Patents Assigned to Foundation
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Patent number: 10434515Abstract: A microfluidic device can include a temperature regulator positioned to generate a temperature gradient across a thermally controlled portion of the microfluidic device from a high temperature region to a low temperature region. Additionally, the microfluidic device can include a bi-directional microfluidic serpentine pathway having a first terminus and a second terminus. The bi-directional microfluidic serpentine pathway can be oriented along a longitudinal direction transverse to the temperature gradient. Further, the bi-directional microfluidic serpentine pathway can include a plurality of oscillation segments fluidly coupling the first terminus to the second terminus and forming a flow path adapted to oscillate a fluid between the high temperature region and the low temperature region. The bi-directional microfluidic serpentine pathway can have a uniform cross section to facilitate bi-directional flow.Type: GrantFiled: October 3, 2017Date of Patent: October 8, 2019Assignee: University of Utah Research FoundationInventors: Raheel Samuel, Bruce Gale, Alex Jafek, James Trauba, Kenneth Aston
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Patent number: 10434128Abstract: Provided is a method of treating ovotoxicity of an individual, including administering an Ulmi cortex extract to an individual in need of treatment. The present disclosure may exhibit an effect of preventing, alleviating, or treating ovarian aging or premature ovarian failure by inhibiting oxidative stress or ovotoxicity of the ovaries.Type: GrantFiled: June 28, 2018Date of Patent: October 8, 2019Assignee: Dongguk University Gyeongju Campus Industry-Academy Cooperation FoundationInventors: Dong Il Kim, Ju Hee Lee, Deok Ho Kim, Jae Hyun Han, Su Hyun Kim
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Patent number: 10439250Abstract: Method of making solid-state electrolyte with composition formula Li7-xLa3Zr2-xBixO12. The method includes making a polymerized complex of the metal-ions of the composition formula, and making an agglomerate therefrom to be calcined and sintered to produce the solid-state electrolyte. A solid-state electrolyte with the composition formula Li7-xLa3Zr2-xBixO12 with superior ionic conductivity by choice of the value of x and processing conditions. A battery employing a solid-state electrolyte of superior ionic conductivity with the composition formula Li7-xLa3Zr2-xBixO12.Type: GrantFiled: November 10, 2015Date of Patent: October 8, 2019Assignee: Purdue Research FoundationInventors: Derek Karl Schwanz, Esteban Ernesto Marinero-Caceres
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Patent number: 10438712Abstract: Methods of producing and isolating 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61Cu, 99mTc, 45Ti, 13N, 52Mn, or 44Sc and solution targets for use in the methods are disclosed. The methods of producing 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61Cu, 99mTc, 45Ti, 13N, 52Mn, or 44Sc include irradiating a closed target system with a proton beam. The closed target system can include a solution target. The methods of producing isolated 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61Cu, 99mTc, 45Ti, 52Mn, or 44Sc further include isolating 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61Cu, 99mTc, 45Ti, 52Mn, or 44Sc by ion exchange chromatography. An example solution target includes a target body including a target cavity for receiving the target material; a housing defining a passageway for directing a particle beam at the target cavity; a target window for covering an opening of the target cavity; and a coolant gas flow path disposed in the passageway upstream of the target window.Type: GrantFiled: April 21, 2017Date of Patent: October 8, 2019Assignee: Mayo Foundation for Medical Education and ResearchInventors: Timothy R. DeGrado, Mukesh K. Pandey, John Byrne
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Patent number: 10434142Abstract: Compositions and methods are contemplated for treatment of a wound, and especially a sterile or TLR/NOD ligand-poor wound in which contemporaneous administration of a Ca2+-flux agonist (CFA) and a pattern recognition receptor (PRR) ligand improves wound healing.Type: GrantFiled: December 22, 2017Date of Patent: October 8, 2019Assignee: Chan Soon-Shiong Nanthealth FoundationInventors: Kayvan Niazi, Shahrooz Rabizadeh, Justin Golovato, Oleksandr Buzko, Anne-Laure Le Ny, Patrick Soon-Shiong
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Patent number: 10434081Abstract: A method for reducing macrophage migration inhibitory factor (MIF or MMIF) cytokine or its biological activity, including the step of administering an isothiocyanate functional surfactant to a patient having a disease or condition wherein MIF cytokine or its biological activity is implicated in the disease or condition.Type: GrantFiled: July 2, 2018Date of Patent: October 8, 2019Assignee: The William M. Yarbrough FoundationInventor: Michael E. Silver
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Patent number: 10433554Abstract: The present disclosure relates to deodorizing compounds and compositions for use in methods of repelling insects and methods of reducing or preventing the transmission of mosquito-borne pathogens.Type: GrantFiled: May 1, 2018Date of Patent: October 8, 2019Assignee: Ohio State Innovation FoundationInventors: Peter Marc Piermarini, William L. Marr
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Patent number: 10435418Abstract: A reaction method comprising combining a carbonyl-substituted arylboronic acid or ester and an ?-effect amine in aqueous solution at a temperature between about ?5 C to 55 C, and a pH between 2 and 8 to produce an adduct. A process is also provided comprising: contacting a boron compound having a boron atom bonded to a sp2 hybridized carbon conjugated with a cis-carbonyl, the boron having at least one labile substituent, with an ?-effect amine, in a solvent for a time sufficient to form an adduct, which may proceed to further products.Type: GrantFiled: September 11, 2017Date of Patent: October 8, 2019Assignee: The Research Foundation for the State University oInventors: Susan Bane Tuttle, Ozlem Dilek, Kamalika Mukherjee
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Patent number: 10438688Abstract: An in silico screening method generated compounds that are against laminin receptor 37LR and their anti-cancer functions in prostate cancer cell lines are disclosed herein. A group of derivatives based on the hit compound from the in silico screening are synthesized and tested with improved IC50 value that can have relevant clinical use for prostate cancer or osteoarthritis.Type: GrantFiled: August 27, 2018Date of Patent: October 8, 2019Assignee: Purdue Research FoundationInventors: Marxa L. Figueiredo, Charles Samuel Umbaugh, Herman O. Sintim, Adriana Diaz-Quinones
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Patent number: 10439248Abstract: Systems and methods are disclosed for enhancing the construction and application of batteries by providing a battery system comprising at least one electrochemical panel with at least one electrochemical cell disposed therein, which is configured to enable multi-purpose functionality and applicability of the battery system. Embodiments provide for electrodes and/or current collectors of each electrochemical cell that are transversely orientated with respect to each face of an electrochemical panel. Some embodiments provide for a separator pouch disposed about at least one electrode and/or current collector to electrically insulate the electrode and/or current collector from a structure component of the device. Each electrochemical panel is configured to enable electrical communication with another electrochemical panel and/or an ancillary electric circuit. Each electrochemical panel is configured enable utilization thereof as a structural component of an ancillary structure.Type: GrantFiled: November 26, 2014Date of Patent: October 8, 2019Assignee: The Penn State Research FoundationInventors: Christopher D. Rahn, Charles E. Bakis, Michael Hickner, Yancheng Zhang
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Patent number: 10435770Abstract: A carbothermic reduction method is provided for reducing a La-, Ce-, MM-, and/or Y-containing oxide in the presence of carbon and a source of a reactant element comprising Si, Ge, Sn, Pb, As, Sb, Bi, and/or P to form an intermediate alloy material including a majority of La, Ce, MM, and/or Y and a minor amount of the reactant element. The intermediate material is useful as a master alloy for in making negative electrode materials for a metal hydride battery, as hydrogen storage alloys, as master alloy additive for addition to a melt of commercial Mg and Al alloys, steels, cast irons, and superalloys; or in reducing Sm2O3 to Sm metal for use in Sm—Co permanent magnets.Type: GrantFiled: November 10, 2016Date of Patent: October 8, 2019Assignee: Iowa State University Research Foundation, Inc.Inventors: Karl A. Gschneidner, Jr., Frederick A. Schmidt
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Patent number: 10440659Abstract: The present disclosure relates to a 5th Generation (5G) or a pre-5G communication system provided to support a higher data transmission rate than a system beyond a 4th Generation (4G) communication system such as Long Term Evolution (LTE). The purpose of the present disclosure is to maximize adaptive transmission performance by designing a puncturing order and a repetition order individually in optimized order. An operation method of a transmission device for adaptive transmission of a codeword according to an embodiment of the present disclosure includes generating a codeword using a polar code and transmitting a packet including at least one codeword indicated by a repetition order when bit repetition is needed. The repetition order is determined based on at least one of channel polarization or channel quality information.Type: GrantFiled: December 22, 2016Date of Patent: October 8, 2019Assignees: Samsung Electronics Co., Ltd., Research & Business Foundation Sungkyunkwan UniversityInventors: Min Jang, Sang-Hyo Kim, Jong-Hwan Kim, Hyunseok Ryu, Wonjun Hwang, Eun Chong Baek, Kyungmin Lee
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Patent number: 10439851Abstract: Example systems and methods described herein relate to radio communication architectures and techniques for beamforming and down-conversion without a priori knowledge of the source location or frequency. An example radio receiver includes a plurality of antenna elements that include a first element, a second element, and a third element. The radio receiver also includes a plurality of mixers coupled to the plurality of antenna elements and a combiner coupled to the plurality of antenna elements. A signal incident on the first element is mixed with itself via a first mixer of the plurality of mixers. An output of the first mixer is mixed with a signal incident on the second element via a second mixer of the plurality of mixers, and an output of the second mixer is combined via the combiner with a signal incident on the third element.Type: GrantFiled: September 19, 2017Date of Patent: October 8, 2019Assignee: Ohio State Innovation FoundationInventors: Markus H. Novak, Satheesh Bojja Venkatakrishnan, John L. Volakis
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Patent number: 10434068Abstract: A microparticle for cell encapsulation is provided, having a core which comprises continuous fibers of decellularized extracellular matrix (ECM) and, optionally, an outer layer. Also provided are methods of encapsulating cells in the microparticle, pharmaceutical compositions comprising the microparticle, and methods of treating disease in animals employing the microparticles of the invention, for example, treating Diabetes.Type: GrantFiled: September 25, 2018Date of Patent: October 8, 2019Assignee: Technion Research & Development Foundation LimitedInventors: Marcelle Machluf, Deborah Chaimov
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Patent number: 10435755Abstract: Provided herein is technology for esophageal disorder screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of esophageal disorders (e.g., Barrett's esophagus, Barrett's esophageal dysplasia, etc.). In addition, the technology provides methods, compositions and related uses for distinguishing between Barrett's esophagus and Barrett's esophageal dysplasia, and between Barrett's esophageal low-grade dysplasia, Barrett's esophageal high-grade dysplasia, and esophageal adenocarcinoma within samples obtained through endoscopic brushing or nonendoscopic whole esophageal brushing or swabbing using a tethered device (e.g. such as a capsule sponge, balloon, or other device).Type: GrantFiled: March 23, 2016Date of Patent: October 8, 2019Assignees: Exact Sciences Development Company, LLC, Mayo Foundation for Medical Education and ResearchInventors: David A. Ahlquist, William R. Taylor, John B. Kisiel, Douglas W. Mahoney, Tracy C. Yab, Graham P. Lidgard, Hatim T. Allawi
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Patent number: 10437525Abstract: Methods for distributed storage in accordance with embodiments of the invention enable secret sharing. One embodiment includes encoding source data using an encoding system to produce a plurality of sets of encoded data, where: the source data can be recovered from at least a portion of less than all of the plurality of sets of encoded data; and the source data cannot be recovered using less than a threshold number of the plurality of sets of encoded data; storing each of the plurality of sets of encoded data on a storage device from a set of storage devices on which encoded data is stored; determining a set of storage devices that are available using a decoding system, where the set of storage devices that are available does not include all of the storage devices in the set of storage devices on which encoded data is stored.Type: GrantFiled: May 27, 2016Date of Patent: October 8, 2019Assignees: California Institute of Technology, The Research Foundation For the State University of New York, New Jersey Institute of TechnologyInventors: Wentao Huang, Michael Langberg, Joerg Kliewer, Jehoshua Bruck
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Patent number: 10433544Abstract: Provided herein are SDH substrates that have use as herbicides in treating pre-emergent and post-emergent weed control. The presently-disclosed subject matter includes an herbicide including SDH substrates such as ribitol and a growth inhibitive effective amount of another adjuvant SDH substrate and/or adjuvant. Methods of treating pre-emergent and post-emergent weeds comprising applying the herbicides disclosed herein in an effective amount to suppress weed growth are also provided.Type: GrantFiled: March 29, 2017Date of Patent: October 8, 2019Assignee: University of Kentucky Research FoundationInventors: Douglas Archbold, Marta Nosarzewski
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Patent number: 10435068Abstract: A suspension system for a vehicle may include a knuckle rotatably supporting a wheel and a plurality of arms connecting the knuckle with a vehicle body wherein an arm among the plurality of arms may be a virtual link formed by a virtual link module and a point at which the virtual link applies a constraint force to the knuckle may be formed at a virtual space.Type: GrantFiled: August 10, 2017Date of Patent: October 8, 2019Assignees: Hyundai Motor Company, Kia Motors Corporation, Seoul National University R&DB FoundationInventors: Seungmin Kwon, Yong Sub Yi, Seung Hoon Woo, Yoon Young Kim, Suh In Kim
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Patent number: 10435740Abstract: The subject invention pertains to a method of determining methylation state and chromatin structure of target loci. The method comprises treating the genetic material obtained from the cells with DNA methyltransferase, capturing target genetic loci using a set of oligonucleotides, ligating the target loci with oligonucleotide patches that flank the target loci, treating the target loci flanked by oligonucleotide patches with bisulfite, optionally amplifying the target loci by polymerase chain reaction, sequencing the PCR products, and analyzing the sequences to determine methylation state and chromatin structure of the target loci. The current invention also provides a method to identify genes associated with a disease. The invention also provides a method to detect cells suffering from a disease in a group of cells. The current invention also provides kits suitable for carrying out the method of determining methylation state and chromatin structure of the target loci.Type: GrantFiled: April 1, 2014Date of Patent: October 8, 2019Assignee: University of Florida Research Foundation, IncorporatedInventors: Michael P. Kladde, Nancy H. Nabilsi, Carolina E. Pardo
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Patent number: 10434322Abstract: A bio-stimulation robot includes a stationary platform, a plurality of drive modules coupled to the stationary platform, and a motion platform coupled to the drive modules to operate to change a position of the motion platform. Each of the drive modules includes a first guide member having an arc shape, a motion member coupled to the first guide, and a leg member having a first end coupled to the motion member and a second end fixed to the motion platform. The motion member slides along the first guide member. The second end of the leg member is rotatably connected to the motion platform. The second end of the leg member is rotatably connected to the motion platform.Type: GrantFiled: May 17, 2016Date of Patent: October 8, 2019Assignees: Center of Human-Centered Interaction for Coexistence, Industry University-Cooperation Foundation Hanyang University Erica CampusInventors: Sungon Lee, Jun-Woo Kim, Woo-Seok Ryu, Sung-Teak Cho, Hyung-Min Kim, Bum-Jae You