Patents Assigned to GE Healthcare Bio-Sciences AB
  • Patent number: 10105622
    Abstract: The invention discloses a normal flow filtration cassette (1) stackable with like cassettes, said cassette comprising: at least three port conduits (2,3,4); an inlet chamber (5) in fluid communication at least with a first of said port conduits (2); an outlet chamber (6) in fluid communication at least with a second of the port conduits (3); and a filter medium (7) between said inlet chamber and said outlet chamber, wherein said at least three port conduits (2,3,4) are each in fluid communication with a corresponding inlet port (8,9,10) and are each in fluid communication also with one of a corresponding set of outlet ports (11,12,13), and wherein each of said set of inlet ports (8,9 10) is arranged to cooperate with a respective complementary outlet port of an adjacent like cassette when in a stack and said outlet ports (11,12,13) are each arranged to cooperate with a respective complementary inlet port of a further adjacent like cassette when in a stack.
    Type: Grant
    Filed: May 29, 2013
    Date of Patent: October 23, 2018
    Assignee: GE HEALTHCARE BIO-SCIENCES AB
    Inventors: Charles Lambalot, William Larsen
  • Patent number: 10099047
    Abstract: A separation or reaction unit (1; 1?; 81; 81?; 101) and a method for aseptically connecting such units. The separation or reaction unit (1; 1?; 81; 81?; 101) comprises at last one fluid inlet (3a, 3b, 5a, 5b; 3a?, 3b?, 5a?, 5b?; 85a, 85b; 103a, 103b) and at least one fluid outlet (3a, 3b, 5a, 5b; 3a?, 3b?, 5a?, 5b?; 85a, 85b; 103a, 103b). At least one of the inlet or outlet is sealed by at least one film (7, 9; 11; 87a, 87b; 107a, 107b) and the contact surface between the film and the separation or reaction unit is aseptic. The films are adapted to be mated with a corresponding film on another separation or reaction unit or on a fluid distribution unit (20; 57; 61) which the separation or reaction unit possibly should be connected with and said mated films are adapted to be pulled out together two and two after mating such that corresponding fluid inlets/outlets on the two connected units are mated aseptically.
    Type: Grant
    Filed: January 10, 2011
    Date of Patent: October 16, 2018
    Assignee: GE Healthcare Bio-Sciences AB
    Inventor: Klaus Gebauer
  • Patent number: 10101347
    Abstract: Automated fluid handling system comprising a controller arranged to control the operation of the fluid handling system in accordance with a predefined or user-defined operation process, the fluid handling system comprising a power source input for connection to an external power source, the fluid handling system comprising a back-up power source arranged to supply back-up power to the controller, wherein the controller is arranged to monitor the power source input and in response to a detected power shortage initialize suspend mode of operation powered by the back-up power source, and during suspend mode saving information relating to status of the operation process at the time of power shortage in response to a detected power up initialize a boot procedure comprising a verification if the boot procedure is initialized following a suspend mode or not: if the boot procedure is not initialized following a suspend mode, then proceed according to normal boot procedure to enable start of a new operation proces
    Type: Grant
    Filed: September 11, 2014
    Date of Patent: October 16, 2018
    Assignee: GE HEALTHCARE BIO-SCIENCES AB
    Inventors: Anoop Bhargav, Jeganathan Srinivasan, Babu Rasool Nabi
  • Patent number: 10094770
    Abstract: The present invention relates to a flow cell (10) comprising a fluid inlet (16) and a fluid outlet (18) separated by a sample flow-through chamber (12) comprising at least one UV-transparent window (22?), wherein the at least one UV-transparent window (22?) is made of a polymer material and has been subjected to Gamma radiation sterilisation. In one aspect, the flow cell is combustible.
    Type: Grant
    Filed: July 1, 2016
    Date of Patent: October 9, 2018
    Assignee: GE Healthcare Bio-Sciences AB
    Inventor: Hanno Ehring
  • Patent number: 10094481
    Abstract: The present invention relates to a device (1) for delivery of fluid, said device comprising at least two fluid ducts (12-17) of flexible material, each of which in one end can be connected to a fluid source and in the opposite end is connected to a manifold (18) having an inlet end and an outlet end, each of said fluid ducts (12-17) comprising a pinch valve (19) for closing and opening the duct. According to the invention a check valve (20) is disposed in at least one of said fluid ducts (12-17) in the end thereof connected to the manifold (18).
    Type: Grant
    Filed: March 28, 2013
    Date of Patent: October 9, 2018
    Assignee: GE Healthcare Bio-Sciences AB
    Inventors: Klaus Gebauer, Ekta Mahajan, Eric Faldt
  • Patent number: 10089850
    Abstract: Methods, systems, and apparatus to monitor component status in a bioprocessing environment are disclosed and described. Certain examples provide a sensor device for a disposable bioprocessing component. The example sensor device includes a first portion affixed to the component, the first portion configured to provide an identifier associated with the component. The example sensor device also includes a second portion configured to provide a status indication based on a state of the component. The example sensor device is configured to transmit the identifier and status indication to a control computer associated with a bioprocessing platform including the component.
    Type: Grant
    Filed: January 16, 2017
    Date of Patent: October 2, 2018
    Assignee: GE Healthcare Bio-Sciences AB
    Inventors: Radislav A. Potyrailo, Klaus Gebauer, Kajsa Stridsberg-Friden, Timothy A. Wortley
  • Patent number: 10081135
    Abstract: An integrated system for fusing and sealing of a plurality of tubes is disclosed. The integrated system includes one or more fusing units configured to cut one or more tubes of multiple tubes simultaneously, and fusing the one or more tubes together along their respective cut ends; one or more sealing units configured to seal an end of the tube of the multiple tubes; and a control unit for controlling functions of the one or more fusing units and the one or more sealing units.
    Type: Grant
    Filed: February 19, 2015
    Date of Patent: September 25, 2018
    Assignee: GE HEALTHCARE BIO-SCIENCES AB
    Inventors: Haresh Digambar Patil, Partha Sarathy Doddapadam Srinivasa Raghavachar, Ganesan Mariyappan, Prashanth Hosabettu Mohan
  • Patent number: 10047332
    Abstract: The invention relates to a bag locking mechanism comprising, a fixed locking means (106), provided with a first abutment surface (116), a movable locking means (108; 208), which is movable between a locking position and a releasing position, and a second abutment surface (118; 218) arranged on the movable locking means (108; 208). The fixed locking means (106) defines by its configuration, at least partly a restricted locking space (114), in which the movable locking means (108; 208) is movable between the locking and releasing position.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: August 14, 2018
    Assignee: GE HEALTHCARE BIO-SCIENCES AB
    Inventor: Patrik Akerstrom
  • Patent number: 10047869
    Abstract: A rotary valve comprising a stator with an inner stator face, and a rotor with an inner rotor face arranged in sealing contact with the inner stator face, the rotor is rotatably movable to a plurality of rotor positions about a rotational axis relative to the inner stator face, the stator comprises a plurality of connection ports each being in fluidic contact with a corresponding valve orifice at the inner stator face and the rotor comprises two or more interconnection paths for selective fluidic interconnection of said valve orifices with respect to the rotor position, wherein the stator comprises, an inlet port, an outlet port, a component feed port, a component return port, and wherein the interconnection paths in the rotor are arranged to: —in a first rotor position interconnect the inlet port with the outlet port, —in a second rotor position interconnect the inlet port with the component feed port and the component return port with the outlet port, —in a third rotor position interconnect the inlet port w
    Type: Grant
    Filed: April 12, 2017
    Date of Patent: August 14, 2018
    Assignee: GE Healthcare Bio-Sciences AB
    Inventors: Olle Bjernulf, Christer Olof Eriksson
  • Publication number: 20180221822
    Abstract: The disclosure generally relates to methods and apparatus for the efficient quantitative recovery of valuable biological fluids from filtration systems, more particularly to efficient quantitative recovery of valuable biological fluids from high precision separation systems suitable for use in the pharmaceutical and biotechnology industries.
    Type: Application
    Filed: August 17, 2016
    Publication date: August 9, 2018
    Applicant: GE Healthcare Bio-Sciences AB
    Inventors: Sasi Kumar Nutalapati, Klaus Gebauer, Karl Axel Jakob Liderfelt, Nachiket Karmarkar, Amit S. Vernekar, Ajit Kumar Sharma, Fredrik Oskar Lundstrom, Sangeetha Raghu Ramachandran
  • Patent number: 10040073
    Abstract: A method for purifying a substance in a solution in a simple streamlined process using a magnetic porous particle. For easy small scale purification of a substance, the magnetic porous particle is coated with either a hydrophilic or hydrophobic liquid and transferred into a second liquid containing the substance under conditions which allow said substance to partition into the first liquid within said magnetic porous particle. Finally the magnetic porous particle is removed from said second liquid, wherein the first and second liquid are substantially immiscible and the partition coefficient P of the substance between the first and second liquid is greater than 1.
    Type: Grant
    Filed: January 29, 2014
    Date of Patent: August 7, 2018
    Assignee: GE Healthcare Bio-Sciences AB
    Inventors: Nils Norrman, Pierre Le Greves
  • Patent number: 10023833
    Abstract: A temperature sensor means comprising a thermally conducting layer arranged to face the surface to be measured, a thermally insulating layer attached to the thermally conducting layer on the opposite side to the surface to be measured, a temperature sensor provided between the thermally conducting layer and the thermally insulating layer and being completely surrounded on all its sides by either the thermally conducting or the thermally insulating layers.
    Type: Grant
    Filed: June 16, 2014
    Date of Patent: July 17, 2018
    Assignee: GE HEALTHCARE BIO-SCIENCES AB
    Inventors: Patrik Akerstrom, Hakan Wahlnas
  • Patent number: 10011816
    Abstract: A method for stem or progenitor cell culture. More precisely, the invention relates to a method for cell culture using one or more I?I (inter-alpha trypsin inhibitor or inter-alpha inhibitor) protein(s) or part(s) thereof as a component in a cell culture media or a coating on a cell culture surface material. Furthermore the invention relates to a cell culture media and a cell culture coating/matrix provided with one or more I?I proteins(s) or part(s) thereof.
    Type: Grant
    Filed: October 7, 2016
    Date of Patent: July 3, 2018
    Assignee: GE HEALTHCARE BIO-SCIENCES AB
    Inventors: Sara Pijuan Galito, Christoffer Tamm, Cecilia Anneren
  • Patent number: 9994807
    Abstract: A temperature sensor means comprising a thermally conducting layer arranged to face the surface to be measured, a thermally insulating layer attached to the thermally conducting layer on the opposite side to the surface to be measured, a temperature sensor provided between the thermally conducting layer and the thermally insulating layer and being completely surrounded on all its sides by either the thermally conducting or the thermally insulating layers.
    Type: Grant
    Filed: June 16, 2014
    Date of Patent: June 12, 2018
    Assignee: GE HEALTHCARE BIO-SCIENCES AB
    Inventors: Patrik Akerstrom, Hakan Wahlnas
  • Publication number: 20180157229
    Abstract: A system for providing an improved way of user intuitive visual management of bioprocess automation is disclosed. The system includes a processor and a memory. The processor is configured to present a graphical presentation of the bioprocess automation script and results associated with execution of the bioprocess automation script of a bioprocess, wherein the graphical presentation comprises an anticipated result and an anticipated flow path associated with the bioprocess; and modify the graphical presentation by varying at least one of the anticipated result and the anticipated flow path.
    Type: Application
    Filed: April 21, 2016
    Publication date: June 7, 2018
    Applicant: GE Healthcare Bio-Sciences AB
    Inventors: Dalesh Dharamshi, Sudheer Mygapula
  • Patent number: 9987628
    Abstract: The present invention provides methods and systems for eluting and an analyte from a solid phase. The invention further provides methods and systems for transferring liquid analyte reagent mixtures from a solid phase to a second vessel, such as a microtiter plate well. The invention is useful in the manipulation of biological molecules such as nucleic acids, carbohydrates, proteins and peptides. In particular, the invention has utility for manipulating proteins and peptides in isoelectric focusing gels.
    Type: Grant
    Filed: November 26, 2014
    Date of Patent: June 5, 2018
    Assignee: GE HEALTHCARE BIO-SCIENCES AB
    Inventors: Tobias Ingemar Solderman, Nils Norrman, Henrik Ostlin, Susanna Lindman, David Carl Martin Bergman, Peter Mats Oliviusson
  • Patent number: 9983203
    Abstract: Provided are methods for protein analysis in which proteins to be analyzed are displayed on a population of discrete and dispersible structures, such as beads or other particles, for subsequent affinity reactions and analysis/detection. The proteins to be analyzed may be provided as denatured protein samples in the presence of a denaturing agent.
    Type: Grant
    Filed: February 12, 2015
    Date of Patent: May 29, 2018
    Assignee: GE HEALTHCARE BIO-SCIENCES AB
    Inventors: Daniel Ivansson, Camilla Estmer Nilsson, Therese Graner, Johan Ohman
  • Patent number: 9975123
    Abstract: The invention relates to a method for making a laminated microfluidics with membrane valves. The method comprises (a) generating a membrane valve assembly comprising (1) laminating three plastic foils together, the top foil comprising one through hole for each valve, the middle foil has a slit pattern connecting each valve hole of the top foil, and the bottom foil has one through hole for each valve and one additional hole entering the slit pattern; (2) placing the laminated foil, bottom foil down on a mould half having a smooth mould surface with one or more perpendicularly protruding cylinders that concentrically fit within the through holes of the laminated foil yet leave room for a membrane to form, and clamping a second mould half to close the mould; (3) injecting and allowing to cure a liquid rubber through a funnel associated with the bottom mould half and the additional hole on the bottom foil layer; and (b) laminating the membrane valve assembly and a flow path.
    Type: Grant
    Filed: November 28, 2014
    Date of Patent: May 22, 2018
    Assignee: GE HEALTHCARE BIO-SCIENCES AB
    Inventor: Stefan Sjolander
  • Patent number: 9976117
    Abstract: A method for stem or progenitor cell culture. More precisely, the invention relates to a method for cell culture using one or more I?I (inter-alpha trypsin inhibitor or inter-alpha inhibitor) protein(s) or part(s) thereof as a component in a cell culture media or a coating on a cell culture surface material. Furthermore the invention relates to a cell culture media and a cell culture coating/matrix provided with one or more I?I proteins(s) or part(s) thereof.
    Type: Grant
    Filed: October 7, 2016
    Date of Patent: May 22, 2018
    Assignee: GE HEALTHCARE BIO-SCIENCES AB
    Inventors: Sara Pijuan Galito, Christoffer Tamm, Cecilia Anneren
  • Patent number: 9975658
    Abstract: A disposable container comprising a side wall, top and bottom, wherein the side wall comprises a first flexible material and the bottom comprises a rigid or semi-rigid material. The side wall top and bottom are joined together to define the container with an interior compartment for keeping a fluid inside the container. The bottom comprises at least one opening that is fluid-tightly covered with an assembly comprising a second flexible material. The assembly comprises at least one port which provides access to the interior compartment of the container. The invention also relates to a mixing system comprising the disposable container.
    Type: Grant
    Filed: June 2, 2014
    Date of Patent: May 22, 2018
    Assignee: GE HEALTHCARE BIO-SCIENCES AB
    Inventors: David Rönnholm, Klaus Gebauer, Rolf Hjorth, Patrick Jonsson