Patents Assigned to GE Healthcare Bio-Sciences AB
  • Patent number: 10047332
    Abstract: The invention relates to a bag locking mechanism comprising, a fixed locking means (106), provided with a first abutment surface (116), a movable locking means (108; 208), which is movable between a locking position and a releasing position, and a second abutment surface (118; 218) arranged on the movable locking means (108; 208). The fixed locking means (106) defines by its configuration, at least partly a restricted locking space (114), in which the movable locking means (108; 208) is movable between the locking and releasing position.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: August 14, 2018
    Assignee: GE HEALTHCARE BIO-SCIENCES AB
    Inventor: Patrik Akerstrom
  • Patent number: 10047869
    Abstract: A rotary valve comprising a stator with an inner stator face, and a rotor with an inner rotor face arranged in sealing contact with the inner stator face, the rotor is rotatably movable to a plurality of rotor positions about a rotational axis relative to the inner stator face, the stator comprises a plurality of connection ports each being in fluidic contact with a corresponding valve orifice at the inner stator face and the rotor comprises two or more interconnection paths for selective fluidic interconnection of said valve orifices with respect to the rotor position, wherein the stator comprises, an inlet port, an outlet port, a component feed port, a component return port, and wherein the interconnection paths in the rotor are arranged to: —in a first rotor position interconnect the inlet port with the outlet port, —in a second rotor position interconnect the inlet port with the component feed port and the component return port with the outlet port, —in a third rotor position interconnect the inlet port w
    Type: Grant
    Filed: April 12, 2017
    Date of Patent: August 14, 2018
    Assignee: GE Healthcare Bio-Sciences AB
    Inventors: Olle Bjernulf, Christer Olof Eriksson
  • Publication number: 20180221822
    Abstract: The disclosure generally relates to methods and apparatus for the efficient quantitative recovery of valuable biological fluids from filtration systems, more particularly to efficient quantitative recovery of valuable biological fluids from high precision separation systems suitable for use in the pharmaceutical and biotechnology industries.
    Type: Application
    Filed: August 17, 2016
    Publication date: August 9, 2018
    Applicant: GE Healthcare Bio-Sciences AB
    Inventors: Sasi Kumar Nutalapati, Klaus Gebauer, Karl Axel Jakob Liderfelt, Nachiket Karmarkar, Amit S. Vernekar, Ajit Kumar Sharma, Fredrik Oskar Lundstrom, Sangeetha Raghu Ramachandran
  • Patent number: 10040073
    Abstract: A method for purifying a substance in a solution in a simple streamlined process using a magnetic porous particle. For easy small scale purification of a substance, the magnetic porous particle is coated with either a hydrophilic or hydrophobic liquid and transferred into a second liquid containing the substance under conditions which allow said substance to partition into the first liquid within said magnetic porous particle. Finally the magnetic porous particle is removed from said second liquid, wherein the first and second liquid are substantially immiscible and the partition coefficient P of the substance between the first and second liquid is greater than 1.
    Type: Grant
    Filed: January 29, 2014
    Date of Patent: August 7, 2018
    Assignee: GE Healthcare Bio-Sciences AB
    Inventors: Nils Norrman, Pierre Le Greves
  • Patent number: 10023833
    Abstract: A temperature sensor means comprising a thermally conducting layer arranged to face the surface to be measured, a thermally insulating layer attached to the thermally conducting layer on the opposite side to the surface to be measured, a temperature sensor provided between the thermally conducting layer and the thermally insulating layer and being completely surrounded on all its sides by either the thermally conducting or the thermally insulating layers.
    Type: Grant
    Filed: June 16, 2014
    Date of Patent: July 17, 2018
    Assignee: GE HEALTHCARE BIO-SCIENCES AB
    Inventors: Patrik Akerstrom, Hakan Wahlnas
  • Patent number: 10011816
    Abstract: A method for stem or progenitor cell culture. More precisely, the invention relates to a method for cell culture using one or more I?I (inter-alpha trypsin inhibitor or inter-alpha inhibitor) protein(s) or part(s) thereof as a component in a cell culture media or a coating on a cell culture surface material. Furthermore the invention relates to a cell culture media and a cell culture coating/matrix provided with one or more I?I proteins(s) or part(s) thereof.
    Type: Grant
    Filed: October 7, 2016
    Date of Patent: July 3, 2018
    Assignee: GE HEALTHCARE BIO-SCIENCES AB
    Inventors: Sara Pijuan Galito, Christoffer Tamm, Cecilia Anneren
  • Patent number: 9994807
    Abstract: A temperature sensor means comprising a thermally conducting layer arranged to face the surface to be measured, a thermally insulating layer attached to the thermally conducting layer on the opposite side to the surface to be measured, a temperature sensor provided between the thermally conducting layer and the thermally insulating layer and being completely surrounded on all its sides by either the thermally conducting or the thermally insulating layers.
    Type: Grant
    Filed: June 16, 2014
    Date of Patent: June 12, 2018
    Assignee: GE HEALTHCARE BIO-SCIENCES AB
    Inventors: Patrik Akerstrom, Hakan Wahlnas
  • Publication number: 20180157229
    Abstract: A system for providing an improved way of user intuitive visual management of bioprocess automation is disclosed. The system includes a processor and a memory. The processor is configured to present a graphical presentation of the bioprocess automation script and results associated with execution of the bioprocess automation script of a bioprocess, wherein the graphical presentation comprises an anticipated result and an anticipated flow path associated with the bioprocess; and modify the graphical presentation by varying at least one of the anticipated result and the anticipated flow path.
    Type: Application
    Filed: April 21, 2016
    Publication date: June 7, 2018
    Applicant: GE Healthcare Bio-Sciences AB
    Inventors: Dalesh Dharamshi, Sudheer Mygapula
  • Patent number: 9987628
    Abstract: The present invention provides methods and systems for eluting and an analyte from a solid phase. The invention further provides methods and systems for transferring liquid analyte reagent mixtures from a solid phase to a second vessel, such as a microtiter plate well. The invention is useful in the manipulation of biological molecules such as nucleic acids, carbohydrates, proteins and peptides. In particular, the invention has utility for manipulating proteins and peptides in isoelectric focusing gels.
    Type: Grant
    Filed: November 26, 2014
    Date of Patent: June 5, 2018
    Assignee: GE HEALTHCARE BIO-SCIENCES AB
    Inventors: Tobias Ingemar Solderman, Nils Norrman, Henrik Ostlin, Susanna Lindman, David Carl Martin Bergman, Peter Mats Oliviusson
  • Patent number: 9983203
    Abstract: Provided are methods for protein analysis in which proteins to be analyzed are displayed on a population of discrete and dispersible structures, such as beads or other particles, for subsequent affinity reactions and analysis/detection. The proteins to be analyzed may be provided as denatured protein samples in the presence of a denaturing agent.
    Type: Grant
    Filed: February 12, 2015
    Date of Patent: May 29, 2018
    Assignee: GE HEALTHCARE BIO-SCIENCES AB
    Inventors: Daniel Ivansson, Camilla Estmer Nilsson, Therese Graner, Johan Ohman
  • Patent number: 9975123
    Abstract: The invention relates to a method for making a laminated microfluidics with membrane valves. The method comprises (a) generating a membrane valve assembly comprising (1) laminating three plastic foils together, the top foil comprising one through hole for each valve, the middle foil has a slit pattern connecting each valve hole of the top foil, and the bottom foil has one through hole for each valve and one additional hole entering the slit pattern; (2) placing the laminated foil, bottom foil down on a mould half having a smooth mould surface with one or more perpendicularly protruding cylinders that concentrically fit within the through holes of the laminated foil yet leave room for a membrane to form, and clamping a second mould half to close the mould; (3) injecting and allowing to cure a liquid rubber through a funnel associated with the bottom mould half and the additional hole on the bottom foil layer; and (b) laminating the membrane valve assembly and a flow path.
    Type: Grant
    Filed: November 28, 2014
    Date of Patent: May 22, 2018
    Assignee: GE HEALTHCARE BIO-SCIENCES AB
    Inventor: Stefan Sjolander
  • Patent number: 9976117
    Abstract: A method for stem or progenitor cell culture. More precisely, the invention relates to a method for cell culture using one or more I?I (inter-alpha trypsin inhibitor or inter-alpha inhibitor) protein(s) or part(s) thereof as a component in a cell culture media or a coating on a cell culture surface material. Furthermore the invention relates to a cell culture media and a cell culture coating/matrix provided with one or more I?I proteins(s) or part(s) thereof.
    Type: Grant
    Filed: October 7, 2016
    Date of Patent: May 22, 2018
    Assignee: GE HEALTHCARE BIO-SCIENCES AB
    Inventors: Sara Pijuan Galito, Christoffer Tamm, Cecilia Anneren
  • Patent number: 9975658
    Abstract: A disposable container comprising a side wall, top and bottom, wherein the side wall comprises a first flexible material and the bottom comprises a rigid or semi-rigid material. The side wall top and bottom are joined together to define the container with an interior compartment for keeping a fluid inside the container. The bottom comprises at least one opening that is fluid-tightly covered with an assembly comprising a second flexible material. The assembly comprises at least one port which provides access to the interior compartment of the container. The invention also relates to a mixing system comprising the disposable container.
    Type: Grant
    Filed: June 2, 2014
    Date of Patent: May 22, 2018
    Assignee: GE HEALTHCARE BIO-SCIENCES AB
    Inventors: David Rönnholm, Klaus Gebauer, Rolf Hjorth, Patrick Jonsson
  • Publication number: 20180120271
    Abstract: The present invention relates to a method for performing liquid chromatography purification of one or more target molecules from a sample comprising: providing an eluent flow having one or more target molecules, measuring an output parameter indicative of the content of the one or more target molecules in the eluent flow, storing output parameter data, and dividing the eluent flow into consecutive eluent fractions, dividing the output parameter data into corresponding data fractions, in each data fraction obtaining a value indicative of characteristic behavior of the measured output parameter, identifying trends in the measured output parameter based upon the obtained value in consecutive data fractions, and identifying peak(s) in the measured output parameter correlated to eluent fractions based upon the identified trends, whereby information of identified peak(s) and correlated eluent fraction(s) can be presented and purified sample(s) from the eluent may be collected.
    Type: Application
    Filed: November 16, 2015
    Publication date: May 3, 2018
    Applicant: GE Healthcare Bio-Sciences AB
    Inventors: Lena Nyholm, Lotta Hedkvist, Johan Arthursson, Eva Cecilia Olsson, Henrik Larsson
  • Patent number: 9958438
    Abstract: A flow cell unit to be docked against a flat lid surface to form a closed flow cell arrangement, the flow cell unit comprising a top surface with protruding walls of elastic material defining three or more adjacent elongated flow channels, each flow channel comprises a first fluid port and a second fluid port, wherein the walls separating adjacent flow channels comprises a valve section of reduced height, thereby allowing selective opening and closing of a flow path transverse to the elongated flow channels by controlling the docking force between flow cell and the lid surface to an open docking state and a closed docking state respectively.
    Type: Grant
    Filed: September 28, 2012
    Date of Patent: May 1, 2018
    Assignee: GE HEALTHCARE BIO-SCIENCES AB
    Inventor: Stefan Sjolander
  • Publication number: 20180106388
    Abstract: Disclosed is a rotary valve 1 comprising a stator 20 and a rotor 40 generally in rotary sliding engagement with the said stator about a valve axis RA, the stator including a plurality of fluid ports 22, 26, 28, the rotor 40 being operable to selectively fluidically interconnect two or more of said ports during its rotary sliding engagement. The valve further includes an actuator (70) for disengagement of the rotor from the stator to enable efficient cleaning of the valve interconnections.
    Type: Application
    Filed: December 18, 2017
    Publication date: April 19, 2018
    Applicant: GE HEALTHCARE BIO-SCIENCES AB
    Inventor: Bjorn Olovsson
  • Patent number: 9945810
    Abstract: An integrated system for performing electro-blotting, probing and drying of the membrane is disclosed. The integrated system comprises a transfer unit for receiving one or more transfer sandwich holder. Each transfer sandwich holder holding a transfer sandwich comprises a gel member and the membrane. The transfer unit is configured to transfer samples from the gel member to the membrane. The integrated system also includes a probing unit for receiving the membrane therewithin. The membrane is exposed to a plurality of antibodies for binding with the samples in the membrane. A drying unit is also present for drying the membrane with hot air.
    Type: Grant
    Filed: November 21, 2014
    Date of Patent: April 17, 2018
    Assignee: GE HEALTHCARE BIO-SCIENCES AB
    Inventors: Urban Jonsson Axelsson, Lars Erik Hammarstrand, Girish Kittur, Shekar Ambepu, Bharath Subrahmanya, Mahesh Bhat, Kalyana Chakravarthy Duggirala
  • Patent number: 9944895
    Abstract: A method for stem or progenitor cell culture. More precisely, the invention relates to a method for cell culture using one or more I?I (inter-alpha trypsin inhibitor or inter-alpha inhibitor) protein(s) or part(s) thereof as a component in a cell culture media or a coating on a cell culture surface material. Furthermore the invention relates to a cell culture media and a cell culture coating/matrix provided with one or more I?I proteins(s) or part(s) thereof.
    Type: Grant
    Filed: June 22, 2016
    Date of Patent: April 17, 2018
    Assignee: GE HEALTHCARE BIO-SCIENCES AB
    Inventors: Sara Pijuan Galito, Christoffer Tamm, Cecilia Anneren
  • Patent number: 9880093
    Abstract: Absorption monitor system comprising a light source and a light detector arranged so as to define an absorption detection light path there between, and a controller arranged to control the operation of the light source, wherein the light source comprises a Light Emitting Diode capable of emitting light in the UV range (UV-LED) and wherein the absorption monitor system does not comprise a reference light-detector and the controller is arranged to compensate for fluctuations in light output intensity from the UV-LED.
    Type: Grant
    Filed: September 18, 2014
    Date of Patent: January 30, 2018
    Assignee: GE Healthcare Bio-Sciences AB
    Inventors: Anoop Bhargav, Jeganathan Srinivasan
  • Patent number: 9857364
    Abstract: The present invention relates to a method for detection of binding or interaction events between a binding agent and its corresponding analyte (such as an antibody and an antigen) in which a signal is detected which is substantially more amplified and thus easier to detect than in prior art systems. The method comprises simultaneous but separate addition of a first enhancement reagent having affinity for said analyte and a second enhancement reagent having affinity for the first enhancement reagent wherein the first enhancement reagent binds to the analyte and the second enhancement reagent binds to the first enhancement reagent, and, wherein the first and second enhancement reagents have more than one binding site so that they are able to bind to each other to thereby amplify a detectable signal from the binding event.
    Type: Grant
    Filed: December 21, 2012
    Date of Patent: January 2, 2018
    Assignee: GE Healthcare Bio-Sciences AB
    Inventors: Tanja Jarhede, Anita Larsson