Abstract: Immunochemical assays for human amylase isoenzymes are disclosed. These assays utilize monoclonal antibodies which are produced from hybridoma cell lines and are specific for human salivary amylase and ovarian tumor amylase but not human pancreatic amylase. The assays involve reacting this monoclonal antibody with the unknown sample for the purpose of studying quantitatively and qualitatively the amylase isoenzymes present. The results from such assays are useful in the diagnosis of disease or ruling out disease. Antibody producing hybridoma cell lines and their production are described.
Type:
Grant
Filed:
July 2, 1991
Date of Patent:
January 19, 1993
Assignee:
University of Virginia Alumni Patents Foundation
Abstract: Insect control agents comprising aThis invention was made with funding from the National Institutes of Health (Grant No. AI-23719) and with Hatch Act funding from the U.S. Department of Agriculture (Grant No. GE000918). The U.S. government may have certain rights in this invention.
Type:
Grant
Filed:
June 29, 1989
Date of Patent:
January 19, 1993
Assignee:
University of Georgia Research Foundation, Inc.
Abstract: An adhesion receptor for laminin is provided. The receptor is isolated from cell or tissue extracts and fractionated on an affinity column composed of cell attachment-promoting fragments of laminin coupled to Sepharose.TM. in the presence of divalent cations. This receptor can be used to prepare specific antibodies for the analysis of the amount of laminin receptor expressed by cells and has other applications in cellular and tumor biology.
Type:
Grant
Filed:
May 25, 1989
Date of Patent:
January 19, 1993
Assignee:
La Jolla Cancer Research Foundation
Inventors:
Erkki I. Ruoslahti, Eva Engvall, Kurt R. Gehlsen
Abstract: Method for specifically cleaving a single stranded DNA molecule. The method includes providing an RNA molecule having a deoxyribonuclease activity independent of any protein, and contacting that RNA molecule with the single stranded DNA molecule to cause the single stranded DNA molecule to be cleaved.
Type:
Grant
Filed:
March 21, 1990
Date of Patent:
January 19, 1993
Assignee:
The University of Colorado Foundation, Inc.
Abstract: The invention relates to the fibroblast proteoglycan, versican. The versican core protein has the amino acid sequence, and is encoded by the nucleotide sequence, as shown in FIG. 1. The nucleotide sequence and method of hyaluronic acid binding domain is provided and methods of preparing recombinant proteins having hyaluronic acid binding activity are provided. Such protein can be used to determine the presence of hyaluronic acid and as a vehicle to bring other molecules in contact with hyaluronic acid. The complete versican sequence will allow the production of the entire versican molecule to be used, for example, in tissue reconstruction. Nucleic acid probes are provided which are useful for detecting nucleic acid sequences encoding versican. The invention also provides antibodies reactive with versican.
Abstract: An asymmetric process for the preparation of enantiomerically pure .beta.-D-(-)-dioxolane-nucleosides. The enantiomerically pure dioxolane nucleosides are active HIV agents, that are significantly more effective than the prior prepared racemic mixtures of the nucleosides. The anti-viral activity of the compounds is surprising in light of the generally accepted theory that moieties in the endo conformation, including these dioxolanes, are not effective antiviral agents. The toxicity of the enantiomerically pure dioxolane nucleosides is lower that that of the racemic mixture of the nucleosides, because the nonnaturally occurring .alpha.-isomer is not included.The product can be used as a research tool to study the inhibition of HIV in vitro or can be administered in a pharmaceutical composition to inhibit the growth of HIV in vivo.
Type:
Grant
Filed:
December 5, 1990
Date of Patent:
January 12, 1993
Assignee:
University of Georgia Research Foundation, Inc.
Abstract: Antibodies, hybridomas, and immunoassays relating to a fast homoargenine-sensitive alkaline phosphatase cancer complex in serum ("FHAP") are disclosed. FHAP is a disease (e.g. cancer) marker. One aspect of the disclosure is the measuring of the physical association of two different components of FHAP as part of the assay.
Abstract: A method and device for trajectory control of robot manipulators include selecting a trajectory pattern which corresponds to a desired trajectory which the robot manipulator is to follow. The trajectory pattern is in the form of a sinusoidal time function and a selected number of its harmonics. A signal generator generates a sinusoidal time-varying signal and selected harmonic signals. The signals are provided to a trajectory synthesizer and to a constant matrix gain stage. The trajectory synthesizer provides desired position and velocity vector signals, and the constant matrix gain stage provides a feedforward torque vector signal. First and second subtractors subtract actual position and velocity vector signals respectively from the desired position and velocity vector signals. The subtractors provide position and velocity error vector signals.
Type:
Grant
Filed:
August 8, 1990
Date of Patent:
January 12, 1993
Assignee:
The Research Foundation of State University of New York
Abstract: Mechanically movable microstructure fabricated from a single crystal such as silicon and actuator structures for providing a high degree of controlled, precision motion of nanometer-scale.
Abstract: An anti-inflammatory drug which is phenylacetic acid derivative and methods of using the same in topically controlling eye inflammations. The preferred drug is 2-[4(2-hydroxypropoxy)phenyl]propionic acid.
Type:
Grant
Filed:
October 1, 1990
Date of Patent:
January 12, 1993
Assignee:
University of Iowa Research Foundation
Inventors:
Ronald D. Schoenwald, Charles F. Barfknecht
Abstract: A self-powered liquid crystal spatial light modulator is disclosed having a pair of spaced transparent glass plates, on each plate of which a transparent electrically conductive film is coated so as to be in confronting relation. A voltage/current generating, photovoltaic/photodiode, light sensitive layer is coated onto one of the conductive films. A liquid crystal layer is confined between the other conductive film and the light sensitive layer. A shorting circuit element connects the two conductive films. This shorting circuit element may be internal or external to the spatial light modulator. A pixel area of the spatial light modulator is addressed by a beam of light that illuminates the pixel area and operates to activate a corresponding area of the light sensitive layer. The voltage/current that is generated in this area of the light sensitive film causes a current to flow through the shorting circuit element, to thereby activate, switch or charge the corresponding area of the liquid crystal layer.
Type:
Grant
Filed:
April 24, 1990
Date of Patent:
January 5, 1993
Assignee:
The University of Colorado Foundation, Inc.
Abstract: A process for producing salt free titanium powder by reacting zinc and a titanium halide in the presence of a reducing agent to form a solid zinc titanium product. Titanium halide vapor is introduced into a liquid alloy of zinc and the reducing agent at a temperature between 650.degree.-907.degree. C. The titanium halide is introduced beyond the titanium solubility limit in zinc to precipitate a zinc titanium intermetallic compound and also produce a liquid halide salt. The intermetallic compound forms and accumulates at an interface between the salt and liquid alloy. The compound is periodically removed from the interface, crushed into a powder, and the zinc is evaporatively separated from the titanium to produce pure titanium powder. The process preferably occurs above the peritectic decomposition temperature of Zn.sub.3 Ti, and most preferably above the peritectic decomposition temperature of Zn.sub.2 Ti, to maximize the titanium content of the resulting product.
Type:
Grant
Filed:
October 11, 1990
Date of Patent:
January 5, 1993
Assignee:
Idaho Research Foundation, Inc.
Inventors:
Robert W. Bartlett, Lee S. Richardson, Kay D. Bowles, James J. Hemenway
Abstract: A method to treat or prevent retroviral infection by administering a novel conjugate is described. Lucifer Yellow and its analogs are conjugated to compounds having carbonyl functional groups for reaction with the semicarbazide moiety of Lucifer Yellow to obtain the semicarbazone conjugate.
Type:
Grant
Filed:
September 11, 1989
Date of Patent:
January 5, 1993
Assignee:
The Scripps Clinic and Research Foundation
Abstract: Lignin, or a lignin derived material, which has been significantly demethylated (e.g., the demethylated lignin found in the raffinate produced as a by-product of dimethyl sulfide production which can be carried out using the spent liquor from wood pulping operations) can be isolated by a process wherein an organic solvent is added to a lignin-containing aqueous solution. The organic solvent is typically a polar, and at least a partially water-immiscible substance such as, for example, ethyl acetate. The resulting lignin-containing aqueous solution/organic solvent mixture is acidified to produce a water layer which is discarded and an organic solvent layer which contains the demethylated lignin. Upon its recovery, the demethylated lignin is dissolved in an alkaline solution to which an aldehyde source is added to produce a resol-type resin. The aldehyde source may be formaldehyde in solution, paraformaldehyde, hexamethylenetetramine, or other aldehydes including acetaldehyde, furfural, and their derivatives.
Type:
Grant
Filed:
May 29, 1991
Date of Patent:
January 5, 1993
Assignee:
Colorado State University Research Foundation
Abstract: Rare earth-transition metal (e.g., iron) scrap (e.g., Nd-Fe-B scrap) is flux (slag) remelted to reduce tramp non-metallic impurities, such as oxygen and nitrogen, and metallic impurities, such as Li, Na, Al, etc., picked up by the scrap from previous fabrication operations. The tramp impurities are reduced to concentrations acceptable for reuse of the treated alloy in the manufacture of end-use articles, such as permanent magnets. The scrap is electroslag or inductoslag melted using a prefused, rare earth fluoride-bearing flux of CaF.sub.2, CaCl.sub.2 or mixtures thereof or the slag resulting from practice of the thermite reduction process to make a rare earth-iron alloy.
Type:
Grant
Filed:
October 1, 1990
Date of Patent:
December 29, 1992
Assignee:
Iowa State University Research Foundation, Inc.
Inventors:
Frederick A. Schmidt, David T. Peterson, John T. Wheelock, Lawrence L. Jones
Abstract: Components, usually but not exclusively gaseous components, are removed in a liquid medium from gas streams and chemically converted into an insoluble phase or physically removed. Specifically, hydrogen sulfide may be removed from streams by oxidation in aqueous chelated transition metal solution in a modified agitated flotation cell. A gas-liquid contact apparatus, generally a combined chemical reactor and solid product separation device, comprising such modified agitated flotation cell also is described. In order to effect efficient mass transfer and rapid reaction, gas bubbles containing hydrogen sulfide and oxygen are formed by rotating an impeller at a blade tip velocity of at least about 350 in/sec. to achieve the required shear. To assist in the reaction, a surrounding shroud has a plurality of openings, generally of aspect ratio of approximately 1, of equal diameter and arranged in uniform pattern, such as to provide a gas flow therethrough less than about 0.02 lb/min/opening in the shroud.
Type:
Grant
Filed:
December 5, 1990
Date of Patent:
December 29, 1992
Assignee:
University of Toronto Innovations Foundation
Inventors:
James W. Smith, David T. R. Ellenor, John N. Harbinson
Abstract: Linear displacement and strain measuring apparatus includes a linearly movable element, an emitter disposed on the movable element to move as the element is moved, for developing predetermined paterns of electric fields which vary linearly on the emitter in the direction of movement of the element, and a detector disposed in close proximity to the emitter adjacent the path in which the emitter moves to detect variations in the electric field patterns as the emitter is moved, for producing output signals representing variation in the electric field patterns and thus the linear displacement of the movable element relative to the detector. By attaching the movable element and the detector to spaced apart locations on a specimen, strain in the specimen can be measured.
Type:
Grant
Filed:
June 21, 1991
Date of Patent:
December 29, 1992
Assignee:
University of Utah Research Foundation
Inventors:
Stephen C. Jacobsen, Clark C. Davis, Michael G. Mladejovsky
Abstract: Description and specifications of a new and distinct rabbiteye blueberry variety which originated from seed produced by a hand-pollinated cross of Florida K and NC 1830 is provided. The new rabbiteye blueberry variety can be distinguished from all others by its low chilling requirement and its combination of late flowering with early ripening.
Type:
Grant
Filed:
January 10, 1991
Date of Patent:
January 5, 1993
Assignee:
University of Florida Research Foundation, Inc.
Abstract: Description and specifications of a new and distinct rabbiteye blueberry variety which originated from seed produced by a hand-pollinated cross of Florida 79-19 and Florida 79-27 is provided. The new rabbiteye blueberry variety can be distinguished from all others by its low chilling requirement, its early flowering, and its early ripening, and by its high-quality fruit that can be mechanically harvested for the fresh market.
Type:
Grant
Filed:
January 10, 1991
Date of Patent:
January 5, 1993
Assignee:
University of Florida Research Foundation, Inc.