Abstract: A p53 degradation inducing molecule which can induce degradation of p53 proteins or p53 composites, and a pharmaceutical composition containing said p53 degradation inducing molecule are provided. This p53 degradation inducing molecule is a conjugate of a p53 affinity molecule which has affinity for p53 proteins or p53 composites, and a proteolysis induction tag which has affinity for protease and which does not inhibit proteolysis of proteins by protease.

Abstract: A method or apparatus for creating a three-dimensional tissue construct of a desired shape for repair or replacement of a portion of an organism. The method may comprise injecting at least one biomaterial in a three-dimensional pattern into a first material such that the at least one biomaterial is held in the desired shape of the tissue construct by the first material. The apparatus may comprise an injector configured to inject at least one biomaterial in a three-dimensional pattern into a first material such that the at least one biomaterial is held in the desired shape of the tissue construct by the first material. The first material may comprise a yield stress material, which may be a material exhibiting Herschel-Bulkley behavior. The tissue construct may have a smallest feature size of ten micrometers or less.

Abstract: The present disclosure relates to a novel and improved synthesis of 5-hydroxymethylfurfural (HMF) from a glucose source. The synthesis of 5-hydroxymethylfurfural (HMF) is carried out by reacting a mixture comprising a Brønsted acid, a Lewis acid, water, dimethyl sulfoxide (DMSO), acetonitrile, and a glucose source.

Abstract: In one aspect, the disclosure relates to methods for preparation of intermediates useful for the preparation of terpenoid cores. In a further aspect, the disclosed methods pertain to the preparation of compounds comprising a terpenoid core or scaffold, such as 6/7/5 tricycloalkanes. The disclosed methods utilize abundant starting materials and simple reaction sequences that can be used to tunably and scalably assemble common terpenoid cores. In various aspects, the present disclosure pertains to compounds prepared using the disclosed methods. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

Abstract: A field effect transistor (FET) biosensor for virus detection of a selected virus within a sample volume is disclosed. The FET comprises a semiconductor substrate, a source and drain electrode on the substrate, the electrodes spaced to form a channel. A gate electrode carried on the substrate and located in the channel between the source and drain electrodes. An insulating layer is coupled to a top surface of the gate electrode and a bottom surface of the source and drain electrodes, with an open channel above the insulating layer. A channel material is coupled to the insulating layer. Aptamers are oriented within the open channel to bind to the channel material and with the selected virus to enable a detection of the selected virus by the FET biosensor based on a change in drain-source current at a selected gate voltage.

Abstract: Disclosed herein are amide 7-carboxybenzo[1,2,3]thiadiazoles and derivatives thereof having a general Formula I, as described herein. Combinations and compositions of these compounds are also disclosed. The compounds and compositions can be used as a plant stimulant. For example, the compounds compositions can be used to regulate the plant's growth, regulate the plant's metabolic processes, regulate the plant's physiological processes, prevent against effects of biotic stress in the plant, or prevent against effects of abiotic stress in the plant. In some embodiments, the composition can provide multiple disease resistance to plants infected with a fungus, virus, or bacteria.

Abstract: An implant is provided comprising a substrate having one or more nanoceria coatings coated at least partially thereon, wherein the one or more nanoceria coatings comprise surface cerium having a 3+/4+ oxidation state ratio such that the one or more nanoceria coatings exhibit catalase mimetic activity, superoxide dismutase mimetic activity, or both. Methods are provided for forming a nanoceria coaling. The coating has nanoceria having a surface cerium 3+/4+ oxidation state ratio such that such that the coating exhibits catalase mimetic activity, superoxide dismutase mimetic activity, or both. Also disclosed is a method of reducing degradation of an implant by placing nanoceria in proximity to a bone-implant interface.

Abstract: An improved method of performing object segmentation and classification that reduces the memory required to perform these tasks, while increasing predictive accuracy. The improved method utilizes a capsule network with dynamic routing. Capsule networks allow for the preservation of information about the input by replacing max-pooling layers with convolutional strides and dynamic routing, allowing for the reconstruction of an input image from output capsule vectors. The present invention expands the use of capsule networks to the task of object segmentation and medical image-based cancer diagnosis for the first time in the literature; extends the idea of convolutional capsules with locally-connected routing and propose the concept of deconvolutional capsules; extends the masked reconstruction to reconstruct the positive input class; and proposes a capsule-based pooling operation for diagnosis.

Abstract: Embodiments of the present disclosure provide for electroactive supramolecular polymeric assemblies, methods of making electroactive supramolecular polymeric assemblies, methods of using electroactive supramolecular polymeric assemblies, and the like.

Abstract: Thermoelectric devices and methods of using thermoelectric devices. A thermoelectric device includes a thermoelectric element comprised of a material having a non-zero Berry curvature. The device may operate as a Nernst generator that generates electricity in response to application of a temperature gradient to the thermoelectric element, or as an Ettingshausen cooler that pumps heat into or out of an object to be heated or cooled in response to application of a current to the thermoelectric element. In either application, the non-zero Berry curvature of the material allows the device to operate without an externally applied magnetic field.

Abstract: Provided are a microscope apparatus and a method for correcting a position of a light source according to an exemplary embodiment of the present disclosure. The microscope apparatus for correcting the position of the light source according to the exemplary embodiment of the present disclosure includes: a light source unit which includes a light emitting element array including multiple light emitting elements and is configured to emit light to a subject; an optical unit which is disposed in parallel with the subject and configured to form an enlarged image of the subject to which the light is emitted; an image sensor which is configured to acquire the enlarged image of the subject by capturing the enlarged image formed by the optical unit; and a processor which is operably connected to the light source unit, the optical unit, and the image sensor and corrects a position of the light source unit based on the image acquired by the image sensor.

Abstract: Disclosed herein are methods for neurostimulation therapy for spinal cord injury. More particularly, the present invention relates to methods for neurostimulation therapy for spinal cord injury. More particularly, the present invention relates to methods for providing multiple independent, simultaneous waveforms in neurostimulation therapy while minimizing or substantially eliminating undesirable interactions between the waveforms.

Abstract: A reactive burning rate accelerator is provided that is configured to be at least partially embedded in a solid energetic material and comprises at least one metallic component and at least one non-metallic component. The reactive burning rate accelerator is configured to ignite and combust to increase the mass burning rate of the solid energetic material. Also provided are solid energetic materials comprising the reactive burning accelerator and methods of manufacturing and using the same.

Abstract: A biochemical detection device with a controlled reaction incubation time includes a substrate; a probe disposed on the substrate; a dissolvable material layer disposed on the substrate, wherein the dissolvable material layer has a first opening defined therein, wherein the probe is received in the first opening; an absorbing material layer disposed on the dissolvable material layer and having a second opening defined therein, wherein the first opening communicates with the second opening and is smaller than the second opening; and a non-dissolvable material layer disposed on an inner face of the second opening of the absorbing material layer and on an exposed top face of the dissolvable material layer.

Abstract: A system including a first micro-retarder array, wherein the first micro-retarder array is configured to convert a purely polarized light of an incident light into two components. The system additionally includes an optical device, wherein the optical device is configured to collimate the two components to two foci planes. Moreover, the system includes a second micro-retarder array, wherein the second micro-retarder array is configured to combine a set of two components of the incident light, thereby producing a second purely polarized light. Further the system includes a detector, wherein the detector is configured to receive the second purely polarized light.

Abstract: Systems, methods, and apparatus for meta-materials which are stretchable and tunable using an array of liquid conductor meta-atoms encased in one or more layers of elastomer. Fabrication techniques allow effective manufacture of the metamaterial in a number of form factors for a number of applications, including but not limited to fabrics or wraps around three-dimensional shapes.

Abstract: Metamaterials are provided that may include a first substrate including a high temperature dielectric material, and a first array of conductive resonators arranged on the first substrate. The conductive resonators may include a noble metal, a noble metal alloy, a high temperature ceramic semiconductor, or a combination thereof. Radomes including metamaterials also are provided.

Abstract: Provided are an engineering plastic composite and a method for producing the same. The engineering plastic composite includes a carbon fiber having a surface modified by a hydrogen plasma and including a functional group and an engineering plastic. The carbon fiber is mixed with the engineering plastic to constitute a composite.

Abstract: Electrochemical cells and photoelectrochemical cells for the reduction of furfurals are provided. Also provided are methods of using the cells to carry out the reduction reactions. Using the cells and methods, furfurals can be converted into furan alcohols or linear ketones.

Abstract: Provided are an apparatus and method for K-edge based interior tomography image processing. The apparatus efficiently performs tomography image reconstruction by acquiring different material images using an energy-selective detector, such as a photon counting detector.