Abstract: A system and method includes generating, with a configuration controller, a configuration bitstream including configuration bits to dynamically define the configuration of a reconfigurable integrated circuit by setting a state of a subset of configuration state memory units. The configuration controller accesses individual configuration state memory units of the subset according to a scan path through the configuration state memory units traversed according to a delay factor based, at least in part, on clock frequency of a clock signal produced by a configuration clock and configures the individual configuration state memory units with corresponding configuration bits of the configuration bitstream.

Abstract: This document relates to methods and materials for reducing the risk of infection after a shoulder surgery or medical procedure. For example, this document relates to methods and materials for using a topical composition containing clindamycin or erythromycin to reduce the risk of or to prevent infection associated with shoulder surgeries or medical procedures.

Abstract: Disclosed are capsid-modified rAAV expression vectors, as well as infectious virions, compositions, and pharmaceutical formulations containing them. Also provided are methods of preparing and using the disclosed capsid-protein-mutated rAAV constructs in a variety of diagnostic and therapeutic modalities, including, inter alia, as mammalian cell-targeting delivery agents, and as human gene therapy vectors. Also disclosed are large-scale production methods for capsid-modified rAAV expression vectors, viral particles, and infectious virions having improved transduction efficiencies over those of the corresponding, un-modified, rAAV vectors, as well as use of the disclosed compositions in the manufacture of medicaments for a variety of in vitro and/or in vivo applications.

Abstract: A two-terminal stochastic switch is disclosed. The switch includes a magnetic tunnel junction (MTJ) stack, an access switch controlled by a first terminal and coupled to the MTJ stack, such that when the access switch is on, electrical current flows from a first source coupled to the MTJ stack, through the MTJ stack, and through the access switch to a second source, and a digital buffer coupled to the MTJ stack and the access switch which is configured to transform an analog signal associated with a voltage division across the MTJ stack and the access switch to a digital signal, output of the digital buffer forming a second terminal.

Abstract: The invention described herein pertains to selective Janus kinase (JAK) inhibitors and methods of use thereof. Also described are methods for treating diseases involved abnormal JAK/STAT signaling pathway in mammals using the described selective JAK inhibitors or a pharmaceutical formulation thereof.

Abstract: The present invention provides a method of manufacturing a customized breast prosthesis in such a manner as to perform three-dimensional scanning of user's body and apply the same shape, the same volume, and the same density as the actual breast to have the same weight, a system for manufacturing the same, a computer program and computer-readable record medium for the same, a customized breast prosthesis manufacture by the above method, and a customized correction brassiere for accommodating the customized breast prosthesis.

Abstract: The present disclosure relates to a technique for manufacturing a self-humidifying membrane including a hydrophobic thin film-coating layer having a nano-sized crack morphology pattern on the surface of an aromatic hydrocarbon-based polymer ion exchange membrane and applying the membrane to a reverse electrodialysis process. The self-humidifying membrane including a hydrophobic thin film-coating layer having a nano-sized crack morphology pattern on the surface of an aromatic hydrocarbon-based polymer ion exchange membrane, manufactured according to the present disclosure, embodies a low bulk resistance of the ion exchange membrane and significantly improves ion selectivity, thereby overcoming the trade-off relationship between membrane resistance and ion selectivity, and thus may be commercially available as an anion and cation exchange membrane of a reverse electrodialysis device.

Abstract: There is provided a method of design and analysis of a geometric object comprising: receiving an initial definition of the geometric object in a coordinate system; generating a volumetric model according to the initial definition, the volumetric model comprises: volumetric cells each represented by one or more multivariate of three variables or more functions, and intra object general border surfaces in general orientation each defines topological adjacency between at least two of said plurality of volumetric cells.

Abstract: Provided is a method and apparatus for predicting a posttraumatic behavior problem that may predict a posttraumatic violent behavior problem of an individual, in detail, that may determine a biological phenotype of an individual experiencing a traumatic event within a predetermined period after the individual is exposed to the traumatic event, predict a violent symptom presentation probability of the individual based on the biological phenotype of the individual, and suggest an objective basis for preventive intervention in a development of posttraumatic stress disorder (PTSD) of the individual based on a prediction result.

Abstract: Disclosed are recombinant polypeptides that include (a) a filaggrin amino acid sequence and (b) a cell importation signal sequence that includes a motif of two to fifteen amino acids, wherein the motif includes at least one arginine residue and at least one methionine residue. Also disclosed are nucleic acids encoding the recombinant polypeptides of the present invention, and compositions that include the recombinant polypeptides and nucleic acids of the present invention. Methods of treating or preventing a skin disease or skin disorder using the compositions of the present invention are also included, as well as kits that include a sealed containing that includes a recombinant polypeptide of the present invention.

Abstract: Apparatus for delivering in vivo hyperthermia treatments to a subject and methods of performing such treatments are provided. The apparatus comprises an imaging device, such as an MRI scanner, a microwave applicator, and a controller to target particular tissues within the subjects body for hyperthermia treatment. The microwave applicator emits microwave energy toward the target tissue and the imaging device provides real-time feedback as to the position of the applicator relative to the target tissues and thermometry data so as to permit real-time adjustment of the applicators operating parameters.

Abstract: The present disclosure relates to a contact lens containing ceria particles. Further, the present disclosure relates to a method for manufacturing a contact lens containing ceria particles. The method includes preparing ceria particles; preparing poly-2-hydroxyethyl methacrylate (PHEMA or poly-HEMA) in a form of cross-linked hydrogel; mixing the ceria particles and the monomer mixture for poly-2-hydroxyethyl methacrylate (PHEMA or poly-HEMA) with each other to form a mixture; and injecting the mixture in a mold having a contact lens shape; and performing photo-curing polymerization of the mixture. The contact lens effectively eliminates the reactive oxygen species and harmful radicals that are identified as a cause of eye diseases.

Abstract: The present invention relates to a low-cost, thermally reversible valve for paper-fluidic diagnostic devices. In particular, this invention demonstrates a tunable valve mechanism fabricated by wax-ink printing and localized heating via thin-film resistors to sequentially release liquids through a cellulose or nitrocellulose membrane. The wax-ink valve can obstruct fluid flow for a sustained time and are thermally actuated to release a controlled amount of liquid past the valve. This integrated paper-fluidic diagnostic assay device requires minimal user involvement, can be easily manufactured and tuned to meet various fluid delivery timing and incubation needs.

Abstract: Methicillin-resistant Staphylococcus aureus (MRSA) possesses array of strategies to evade antibiotics through mutational inactivation, hiding inside host immune cells or concealing inside the biofilm in a sessile form. We report a drug-free approach to eradicate MRSA through blue-light bleaching of staphyloxanthin (STX), an anti-oxidative carotenoid residing inside the cell membrane of S. aureus. The photobleaching process, uncovered through a transient absorption imaging study and quantitated by mass spectrometry, decomposes STX and sensitizes MRSA to reactive oxygen species attack. Consequently, photobleaching using low-level blue light exhibits high-level synergy when combined with low-concentration of hydrogen peroxide. Antimicrobial effectiveness of this synergistic therapy is validated in MRSA culture, MRSA-infected macrophage cells, biofilm, and a mouse wound infection model. Collectively, these findings highlight broad applications of STX photobleaching for MRSA-infected diseases.

Abstract: The present invention relates to an adoptive T cell therapy using cells generated by genetically or biochemically reprogramming T cells to produce T memory stem cells (Tscm) that persist longer in vivo and are superior anti-tumor effector cells.

Abstract: An assay for a GCH1 allele and associated genotype for the screening, prediction, diagnosis, prognosis, treatment and treatment response of psychiatric, neuropsychiatric, and neurological disorders, such as schizophrenia, schizoaffective disorder and bipolar disorder, and for defining treatments of such disorders. The presence of a variant in the GCH1 gene, alone or in conjunction with a measurement of low or altered biopterin, or altered BH4 system measures, is used to screen or diagnose subjects at risk for developing a psychiatric, neuropsychiatric, or neurological disorder. The genetic assay, with or without a biopterin or BH4 system assay, may also be used to determine treatment regimens. For subjects with an impaired BH4 system, treatments to increase or normalize biopterin, BH4, or the BH4 system can also be used, such as BH4 supplementation, lithium treatment, phenylalanine treatment, or other treatments and therapies.

Abstract: A polyHIPE-templated composition-of-matter afforded by interfacial polymerization, comprising a polymer of alternating residues of hydrophobic and hydrophilic monomers. The described composition-of-matter is characterized by an open-, quasi-closed- or a truly closed-cell microstructure, whereas the latter is capable of non-releasably or releasably encapsulating an organic or aqueous composition therein for extended periods of time, as well as various uses thereof.

Abstract: A non-transitory computer-readable medium encoded with a computer-readable program, which when executed by a processor, will cause the processor to execute an image processing method, the image processing method including establishing a zero crossing region from a target image onto a screen, wherein the zero crossing region comprises a corresponding value. The method further includes receiving a variable input and an integration time input, wherein the variable input comprises a frequency number for an image accumulation procedure, and wherein the integration time comprises a time period for which an aperture for a sensor receives incoming signals. Additionally, the method includes performing the image accumulation procedure. Moreover, the method includes producing a final greyscale image by adding a plurality of sets of vertically shifted pixel values, wherein the frequency number for the image accumulation procedure ranges from 3 to 20.

Abstract: The present disclosure relates to a novel method of inhibiting sugar crystallization and/or sugar crystal growth with at least one glycoside as the sugar crystallization and/or sugar crystal growth inhibitor, and novel compositions comprising amorphous sugar and at least one glycoside as the sugar crystallization and/or sugar crystal growth inhibitor.

Abstract: Provided is a negative active material for a secondary battery which provides high capacity, high efficiency charging-discharging characteristics. The negative active material includes: a silicon single phase; and a silicon-metal alloy phase interfaced with the silicon single phase and surrounding the silicon single phase, wherein an X-ray diffraction spectrum of the negative active material has first and second peaks that are originated from the silicon-metal alloy phase, and the first peak is located at 49.1+/?0.5 degrees (°) and the second peak is located at 38.0+/?0.5 degrees (°), and a diffraction intensity of the first peak is 2 or less times that of to the second peak.