Patents Assigned to GE Healthcare Bio-Sciences AB
  • Patent number: 9845894
    Abstract: Disclosed is a rotary valve 1 comprising a stator 20 and a rotor 40 generally in rotary sliding engagement with the said stator about a valve axis RA, the stator including a plurality of fluid ports 22, 26, 28, the rotor 40 being operable to selectively fluidically interconnect two or more of said ports during its rotary sliding engagement. The valve further includes an actuator (70) for disengagement of the rotor from the stator to enable efficient cleaning of the valve interconnections.
    Type: Grant
    Filed: October 8, 2014
    Date of Patent: December 19, 2017
    Assignee: GE Healthcare Bio-Sciences AB
    Inventor: Bjorn Olovsson
  • Patent number: 9845455
    Abstract: The present invention relates to a method for cell expansion. More closely, it relates to a method for expansion of cells, such as mesenchymal stem cells, on microcarriers in a plastic bag bioreactor. The invention enables expansion to therapeutic amounts of stem cells. The method comprises the following steps: a) addition of cells in cell culture medium and microcarriers to a plastic bag container; b) allowing the cells to adhere to the microcarriers while the container is kept substantially still; c) addition of further cell culture medium once the cells have adhered; d) culturing the cells under gentle and constant agitation; e) increase the surface area for continued culturing; and f) final harvesting of cells by an active detachment and separation step.
    Type: Grant
    Filed: April 19, 2013
    Date of Patent: December 19, 2017
    Assignee: GE Healthcare Bio-Sciences AB
    Inventors: Cecilia Anneren, Christian Kaisermayer, Mats Lundgren, Johanna Tschop, Therese Lundstrom, Ann-Christin Magnusson, Gerald Blueml
  • Publication number: 20170320922
    Abstract: The invention discloses a polypeptide with improved alkaline stability, which polypeptide comprises a mutant of a B or C domain of Staphylococcus Protein A (SpA), as specified by SEQ ID NO 1 or SEQ ID NO 2, or of Protein Z, as specified by SEQ ID NO 3, wherein at least the glutamic acid residue at position 15 has been mutated to an amino acid other than asparagine. The invention also discloses multimers of said polypeptide, as well as separation matrices comprising the multimers or polypeptides.
    Type: Application
    Filed: May 18, 2017
    Publication date: November 9, 2017
    Applicant: GE HEALTHCARE BIO-SCIENCES AB
    Inventors: Mats ANDER, Goran BAUREN, Tomas BJORKMAN, Gustav RODRIGO
  • Publication number: 20170313967
    Abstract: The present invention relates to a bioreactor including at least one reactor vessel in form of a plastic bag, a tray (4) for holding said at least one bag, a rocking device for limited rocking motions of the tray (4) around a rocking axis (2). According to the invention the bioreactor comprises a device (6,7,8,9) for enabling swinging of the tray (4) around a second axis (7) parallel to and distanced from the rocking axis (2).
    Type: Application
    Filed: July 18, 2017
    Publication date: November 2, 2017
    Applicant: GE HEALTHCARE BIO-SCIENCES AB
    Inventors: Andreas Andersson, Johan L. Carlsson, Christian Elnegard, Henrik K. Eriksson, Thomas Falkman, Patric Fricking, Linnea Pauler, Claes Petterson
  • Patent number: 9795909
    Abstract: A gas exhaust filter device for a bioreactor with reduced blockage by condensed liquid is disclosed, which comprises a housing with a filter medium, a gas inlet and a gas outlet and also further comprises a plurality of ribs extending from at least one inner wall of the housing in a region between the gas inlet and the filter medium.
    Type: Grant
    Filed: August 29, 2012
    Date of Patent: October 24, 2017
    Assignee: GE Healthcare Bio-Sciences AB
    Inventors: Henrik K. Eriksson, Patric Fricking, L. Johan Carlsson
  • Patent number: 9797871
    Abstract: The invention relates to a system and method for the stable storage of sensitive biological or chemical target substance, in a bound form on certain capture media. The method comprised providing a sample containing the target substance in a suitable buffer; combining the sample with a capture media to effect reversible binding of the target substance to the capture media; and storing the capture media with the target substance at between about ?20 and 20° C.; and recovering the target substance from the capture media. The target substance recovered maintains the desired activity. Also provides are methods for reducing aggregates in the sensitive biological or chemical target substance.
    Type: Grant
    Filed: April 28, 2011
    Date of Patent: October 24, 2017
    Assignee: GE Healthcare Bio-Sciences AB
    Inventors: James Van Alstine, Johan Ohman, Philippe Busson, Ronnie Palmgren, Klas Allmer, John Daicic
  • Publication number: 20170292909
    Abstract: The present invention discloses a flow cell optical detection system comprising a light source, a flow cell and a light detector, wherein the light detector is arranged in a separate detector unit that is arranged to be releasably attached to a detector interface, the detector interface being in optical communication with the light source and comprises optical connectors for optically connecting the flow cell and the detector unit in the light path from the light source, and wherein the flow cell is an interchangeable unit arranged to be held in position by the detector unit when attached to the detector interface.
    Type: Application
    Filed: June 26, 2017
    Publication date: October 12, 2017
    Applicant: GE HEALTHCARE BIO-SCIENCES AB
    Inventors: Hakan Frojdh, Mikael Hornqvist, Stig Tormod, Patrik Akerstrom
  • Publication number: 20170281921
    Abstract: The invention relates to a An aseptic connector comprising a first connection unit (102; 202; 302; 402; 502) provided with a first terminal end surface (104; 204; 304; 404; 504) and a second connection unit (106; 206; 306; 406; 506) provided with a second terminal end surface (108; 208; 308; 408; 508); said first and second terminal end surfaces are each provided with at least one first and second opening (110, 112; 210, 212; 310, 312; 410, 412; 510, 512), which openings are orientated to substantially coincide when said first and second connection units are connected to each other; said first and second openings are sealed by at least one film (114; 214; 314; 414; 514) arranged on said first and second connection units, so that the contact between the film and each connection unit is aseptic; said at least one film is adapted to be mated with a corresponding film on the other connection unit when said first and second connection units are connected to each other; and said mated films are adapted to be pulled
    Type: Application
    Filed: June 16, 2017
    Publication date: October 5, 2017
    Applicant: GE HEALTHCARE BIO-SCIENCES AB
    Inventors: Eric Faldt, Klaus Gebauer
  • Publication number: 20170248240
    Abstract: A rotary valve comprising a stator with an inner stator face, and a rotor with an inner rotor face arranged in sealing contact with the inner stator face, the rotor is rotatably movable to a plurality of rotor positions about a rotational axis relative to the inner stator face, the stator comprises a plurality of connection ports each being in fluidic contact with a corresponding valve orifice at the inner stator face and the rotor comprises two or more interconnection paths for selective fluidic interconnection of said valve orifices with respect to the rotor position, wherein the stator comprises, an inlet port, an outlet port, a component feed port, a component return port, and wherein the interconnection paths in the rotor are arranged to: in a first rotor position interconnect the inlet port with the outlet port, in a second rotor position interconnect the inlet port with the component feed port and the component return port with the outlet port, in a third rotor position interconnect the inlet port with
    Type: Application
    Filed: April 12, 2017
    Publication date: August 31, 2017
    Applicant: GE Healthcare Bio-Sciences AB
    Inventors: Olle Bjernulf, Christer Olof Eriksson
  • Patent number: 9738863
    Abstract: The present invention relates to a bioreactor including at least one reactor vessel in form of a plastic bag, a tray (4) for holding said at least one bag, a rocking device for limited rocking motions of the tray (4) around a rocking axis (2). According to the invention the bioreactor comprises a device (6,7,8,9) for enabling swinging of the tray (4) around a second axis (7) parallel to and distanced from the rocking axis (2).
    Type: Grant
    Filed: February 21, 2012
    Date of Patent: August 22, 2017
    Assignee: GE Healthcare Bio-Sciences AB
    Inventors: Andreas Andersson, Johan L. Carlsson, Christian Elnegard, Henrik K. Eriksson, Thomas Falkman, Patric Fricking, Linnea Pauler, Claes Petterson
  • Publication number: 20170232363
    Abstract: The invention discloses a method for predicting the pH error during mixing of an aqueous buffer comprising at least one weak acid species and/or at least one weak base species, which comprises the steps of: a) selecting a start composition of the buffer, giving start values for pH and/or buffer concentration; b) calculating the concentrations of all ionic species present in the buffer at a specified pH value from the total composition of the buffer and available dissociation constants; c) calculating the contribution of each of said ionic species to a total pH variance from the specified pH value, the buffer concentration, the calculated concentrations of the ionic species and variances in amounts of buffer components; d) calculating the pH variance, and; e) setting the variance or the square root of the pH variance as the pH error.
    Type: Application
    Filed: October 26, 2015
    Publication date: August 17, 2017
    Applicant: GE Healthcare Bio-Sciences AB
    Inventors: Enrique Napoleon CARREDANO, Elenor Strandberg
  • Patent number: 9719917
    Abstract: The present invention discloses a flow cell optical detection system comprising a light source, a flow cell and a light detector, wherein the light detector is arranged in a separate detector unit that is arranged to be releasably attached to a detector interface, the detector interface being in optical communication with the light source and comprises optical connectors for optically connecting the flow cell and the detector unit in the light path from the light source, and wherein the flow cell is an interchangeable unit arranged to be held in position by the detector unit when attached to the detector interface.
    Type: Grant
    Filed: November 23, 2009
    Date of Patent: August 1, 2017
    Assignee: GE Healthcare Bio-Sciences AB
    Inventors: Hakan Frojdh, Mikael Hornqvist, Stig Tormod, Patrik Akerstrom
  • Patent number: 9714415
    Abstract: A method for stem or progenitor cell culture. More precisely, the invention relates to a method for cell culture using one or more I?I (inter-alpha trypsin inhibitor or Inter-alpha inhibitor) protein(s) or part(s) thereof as a component in a cell culture media or a coating on a cell culture surface material. Furthermore the invention relates to a cell culture media and a cell culture coating/matrix provided with one or more I?I proteins(s) or part(s) thereof.
    Type: Grant
    Filed: October 7, 2016
    Date of Patent: July 25, 2017
    Assignee: GE Healthcare Bio-Sciences AB
    Inventors: Sara Pijuan Galito, Christoffer Tamm, Cecilia Anneren
  • Patent number: 9709589
    Abstract: Automated fluid handling system comprising a housing and two or more fluid handling units arranged as interchangeable modular components with an external fluidics section and an internal non fluidics section, and wherein the housing comprises a liquid handling panel with two or more of component positions for receiving said interchangeable modular components such that the external fluidics section is separated from the non fluidics section by the liquid handling panel.
    Type: Grant
    Filed: May 26, 2016
    Date of Patent: July 18, 2017
    Assignee: GE HEALTHCARE BIO-SCIENCES AB
    Inventors: Johan Blomberg, Mats Lundkvist
  • Patent number: 9709590
    Abstract: Automated fluid handling system comprising a housing and two or more fluid handling units arranged as interchangeable modular components with an external fluidics section and an internal non fluidics section, and wherein the housing comprises a liquid handling panel with two or more of component positions for receiving said interchangeable modular components such that the external fluidics section is separated from the non fluidics section by the liquid handling panel.
    Type: Grant
    Filed: July 8, 2016
    Date of Patent: July 18, 2017
    Assignee: GE HEALTHCARE BIO-SCIENCES AB
    Inventors: Johan Blomberg, Mats Lundkvist
  • Patent number: 9709591
    Abstract: Automated fluid handling system comprising a housing and two or more fluid handling units arranged as interchangeable modular components with an external fluidics section and an internal non fluidics section, and wherein the housing comprises a liquid handling panel with two or more of component positions for receiving said interchangeable modular components such that the external fluidics section is separated from the non fluidics section by the liquid handling panel.
    Type: Grant
    Filed: July 8, 2016
    Date of Patent: July 18, 2017
    Assignee: GE HEALTHCARE BIO-SCIENCES AB
    Inventors: Johan Blomberg, Mats Lundkvist
  • Patent number: 9687756
    Abstract: A method for conducting maintenance on a chromatography column (1; 51), said column comprising a column tube (32), a top end cell (20) and a bottom end cell (26), where during chromatography said column tube (32) is secured between said top end cell (20) and said bottom end cell (26). Said method comprises the step of rotating at least the top end cell (20) 180 degrees around a horizontal axis before maintenance is conducted to the top end cell (20).
    Type: Grant
    Filed: January 21, 2014
    Date of Patent: June 27, 2017
    Assignee: GE Healthcare Bio-Sciences AB
    Inventors: Per Lofving, Kyril Dambuleff, John Davis
  • Patent number: 9675947
    Abstract: The present invention relates to a mixing system comprising a vessel (1) for housing a disposable fluid mixing bag (2), which vessel (1) comprises a base (3) supporting the fluid mixing bag (2) and a sidewall (4) extending vertically upwards from the base (3). The sidewall (4) of the vessel comprises a door opening (5) which is closable by a sliding door (6). The system with the sliding door provides an easy access to the inside of the vessel (1) in a space saving manner.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: June 13, 2017
    Assignee: GE Healthcare Bio-Sciences AB
    Inventors: Klaus Gebauer, Patrick Jonsson, David Ronnholm
  • Patent number: 9671420
    Abstract: Automated fluid handling system comprising a housing and two or more fluid handling units arranged as interchangeable modular components with an external fluidics section and an internal non fluidics section, and wherein the housing comprises a liquid handling panel with two or more of component positions for receiving said interchangeable modular components such that the external fluidics section is separated from the non fluidics section by the liquid handling panel.
    Type: Grant
    Filed: September 9, 2016
    Date of Patent: June 6, 2017
    Assignee: GE HEALTHCARE BIO-SCIENCES AB
    Inventors: Johan Blomberg, Mats Lundkvist
  • Patent number: D802710
    Type: Grant
    Filed: June 7, 2016
    Date of Patent: November 14, 2017
    Assignee: GE HEALTHCARE BIO-SCIENCES AB
    Inventors: Amit Kumar Singh, Klaus Gebauer, Supti Datta, Karl Axel Jakob Liderfelt, Nachiket Karmarkar, Ajit S. Vernekar, Mats Olsson, Amit Kumar Sharma, Sasi Kumar Nutalapati, Fredrik Oskar Lundstrom, Jean Pierre Neff