differentiation of various classes of progenitor cells. TLR2 and TLR4 agonists (natural ligands, mimetics, antibodies) are particularly useful in these methods. The cells can be isolated and used for various purpose including tissue regeneration and grafting. In contrast, antagonists of TLRs can be used to protect cells from various insults such as chemo- and radiotherapy, acute and chronic infection, and transplantation by inhibiting activation and differentiation. TLR2, TLR4 and TLR9 pathway antagonists (soluble TLR, mimetics, antibodies) are particularly useful in these methods. Cells can be isolated and used for various purposes including transplantation.
    Type: Grant
    Filed: September 29, 2006
    Date of Patent: September 22, 2009
    Assignee: Oklahoma Medical Research Foundation
    Inventors: Yoshinori Nagai, Paul W. Kincade
  • Patent number: 7592239
    Abstract: The present invention relates to a flexible single-crystal film and a method of manufacturing the same from a single-crystal wafer. That is, the present invention can manufacture a silicon-on-insulator (SOI) wafer comprising a base wafer, one or more buried insulator layers, and a single-crystal layer into a flexible single-crystal film with a desired thickness by employing various wafer thinning techniques. The method for manufacturing a flexible film comprises the steps of (i) providing a SOI wafer comprising a base wafer, one or more buried insulator layers on the base wafer, and a single-crystal layer on said one or more buried insulator layers, (ii) forming one or more protective insulator layers on said single-crystal layer, (iii) removing said base wafer, and (iv) removing one or more of the insulator layers.
    Type: Grant
    Filed: April 28, 2004
    Date of Patent: September 22, 2009
    Assignee: Industry University Cooperation Foundation-Hanyang University
    Inventors: Jong-Wan Park, Jea-Gun Park
  • Patent number: 7591995
    Abstract: The invention provides detectably labeled cobalamin derivatives which are useful for medical treatment and diagnosis.
    Type: Grant
    Filed: October 31, 2006
    Date of Patent: September 22, 2009
    Assignees: Mayo Foundation for Medical Education and Research, Regents of the University of Minnesota
    Inventors: Douglas A. Collins, Henricus P. C. Hogenkamp
  • Patent number: 7593013
    Abstract: A visualization system for heterogeneous data sets comprises: a unique visualization interface created by a visualization engine. The visualization interface comprises a first area defining a center of attention, second area defining a parameter space and a plurality of correlation elements. The first area is a two-dimensional space for the display of items of interest. The second area provides a space in which parameters associated with the items of interest can be displayed. The correlation elements indicate relationships and their strength between items of interest and parameters in the second area. The visualization engine preferably comprises an input module, a control module, a retrieving module, a rendering module, and an analysis module. These components are coupled together to receive input from a user, retrieve data from a data source, and present the unique visualization interface to the user.
    Type: Grant
    Filed: March 9, 2006
    Date of Patent: September 22, 2009
    Assignee: University of Utah Research Foundation
    Inventors: James Agutter, Stefano Foresti, Shaun Moon, Julio Bermudez, Yarden Livnat, Thomas Morahan
  • Patent number: 7592475
    Abstract: A branched ?-cyanostilbene fluorescent materials with a new structure useful to the organic electroluminescence display (OELD), which includes the organic substance in the state of powder, liquid and film with the stilbene core structure and the terminal branched phenyl structure. The fluorescent materials of the invention exhibits the high luminescent efficiency and is capable of tuning the fluorescent colors of red, green and blue according to the core structure in the molecular, i.e., the structure of stilbene radical, particularly it exhibits the higher luminescent efficiency in the state of solid more than solution.
    Type: Grant
    Filed: June 29, 2002
    Date of Patent: September 22, 2009
    Assignees: Dongwoo Fine-Chem Co., Ltd., Seoul National University Industry Foundation
    Inventors: Sooyoung Park, Soonki Kwon, Byeongkwan An
  • Patent number: 7591927
    Abstract: A method for manufacturing a wastepaper shock absorbing material using a vacuum forming principle is provided. The method includes disintegrating wastepaper selected from at least one of old corrugated containers, old newspapers and milk cartons, diluting the disintegrated wastepaper to form a pulp suspension, mixing the pulp suspension with a cationic starch to form a mixture, and vacuuming the mixture by applying a first vacuum in a first direction and a second vacuum in a second direction in a vacuum former to vacuum-dehydrate the mixture and provide a shock absorbing material. The first direction is substantially opposite to the second direction. The method further includes drying the shock absorbing material and performing a surface sizing process on a surface of the shock absorbing material. The wastepaper shock absorbing material has a low elastic modulus and density and can be manufactured without using the conventional press process performed by a press plate.
    Type: Grant
    Filed: December 1, 2006
    Date of Patent: September 22, 2009
    Assignee: Industry-Academic Cooperation Foundation Gyeongsang National University
    Inventors: Chul hwan Kim, Young min Lee, Dae bin Song
  • Patent number: 7592506
    Abstract: Methods for altering levels in plants of one or more phenolic compounds that are intermediates or final products of the plant phenylpropanoid pathway are provided. One method comprises transforming a plant cell with an expression construct comprising a nucleic acid which encodes a transactivator protein comprising the myb domain of the maize “ZmMyb-IF35” protein and an activation domain. Another method comprises transforming a plant cell with an expression construct comprising a transgene which encodes an antisense ZmMyb-IF35 RNA. The present invention also relates to expression constructs and vectors used in the present methods, transformed plant cells and transgenic plants prepared according to the present methods, and the seeds of such transgenic plants.
    Type: Grant
    Filed: December 22, 2006
    Date of Patent: September 22, 2009
    Assignee: The Ohio State University Research Foundation
    Inventors: Erich Grotewold, Anusha P Dia, Edward L. Braun
  • Patent number: 7592159
    Abstract: The present invention relates to two recombinant colicin expression systems, one utilizing a yeast expression system that produces a protein that is inexpensive to purify, and the other utilizing a plasmid expression system to be used as a probiotic culture. The recombinant colicins provide effective alternatives to conventional antibiotics and may be used to improve the efficiency of pork production, and the safety of its products.
    Type: Grant
    Filed: January 6, 2006
    Date of Patent: September 22, 2009
    Assignee: Iowa State University Research Foundation, Inc.
    Inventor: Chad H. Stahl
  • Patent number: 7591556
    Abstract: The present invention provides a scleral lens which includes channels on its posterior bearing surface that improve the flow of tears between the bearing surface of the device and the underlying scleral eyes tissue into the space between the optic of the lens and cornea. The channels are disposed on the inside surface of the lens and extend generally radially from the inside of the haptic and the outside rim of the lens. Various configurations are possible for the channels, as described in more detail below. Additionally, the channels can have a serpentine or arcuate configuration to allow for the appropriate amount of fluid flow between the space under the lens and the scleral surface of the eye. In another embodiment, microchannels can be formed in the lens to increase the oxygen permeability of the lens. The microchannels can have many configurations that reduce the volume of the lens material.
    Type: Grant
    Filed: June 22, 2006
    Date of Patent: September 22, 2009
    Assignee: Boston Foundation for Sight
    Inventor: Perry Rosenthal
  • Patent number: 7591897
    Abstract: A process for the rapid synthesis of metal oxide nanoparticles at low temperatures and methods which facilitate the fabrication of long metal oxide nanowires. The method is based on treatment of metals with oxygen plasma. Using oxygen plasma at low temperatures allows for rapid growth unlike other synthesis methods where nanomaterials take a long time to grow. Density of neutral oxygen atoms in plasma is a controlling factor for the yield of nanowires. The oxygen atom density window differs for different materials. By selecting the optimal oxygen atom density for various materials the yield can be maximized for nanowire synthesis of the metal.
    Type: Grant
    Filed: March 20, 2006
    Date of Patent: September 22, 2009
    Assignee: University of Louisville Research Foundation, Inc.
    Inventors: Mahendra Kumar Sunkara, Sreeram Vaddiraju, Miran Mozetic, Uros Cvelbar
  • Patent number: 7592175
    Abstract: The present invention is of methods of establishing and propagating human embryonic stem cell lines using feeder cells-free, xeno-free culture systems and stem cells which are capable of being maintained in an undifferentiated, pluripotent and proliferative state in culture which is free of xeno contaminants and feeder cells.
    Type: Grant
    Filed: December 7, 2003
    Date of Patent: September 22, 2009
    Assignee: Technion Research & Development Foundation Ltd.
    Inventors: Michal Amit, Joseph Itskovitz-Eldor
  • Patent number: 7592176
    Abstract: This invention relates to methods of producing a substantially homogenous population of mesenchymal stem cells derived from embryonic stem cells. Also, disclosed is a homogenous population of mesenchymal stem cells capable of further differentiating into a variety of specific cell types, characterized by various morphological factors and cell-specific markers. The compositions and methods described in this disclosure are useful for a variety of commercially important diagnostic, drug screening, and therapeutic applications.
    Type: Grant
    Filed: May 6, 2005
    Date of Patent: September 22, 2009
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: J. Wesley Pike, Nirupama K. Shevde