Abstract: The present disclosure relates to novel sesquiterpenoid compounds as SHP2 and/or POLE3 inhibitors for potential treatment for cancers, and to methods of making and using the sesquiterpenoid compounds. The present invention therefore provides a method of using the disclosed compounds as chemosensitizations agent to a DNA damaging thugs for cancers.

Abstract: The present invention is related to compositions and methods useful in treating heart conditions. The disclosed compositions and methods are based on an AAV therapy comprising a recombinant AAV vector for delivering two or more transgenes into the heart of a subject, wherein the transgenes comprise an S100 family protein and an apoptotic inhibitor. In some aspects, targeting multiple sources of one or more heart conditions can provide synergistic benefits during treatment.

Abstract: This invention discloses a method for the induction of arterial-type of hemogenic endothelium and method of differentiating T cells from hemogenic endothelial cells.

Abstract: The present application discloses a novel fusion peptide of IL-2 and IL-33 and its use. It comprises a biologically active domain of Interleukin-2 (IL-2) or a biologically active fragment or homolog thereof, and a biologically active domain of Interleukin-33 (IL-33) or a biologically active fragment or homolog thereof. The two portions can be linked by a linker sequence. The application discloses that combination therapies using IL-2 and IL-33 or a therapy using the IL233 fusion protein are effective in preventing or treating diseases and disorders such as autoimmune diseases and disorders, inflammation, etc. Depending on the subject's disease or disorder, the compositions of the invention are useful for preventing certain symptoms, treating the disease, and alleviating at least some of the symptoms.

Abstract: Provided is a composition for the prevention and treatment of one or more cancers selected from the group consisting of breast cancer, liver cancer, and gastric cancer, the composition comprising selenopsammaplin A as active ingredients. The selenopsammaplin A and derivatives thereof of the present invention have been confirmed to exhibit excellent anticancer activity against breast cancer, liver cancer, and gastric cancer cells, and exhibit not only a strong effect of suppressing breast cancer growth compared to existing psammaplin A but also an excellent effect of suppressing the metastasis of breast cancer cells, and thus the selenopsammaplin A and derivatives thereof are expected to be effectively usable as a pharmaceutical composition for the prevention and treatment of breast cancer, liver cancer, and/or gastric cancer, and for the suppression of breast cancer metastasis.

Abstract: Compounds, pharmaceutical formulations, and methods of treating bacterial infections are disclosed.

Abstract: Provided is a method where mobile relay performs bidirectional inter-terminal communication in wireless communication system. The method includes determining optimal values of predetermined variables for maximizing a transmission ratio for the bidirectional inter-terminal communication during a predetermined time segment using pieces of basic information of at least one of the mobile relay, a first terminal, or a second terminal, transmitting setting information on the optimal values to at least one of the first terminal and the second terminal, and performing the bidirectional inter-terminal communication on the basis of the optimal values. The predetermined variables include at least one of a position of the mobile relay, a speed of the mobile relay, acceleration of the mobile relay, a downlink transmission power of the mobile relay, an uplink transmission power of the first terminal, an uplink transmission power of the second terminal, or a transmission resource allocation ratio for uplink and downlink.

Abstract: A system including a first micro-retarder array, wherein the first micro-retarder array is configured to convert a purely polarized light of an incident light into two components. The system additionally includes an optical device, wherein the optical device is configured to collimate the two components to two foci planes. Moreover, the system includes a second micro-retarder array, wherein the second micro-retarder array is configured to combine a set of two components of the incident light, thereby producing a second purely polarized light. Further the system includes a detector, wherein the detector is configured to receive the second purely polarized light.

Abstract: The present invention relates to a dielectric barrier discharge (DBD) plasma reactor for the preparation of C2+ hydrocarbons from methane, wherein the DBD plasma reactor comprises macroporous silica, as a dielectric material, and optionally a photocatalyst that is impregnated into the pores of the macroporous silica.

Abstract: An accelerator, an operation method of the accelerator, and an accelerator apparatus including the accelerator are disclosed. The operation method includes receiving one or more workloads assigned by a main processor, performing at least one operation involved with the workloads in an internal memory of the accelerator or in a direct memory access (DMA) configured to control data input to or output from the internal memory, and providing a result of performing the at least one operation.

Abstract: A gastric electric stimulation (GES) system is disclosed which includes a processing system, and at least one of a left vagus nerve sensor (L/R Sensors) and a right vagus nerve sensor coupled to the processing system, the processing system is configured to receive a model which statistically correlates sensed compound nerve action potential (CNAP) parameters measured from at least one of left and right vagus nerves of subjects within a population to feedback surveys of the subjects corresponding to a plurality of gastric symptoms and symptom parameters, receive one or more gastric symptoms of a subject outside of the population (Subjectout), determine CNAP parameters that correspond to the gastric symptoms with least severity (CNAPmin), measure CNAP activity of the Subjectout from the L/R sensors while modifying GES parameters for the Subjectout, select the GES parameters that corresponds to the CNAPmin (GESout), and output the GESout.

Abstract: Disclosed are compounds that can penetrate the mitochondrial membrane and that are able to deliver cargo (e.g., therapeutic agents) specifically to the mitochondria.

Abstract: The present invention relates to a flexible electrode, a biofuel cell using the same, and a method for manufacturing the same. The electrode according to the present invention comprises: a non-electrically conductive substrate (10); a base layer (20) disposed on the outer surface of the substrate (10); a nanoparticle layer (31) including metallic nanoparticles and disposed on the outer surface of the base layer (20); and a monomolecular layer (33) including a monomolecular material having an amine group and disposed on the outer surface of the nanoparticle layer (31).

Abstract: Described herein are methods and compositions for modulating bovine birth rate by following a breeding scheme based on the presence of the trio haplotype, which is strongly linked to the propensity to give birth to multiple calves in one event.

Abstract: The present invention provides a composition containing an inorganic nano-particle structure absorbing blue light and then emitting light and a siloxane compound; a light-conversion thin-film made of the composition; and a display panel using the film. When using the composition, the light-conversion thin-film as an optical member may have high stability. Further, when using the film, a display panel with excellent stability even under high-temperature and high-water conditions may be realized.

Abstract: Methods and devices are disclosed for joint (e.g., shoulder) arthroplasty. In one aspect, there is provided a device for determining inclination and/or version of a prosthetic head with respect to a prosthetic stem. In another aspect, there is provided a joint (e.g., shoulder) prosthesis. In another aspect, there is provided a method for setting an inclination angle and/or a version angle of a prosthetic head with respect to a stem implanted or to be implanted in a bone of a joint (e.g., shoulder).

Abstract: Disclosed are recombinant polypeptides that include (a) a filaggrin amino acid sequence and (b) a cell importation signal sequence that includes a motif of two to fifteen amino acids, wherein the motif includes at least one arginine residue and at least one methionine residue. Also disclosed are nucleic acids encoding the recombinant polypeptides of the present invention, and compositions that include the recombinant polypeptides and nucleic acids of the present invention. Methods of treating or preventing a skin disease or skin disorder using the compositions of the present invention are also included, as well as kits that include a sealed containing that includes a recombinant polypeptide of the present invention.

Abstract: The present invention provides aryl isonitrile compounds that have antibacterial properties. More specifically, the aryl isonitrile compounds of the present invention are potent inhibitors of drug resistant strains of Staphylococcus aureus.

Abstract: The present disclosure is related to a pre-5th-Generation (5G) or 5G communication system to be provided for supporting higher data rates beyond 4th-Generation (4G) communication system such as Long Term Evolution.

Abstract: An operation method of a first communication node for transmitting a message in a vehicle-to-everything (V2X) communication network is provided. The method includes receiving information regarding a time period including a plurality of transmission slots from a second communication node and selecting one transmission slot included in the time period based on a first index configured based on the information regarding the time period. A message is transmitted through the one transmission slot and the information regarding the time period includes information regarding a number of the plurality of transmission slots included in the time period.