Abstract: Devices and methods can be used to treat long gap esophageal atresia, while obviating much of the delay and complexities associated with current procedures. The devices and methods involve actively stretching the esophagus portions with traction to promote growth of the esophagus portions. Moreover, the devices and methods provided allow for a compression anastomosis to occur between the esophageal ends. This eliminates the need for a second operation to suture the esophageal ends together.
Type:
Grant
Filed:
April 12, 2019
Date of Patent:
May 18, 2021
Assignee:
Mayo Foundation for Medical Education and Research
Abstract: A variable speed drive for an electrostatic motor provides feedback control according to rotor position and/or rotor rotational rate deduced from back currents (back-MMF). Extraction of the back currents is performed by a modeling of the stator and the development of isolated stator voltages from plate voltage measurements.
Type:
Grant
Filed:
September 10, 2019
Date of Patent:
May 18, 2021
Assignee:
Wisconsin Alumni Research Foundation
Inventors:
Daniel Colin Ludois, Aditya N. Ghule, Peter Killeen
Abstract: Disclosed is a bus stop using a large-scale perovskite solar cell in which a perovskite solar cell is prepared using a hybrid structure including a graphene-carbon nanotube. The bus stop includes a body unit fixed to the ground to maintain the overall shape, a solar cell unit for producing electrical energy from sunlight, and an energy storage system (ESS) for storing the electrical energy produced by the solar cell part.
Type:
Grant
Filed:
August 17, 2020
Date of Patent:
May 18, 2021
Assignee:
Pusan National University Industry-University Cooperation Foundation
Inventors:
Sung Ho Jin, Jinhwan Yoon, Heon Cheol Shin, Yang Do Kim, Jin Woo Oh, Sung Il Ahn, Hyun Deog Yoo, Hyung Woo Lee, Mi Ra Kim
Abstract: The present invention provides halogenated quinoline derivatives, such as compounds of Formula (I) or (I?), and pharmaceutically acceptable salts thereof, and methods of preparing the halogenated quinoline derivatives. The halogenated quinoline derivatives are expected to be antimicrobial agents and may act through an iron(II)-dependent mode of action. The present invention also provides pharmaceutical compositions, kits, uses, and methods that involve the halogenated quinoline derivatives and may be useful in preventing or treating a microbial infection (e.g., a bacterial infection) in a subject, inhibiting the growth and/or reproduction of a microorganism (e.g., a bacterium), killing a microorganism (e.g., a bacterium), inhibiting the formation and/or growth of a biofilm, reducing or removing a biofilm, and/or disinfecting a surface.
Type:
Grant
Filed:
September 23, 2016
Date of Patent:
May 18, 2021
Assignee:
University of Florida Research Foundation, Incorporated
Inventors:
Robert William Huigens, III, Akash Basak, Yasmeen Abouelhassan
Abstract: Devices, systems, and methods for determining a distance between at least two points are disclosed and described, wherein interferometry technology is utilized to determine such distances.
Abstract: The present invention describes compositions and method for improving outcomes after injury to the central nervous system wherein complement signaling is activated. In one aspect, the method comprises administering to a subject a therapeutically effective amount of a therapeutic agent comprising a targeted inhibitor molecule comprising a targeting portion and an inhibitor portion, wherein the molecule inhibits complement, and wherein therapeutic agent is administered in combination with rehabilitation therapy or thrombolytic agent.
Type:
Grant
Filed:
October 17, 2017
Date of Patent:
May 18, 2021
Assignees:
MUSC Foundation For Research Development, United States Government as Represented by the Department of Veterans Affairs
Inventors:
Stephen Tomlinson, DeAnna Adkins, Ali Alawieh
Abstract: A method for preparing a nanowire or nanorod on a patterned monolayer or thin film supported by a 2D material substrate in a nonpolar environment comprises the steps of: functionalizing a supporting 2D material substrate using a patterned monolayer or thin film of a polymerized amphiphiles comprising both hydrophobic and hydrophilic constituents; and then growing a nanowire or nanorod on the functionalized supporting 2D material substrate in a salt solution or suspension, wherein the patterned monolayer or thin film comprises a polymerizable phospholipid with a terminal amine. A gold nanowire or nanorod so prepared has a highly controlled diameter of about 2 nm, and a length of about 100 nm, dependent in part on molecular domain sizes in the monolayer.
Abstract: The present disclosure generally relates to novel compounds as a fatty acid synthase inhibitor useful for the treatment of infection diseases, cancers, or metabolic diseases that malfunction of fatty acid synthase is involved. In particular this present invention directs to malonyl-coenzyme A (CoA) mimetics and methods of use thereof. The invention described herein also pertains to pharmaceutical compositions and methods for treating diseases in mammals using compounds disclosed herein.
Abstract: A permanent magnet synchronous motor includes a stator, a rotor rotatable relative to the stator, and a magnetic structure with a low coercive force magnet and a high coercive force magnet that are arranged magnetically in series with respect to each other to define a pole-pair of the permanent magnet synchronous motor. A magnetization level of the low coercive force magnet is changeable by a stator current pulse such that a stator magnetomotive force at a rated current is equal to or larger than a product of a magnetic field strength for fully magnetizing the low coercive force magnet and a thickness of the low coercive force magnet.
Type:
Grant
Filed:
July 31, 2015
Date of Patent:
May 18, 2021
Assignees:
Nissan Motor Co., Ltd., Wisconsin Alumni Research Foundation
Inventors:
Kensuke Sasaki, Takashi Fukushige, Takashi Katou, Apoorva Athavale, Robert D. Lorenz
Abstract: Double stranded mRNA (ds mRNA), e.g., produced in vitro, where one strand encodes a protein of interest and the other strand is hydrogen bonded to at least a portion of the coding region for the protein, as well as methods of making and using the ds mRNA, are provided.
Abstract: Described herein are methods and compositions relating to tunable nanoporous coatings. In certain aspects, described herein are methods and compositions wherein a tunable nanoporous coating comprises a tunable nanoporous membrane which transitions from opaque to transparent upon the application of force, and from transparent to opaque after washing with a solvent.
Type:
Grant
Filed:
February 15, 2019
Date of Patent:
May 18, 2021
Assignee:
University of Florida Research Foundation, Inc.
Abstract: The present invention relates to methods of treating a subject suffering from or at risk of suffering from graft versus host disease (GvHD) comprising administering a therapeutically effective amount of at least one of pregnancy specific glycoprotein 1 (PSG1) or PSG9 to a subject in need thereof.
Type:
Grant
Filed:
September 16, 2016
Date of Patent:
May 18, 2021
Assignees:
The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., The United States of America, as represented by the Secretary, Department of Health and Human Services
Abstract: A data receiving circuit may include: a variable delay circuit suitable for generating a delayed strobe signal by delaying a strobe signal; a receiving circuit suitable for sampling data in synchronization with the delayed strobe signal; a phase shift circuit suitable for generating a shifted strobe signal by shifting a phase of the delayed strobe signal; a phase comparison circuit suitable for comparing phases of the data and the shifted strobe signal; and a delay adjusting circuit suitable for adjusting a delay value of the variable delay circuit in response to the phase comparison result of the phase comparison circuit.
Type:
Grant
Filed:
September 25, 2019
Date of Patent:
May 18, 2021
Assignees:
SK hynix Inc., Seoul National University R&DB Foundation
Abstract: A system for generating cold plasma is presented, suitable for use in in-vivo treatment of biological tissue. The system comprising: a control unit connectable to an elongated member at a first proximal end of the elongated member. The elongated member comprises a plasma generating unit at a second distal end thereof and gas and electricity transmission channels extending from said first proximal end towards said plasma generating unit. The control unit comprises a gas supply unit configured to provide predetermined flow rate of selected gas composition through said gas transmission channel and a power supply unit configured to generate selected sequence of high-frequency electrical pulses, typically in mega Hertz range, directed through said electricity transmission channel, thereby providing power and gas of said selected composition to the plasma generating unit for generating cold plasma.
Type:
Grant
Filed:
November 19, 2015
Date of Patent:
May 18, 2021
Assignees:
Technion Research & Development Foundation Limited, Rambam Med-Tech Ltd.
Abstract: An analog-to-digital converter (ADC) includes an input circuit configured to receive a first analog signal output from a first sensor or a second analog signal output from a second sensor according to an operation mode and a bit stream; a filter configured to filter an output signal from the input circuit; a quantization circuit configured to generate the bit stream from an output signal of the filter; and a digital circuit configured to generate a first digital signal corresponding to the first analog signal or a second digital signal corresponding to the second analog signal by filtering the bit stream, wherein the operation mode includes a first mode selecting the first sensor and a second mode selecting the second sensor, and wherein the digital circuit refers to the second digital signal generated during the second mode to generate the first digital signal during the first mode.
Type:
Grant
Filed:
November 22, 2019
Date of Patent:
May 18, 2021
Assignee:
Seoul National University R&DB Foundation
Abstract: The present invention relates to a nitrogen-doped sulfide-based solid electrolyte for all-solid batteries. The a nitrogen-doped sulfide-based solid electrolyte for all-solid batteries includes a compound with an argyrodite-type crystal structure represented by the following Formula 1: LiaPSbNcXd??[Formula 1] wherein 6?a?7, 3<b<6, 0<c?1, 0<d?2, and each X is the same or different halogen atom selected from the group consisting of chlorine (Cl), bromine (Br), and iodine (I).
Type:
Grant
Filed:
October 17, 2018
Date of Patent:
May 18, 2021
Assignees:
Hyundai Motor Company, Kia Motors Corporation, IUCF-HYU (Industry-University Cooperation Foundation Hanyang University)
Inventors:
Ju Yeong Seong, Yong Jun Jang, Hong Seok Min, Sa Heum Kim, Yong Sub Yoon, Pil Gun Oh, Dong Wook Shin, Chan Hwi Park, Jin Oh Son
Abstract: The present invention relates to a pharmaceutical composition containing stem cells in which vascular endothelial growth factor (VEGF) is overexpressed as an effective ingredient for preventing or treating neurodegenerative diseases. The stem cells in which VEGF is overexpressed according to the present invention effectively act against the neurodegenerative disease-induced VEGF reduction of neural stem cells in the SVC to inhibit the abnormal migration of neural stem cells, suppress inflammatory responses, and restrain the accumulation of cholesterol and spingolipids in the cerebral cortex, thus restoring the behavior exercise capacity of animal models, whereby the pharmaceutical composition can be used as an effective therapeutic agent for neurodegenerative diseases.
Type:
Grant
Filed:
February 3, 2017
Date of Patent:
May 18, 2021
Assignee:
Kyungpook National University Industry-Academic Cooperation Foundation
Inventors:
Jae Sung Bae, Hee Kyung Jin, Min Hee Park
Abstract: An apparatus method for driving light emitting diodes (LEDs), comprising: receiving an alternating current input; producing a DC current having a voltage with an AC-DC boost power-factor correction stage, having a variable-frequency operation, and a set of switches controlled in dependence on the voltage to limit a peak LED current; and producing an LED drive current with a DC-DC power conversion stage having a set of switches to selectively pulse-width modulate the LEDs to control a brightness, wherein the set of switches in the AC-DC boost power-factor correction stage and the set of switches in the DC-DC power conversion stage are each controlled to switch at zero current.
Type:
Grant
Filed:
May 15, 2020
Date of Patent:
May 18, 2021
Assignee:
The Research Foundation for The State University