Abstract: Methods and systems for patient participatory care and monitoring are provided for applications including respiratory care, ECG monitoring, capnography, infusion pump alarm prevention/management, pressure sore prevention, incentive spirometry, consciousness monitoring during sedation, pain management and other care and monitoring modalities. A patient in-the-loop system includes an input interface for receiving data acquired from a monitoring, controlling or sensing device, a storage device for storing the data at a first location, and a processor for analyzing artifacts in the data and determining whether the patient provided a deliberate action with respect to the device as a response to a prompt or query. The processor can further initiate a variety of prompts and/or output queries stored in the storage device at a second location to the patient.

Abstract: Compositions and methods for monitoring the quantity of actinides present in a test sample are disclosed. Compositions and methods for monitoring the motion of special nuclear materials through space are also described. Compositions and methods for monitoring the quantity of a fissile special nuclear material present in a test sample are disclosed. Compositions and methods for monitoring actinides during reprocessing of spent nuclear fuel after 30-year cool down are disclosed. Compositions and methods for monitoring actinides during reprocessing of spent nuclear fuel after 180 day cool down are also disclosed.

Abstract: This invention relates to antibody-albumin nanoparticle complexes comprising albumin, bevacizumab, and paclitaxel, wherein the nanoparticle complex has been pre-formed in vitro such that the nanoparticle complex has antigen-binding specificity (e.g., VEGF binding specificity), for the purpose of providing cancer (e.g., VEGF-related cancer) treatments in a subject in need thereof.

Abstract: The present invention relates to tackifier compounds and methods of using the same. In various embodiments, the present invention provides a tackifier compound including independently substituted or unsubstituted fused rings A and B each independently chosen from (C5-C10)cycloalkyl and (C2-C10)heterocyclyl. Fused ring A is substituted with (R1)1-8 and fused ring B is substituted with —(OC(O)R?C(O)R2)1-8. At each occurrence R? is independently chosen from (C2-C10)alkanylene, (C2-C10)alkenylene, (C2-C10)alkynylene, C5-C20(arylene), and (C1-C20)heteroarylene, wherein R? is unsubstituted or substituted. At each occurrence R1 is independently selected from —OH, —OR3, and —OC(O)R?C(O)R2. At each occurrence R2 is independently chosen from —OH, —OR3, —NH2, —NHR3, and —NR32. At each occurrence R3 is independently chosen from (C1-C10)alkanyl, (C2-C10)alkenyl, (C2-C10)alkynyl, C5-C20(aryl), and (C1-C20)heteroaryl, wherein R3 is unsubstituted or substituted.

Abstract: Provided herein is a field-effect transistor based sensor for real-time detection of water contaminants and methods of use thereof.

Abstract: The present invention features, inter alia, biocompatible compositions that include a poloxamer and one or more additives such as hyaluronic acid, gelatin, fibronectin, or a peptide fragment of fibronectin. The compositions are useful in tissue repair or remodeling, including repair of an injured spinal disc, in drug delivery, in cell culture, and in inhibiting the formation of adhesions.

Abstract: In accordance with some embodiments, systems, methods and media for simulating deformation of an elastic body are provided. In some embodiments, a method comprises: determining for each macroblock, a stiffness matrix Ki of a portion of a model of a non-linear elastic solid partitioned into cells; converting Ki into block form to include a submatrix KIiIi for nodes between internal cells of a first macroblock; determining at least a portion of KIiIi?1; receiving input corresponding to force applied to cells of the model; determining displacements of exterior nodes of the first macroblock using the input and the portion of KIiIi?1; determining displacements of interior nodes of the first macroblock using the input and the displacements of exterior nodes; determining updated positions of the cells based on the displacements of the exterior nodes; and, causing the model to be presented using the updated positions.

Abstract: Aspects of the present disclosure generally relate to compounds for targeting and healing bone fractures. Some of these compounds include a negatively charged oligopeptide comprising an acidic oligopeptide, a linker, which may be hydrolyzable or may be a substrate for the protease cathepsin K, and at least one molecule that promotes bone healing. In some compounds the molecule that promotes bone healing is an anabolic compound that inhibits GSK3?, in some compounds the molecule that promotes the healing of bone fracture is a pro-inflammatory agent such as PGE1. Other embodiments include methods of treating a bone fracture comprising administering a therapeutic amount of any one of the compounds disclosed herein.

Abstract: An optimal operating configuration for a power system may be derived from a continuous-time model of generation and ramping constraints of power generation units available within the power system. The optimal operating configuration may be leveraged to calculate a valuation metric for power generated by the power generating units. The valuation metric may include costs incurred by the power generating units due to ramping events. In addition, incremental generation and ramping cost metrics may be used to identify power generation units to use in responding to short-term load variations. Power generating units may be selected based, at least in part, on the incremental ramping costs of the power generating units.

Abstract: A method for producing a solution including a positron emitting zinc cation of 63Zn, and the method comprises bombarding a solution target including 63Cu with high energy protons to produce a solution including a positron emitting zinc cation. A method for detecting or ruling out Alzheimer's disease in a patient comprises administering to a patient a detectable amount of a compound including a positron emitting zinc cation, wherein the zinc cation is targeted to beta-amyloid in the patient, and acquiring an image to detect the presence or absence of beta-amyloid in the patient.

Abstract: A method of providing an image Completely Automatic Public Turing test to tell Computers and Humans Apart (CAPTCHA), and a server thereof. The method includes: outputting an image CAPTCHA including a plurality of images including a determination object image; receiving an image selection from the image CAPTCHA; determining whether a test of the image CAPTCHA is passed, based on the received image selection; and determining what the determination object image means. The images include a first group of images used to determine whether an accessing party passes the image CAPTCHA test and a second group of images unused to determine whether the accessing party passes the image CAPTCHA test. The second group includes the determination object image. The determining of the pass of the image CAPTCHA test is performed by selecting an image representing a correct or incorrect answer from the first group.

Abstract: An electronic device may include a topological insulating layer including first and second surfaces facing each other and a transition metal oxide layer provided on the first surface of the topological insulating layer. The topological insulating layer may have a thickness ranging from 1 nm to 10 nm.

Abstract: Provided is an apparatus and method for reproducing a three-dimensional (3D) image. A 3D image reproduction apparatus may include an image selector configured to select a left-eye image and a right-eye image based on a broadcast standard of a broadcast stream, and an image outputter configured to output the 3D image by synthesizing and output the left-eye image and the right-eye image in a 3D image format.

Abstract: Described is an elemental analysis system and methods for use thereof that can be utilized in examination of samples in their native state. The systems utilize a liquid sampling—atmospheric pressure glow discharge (LS-APGD) device for ambient desorption sampling and excitation of a solid sample in combination with optical emission detection. This approach can find application across a broad spectrum of analytical challenges including metals, soils, and volume-limited samples.

Abstract: A nuclear thermoacoustic device includes a housing defining an interior chamber and a portion of nuclear fuel disposed in the interior chamber. A stack is disposed in the interior chamber and has a hot end and a cold end. The stack is spaced from the portion of nuclear fuel with the hot end directed toward the portion of nuclear fuel. The stack and portion of nuclear fuel are positioned such that an acoustic standing wave is produced in the interior chamber. A frequency of the acoustic standing wave depends on a temperature in the interior chamber.

Abstract: The application discloses compositions, methods, systems, and apparatuses for rapid sequence analysis of proteins, including location of post-translational modifications and disulfide bonds. Limited digestion of fully denatured antibody occurs in seconds by flowing sample in 8M urea at constant pressure through a micro column reactor containing immobilized aspergillopepsin I, resulting in a product mixture containing 3-10 kDa peptides, which is then fractionated by capillary column chromatography and analyzed by both electron transfer dissociation (ETD) and collision activated dissociation mass spectrometry. This method provides 95% sequence coverage of a mAb and detects numerous post-translational modifications. For disulfide bond location, native mAb is subjected to longer digestion times. Release of disulfide containing peptides from accessible regions of the folded protein occurs with short digestion times.

Abstract: The present invention relates to a technology for estimating a position of a terminal using a positioning reference signal. More specifically, the present invention relates to a method and apparatus for controlling a transmission period or transmission power of a positioning reference signal in order to accurately measure a position of a terminal. In particular, the present invention provides a method and apparatus for estimating a position of a terminal, the method comprising the steps of: receiving a positioning reference signal from each of a serving cell and one or more neighboring cells; generating reference signal time difference (RSTD) information on the basis of information on a reception time of the positioning reference signal; and estimating a position of a terminal on the basis of the RSTD information.

Abstract: Systems and methods for epicardial pacing are provided. For example, this document provides epicardial pacing using a percutaneously delivered bifurcated pacing lead that has multiple electrodes that are directionally insulated to prevent extracardiac stimulation, including prevention of phrenic stimulation. In addition, the devices, systems, and methods provided can be used for ablation, defibrillation, and/or defibrillation in combination with pacing.

Abstract: A system and method includes generating, with a configuration controller, a configuration bitstream including configuration bits to dynamically define the configuration of a reconfigurable integrated circuit by setting a state of a subset of configuration state memory units. The configuration controller accesses individual configuration state memory units of the subset according to a scan path through the configuration state memory units traversed according to a delay factor based, at least in part, on clock frequency of a clock signal produced by a configuration clock and configures the individual configuration state memory units with corresponding configuration bits of the configuration bitstream.

Abstract: In some examples, an article may include a substrate and a coating on the substrate. The substrate may include a superalloy, a ceramic, or a ceramic matrix composite. The coating may include a layer comprising a matrix material and a plurality of nanoparticles. The matrix material may include at least one of silica, zirconia, alumina, titania, or chromia, and the plurality of nanoparticles may include nanoparticles including at least one of yttria, zirconia, alumina, or chromia. In some examples, an average diameter of the nanoparticles is less than about 400 nm.