Abstract: A method of treating a patient to prevent heart failure readmission can include identifying one or more risk factors for the patient, and selecting one or more interventions relating to the one or more risk factors in a graphical user interface (GUI) of a treatment support system. The method also includes receiving a statistical score of the one or more interventions to determine the effect of the one or more selected interventions on heart failure readmission, and treating the patient as a function of the received statistical score using the one or more interventions.

Abstract: Provided herein are compositions, systems, kits, and methods for treating cancer in at least one bone of a subject using nanoparticles encapsulating, or conjugated to, an anti-cancer agent. In other embodiments, provided herein are composition, systems, kits, and methods for treating a bone disease (e.g., osteoporosis) in a subject using nanoparticle encapsulating, or conjugated to, a RANKL inhibitor. The nanoparticle are, in certain embodiments, neutral or nearly neutral in charge (e.g., zeta potential between ?5 and +5 mV) and less than 250 nm in diameter on average (e.g. have an average diameter between 100 and 200 nm).

Abstract: Provided are methods for assessment of surface rugosity of a layer of live cells using tools that determine contact angle and contact angle hysteresis.

Abstract: A boost converter and a cell applicable to the boost converter are provided. The cell comprises a control circuit configured to generate a bottom control signal related to a bottom plate of a capacitor, and a top control signal related to a top plate of the capacitor to connect the capacitor based on one or more operational phases, and a booster configured to convert the top control signal generated by the control circuit, wherein the capacitor is configured to be sequentially connected to voltage levels through switches, based on the bottom control signal and the converted top control signal.

Abstract: Methicillin-resistant Staphylococcus aureus (MRSA) possesses array of strategies to evade antibiotics through mutational inactivation, hiding inside host immune cells or concealing inside the biofilm in a sessile form. We report a drug-free approach to eradicate MRSA through blue-light bleaching of staphyloxanthin (STX), an anti-oxidative carotenoid residing inside the cell membrane of S. aureus. The photobleaching process, uncovered through a transient absorption imaging study and quantitated by mass spectrometry, decomposes STX and sensitizes MRSA to reactive oxygen species attack. Consequently, photobleaching using low-level blue light exhibits high-level synergy when combined with low-concentration of hydrogen peroxide. Antimicrobial effectiveness of this synergistic therapy is validated in MRSA culture, MRSA-infected macrophage cells, biofilm, and a mouse wound infection model. Collectively, these findings highlight broad applications of STX photobleaching for MRSA-infected diseases.

Abstract: System and Method pertaining to the modification and integration of an existing consumer digital camera, for example, with an optical imaging module to enable point and shoot fundus photography of the eye. The auto-focus macro capability of existing consumer cameras is adapted to photograph the retina over an extended diopter range, eliminating the need for manual diopter focus adjustment. The thru-the-lens (TTL) auto-exposure flash capability of existing consumer cameras is adapted to photograph the retina with automatic flash exposure eliminating the need for manual flash adjustment. The consumer camera imaging sensor and flash are modified to allow the camera sensor to perform both non-mydriatic focusing of the retina using infrared illumination and standard color flash photography of the retina without the need for additional imaging sensors or mechanical filters.

Abstract: Provided herein are nanocapsules comprising a single ribonucleoprotein (RNP) complex as a core and an biodegradable crosslinked polymer shell that encapsulates the core, wherein the RNP complex comprises a Cas9 polypeptide and a guide RNA, and the biodegradable crosslinked polymer shell comprises polymerized monomers of imidazolyl acryloyl monomers, bisacryloyl disulfide monomers (a biodegradable cross-linker), optionally PEG acryloyl monomers, and either cationic acryloyl monomers, anionic acryloyl monomers, or both cationic and anionic acryloyl monomers (optionally in combination with non-ionic acryloyl monomers) as defined herein. Also provided are methods of making the nanocapsules, kits containing the nanocapsules and methods of delivering the encapsulated RNP to cells.

Abstract: Embodiments facilitate predicting a patient prostate cancer (PCa) DECIPHER risk group. A first set of embodiments relates to training of a machine learning classifier to compute a probability that a patient is a member of a DECIPHER low/intermediate risk group based on radiomic features extracted from bi-parametric magnetic resonance imaging (bpMRI) images. A second set of embodiments relates to classifying a patient as a member of DECIPHER low/intermediate risk group, or DECIPHER high-risk group, based on radiomic features extracted from bpMRI imagery of the patient.

Abstract: Disclosed herein is a shape memory alloy comprising 48 to 50 atomic percent nickel, 15 to 30 atomic percent hafnium, 1 to 5 atomic percent aluminum; with the remainder being titanium. Disclosed herein too is a method of manufacturing a shape memory alloy comprising mixing together to form an alloy nickel, hafnium, aluminum and titanium in amounts of 48 to 50 atomic percent nickel, 15 to 30 atomic percent hafnium, 1 to 5 atomic percent aluminum; with the remainder being titanium; solution treating the alloy at a temperature of 700 to 1300° C. for 50 to 200 hours; and aging the alloy at a temperature of 400 to 800° C. for a time period of 50 to 200 hours to form a shape memory alloy.

Abstract: Disclosed is a deep neural network-based method and apparatus for combining noise and echo removal. The deep neural network-based method for combining noise and echo removal according to one embodiment of the present invention may comprise the steps of extracting a feature vector from an audio signal that includes noise and echo; and acquiring a final audio signal from which both noise and echo have been removed, by using a combined nose and echo removal gain estimated by means of the feature vector and deep neural network DNN.

Abstract: A controller hardware in the loop (CHIL) interface is disclosed. The CHIL interface comprises software and hardware that redirects a signal flow, including modulation signals and measurements exchanged between controller logic and a power electronics converter (PEC), to a CHIL port. Accordingly, the CHIL port provides access to the controller logic, at a digital level, throughout phases of the controller's lifetime (i.e., design, installation, maintenance, upgrade). Thus, the CHIL interface facilitates the use of PEC simulators for testing. The CHIL interface can detach the actual PEC from the control logic so testing can be performed with or without an operating PEC and can avoid the need for dedicated and error prone signal conditioning circuitry that is external to the controller.

Abstract: A method for detecting a pattern of events, comprising: receiving a template defining the pattern of events to detect; producing a join query for a relational database from the template; selecting a cost function for the join query, wherein a computation cost of the join query is equivalent to a computation cost of matching between a plurality of events from a plurality of streams of events and the template; identifying a preferred plan for executing the join query according to a minimal value of the cost function; producing an ordered set of a plurality of patterns, according to the preferred plan, by converting a plurality of database operations of the preferred plan into the ordered set of the plurality of patterns; and using the ordered set as an input for detecting a plurality of matches between the plurality of patterns and the plurality of events.

Abstract: A multi-hypervisor system, comprising: a plurality of hypervisors comprising a first hypervisor and a second hypervisor, at least one of the plurality of hypervisors being a transient hypervisor; and at least one Span VM, concurrently executing on each of the plurality of hypervisors, the at least one transient hypervisor being adapted to be dynamically at least one of injected and removed under the at least one Span VM concurrently with execution of the at least one Span VM on another hypervisor, wherein the at least one Span VM has a single and consistent at least one of memory space, virtual CPU state, and set of input/output resources, shared by the plurality of hypervisors.

Abstract: A wavefront sensor system suitable for integration into an integrated circuit light detector may provide for wave angle sensors having varying functional relationships between the wave angle and signal to provide improved dynamic range. These wave angle sensors may be combined with integrated circuit phase angle sensors for a more complete analysis of the waveform.

Abstract: Antiviral protease inhibitors are disclosed, along with related antiviral dipeptidyl compounds, macrocyclic derivatives thereof and methods of using the same to treat or prevent viral infection and disease from coronaviruses, caliciviruses, and picornaviruses.

Abstract: A free standing liquid membrane is disclosed that can selectively separate objects based on the kinetic energy value of the objects such that either an object having a first kinetic energy value can pass through the free standing liquid membrane while retaining the membrane and/or an object having a second kinetic energy value is prevented from passing through the membrane while retaining the membrane. Advantageously, the free standing liquid membrane can remain intact for seconds to hours with multiple objects passing through the membrane.

Abstract: Described are compositions containing quinones that show activity in enhance DNA repair and/or prevent damage to DNA and/or upregulate genes associated with wound healing. The quinones are thymoquinone, lapachol, myrtucommulone C, or mixtures thereof, and can be formulated into cosmetic compositions for topical administration to a subject in need thereof. The cosmetic compositions can also include sunscreens, surfactants, sunless tanning agents, desquamation agents, antiperspirants, colorants, preservatives and mixtures; and a cosmetically acceptable carrier. The compositions should find use in methods for treating the signs of ageing in mammals, dermatitis and wound healing via topical application to a site in need thereof, such as the skin or hair of the mammals or a wound site.

Abstract: A first radial force value and a second radial force value is received by a radial magnetic bearing controller. Coefficients are computed for a first equation using the first and second radial force values. The first equation is solved to define first solution values. A second solution value paired with each first solution value is computed using the first radial force value and a respective first solution value to define second solution values. Control current sets are computed for each unique paired solution of the second solution values and the first solution values. Each control current set includes a control current value for each of three control currents. A control current value for each of the three control currents is selected from the control current sets. The control current value for each of the three control currents is output to a respective radial winding of a three-pole radial magnetic bearing.

Abstract: Systems and techniques are provided for a resource stabilization in a distributed network. A computing device in a distributed network may check the median value of a transactional resource in relation to a specified external resource. The computing device in the distributed network may compare the median value of the transactional resource to a threshold value for the transactional resource to determine whether the median value of the transactional resource is above the threshold value or below the threshold value. The supply of the transactional resource in the distributed network may be increased in response to determining that the transactional resource is above the threshold value or may be in response to determining that the transactional resource is below the threshold value.

Abstract: A directional overcurrent relay using a superconducting fault current limiter voltage as a relay element includes: a current measuring circuit measuring a current of a line connected from a system power source to a load, a voltage measuring circuit measuring a voltage at both ends of a superconducting fault current limiter connected to the line, and a correcting circuit correcting a tripping time Ttrip by using a fault current If that is the current of the line and a superconducting fault current limiter voltage VSFCL that is the voltage at both ends of the superconducting fault current limiter and the tripping time Ttrip is maintained consistently regardless of whether the superconducting fault current limiter operates or not.