Abstract: The invention provides methods for determining and evaluating the in vitro-in vivo activity relationship of the efficacy of families of compounds for infectious diseases such as tuberculosis. The validity of the methods can be confirmed by evaluation of the compounds in animal models, for example, in murine models of tuberculosis. Examples of families of antibacterial compounds that can be evaluated for in vivo efficacy using the in vitro methods described herein include benzimidazoles, pyridopyrazines, pteridines, diphenyl ethers, beta-lactams, PBP inhibitors, and compounds that are non-ribonucleic acid and protein synthesis inhibitors. The methods can be used to evaluate classes of small molecule compounds and inhibitors that may be effective against any bacterial pathogen.

Abstract: A vaccine composition is disclosed that contains a vaccine antigen and a neutrophil inhibitor in amounts effective to promote an IgA response to the antigen in a subject. Also disclosed is a method for enhancing immune response to a vaccine antigen in a subject that involves co-administering to the subject the vaccine antigen and an adjuvant composition comprising a neutrophil inhibitor in an amount effective to promote an IgA response to the vaccine antigen in the subject.

Abstract: This document relates to methods and materials involved in treating cancer (e.g., melanoma). For example, methods and materials involved in using an anti-chronic inflammation treatment (e.g., chemotherapy) in combination with a cancer treatment agent (e.g., a cancer vaccine) to treat cancer are provided.

Abstract: A method of occluding an appendage of the heart with a clamp including at least first and second elongate clamping portions, the first and second elongate clamping portions including tissue engaging surfaces that promote tissue ingrowth. The method includes implanting the clamp by positioning the first and second elongate clamping portions on opposite sides of the appendage. At least one of the first or second elongate clamping portions is biased toward the other of the first and second elongate clamping portions to place the clamp into a clamping position on the appendage. Tissue ingrowth into the tissue engaging surfaces retains the clamp in place on the appendage.

Abstract: A digital constant on-time controller adaptable to a direct-current (DC)-to-DC converter includes a current sensing circuit that senses stored energy of the DC-to-DC converter, thereby generating a sense voltage; an offset cancellation circuit coupled to receive the sense voltage, thereby generating an offset-removed sense voltage according to a valley voltage of the sense voltage; a comparator that compares the offset-removed sense voltage with a reference signal; and a pulse-width modulation (PWM) generator that generates a switch control signal according to a comparison result of the comparator.

Abstract: The disclosure describes alterations in ERG gene expression. ERG isoforms and promoter sequence of the ERG gene that are involved in, or associated with, prostate cancer are provided. The disclosure further provides therapeutic compositions and methods of detecting, diagnosing, prognosing, and treating prostate cancer, including biomarkers for detecting the expression of two or more of the following genes: PSA/KLK3, PMEPA1, NKX3.1, ODC1, AMD1, and ERG.

Abstract: Embodiments are directed to extracting specified data items from narrative text. In one scenario, a computer system accesses narrative textual information which includes data items that are to be identified and extracted. The computer system identifies specified data items in the narrative textual information that are to be extracted from the narrative textual information. The computer system then filters the identified data items to remove false positive identifications. The false positive filtering includes classifying the identified data items as specified data items, so that classified data items are identified as true positive items that are to be extracted from the narrative textual information. The computer system further extracts, from the narrative textual information, those filtered data items that were classified as being true positive items.

Abstract: The invention generally relates to systems and methods for transferring ions for analysis. In certain embodiments, the invention provides a system for analyzing a sample including an ionizing source for converting molecules of a sample into gas phase ions in a region at about atmospheric pressure, an ion analysis device, and an ion transfer member operably coupled to a gas flow generating device, in which the gas flow generating device produces a laminar gas flow that transfers the gas phase ions through the ion transfer member to an inlet of the ion analysis device.

Abstract: Existing methods of producing high quality graphene/graphite oxides are generally accomplished by exfoliating graphite into flakes and oxidizing the graphite flakes with strong oxidizers under extreme conditions and require careful purification. The oxidizers are typically strong acids used in high concentrations at elevated temperatures requiring complicated purification processes to yield oxidized graphene/sheets. The existing processes can cost up to $12,000/gram. This invention uses a mild oxidant combined with mechanical processing where the sole products are oxidized graphite/graphene and water without the need for further purification.

Abstract: The present invention relates to a method for transmitting and receiving data in a wireless communication system supporting device to device (D2D) communication. The method performed by first User Equipment (UE) includes receiving first control information related to D2D communication from an eNB, transmitting second control information, including resource information related to D2D data transmission, to second UE based on the received first control information, and transmitting the D2D data to the second UE. Receiving the first control information includes allocating, by the eNB, a resource pool related to the D2D communication through high layer signaling.

Abstract: A shape compliant gripper with which an atypical object having various shapes, sizes and materials can be picked. The shape compliant gripper comprises a body and a shape compliant module disposed on the body and having rigidity capable of being variably controlled. Further, the shape compliant module comprises a magnetorheological elastomer, a magnet part, and a control part for controlling a position of the magnet part with respect to the magnetorheological elastomer.

Abstract: Systems, methods, and apparatus are described herein for obtaining medical diagnostic measurements from implanted sensors. In various embodiments, an apparatus may include two or more clamps to be rigidly clamped to the spinal fusion rod at a distance from one another, and a strain-sensing system that is removably mountable to the two or more clamps to span the distance. The strain-sensing system may include one or more strain-sensing elements. In various embodiments, the two or more clamps may be configured to transfer strain detected in the spinal fusion rod to the one or more strain-sensing elements of the strain-sensing system.

Abstract: Aspects of the present invention provide a memory system comprising a plurality of stacked memory layers, each memory layer divided into memory sections, wherein each memory section connects to a neighboring memory section in an adjacent memory layer, and a logic layer stacked among the plurality of memory layers, the logic layer divided into logic sections, each logic section including a memory processing core, wherein each logic section connects to a neighboring memory section in an adjacent memory layer to form a memory vault of connected logic and memory sections, and wherein each logic section is configured to communicate directly or indirectly with a host processor. Accordingly, each memory processing core may be configured to respond to a procedure call from the host processor by processing data stored in its respective memory vault and providing a result to the host processor. As a result, increased performance may be provided.

Abstract: A stent graft (2) for placement in the thoracic arch of a patient has a first tubular body portion (6) with a first lumen therein for placement in the ascending aorta of a patient and a second tubular body portion (8) to extend along the thoracic arch and down the descending aorta. The second tubular body portion is of a lesser diameter than the first tubular body portion. There is a step portion (10) between the first body portion and the second body portion. The step portion is joined to and continuous with the first portion and the second portion. A first side of each of the first body portion, the step portion and the second body portion are substantially aligned so that there is a step (18) defined on a second side opposite to the first side of the body portion. There is an aperture (30) in the step portion and an internal tube (32) extending from the aperture towards the first body portion.

Abstract: The present invention relates to methods, formulations, and compositions for the treatment of biofilms. In particular, the application discloses isothiocyanate functional surfactants either alone or combination with adjunct agents to treat biofilms.

Abstract: Disclosed herein are methods for detecting Pgrmc1 in bodily fluids, e.g., blood, plasma and serum, wherein detection of Pgrmc1 is a biomarker for the presence of cancer, e.g., lung cancer or head or neck cancer. Pgrmc1 levels in bodily fluids may be used to predict patient prognosis, e.g., survival and response to therapy.

Abstract: The invention generally relates to sensors, methods of manufacture thereof, methods of use thereof for sensing analytes, such as small molecules and biomolecules, and methods of immobilization. In certain embodiments, the invention provides a multi-analyte sensor. The multi-analyte sensor includes a plurality of sensing electrodes. Each sensing electrode is functionalized with a different molecule (e.g., biomolecule), at least two of the sensing electrodes are spaced apart prior to and after functionalization by 100 ?m or less, and there is no cross-talk between the plurality of sensing electrodes.

Abstract: Disclosed is a method to make N-acetyl-p-aminophenol. The method includes steps for converting biomass-derived p-hydroxybenzoates to p-hydroxybenzamide, then to p-aminophenol; and then N-acetylating the p-aminophenol.

Abstract: The present invention relates to a composition using a SLIT-ROBO system for preventing or treating sarcopenia and, more specifically, to a composition comprising a gene selected from among slit1, slit2, slit3, robo1, robo2, and fragments thereof, or a protein expressed from the gene as an effective ingredient for preventing or treating a muscle disease or for improving muscular function.

Abstract: A microchip includes a first chamber and second chamber formed to a predetermined depth in a member made of polydimethylsiloxane (PDMS); and a channel (microchannel) connecting the first chamber to the second chamber. These components mimic in vivo organs which produce by selecting capacitated motile sperm from semen and causing the selected sperm to meet mature oocyte, and these components are capable of effectively producing motile capacitated good-quality sperms from sperms ejaculated outside the body.