Patents Assigned to Foundation
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Patent number: 7582296Abstract: The present invention discloses anti-idiotypic antibodies and fragments thereof against inhibitory Factor VIII anti-bodies, said inhibitory antibodies having an affinity for the C2 domain of Factor VIII. The anti-idiotypic antibodies of the present invention are able to completely neutralise in vitro and in an in vivo mouse model the inhibitory activity of FVIII inhibitors. The anti idiotypic antibodies of the present invention can be applied for the prevention, treatment or reduction of bleeding disorders of hemophilia patients with inhibitory antibody against the C2 domain of Factor VIII.Type: GrantFiled: July 28, 2003Date of Patent: September 1, 2009Assignee: D. Collen Research Foundation VZWInventors: Jean Guy G. Gilles, Jean-Marie R. Saint-Remy, Marc G. Jacquemin
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Patent number: 7582610Abstract: The present invention relates to novel chimeric peptides and templates containing a combination of antagonist and agonist endogenous ligand residues. In particular, the present invention relates to novel chimeric peptides and templates thereof based upon melanocortin agonist peptides and agouti related protein (AGRP). The present invention provides multifunctional chimeric peptides having specific bioactivity at melanocortin receptors and their use as drugs to treat various diseases and conditions.Type: GrantFiled: July 24, 2006Date of Patent: September 1, 2009Assignee: University of Florida Research Foundation, Inc.Inventor: Carrie Haskell-Luevano
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Patent number: 7583780Abstract: A method for reconstructing an image in a tomographic imaging system is described. The method includes improving a spatial resolution of the image by iteratively reconstructing the image.Type: GrantFiled: June 22, 2006Date of Patent: September 1, 2009Assignees: General Electric Company, Purdue Research Foundation, The University of Notre Dame du LacInventors: Jiang Hsieh, Jean-Baptiste Thibault, Ken David Sauer, Charles Addison Bouman
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Patent number: 7582561Abstract: A method for depositing one or more materials on a substrate, such as for example, a semiconductor substrate that includes providing the substrate; applying a polymer film to at least a portion of a surface of the substrate; and exposing the semiconductor substrate to a supercritical fluid containing at least one reactant for a time sufficient for the supercritical fluid to swell the polymer and for the at least one reactant to penetrate the polymer film. The reactant is reacted to cause the deposition of the material on at least a portion of the substrate. The substrate is removed from the supercritical fluid, and the polymer film is removed. The process permits the precise deposition of materials without the need for removal of excess material using chemical, physical, or a combination of chemical and physical removal techniques.Type: GrantFiled: September 1, 2005Date of Patent: September 1, 2009Assignees: Micron Technology, Inc., Idaho Research Foundation, Inc.Inventors: Chien M. Wai, Hiroyuki Ohde, Steve Kramer
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Patent number: 7582429Abstract: Methods are provided for nucleic acid analysis wherein a target nucleic acid that is at least partially double stranded is mixed with a dsDNA binding dye having a percent saturation of at least 50% to form a mixture. In one embodiment, the nucleic acid is amplified in the presence of the dsDNA binding dye, and in another embodiment a melting curve is generated for the target nucleic acid by measuring fluorescence from the dsDNA binding dye as the mixture is heated. Dyes for use in nucleic acid analysis and methods for making dyes are also provided.Type: GrantFiled: October 22, 2003Date of Patent: September 1, 2009Assignee: University of Utah Research FoundationInventors: Carl T. Wittwer, Gudrun Reed, Virginie Dujols, Luming Zhou
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Patent number: 7583272Abstract: There are disclosed methods to provide stable pose determinations of various three dimensional shapes. Methods are also disclosed for determining multiple, unique drawing descriptors for two dimensional drawings, and for obtaining intermediate three dimensional representations of two dimensional drawings as one way to determine the descriptor. Methods are also disclosed to provide for searching of two dimensional drawings and three dimensional shapes using user-defined input, which may be a drawing or sketch. User interactivity is provided to further refine search results.Type: GrantFiled: November 29, 2005Date of Patent: September 1, 2009Assignee: Purdue Research FoundationInventors: Karthik Ramani, Jiantao Pu
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Patent number: 7582475Abstract: The present invention includes vectors and methods for high throughput co-expression.Type: GrantFiled: January 6, 2006Date of Patent: September 1, 2009Assignee: University of Georgia Research Foundation, Inc.Inventors: Peter S. Horanyi, James Griffith, Bi-Cheng Wang, Francis E. Jenney, Jr.
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Patent number: 7582479Abstract: A purified preparation of primate embryonic stem cells is disclosed. This preparation is characterized by the following cell surface markers: SSEA-1 (?); SSEA-4 (+); TRA-1-60 (+); TRA-1-81 (+); and alkaline phosphatase (+). In a particularly advantageous embodiment, the cells of the preparation are human embryonic stem cells, have normal karyotypes, and continue to proliferate in an undifferentiated state after continuous culture for eleven months. The embryonic stem cell lines also retain the ability, throughout the culture, to form trophoblast and to differentiate into all tissues derived from all three embryonic germ layers (endoderm, mesoderm and ectoderm). A method for isolating a primate embryonic stem cell line is also disclosed.Type: GrantFiled: January 14, 2005Date of Patent: September 1, 2009Assignee: Wisconsin Alumni Research FoundationInventor: James A. Thomson
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Patent number: 7582310Abstract: Disclosed herein is a biodegradable and bioactive glass-ceramic fabricated by mixing a slowly biodegradable glass-ceramic and a highly biodegradable glass-ceramic in a predetermined mixing ratio wherein the bioactivity is maintained to be constant, and the biodegradation rate is controlled by the mixing ratio. The biodegradable and bioactive glass-ceramic is fabricated from a composition consisting of calcium oxide (CaO), silica (SiO2), boron oxide (B2O3), magnesium oxide (MgO), calcium fluoride (CaF2) and phosphorus pentoxide (P2O5).Type: GrantFiled: August 27, 2003Date of Patent: September 1, 2009Assignee: Seoul National University Industry FoundationInventors: Hyun Seung Yu, Kug Sun Hong, Hwan Kim, Dong Ho Lee, Choon Ki Lee, Bong Soon Chang, Deug Joong Kim, Jun Hyuk Seo, Jae Hyup Lee, Ki Soo Park
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Patent number: 7582422Abstract: Chemically-modified surfaces on unoxidized carbon, silicon, and germanium substrates are disclosed. Ultraviolet radiation mediates the reaction of protected ?-modified, ?-unsaturated aminoalkenes (preferred) with hydrogen-terminated carbon, silicon, or germanium surfaces. Removal of the protecting group yields an aminoalkane-modified silicon surface These amino groups can be coupled to terminal-modified oligonucleotides using a bifunctional crosslinker, thereby permitting the preparation of modified surfaces and arrays. Methods for controlling the surface density of molecules attached to the substrate are also disclosed.Type: GrantFiled: October 11, 2002Date of Patent: September 1, 2009Assignee: Wisconsin Alumni Research FoundationInventors: Todd C. Strother, Lloyd M. Smith, Robert J. Hamers
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Patent number: 7583439Abstract: Apparatus and methods for a polarization converter comprising a polarization beam splitter for receiving an input light beam and allows a transverse magnetic to pass through the polarization beam splitter and reflects a transverse electric wave and a diffraction grating having a reflectivity and polarization convertible grating for receiving the transverse electric wave reflects back a reflected transverse electric wave having a polarization rotation. The broadband wide-angle polarization beam splitter can be alternative optical elements such as a prism or an optical device having multi-layered films.Type: GrantFiled: August 9, 2007Date of Patent: September 1, 2009Assignees: University of Central Florida Research Foundation, Inc., Chi Mei Optoelectronics Corp.Inventors: Chang-Ching Tsai, Shin-Tson Wu, Wang-Yang Li, Chung-Kuang Wei
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Patent number: 7582435Abstract: This invention relates to a body fluids identification method and kit. A parallel, multiplex reverse transcription-polymerase chain reaction (RT-PCR) assay for the definitive identification of body fluids commonly encountered in forensic casework analysis, namely blood, saliva, semen, and vaginal secretions. The methodology is based on gene expression profiling analysis in which the body fluid-specific genes are identified by detecting the presence of appropriate messenger RNA species. Gene-specific primers are labeled with fluorescent dyes, separated and subjected to laser induced fluorescence for identification of body fluid-specific genes present in a sample stain.Type: GrantFiled: July 2, 2007Date of Patent: September 1, 2009Assignee: University of Central Florida Research Foundation, Inc.Inventors: Jack Ballantyne, Jane Juusola
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Patent number: 7582680Abstract: Methods of treating an injured vertebrate spinal cord are described. In one aspect of the invention, a method of treating an injured vertebrate spinal cord includes contacting the spinal cord with a biomembrane fusion agent such as a polyalkylene glycol, especially polyethylene glycol. In alternative embodiments of the invention, methods of treating an injured vertebrate spinal cord include contacting the cord with a biomembrane fusion agent and a potassium channel blocker. Other aspects of the invention include compositions for treating a vertebrate nervous system. A preferred composition includes a biomembrane fusion agent, such as a polyalkylene glycol, and a potassium channel blocker, such as an amino-substituted pyridine.Type: GrantFiled: November 12, 1999Date of Patent: September 1, 2009Assignees: Purdue Research Foundation, The United States of America as represented by the Secretary of the Army, National Science FoundationInventors: Riyi Shi, Richard B. Borgens
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Patent number: 7583992Abstract: A magnetic resonance angiogram (MRA) is acquired using a contrast enhancement method in which a series of NMR images are rapidly acquired during a time resolved phase of the examination in which the contrast bolus makes a first pass through the arteries and veins. Arterial and venous voxels are automatically identified in the images using either of two disclosed methods. The signals from identified arterial voxels are used to produce an arterial contrast enhancement reference curve that is used to segment arterial voxels by a correlation process. Venous voxels are segmented in the same manner using a calculated venous contrast enhancement reference curve.Type: GrantFiled: March 16, 2001Date of Patent: September 1, 2009Assignee: Wisconsin Alumni Research FoundationInventors: Charles A. Mistretta, Yousef Mazaheri, Timothy J. Carroll, Jiang Du
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Patent number: 7582304Abstract: The present invention is drawn to an immunogenic composition comprising OspC polypeptides from Lyme Disease causing Borrelia. In one embodiment, the immunogenic composition of the present invention comprises at least one OspC polypeptide or immunogenic fragment thereof from each of Borrelia burgdorferi OspC families A, B, I and K. In another embodiment, the immunogenic composition of the present invention comprises at least one OspC polypeptide or immunogenic fragment thereof from each of Borrelia afzelii OspC families A and B.Type: GrantFiled: March 9, 2006Date of Patent: September 1, 2009Assignees: Research Foundation of the State University of New York, Brook Biotechnologies, Inc.Inventors: Raymond J. Dattwyler, Gerald Seinost, Daniel Dykhuizen, Benjamin J. Luft, Maria J. C. Gomes-Solecki
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Patent number: 7583789Abstract: An x-ray imaging system includes an optical device having at least one point-focusing, curved monochromating optic for directing x-rays from an x-ray source towards a focal point. The at least one point-focusing, curved monochromating optic provides a focused monochromatic x-ray beam directed towards the focal point, and a detector is aligned with the focused monochromatic x-ray beam. The optical device facilitates x-ray imaging of an object when the object is located between the optical device and the detector within the focused monochromatic x-ray beam. In various embodiments: each point-focusing, curved monochromatic optic has an optical surface that is doubly-curved; the optical device facilitates passive image demagnification or magnification depending upon placement of the object and detector relative to the focal point; and at least one second point-focusing, curved monochromatic optic can be employed to facilitate refractive index or polarized beam imaging of the object.Type: GrantFiled: July 31, 2006Date of Patent: September 1, 2009Assignees: The Research Foundation of State University of New York, X-Ray Optical Systems, Inc.Inventors: Carolyn A. MacDonald, Noor Mail, Zewu Chen
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Publication number: 20090214956Abstract: A lithium-ion battery having an anode including an array of nanowires electrochemically coated with a polymer electrolyte, and surrounded by a cathode matrix, forming thereby interpenetrating electrodes, wherein the diffusion length of the Li+ ions is significantly decreased, leading to faster charging/discharging, greater reversibility, and longer battery lifetime, is described. The battery design is applicable to a variety of battery materials. Methods for directly electrodepositing Cu2Sb from aqueous solutions at room temperature using citric acid as a complexing agent to form an array of nanowires for the anode, are also described. Conformal coating of poly-[Zn(4-vinyl-4?methyl-2,2?-bipyridine)3](PF6)2 by electroreductive polymerization onto films and high-aspect ratio nanowire arrays for a solid-state electrolyte is also described, as is reductive electropolymerization of a variety of vinyl monomers, such as those containing the acrylate functional group.Type: ApplicationFiled: February 23, 2009Publication date: August 27, 2009Applicant: Colorado State University Research FoundationInventors: Amy L. Prieto, James M. Mosby, Timothy S. Arthur
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Publication number: 20090216288Abstract: Disclosed is a method for improving cognitive function or for improving coordination of function across a patient's cortical regions. The method includes applying electrical stimulation to at least a portion of the patient's subcortical structures involved in the generation and control of generalized efference copy signals. Internally generated movement of the patient is then detected and, in response to such internally generated movement, application of electrical stimulation is controlled. The method of the present invention has a number of benefits, including increasing flexibility in identifying targets for stimulation, improving the probability of successfully treating brain injury, and permitting patient biofeedback and self-regulation.Type: ApplicationFiled: May 5, 2009Publication date: August 27, 2009Applicant: Cornell Research Foundation, Inc.Inventors: Nicholas D. SCHIFF, Keith PURPURA, Steven KALIK
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Publication number: 20090214603Abstract: The present invention provides streptococcal SspB Adherence Region (BAR) peptides, nucleic acids encoding the BAR peptides, and methods of using the BAR peptides, and methods of screening BAR peptide mimetics.Type: ApplicationFiled: February 25, 2009Publication date: August 27, 2009Applicant: University of Louisville Research FoundationInventors: Donald R. Demuth, Carlo Amorin Daep
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Publication number: 20090212275Abstract: A nano/micro-sized diode and a method of preparing the same, the diode including: a first electrode; a second electrode; and a diode layer that is disposed between the first electrode and the second electrode. The diode layer includes a first layer and a second layer. The first layer is disposed on the first electrode and has a first surface that is electrically connected to the first electrode, and an opposing second surface that has a protrusion. The second layer is disposed between the first layer and the second electrode and has a first surface having a recess that corresponds to the protrusion, and an opposing second surface that is electrically connected to the second electrode.Type: ApplicationFiled: September 29, 2008Publication date: August 27, 2009Applicants: Samsung Electronics Co., Ltd., Sungkyunkwan University Foundation for Corporate CollaborationInventors: Jinhwan PARK, Sungho PARK