Abstract: Provided herein are nanoparticles comprising a polyplex core comprising one or more pH-responsive polymers and one or more anionic immune adjuvants, wherein each pH-responsive polymer comprises ionizable amine groups; and a shell of bacterial cell membrane components at least partially coating the polyplex core, wherein the bacterial cell membrane components comprise TLR 2 and/or TLR 4 agonists. Also provided are methods of stimulating an immune response in a mammal using the nanoparticle.

Abstract: An elongate tape (10) acts as a vaporizing actuator for impulse metalworking. It has an electrically-insulative base layer (20), an electrically-conductive layer (30), and an electrically-insulative top layer (40). In it, the base layer is characterized by the length of the tape and a first width W1, as measured between a pair of side edges. The conductive layer is characterized by the length of the tape and a second width W2, as measured between a pair of side edges; and the top layer is characterized by the length of the tape and a third width W3, as measured between a pair of side edges. The layers are joined to each other to form the elongate tape with the electrically-conductive layer interposed between the electrically-insulative base and top layers.

Abstract: The present disclosure relates to a composition for preventing and treating muscle atrophy, which contains a lycii radicis cortex extract as an active ingredient. The composition of the present disclosure has a remarkable effect of improving muscle atrophy and superior safety and, thus, can be used to prevent and treat muscle atrophy without side effects.

Abstract: Provided are mutant cocaine esterase polypeptides and PEGylated formulations thereof.

Abstract: The present disclosure relates to a composition for detecting a potato virus Y including an M13KO7 bacteriophage and a kit including the same. Since the M13KO7 bacteriophage of the present disclosure may be easily produced using E. coli and is a large aggregate of proteins, the M13KO7 bacteriophage is more stable than antibodies even when exposed to external physical or chemical factors. Therefore, the composition of the present disclosure has an effect of diagnosing only the PVY specifically and accurately and may be usefully used in related industries.

Abstract: This invention provides novel indole, indazole, benzimidazole, benzotriazole, indoline, quinolone, isoquinoline, and carbazole selective androgen receptor degrader (SARD) compounds, pharmaceutical compositions and uses thereof in treating hyperproliferations of the prostate including pre-malignancies and benign prostatic hyperplasia, prostate cancer, advanced prostate cancer, castration resistant prostate cancer, other AR-expressing cancers, androgenic alopecia or other hyper androgenic dermal diseases, Kennedy's disease, amyotrophic lateral sclerosis (ALS), abdominal aortic aneurysm (AAA), and uterine fibroids, and to methods for reducing the levels (through degradation) and/or activity (through inhibition) of any androgen receptor including androgen receptor-full length (AR-FL) including pathogenic and/or resistance mutations, AR-splice variants (AR-SV), and pathogenic polyglutamine (polyQ) polymorphisms of AR in a subject.

Abstract: An electrochromic system is disclosed which includes a first glass layer having a bottom side and a top side, the top side coated with a first transparent conductor layer, an electrolyte layer formed adjacent to the first transparent conductor layer, an electrochromic layer formed adjacent to the electrolyte layer, and a second glass layer having a top side and a bottom side, the bottom side coated with a second transparent conductor layer and coupled to the electrochromic layer.

Abstract: A braking device for a vehicle is provided. The braking device includes a braking member, friction means that can come into contact with the braking member, and an air supply line secured to the friction means and opening out opposite the braking member.

Abstract: A three-dimensional semiconductor integrated circuit includes a first CMOS circuit layer including a plurality of first CMOS circuit blocks; an insulating layer disposed on a top of the first CMOS circuit layer; a plurality of atomic switching elements respectively disposed inside via holes extending through the insulating layer, wherein the plurality of atomic switching elements are electrically connected to the plurality of first CMOS circuit blocks, respectively; a driver circuit layer disposed on a top of the insulating layer, and electrically connected with the atomic switching elements, wherein the driver circuit layer include a driver circuit for selectively turning on and off the atomic switching elements; and a second CMOS circuit disposed on a top of the driver circuit layer and connected to the atomic switching elements.

Abstract: Compositions and methods for improving cardiac structure and/or function in subjects in need thereof. The methods include administering to a subject a succinate dehydrogenase inhibitor in an amount and for a time effective to elicit an improvement in cardiac structure and/or function. The subjects include subjects suffering from cardiac damage, such as damage resulting from myocardial infarction or other cardiac events. Improvements in cardiac function include one or more of an increase in cardiomyocyte proliferation, an increase in ejection fraction, an increase in fractional shortening, a decrease in left ventricle internal diameter diastole, and a decrease in left ventricle internal diameter systole. Improvements in cardiac structure include one or more of decreased fibrosis, an increase in myocardial thickness, an increase in coronary artery formation, an increase in capillary density, an increase in revascularization, and a decrease in myocardial lesion size.

Abstract: An assembly for driving linear movement and roll movement of an elongate surgical tool, comprising: an elongate shaft comprising a central lumen extending along the shaft long axis; the elongate shaft comprising a plurality of apertures extending across walls of the elongate shaft and into the central lumen; a set of wheels positioned opposing each other and aligned on two sides of the central lumen, the set of wheels at least partially extending through the apertures beyond the walls of the elongate shaft and into the central lumen to contact an elongate surgical tool received therein; the set of wheels being coupled to the elongate shaft and configured to rotate with the elongate shaft as a single unit when the elongate shaft is rotated about the shaft long axis.

Abstract: Disclosed are next-generation multi-mutated capside protein-modified rAAV expression vector, as well as infectious virions, compositions, and pharmaceutical formulations that include them. Also disclosed are methods of preparing and using these high transduction efficiency vector constructs in a variety of therapeutic applications including, inter alia, as delivery agents for the treatment or amelioration of one or more diseases or abnormal conditions in an affected mammal using in vivo and/or ex situ viral vector-based gene therapy protocols. Also disclosed are large-scale production methods for the multi-mutated, capsid-modified rAAV expression vector, viral particles, and infectious virions, as well as use of the disclosed compositions in the manufacture of medicaments for use in a variety of in vitro and/or in vivo therapeutic methodologies.

Abstract: Disclosed herein are methods for the production of Cannabis meristem explants from dry seeds. Also described are methods of transforming and gene editing using the Cannabis meristem explants disclosed herein.

Abstract: An integrated electromechanical and hydraulic system is disclosed which includes an electric machine, the electric machine includes a casing, a stator adapted to remain stationary within the casing, one or more electrically insulated windings coupled to the stator, a rotor separated from the stator and the one or more windings by a radial diamagnetic gap, electrical power couplings, and a first mechanical power couplings, and a hydraulic machine also disposed in the housing, the hydraulic machine having hydro-mechanical couplings as well as a second mechanical power couplings, wherein the second mechanical power couplings are coupled to the first mechanical power couplings.

Abstract: Provided is a brain-machine interface based intention determination device using a virtual environment, including: an input unit that receives a control mode; a training output unit that outputs training information; a collection unit that collects a brain signal; a first preprocessing unit that extracts time-frequency information; a second preprocessing unit that generates physical information; a learning unit that learns control information according to a pattern of physical information; a determination unit that determines control information; and a command output unit that outputs a control command matching the control information.

Abstract: A method of using a HBC device includes enabling electro-quasistatic communication on a transmitter, wherein the enabling electro-quasistatic communication includes receiving an activation signal through an input. The enabling the electro-quasistatic communication additionally includes transmitting a digital data signal to a transmitter logic circuit. The enabling the electro-quasistatic communication further includes modulating an electro-quasistatic carrier signal by the digital data signal using a modulator, thereby producing a modulated electro-quasistatic signal. Additionally, the enabling the electro-quasistatic communication includes transmitting the electro-quasistatic signal from the transmitter logic circuit to a general purpose input output circuit. Furthermore, the enabling the electro-quasistatic communication includes coupling the electro-quasistatic signal on a human body through an electrode, thereby enabling electro-quasistatic communication. The transmitter includes the electrode.

Abstract: There is provided an ultrasound device comprising: ultrasound transducer(s), memory storing code, hardware processor(s) coupled to the ultrasound transducer(s) and the memory for executing stored code comprising: activating the transducer(s) for simultaneously transmitting at least one line with a predefined focus width, and receiving an indication of a plurality of narrow-focused received lines, inputting the indication of the narrow-focused received lines into a convolutional neural network (CNN) trained on pairs of ultrasound imaging data capturing rapid motion of the certain tissue of sample patient(s), including a single-line ultrasound imaging data captured based on a single line in response to a transmitted single narrow-focused pulse, and a multiple-line ultrasound imaging data captured based on receiving narrow-focused lines in response to simultaneously transmitted at least one line, outputting adjusted narrow-focused received lines, and computing an adjusted ultrasound image according to the adjust

Abstract: A system and methods for machine anomaly and behavior classification is provided. An audio capture device may attach to a mechanical apparatus comprising a first component and a second component. The first component and second component may separately generate audible noise. The capture device may include a body, a diagraph disposed in the body, and a microphone. The diagraph may vibrate in response to sound generated by the mechanical device. The microphone may generate a signal in response audio caused by the vibrating diagram. The system may receive the signal generated by the microphone of the audio capture device. The system may determine, based on a machine learning model and the signal, an anomalous event associated with the first component, a second component, or a combination thereof. Alternatively, or in addition, the system may classify operation of the machine based on second machine learning model.

Abstract: Methods, systems, and computer readable media for defining risk of adverse health outcomes based on non-intrusive energy usage monitoring are disclosed. One exemplary method includes receiving residential energy usage data associated with a residential location as measured by a residential meter and applying at least one load signature correlation that has been derived using previously collected energy usage data and one or more of health outcome data, the health care resource utilization data, and the clinical outcome data to the received residential energy usage data. The method further includes using an output resulting from applying the at least one load signature correlation to identify a risk or predict a likelihood of specific health outcomes or clinical events associated with at least one target entity associated with the residential location.

Abstract: Improved method for purifying extracts containing phytoglycogen or certain derivatives thereof which comprises the step of subjecting the extracts to ultrafiltration. Methods for providing a lower viscosity phytoglycogen material by subjecting an extract containing phytoglycogen (or purified phytoglycogen) to beta-amylase treatment. Methods for preparing beta-dextrins or derivatives thereof from phytoglycogens or derivatives thereof.