Abstract: A lyophilization method for lyophilizing products inside one or more vials within a lyophilization chamber is disclosed which includes humidifying a charge gas to a predetermined relative humidity, cooling shelves in the lyophilization chamber to a predetermined temperature, pressurizing the chamber with the humidified charge gas to a pressurization threshold to thereby achieving a target relative humidity level within the lyophilization chamber, and suddenly releasing pressure within the lyophilization chamber until a depressurization threshold is reached in a short time interval up to about 4 seconds, during the depressurization, product inside one or more vials nucleate.

Abstract: A method of manufacturing a CNT paste emitter in accordance with an exemplary embodiment of the present disclosure includes a process of mixing first CNT powder, graphite nanoparticles, SiC nanoparticles, Ni nanoparticles, a dispersant and distilled water and then performing a dispersion process by means of ultrasonication, a process of acquiring second CNT powder by filtering a solution dispersed during the dispersion process, a process of mixing the second CNT powder with a graphite binder and then preparing a CNT paste by means of ball milling, and a process of forming an interface layer on a metal or graphite substrate and then bonding the CNT paste.

Abstract: A data processing system and method for accessing a heterogeneous memory system including a processing unit are provided. The heterogeneous memory system includes a memory module and high bandwidth memory (HBM) including a processing-in-memory (PIM) circuit combined with a memory controller. The memory controller is configured to detect a data array required for an arithmetic operation from a memory module or the HBM by using a border index value when the arithmetic operation is performed by the PIM circuit of the HBM and generate a memory module command set and an HBM command set using physical address spaces respectively designated in the memory module and the HBM.

Abstract: Provided herein are methods for detecting a Ewing sarcoma breakpoint region 1 (EWSR1) fusion gene encoding a neoantigen (e.g., in a patient sample), as well as methods of prognosis and treatment related thereto, in some embodiments, the methods further comprise administering a cancer immunotherapy. In some embodiments, the EWSR1 fusion gene is a fusion gene between EWSR1 and WT1, Fill, ERG, FEV, NR4A3, ATF1, CREB1, CREM, CREB3L/CREB3L2, PA7Z1, NFATC2, KLFI5, C11orf93, ZNF444, PBX1, DDIT3, or TFCP2 that encodes a neoantigen.

Abstract: The present disclosure relates to magnetic resonance imaging technology for simultaneously measuring a plurality of magnetic resonance imaging parameters.

Abstract: This document relates to materials and methods for treating cancer. For example, this document provides materials and methods for using PD-L1 targeting domains in bispecific chimeric polypeptides, chimeric transmembrane polypeptides, genetically modified viruses, nucleic acid vectors, and/or fusion-inducing cells to treat cancer.

Abstract: A method performed by a peer to peer healthcare payment platform includes receiving a first amount of resources from one or more first donors in a first account associated with a first patient. The first account stores the first amount of resources and a second amount of surplus resources associated with the first patient. The method further includes receiving a payment request from the first patient. In response to receiving the payment request, the method includes determining if the outstanding medical fee associated with the first patient is greater than the sum of the first amount of resources and the second amount of surplus resources. If the outstanding medical fee is greater than said sum, the method includes identifying one or more second pairing patients for the first patient to fund the fee.

Abstract: The present invention provides a compound having the structure: and use of the compound for inhibiting the growth of or killing

Abstract: A method, implemented by a computer, for positioning based on heterogeneous networks comprises: estimating a position of a personal mobility device (PMD) based on a first wireless signal; determining whether the PMD is within an intermediate area between a first area and a second area, based on an estimated position of the PMD; determining whether the PMD moves to the second area, by using both the first wireless signal and a second wireless signal; and determining position of the PMD by using any one of the first wireless signal and the second wireless signal based on a movement of the PMD to the second area.

Abstract: Provided are a device and method for human parsing. The method includes receiving at least one piece of image data and ground truth values for human parsing, generating a height distribution map and a width distribution map for the image data, acquiring attention maps and scaled feature maps for each of a height and a width of the image data using the distribution maps, calculating a distribution loss rate by concatenating the scaled feature maps, acquiring an improved feature map on the basis of the calculated distribution loss rate, and performing human parsing on an object included in the image data using the improved feature map.

Abstract: A tactile die for playing a game, the die comprising a plurality of sides, wherein each side comprises a face having a braille character, each side comprises 3 or more raised border edges surrounding the face, and wherein one of the 3 or more raised border edges is an indicator edge configured to indicate an orientation of the face, the indicator edge comprising an indent along a length thereof.

Abstract: A method for analyzing dynamic mode change of an anisotropic material includes performing modal analysis of a first physical force applied to an isotropic material specimen and a first vibration signal collected from the isotropic material specimen, acquiring a first modal parameter of the isotropic material specimen, based on the modal analysis result, performing modal analysis of a second physical force applied to the anisotropic material specimen and a second vibration signal collected from the anisotropic material specimen, acquiring a second modal parameter of the anisotropic material specimen, based on the modal analysis result, acquiring a modal assurance criterion (MAC) for each mode of the anisotropic material specimen, based on the first and second modal parameters, and acquiring each similar mode of the anisotropic material specimen to each mode of the isotropic material specimen.

Abstract: In a floating gate semiconductor nanostructure biosensor and a method for manufacturing the biosensor, the nanostructure biosensor includes a substrate, an insulating layer, a nanostructure, a source electrode and a drain electrode, a floating gate and a biological sensing material. The insulating layer is formed on the substrate. The nanostructure is protruded from the insulating layer. The source electrode and the drain electrode are formed on the insulating layer and dispose the nanostructure therebetween. The floating gate has a metal pattern or a polysilicon pattern, and extends with contacting the nanostructure. The biological sensing material has a first end combined with an immobile molecule on the floating gate, and a second end combined with a bio molecule.

Abstract: A thermoelectric conversion element includes a thermoelectric conversion material portion having a compound semiconductor composed of first base material element A and second base material element B and represented by Ax-cBy with value of x being smaller by c with respect to a compound AxBy according to a stoichiometric ratio, a first electrode disposed in contact with the thermoelectric conversion material portion, and a second electrode disposed in contact with the thermoelectric conversion material portion and apart from the first electrode. An A-B phase diagram includes a first region corresponding to low temperature phase, second region corresponding to high temperature phase, and third region corresponding to coexisting phase, sandwiched between the low temperature phase and the high temperature phase, in which the low and high temperature phases coexist. A temperature at a boundary between the first region and the third region changes monotonically with a change in c.

Abstract: The present disclosure provides a protective film for a lithium electrode and a lithium electrode for a lithium secondary battery including the same. The protective film includes a first layer, which includes polyvinyl alcohol (PVA) and polyacrylic acid (PAA) and is porous, and a second layer, which is disposed on the first layer, includes a styrene-butadiene-styrene block copolymer, and is porous.

Abstract: An optical sensor system, comprising refractory plasmonic elements that can withstand temperatures exceeding 2500° C. in chemically aggressive and harsh environments that impose stress, strain and vibrations. A plasmonic metamaterial or metasurface, engineered to have a specific spectral and angular response, exhibits optical reflection characteristics that are altered by varying physical environmental conditions including but not limited to temperature, surface chemistry or elastic stress, strain and other types of mechanical load. The metamaterial or metasurface comprises a set of ultra-thin structured layers with a total thickness of less than tens of microns that can be deployed onto surfaces of devices operating in harsh environmental conditions. The top interface of the metamaterial or metasurface is illuminated with a light source, either through free space or via an optical fiber, and the reflected signal is detected employing remote detectors.

Abstract: Compositions and methods for reprogramming glial cells into neurons are provided. The method entails using a combination of insulin and forskolin generate neurons. The neurons may be generated by converting glial cells into the neurons. The compositions and methods may also include one or both of Vitamin C (VC) and Crizotinub (Cri). Articles of manufacture are provided which include at least one pharmaceutical formulation, packaging, and printed material providing an indication and/or instruction for using the described compounds.

Abstract: The present invention relates to a composition for inhibiting the toxicity with respect to nanoparticles and particulate matters generated from the environment. Since it has been confirmed that a decrease in intracellular ATP, a decrease in cell viability, inflammation-induced morphological changes in cells and cell activation, which are induced by nanoparticles or environmentally-derived particulate matters, are inhibited by means of the composition of the present invention, the composition may be utilized as a reducing substance for the toxicity of nanoparticles and particulate matters.

Abstract: A method for controlling a controlled system by a control device, the method may include transmitting multiple actuation signals to multiple degree of freedom (DOF) points of the controlled system; wherein the multiple actuation signals comprise multiple alternating current (AC) components that are mutually orthogonal, measuring at least one feedback signal from at least one probe point of the controlled system; wherein a number of DOF points exceeds a number of the at least one probe point; determining, based upon the at least one feedback signal, values of line search pulses to be sent to the multiple DOF points during at least one line search iteration; and performing the at least one line search iteration.

Abstract: In one aspect, compounds and compositions that inhibit TXNIP expression and/or that lower hepatic glucose production and methods of identifying, making, and using same are disclosed. The disclosed compounds and compositions can be useful for disorders associated with elevated TXNIP and/or elevated glucagon levels such as, for example, diabetes and associated disorders. Further provided are methods for treating hyperlipidemia or fatty liver disease, optionally associated with elevated TXNIP and/or elevated glucagon levels. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.