Patents Assigned to Foundation
  • Publication number: 20210253519
    Abstract: The present invention provides photo-cleavable anionic surfactants, particularly 4-hexylphenylazosulfonate (Azo) and sodium 4-hexylphenylazosulfonate derivatives, which can be rapidly degraded upon UV irradiation, for top-down and bottom-up proteomics. These surfactants can effectively solubilize proteins and peptide fragments with performance comparable to sodium dodecyl sulfate (SDS) and are compatible with mass spectrometry analysis of the solubilized proteins and peptide fragments. Top-down proteomic studies using the present photo-cleavable anionic surfactants has allowed the detection of 100-fold more unique proteoforms as compared to controls and has enabled the solubilization of membrane proteins for comprehensive characterization of protein post-trans-modifications.
    Type: Application
    Filed: June 4, 2019
    Publication date: August 19, 2021
    Applicant: Wisconsin Alumni Research Foundation
    Inventors: Ying GE, Song JIN, Tania GUARDADO ALVAREZ, Kyle BROWN
  • Publication number: 20210253628
    Abstract: Provided herein are steroid sulfatase inhibitor compounds and androgen receptor inhibitor compounds that can be useful in, for example, the treatment of cancers such as prostate cancer and breast cancer. Pharmaceutical compositions and kits including the compounds are described, as well as methods for the treatment of cancer such as prostate cancer and breast cancer.
    Type: Application
    Filed: April 29, 2021
    Publication date: August 19, 2021
    Applicants: The Regents of the University of California, Ohio State Innovation Foundation
    Inventors: Allen C. Gao, Pui-Kai Li
  • Publication number: 20210251514
    Abstract: The present disclosure relates to a novel device for selective collection and condensation of an exhaled breath, and the method of using the novel device. The novel device is portable and capable of collecting and condensing reproducible volumes of exhaled breath under about 10 minutes by using a unique temperature-based algorithm.
    Type: Application
    Filed: June 18, 2019
    Publication date: August 19, 2021
    Applicant: Purdue Research Foundation
    Inventors: Jacqueline C. Linnes, Divya Tankasala, Shubhankar S. Takle, Orlando S. Hoilett, Gabriel P. Ng, Michael S. Smith
  • Publication number: 20210255995
    Abstract: A method of applying proof of lottery to select block forgers in a blockchain, comprising performing the following at a certain one of a plurality of computing nodes connected to a blockchain network: (1) transmitting one or more of a plurality of participation transactions submitted by at least some of the plurality of computing nodes for participating in selection process conducted to select forgers from the plurality of computing nodes to forge blocks to be added to the blockchain; (2) determining a respective forger, during each selection process, by applying a selection function to an outcome of a hash function and a plurality of participation transactions extracted from a first subset of blocks preceding the respective block, the hash function is applied to a second subset of blocks preceding the respective block; and (3) forging the respective block in case the certain computing node is selected as the respective forger.
    Type: Application
    Filed: May 3, 2021
    Publication date: August 19, 2021
    Applicant: Technion Research & Development Foundation Limited
    Inventor: Oded SHMUELI
  • Publication number: 20210258057
    Abstract: The present embodiments may provide a technique of transmitting, by a terminal, channel state information with regard to one or more beams to a base station. The present embodiments provide a method and an apparatus for transmitting, by a terminal, channel state information with regard to one or more beams, the method comprising the steps of: receiving CSI reporting configuration information from a base station; determining whether or not group-based beams are to be reported on the basis of the CSI reporting configuration information; measuring RSRP with regard to CSI-RS received through one or more CSI-RS resources; and transmitting, to the base station, channel state information including values on a predetermined table on the basis of the group-based beam reporting and the CSI-RS RSRP measurement results.
    Type: Application
    Filed: May 17, 2019
    Publication date: August 19, 2021
    Applicant: IUCF-HYU (Industry-University Cooperation Foundation Hanyang University)
    Inventors: Sun Woo KIM, Min Soo JEONG, Sung Jin KIM, Jeong Wan KANG, Yong Min SONG, Chung Hoon LEE
  • Patent number: 11091468
    Abstract: Compounds with anti-viral properties are provided that are based on the following structures: A variety of heteroaromatic groups have been found to be biologically active against the Zika (ZIKV) virus. In some embodiments, a dimeric compound is provided with each monomer linked by a repeating glycol linking group.
    Type: Grant
    Filed: July 23, 2019
    Date of Patent: August 17, 2021
    Assignees: Research Foundation of the City University of New York, Texas Tech University System
    Inventors: Adam B. Braunschweig, Kalanidhi Palanichamy, M. Fernando Bravo, Milan A. Shlain, Himanshu Garg, Anjali Joshi
  • Patent number: 11091800
    Abstract: A method of increasing detection of low-abundant fragments of cell-free DNA (ccfDNA) in a biological sample is disclosed and discussed. Such a method can include isolating an initial fraction of ccfDNA fragments from a biological sample, ligating a unique molecular identifier (UMI) to each of the ccfDNA fragments in the initial fraction, amplifying the plurality of ccfDNA fragments to generate a ccfDNA library, isolating a short fraction of ccfDNA fragments from the ccfDNA library, where the ccfDNA fragments in the short fraction are limited to a size of less than or equal to 160 base pairs (bp), amplifying the ccfDNA fragments in the short fraction, and sequencing the ccfDNA fragments in the short fraction to generate sequenced ccfDNA fragments.
    Type: Grant
    Filed: September 20, 2018
    Date of Patent: August 17, 2021
    Assignee: University of Utah Research Foundation
    Inventor: Hunter R. Underhill
  • Patent number: 11091597
    Abstract: The present disclosure is directed to films. The films can include polyamic acid (PAA). Methods of making and using the film for food product coverings is also included.
    Type: Grant
    Filed: May 23, 2018
    Date of Patent: August 17, 2021
    Assignee: The Research Foundation for The State University of New York
    Inventors: Omowunmi A. Sadik, Idris Yazgan
  • Patent number: 11093526
    Abstract: A method of processing a query to a graph database using processors. The method comprises providing threads to be executed on processors, each the thread is associated with one of a plurality of unique thread identifiers, providing a graph database having a plurality of graph database nodes and a plurality of graph database edges, each the graph database edge represents a relationship between two of the plurality of graph database nodes, receiving a query tree that defines a tree comprising plurality of query nodes connected by a plurality of query tree edges, and searching at least part of the graph database for a match with the query tree, wherein the searching is executed by the processors, and wherein each processor searches one of a plurality of sub-graphs of the graph database, each the sub-graph is defined by one of the plurality of thread identifiers.
    Type: Grant
    Filed: March 26, 2018
    Date of Patent: August 17, 2021
    Assignee: Technion Research & Development Foundation Limited
    Inventors: Oded Shmueli, Lila Shnaiderman
  • Patent number: 11092550
    Abstract: The present invention provides a method of using Raman spectroscopy for identification of low grade cervical cytology cases likely to progress to high grade/cancer. The Applicant has found that high quality Raman spectra can be successfully acquired from morphologically normal appearing cells from negative, LSIL and HSIL Thinprep® specimens and different grades of cervical pre-cancer can be separated with good sensitivities and specificities. Raman spectroscopy can further identify different categories of the LSIL cases i.e., whether they are likely to regress to negative or progress to HSIL cytology.
    Type: Grant
    Filed: December 20, 2017
    Date of Patent: August 17, 2021
    Assignees: Technological University Dublin, The Provost, Fellows, Foundation Scholars, and the Other Members of Board, of the College of the Holy and Undivided Trinity of Queen Elizabeth Near Dublin
    Inventors: Shiyamala Duraipandian, Fiona Lyng, Damien Traynor, John O'Leary, Cara Martin, Padraig Kearney
  • Patent number: 11094221
    Abstract: A method and system of visually communicating navigation instructions can use translational and rotational arrow cues (TRAC) defined in an object-centric frame while displaying a single principal view that approximates the human's egocentric view of the actual object. A visual guidance system and method can be used to pose a physical object within three-dimensional (3D) space. Received pose data (402) indicates a current position and orientation of a physical object within 3D space, such that the pose data can provide a view of the physical object used to generate a virtual view of the physical object in 3D space. At least two of six degrees of freedom (6DoF) error can be calculated (404) based on a difference between the current position of the physical object and a target pose of the physical object.
    Type: Grant
    Filed: August 2, 2019
    Date of Patent: August 17, 2021
    Assignee: University of Utah Research Foundation
    Inventors: Jacob J Abbott, David E. Usevitch
  • Patent number: 11095234
    Abstract: The present disclosure relates to novel triboelectric nanogenerators with flexible polymeric dielectric layer comprising liquid metal particles, and method of making and using the novel triboelectric nanogenerators.
    Type: Grant
    Filed: October 7, 2019
    Date of Patent: August 17, 2021
    Assignee: Purdue Research Foundation
    Inventors: Wenzhuo Wu, Shengjie Gao
  • Patent number: 11091777
    Abstract: Disclosed are compositions and methods for producing modified adeno-associated virus (AAV) cap genes and combinatorial libraries of chimeric AAV vectors and virions; selecting for virions displaying cell-specific tropisms; and, in certain embodiments, producing helper vectors containing one or more modified AAV cap genes. The synthetic combinatorial AAV capsid libraries of the invention are useful in introducing into selected target host cells one or more nucleic acid molecules. The viral vectors and genetic constructs disclosed herein are also useful in a variety of diagnostic and/or therapeutic gene-therapy regimens.
    Type: Grant
    Filed: December 3, 2018
    Date of Patent: August 17, 2021
    Assignee: University of Florida Research Foundation, Incorporated
    Inventors: Damien Marsic, Sergei Zolotukhin, Mavis Agbandje-McKenna
  • Patent number: 11090378
    Abstract: The present disclosure provides the complete nucleotide sequence for porcine parainfluenza virus 1. Immunogenic compositions comprising portions of the nucleotide sequence and proteins expressed therefrom are also provided.
    Type: Grant
    Filed: January 4, 2017
    Date of Patent: August 17, 2021
    Assignee: Kansas State University Research Foundation
    Inventor: Ben Hause
  • Patent number: 11090357
    Abstract: The present application relates to an animal feed supplement for improving animal health and meat production compromising Next Generation Bioengineered Probiotics (NGBP). In some embodiments, the present application relates to a method for treating or preventing an inflammatory condition of a patient comprising the step of administering a therapeutically effective amount of Generation Bioengineered Probiotics (NGBP), together with one or more pharmaceutically acceptable carriers, diluents, and excipients, to the patient in need of relief from said inflammatory condition. In some other embodiments, the present invention relates to method for improving animal health and/or meat production comprising the step of adding an effective amount of Next Generation Bioengineered Probiotics (NGBP) to the feed of said animal.
    Type: Grant
    Filed: July 1, 2019
    Date of Patent: August 17, 2021
    Assignee: Purdue Research Foundation
    Inventors: Arun K Bhunia, Rishi Drolia, Ok Kyung Koo, Mary Anne Amalaradjou
  • Patent number: 11090373
    Abstract: Described herein are agents and methods for targeting antigen-specific B cells using engineered T cells, such as regulatory T cells or cytotoxic T cells, or bi-specific antibodies. The agents and methods can be used to reduce undesirable immune responses.
    Type: Grant
    Filed: October 6, 2016
    Date of Patent: August 17, 2021
    Assignee: The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
    Inventors: David W. Scott, Yongchan Kim, Aihong Zhang
  • Patent number: 11094438
    Abstract: An active feedback controller for a power supply current of a no-insulation (NI) high-temperature superconductor (HTS) magnet to reduce or eliminate the charging delay of the NI HTS magnet and to linearize the magnet constant.
    Type: Grant
    Filed: November 6, 2018
    Date of Patent: August 17, 2021
    Assignee: The Florida State University Research Foundation, Inc.
    Inventors: Seungyong Hahn, David Larbalestier
  • Patent number: 11092596
    Abstract: A group of peptide compounds and their use in identifying molecules that stimulate proteasome or immunoproteasome are disclosed herein.
    Type: Grant
    Filed: September 12, 2018
    Date of Patent: August 17, 2021
    Assignee: Purdue Research Foundation
    Inventors: Darci Jones Trader, Rachel Anne Coleman
  • Patent number: 11091830
    Abstract: To provide a moth-eye transfer mold and a method of manufacturing a moth-eye transfer mold that provide a simple and inexpensive manufacturing process. A moth-eye transfer mold 1 is characterized by including a base 10, an underlayer 20 formed on the base 10, and a glassy carbon layer 30 formed on the underlayer 20, the glassy carbon layer 30 has an inverted moth-eye structure RM over a surface 30a, and the inverted moth-eye structure RM is randomly arranged cone-shaped pores.
    Type: Grant
    Filed: June 12, 2019
    Date of Patent: August 17, 2021
    Assignees: Tokyo University of Science Foundation, GEOMATEC CO., LTD.
    Inventors: Jun Taniguchi, Hiroyuki Sugawara
  • Patent number: 11091844
    Abstract: A method to make free-standing graphene sheets and the free-standing graphene sheets so formed. The method includes the steps of exfoliating partially oxidized graphene from a carbon-containing electrode into an aqueous solution, acidifying the aqueous solution, and separating from the acidified solution partially oxidized graphene sheet. The partially oxidized graphene is then dried to yield free-standing graphene sheet having a carbon-to-oxygen ratio of at least about 8.0.
    Type: Grant
    Filed: October 31, 2018
    Date of Patent: August 17, 2021
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Sundaram Gunasekaran, Omer Sadak