Patents Assigned to Foundation
  • Patent number: 7595494
    Abstract: A radiation detection system and method suitable for use by a first responder to detect a radiological source. The system includes a container that encloses a chamber containing a pressurized inert gas. Incident gamma rays pass through walls of the container to interact with inert gas atoms within the chamber. Wavelength-shifting fiber elements are disposed within scintillator bars oriented parallel to and radially spaced from the chamber axis. At least one sensor is interconnected with the fiber elements to receive first signals therefrom in response to the scattered gamma rays. An electrically-charged wire is disposed within the container along the axis thereof. The wire is adapted to attract electrons released from atoms of the inert gas that are ionized from being impacted by an incident gamma ray, and then produce second signals in response to the released electrons.
    Type: Grant
    Filed: January 3, 2008
    Date of Patent: September 29, 2009
    Assignee: Purdue Research Foundation
    Inventors: David S. Koltick, Ivan S. Novikov, Howard M. Harmless, Aaron B. Copeland
  • Patent number: 7596589
    Abstract: A time-mode analog computation circuit is provided. The time-mode analog computation circuit includes one or more inputs for receiving one or more temporal input signals. The time-mode analog computation circuit further includes circuitry for performing a mathematical operation based on the one or more temporal input signals. A result of the mathematical operation is expressed in a timing of an output signal generated by the circuit.
    Type: Grant
    Filed: April 12, 2005
    Date of Patent: September 29, 2009
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Vishnu V. Ravinuthula, John G. Harris, Jose A. B. Fortes
  • Patent number: 7595194
    Abstract: Multipotent neuroepithelial stem cells and lineage-restricted oligodendrocyte-astrocyte precursor cells are described. The neuroepithelial stem cells are capable of self-renewal and of differentiation into neurons, astrocytes, and oligodendrocytes. The oligodendrocyte-astrocyte precursor cells are derived from neuroepithelial stem cells, are capable of self-renewal, and can differentiate into oligodendrocytes and astrocytes, but not neurons. Methods of generating, isolating, and culturing such neuroepithelial stem cells and oligodendrocyte-astrocyte precursor cells are also disclosed.
    Type: Grant
    Filed: May 1, 2006
    Date of Patent: September 29, 2009
    Assignee: University of Utah Research Foundation
    Inventors: Mahendra S. Rao, Margot Mayer-Proschel
  • Patent number: 7596401
    Abstract: A method for expanding the domain of imaging software in a diagnostic work-up includes the steps of: imaging a patient's body parts for a first condition using a first imaging technique directed to a first condition; acquiring known patient risk factors indicating a second condition; compensating for differences in accuracy between a first imaging technique directed to a first condition, and a second imaging technique directed to testing for the second condition to generate a set of measures; placing a range and confidence interval around the set of measures; and evaluating for a second condition using the set of measures and known patient risk factors.
    Type: Grant
    Filed: March 16, 2006
    Date of Patent: September 29, 2009
    Assignee: Cornell Research Foundation, Inc.
    Inventors: David F. Yankelevitz, Anthony P. Reeves, Claudia Ingrid Henschke
  • Patent number: 7595395
    Abstract: The present invention provides molecules and methods for the prevention and/or treatment of memory deficit related conditions and/or enhancement of cognizance. In a preferred embodiment, the invention includes compounds, salts and prodrugs thereof for the prevention and/or treatment of these conditions.
    Type: Grant
    Filed: May 16, 2006
    Date of Patent: September 29, 2009
    Assignee: WiSys Technology Foundation
    Inventors: James M. Cook, Dongmei Han, Terry Clayton
  • Patent number: 7595296
    Abstract: The ?-trefoil protein human fibroblast growth factor-1 (FGF-1) is made up of a six-stranded anti-parallel ?-barrel closed off on one end by three ?-hairpins, thus exhibiting a three-fold axis of structural symmetry. The N- and C-termini ?-strands hydrogen bond to each other and are postulated from both NMR and X-ray structure data to represent a structurally-weakened region of the ?-barrel. Val mutations within the N- and C-termini ?-strands are shown to stabilize the structure and to increase van der Waals contacts by filling local cavities present within this region. Mutations that increase van der Waals contacts between both the N- and C-termini ?-strands are generally associated with significant reductions in the unfolding kinetics, and also increase the cooperativity of unfolding. Surprisingly, several mutant polypeptides herein disclosed greatly exceed the wild-type polypeptide in ability to stimulate human fibroblasts to proliferate.
    Type: Grant
    Filed: November 7, 2007
    Date of Patent: September 29, 2009
    Assignee: Florida State University Research Foundation, Inc.
    Inventors: Michael Blaber, Vikash Dubey
  • Patent number: 7594986
    Abstract: An apparatus and method for capillary zone electrophoresis includes a polyelectrolyte multilayer positioned in a capillary tube for analytical separations of macromolecules. The capillary comprises a passage defined by passage walls comprising fused silica. The polyelectrolyte multilayer is positioned within the passage adjacent the walls, and comprises an organic polyelectrolyte. The passage may further comprise nonporous silica particles coated with a multilayer including a plurality of polyelectrolyte layers. An apparatus includes a power supply having a positive electrode and a negative electrode for generating an electric field therebetween. The apparatus includes a capillary having a passage formed by passage walls and comprising therein a polyelectrolyte multilayer positioned substantially within the passage.
    Type: Grant
    Filed: October 18, 2007
    Date of Patent: September 29, 2009
    Assignee: Florida State University Research Foundation, Inc.
    Inventors: Joseph B. Schlenoff, Timothy W. Graul
  • Patent number: 7595687
    Abstract: An apparatus and method for reducing EMI generated by a power conversion device, as well as a power conversion device employing such apparatus or method (and/or devices employing such a power conversion device) are disclosed. In at least some embodiments, the apparatus includes a hybrid filter for use in reducing EMI. The hybrid filter includes a passive filtering component, and an active filtering component coupled at least indirectly to the passive filtering component. The active filtering component includes a voltage controlled voltage source, and the hybrid filter operates to reduce a level of a common mode current, whereby the EMI generated due to the common mode current is reduced.
    Type: Grant
    Filed: July 31, 2006
    Date of Patent: September 29, 2009
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Nicolai B. Mortensen, Venkata Giri Venkataramanan
  • Patent number: 7595147
    Abstract: The invention provides methods to identify moieties which specifically bind the flap-tip helix of the ? subunit of RNA polymerase and to identify inhibitors of the interaction between those moieties and the flap-tip helix.
    Type: Grant
    Filed: April 23, 2002
    Date of Patent: September 29, 2009
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Robert C. Landick, Katherine M. Geszvain, Irina E. Artsimovitch, Innokenti I. Toulokhonov, Rachel A. Mooney
  • Patent number: 7595149
    Abstract: A method is provided for detecting an analyte indicative of a cancer or a metastatic disease condition, which utilizes the ability of the analyte to induce permeability in a barrier. The method includes providing a biosensor having a barrier which is substantially impermeable to an ion, a permeable membrane which is selective for the ion, and a detector capable of detecting the ion. The biosensor is contacted with a sample including at least one of the ion and the analyte, wherein the analyte causes at least a portion of the ion to pass through the barrier and the membrane. Passage of the ion through the barrier and membrane allows detection of the ion, providing indirect detection of the analyte. In one embodiment, the barrier is a cell monolayer, the membrane is selective for potassium, and the analyte is vascular endothelial cell growth factor.
    Type: Grant
    Filed: November 8, 2005
    Date of Patent: September 29, 2009
    Assignee: University of Kentucky Research Foundation
    Inventors: Kimberly W. Anderson, Kimberly M. L. May, Leonidas G. Bachas
  • Publication number: 20090239298
    Abstract: A method of generating embryoid bodies is provided. The method comprising culturing undifferentiated embryonic stem cells on a three dimensional scaffold under conditions suitable for formation of embryoid bodies, thereby generating the embryoid bodies.
    Type: Application
    Filed: August 10, 2005
    Publication date: September 24, 2009
    Applicants: Technion Research & Development Foundation Ltd., Ben Gurion University of the Negev Research and Development Authority
    Inventors: Sharon Gerecht, Smadar Cohen, Joseph Itskovitz-Eldor
  • Publication number: 20090238488
    Abstract: An apparatus and method for image interpolation based on low pass filtering are provided. The apparatus includes an edge direction detector detecting an edge direction for a pixel nearest to a to-be-interpolated pixel among pixels and determining the edge direction of the to-be-interpolated pixel as the detected edge direction, a pixel value calculator calculating pixel values of interpolation points located in a lattice filtering window having a predetermined size by using pixel values of pixels located adjacent to the interpolation points, and a filtering unit performing low pass filtering on the to-be-located pixel according to a low pass filter corresponding to the determined edge direction of the to-be-interpolated pixel, the low pass filter being one of low pass filters corresponding to predetermined vertical, horizontal, left diagonal and right diagonal directions respectively.
    Type: Application
    Filed: March 20, 2009
    Publication date: September 24, 2009
    Applicant: Chung-Ang University Industry-Academy Cooperation Foundation
    Inventors: Paik Joon-Ki, Yoon-Jong Yoo, Jin-Young Youn, Dong-Gyun Kim, Jeong-Ho Shin
  • Publication number: 20090239753
    Abstract: A method of manufacturing a superconducting thin film material includes a vapor phase step of forming a superconducting layer by a vapor phase method and a liquid phase step of forming a superconducting layer by a liquid phase method so that the latter superconducting layer is in contact with the former superconducting layer. Preferably, the method further includes the step of forming an intermediate layer between the former superconducting layer and a metal substrate. The metal substrate is made of a metal, and preferably the intermediate layer is made of an oxide having a crystal structure of any of rock type, perovskite type and pyrochlore type, and the former superconducting layer and the latter superconducting layer both have an RE123 composition. Accordingly, the critical current value can be improved.
    Type: Application
    Filed: January 17, 2007
    Publication date: September 24, 2009
    Applicant: International Superconductivity Technology Center, the Juridical Foundation
    Inventors: Shuji Hahakura, Kazuya Ohmatsu, Munetsugu Ueyama, Katsuya Hasegawa
  • Publication number: 20090239850
    Abstract: The invention relates to protein binding inhibitor compounds and methods of identifying and using them. The invention further relates to pharmaceutical compositions and methods for treating a variety of diseases and disorders, including cell proliferative disorders, especially cancer.
    Type: Application
    Filed: September 15, 2008
    Publication date: September 24, 2009
    Applicant: University of Florida Research Foundation
    Inventors: William G. Cance, Elena Kurenova, Vita Golubovskaya, David A. Ostrov
  • Publication number: 20090239249
    Abstract: The present invention relates to a novel thermostable gluconate dehydratase from the thermoacidophilic archaeon Sulfolobus solfataricus, a coding sequence, and an expression system. The gluconate dehydratase has a molecular weight of about 320,000 to 380,000 daltons as the native protein, and about 40,000 to 50,000 daltons as the monomer protein, and catalyzes the dehydration reaction of aldonic acids to 2-keto-3-deoxy derivatives at temperatures of less than 120° C. The gluconate dehydratase can be produced from native or recombinant host cells and thereby used in the pharmaceutical, agricultural, and other industries.
    Type: Application
    Filed: May 13, 2004
    Publication date: September 24, 2009
    Applicants: POSCO, POSTECH Foundation
    Inventors: Seonghun Kim, Sun Bok Lee
  • Publication number: 20090235809
    Abstract: Systems and methods of generating music tracks are disclosed. One such method, for generating one type of music track from another type of music track, is implemented in a computer. The method includes the steps of receiving a music track input having a first type into an artificial neural network (ANN), and producing a music track output having a second type from the ANN, based upon the music track input having the first type.
    Type: Application
    Filed: March 24, 2009
    Publication date: September 24, 2009
    Applicant: University of Central Florida Research Foundation, Inc.
    Inventors: Kenneth O. Stanley, Michael Rosario, Amy Kathryn Hoover
  • Publication number: 20090239935
    Abstract: Method for the diagnosis of diseases in a mammal, preferably in a human, wherein a probe from the mammal is examined with a view to an elevated level of RNA helicase and the elevated level of RNA helicase indicates the disease. The disease refers to esophagus carcinoma, pancreas carcinoma, stomach carcinoma, hepatocellular carcinoma, hepatoblastoma and cholangiocellular carcinoma.
    Type: Application
    Filed: December 14, 2006
    Publication date: September 24, 2009
    Applicants: Signalomics GMBH, Mayo Foundation for Medical Education and Research
    Inventors: Kathrin Zeller, Sven Laarmann, Karin Mittmann, Christoph Block, Ralf Janknecht
  • Publication number: 20090237614
    Abstract: The invention administers an objective clinical test to an eye that measures the visual sensitivity of the superior retina and the inferior retina, by alternately presenting a stimulus pair comprising a shaped superior light stimulus and a shaped inferior light stimulus that are horizontal mirror images of one another and have shapes encompassing visual field defects. The shaped superior and inferior light stimuli stimulate pupillary responses whose amplitudes are measured. A cycle-averaged pupillary response balance and a luminance ratio are computed for each presentation of a stimulus pair. A stimulus pair response curve is computed by fitting cycle-averaged pupillary response balances to a sigmoid function of the luminance ratios. A balanced luminance ratio at which the cycle-averaged pupillary response balance is equal to about zero is computed from the sigmoid function. The balanced luminance ratio is indicative of the presence and location of retinal nerve damage.
    Type: Application
    Filed: April 24, 2009
    Publication date: September 24, 2009
    Applicant: The Research Foundation of State University of New York
    Inventor: Harry J. WYATT
  • Publication number: 20090239217
    Abstract: Isolation and purification of stem cells from within a bulk sarcoma tumor. These cells express the marker genes of pluripotent embryonic stem cells, Stat 3, Oct 3/4, and Nanog. A subset of these cells show the surface marker of mesenchymal stem cells Stro-1, as well as express attributes of mesodermal, ectodermal, and endodermal differentiation. The isolation, purification and characterization of these stem cells now provides the ideal target for the development of highly effective therapies against tumors.
    Type: Application
    Filed: March 24, 2008
    Publication date: September 24, 2009
    Applicant: University of Florida Research Foundation, Inc.
    Inventors: Charles Parker GIBBS, JR., Dennis STEINDLER
  • Publication number: 20090239565
    Abstract: An apparatus and method for beamforming of a terminal in a Multiple Input Multiple Output (MIMO) wireless communication system are provided. The method includes transmitting sounding signals beamformed through a plurality of beamforming weight vectors in sequence, receiving control information indicative of an uplink weight vector determined by a base station and a maximum channel quality value using the sounding signals and transmitting a transmit signal beamformed with the uplink weight vector via a plurality of antennas.
    Type: Application
    Filed: March 20, 2009
    Publication date: September 24, 2009
    Applicants: SAMSUNG ELECTRONICS CO. LTD., Chungju National University Industry-Academic Cooperation Foundation
    Inventors: Ki-Young HAN, Sang-Woo LEE, June MOON, Byoung-Ha YI, Cheol MUN